Delirium Bibliography

Delirium Bibliography books graphicWhat is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!

How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.

Reference Information

Title
Extracellular Vesicle MicroRNAs as Predictive Biomarkers in Postoperative Delirium After Spine Surgery: Preliminary Study
Authors
Cho, Y. E. Kim, J. Vorn, R. Cho, H. Baek, W. Park, H. Yun, S. Kim, H. S. Cashion, A. K. Gill, J. Koo, B. N. Lee, H.
Year
2024
Journal
J Gerontol A Biol Sci Med Sci
Abstract

Postoperative delirium (POD) can cause poor patient outcomes in older adults who undergo surgery. In this study, we tested plasma extracellular vesicle (EV) miRNAs obtained before the delirium event to find predictive POD biomarkers after spine surgery. We recruited patients who are more than 70 years old and have undergone spine surgery. Finally, POD patients (n = 31) were included, with no-POD patients matched in age, sex, medical history, and type of surgery (n = 31). Peripheral blood was collected from patients in the operating room after the operation was completed. EVs were isolated from plasma, and the 798 miRNA expression level from EVs was measured using a NanoString platform. Sixty-two patients were included in the study; all were Korean, 67.7% were females, and the median age was 75 years. Preoperative medical history was not statistically different between no-POD and POD patients except for hypertension and the American Society of Anesthesiologists physical status. From the miRNA profiling, we identified 142 significantly differentially expressed miRNAs in POD patients compared with no-POD patients, which are associated with psychological/neurological disorders. The top 10 differentially expressed miRNAs including miR-548ar-5p and miR-627-5p were all upregulated in POD patients and the results were validated using qRT-PCR from the independent sets of samples (n = 96). We demonstrated the potential of plasma EV-miRNAs as predictive biomarkers to identify the risk group of POD after spine surgery. It also provides opportunities for future studies investigating the role of EV-miRNAs in delirium pathology.

PMID

PMID: 38970345

PMCID: PMC11398910

Keywords

Humans
Female
Male
Aged
*Extracellular Vesicles/metabolism
*MicroRNAs/blood
*Biomarkers/blood
*Delirium/blood/etiology
*Postoperative Complications/blood
Spine/surgery
Aged, 80 and over
Exosome
Genomics
Prediction

Page(s)
Issue

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Total Records Found: 6272, showing 100 per page
TitleAuthorsJournalYearKeywords
Effect of fasting on hypoxia tolerance of mice in relation to oxygen consumption and heart rate. Watanabe C, Suzuki T Aviation, space, and environmental medicine 1985

Animals, Anoxia, physiopathology, Body Weight, Energy Metabolism, Fasting, Heart Rate, Male, Mice, Mice, Inbred ICR, Oxygen, blood

Acute confusional states in the elderly: an algorithm. Foreman MD Dimensions of critical care nursing : DCCN 1984

Aged, Cognition Disorders, Confusion, Geriatric Nursing, Humans, Nursing Assessment, Nursing Process, Patient Care Planning

Transient cognitive disorders (delirium, acute confusional states) in the elderly. Lipowski ZJ The American journal of psychiatry 1983

Acute Disease, Aged, Cognition Disorders, diagnosis, Confusion, diagnosis, Delirium, diagnosis, Dementia, diagnosis, Diagnosis, Differential, Humans, Stress, Psychological, psychology

Adverse consequences of hospitalization in the elderly. Gillick MR, Serrell NA, Gillick LS Social science & medicine (1982) 1982

Aged, psychology, Boston, Confusion, psychology, Eating Disorders, psychology, Hospital Bed Capacity, 500 and over, Hospitalization, Humans, Iatrogenic Disease, epidemiology, Prospective Studies, Psychophysiologic Disorders, Social Adjustment, Urinary Incontinence, psychology

How to prevent confusion in hospitalized elderly. Remakus BL, Shelly RM Geriatrics 1981

Aged, Cognition Disorders, prevention & control, Confusion, prevention & control, Female, Hospitalization, Humans, Male

The relationship of 'nuclear' and 'atypical' psychoses: some proposals for a classification of disorders in the borderlands of schizophrenia. Roth M, McClelland H Psychiatria clinica 1979

Adult, Brain Diseases, diagnosis, Delirium, Dementia, Amnestic, Cognitive Disorders, diagnosis, Diagnosis, Differential, Humans, Male, Prognosis, Psychoses, Substance-Induced, diagnosis, Psychotic Disorders, classification, Schizophrenia, diagnosis, Schizophrenic Psychology, Substance-Related Disorders, diagnosis, Suicide, Attempted, psychology, Time Factors

A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. Pfeiffer E Journal of the American Geriatrics Society 1975

Aged, Continental Population Groups, Delirium, Dementia, Amnestic, Cognitive Disorders, diagnosis, Educational Status, Humans, Intelligence Tests, Mental Disorders, diagnosis, Psychiatric Status Rating Scales, Psychometrics

The cause of delirium in patients with hip fracture. Brauer C, Morrison RS, Silberzweig SB, Siu AL Archives of internal medicine 2000

Aged, Aged, 80 and over, Confounding Factors (Epidemiology), Delirium, chemically induced, Female, Hip Fractures, complications, Humans, Male, Mental Status Schedule, New York City, epidemiology, Prevalence, Prospective Studies, Risk Factors

Large neutral amino acid changes and delirium in febrile elderly medical patients. Flacker JM, Lipsitz LA The journals of gerontology. Series A, Biological sciences and medical sciences 2000

Aged, Aged, 80 and over, Amino Acids, blood, Chromatography, High Pressure Liquid, Delirium, blood, Female, Fever, blood, Frail Elderly, Humans, Linear Models, Male, Phenylalanine, blood, Prospective Studies, Tryptophan, blood

The role of the advanced practice nurse in facilitating a clinical research study. Screening for delirium. Lacko LA, Dellasega C, Salerno FA, Singer H, DeLucca J, Rothenberger C Clinical nurse specialist CNS 2000

Aged, Aged, 80 and over, Clinical Nursing Research, Delirium, diagnosis, Education, Nursing, Continuing, Female, Geriatric Assessment, Geriatric Nursing, methods, Hospitals, Community, Humans, Male, Mass Screening, nursing, Nurse Clinicians, Nursing Staff, Hospital, Staff Development

A comparison of pain and its treatment in advanced dementia and cognitively intact patients with hip fracture. Morrison RS, Siu AL Journal of pain and symptom management 2000

Aged, Aged, 80 and over, Cognition Disorders, complications, Cohort Studies, Dementia, complications, Female, Hip Fractures, complications, Humans, Male, Pain, complications

Prevalence and detection of delirium in elderly emergency department patients. Elie M, Rousseau F, Cole M, Primeau F, McCusker J, Bellavance F CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2000

Age Factors, Aged, Aged, 80 and over, Confidence Intervals, Confusion, diagnosis, Delirium, diagnosis, Demography, Emergency Service, Hospital, statistics & numerical data, Female, Hospitals, Teaching, Humans, Lung Diseases, diagnosis, Male, Medical Records, Mental Status Schedule, Nervous System Diseases, diagnosis, Prevalence, Quebec, epidemiology, Sensitivity and Specificity, Severity of Illness Index, Single-Blind Method

The bedside confusion scale: development of a portable bedside test for confusion and its application to the palliative medicine population. Stillman MJ, Rybicki LA Journal of palliative medicine 2000
Development and validation of a brief observer-rated screening scale for depression in elderly medical patients. Hammond MF, O'Keeffe ST, Barer DH Age and ageing 2000

Aged, Aged, 80 and over, Depression, diagnosis, Female, Geriatric Assessment, Health Services for the Aged, Humans, Male, Predictive Value of Tests, Psychiatric Status Rating Scales, standards, Sensitivity and Specificity

Predisposing and precipitating factors for delirium in hospitalized older patients. Inouye SK Dementia and geriatric cognitive disorders 1999

Aged, Causality, Cohort Studies, Delirium, epidemiology, Disease Susceptibility, Hospitalization, statistics & numerical data, Humans, Models, Neurological, Prospective Studies

Goal-setting in clinical medicine. Bradley EH, Bogardus ST, Tinetti ME, Inouye SK Social science & medicine (1982) 1999

Aged, Aged, 80 and over, Communication, Dementia, Female, Geriatric Assessment, Goals, Humans, Male, Physician-Patient Relations, Professional-Family Relations, Risk-Taking, Social Values

Epidemiology of delirium. Bucht G, Gustafson Y, Sandberg O Dementia and geriatric cognitive disorders 1999

Aged, Aged, 80 and over, Delirium, epidemiology, Health Services for the Aged, statistics & numerical data, Hospitals, General, statistics & numerical data, Humans, Incidence, Postoperative Complications, Prevalence, World Health

Delirium in an acute geriatric unit: clinical aspects. Feldman J, Yaretzky A, Kaizimov N, Alterman P, Vigder C Archives of gerontology and geriatrics 1999
A multicomponent intervention to prevent delirium in hospitalized older patients. Inouye SK, Bogardus ST, Charpentier PA, Leo-Summers L, Acampora D, Holford TR, Cooney LM The New England journal of medicine 1999

Aged, psychology, Aged, 80 and over, psychology, Clinical Protocols, Delirium, classification, Female, Hospitalization, Humans, Incidence, Logistic Models, Male, Prospective Studies, Risk Factors, Treatment Outcome

Delirium: a symptom of how hospital care is failing older persons and a window to improve quality of hospital care. Inouye SK, Schlesinger MJ, Lydon TJ The American journal of medicine 1999

Aged, Attitude of Health Personnel, Clinical Competence, Delirium, diagnosis, Diagnosis, Differential, Education, Medical, Hospitalization, Humans, Iatrogenic Disease, Nursing Service, Hospital, standards, Organizational Innovation, Quality of Health Care, trends, Total Quality Management, United States

Drug-induced cognitive impairment in the elderly. Moore AR, O'Keeffe ST Drugs & aging 1999

Aged, Anti-Inflammatory Agents, Non-Steroidal, adverse effects, Cholinergic Antagonists, adverse effects, Delirium, chemically induced, Dementia, chemically induced, Histamine H2 Antagonists, adverse effects, Humans, Psychotropic Drugs, adverse effects

Clinical significance of delirium subtypes in older people. O'Keeffe ST, Lavan JN Age and ageing 1999

Aged, Aged, 80 and over, Antipsychotic Agents, therapeutic use, Delirium, classification, Haloperidol, therapeutic use, Humans, Prospective Studies, Psychomotor Disorders, complications, Thioridazine, therapeutic use

Validity of the confusion assessment method in detecting postoperative delirium in the elderly. Rolfson DB, McElhaney JE, Jhangri GS, Rockwood K International psychogeriatrics / IPA 1999

Aged, Confusion, diagnosis, Coronary Artery Bypass, adverse effects, Delirium, diagnosis, Female, Humans, Male, Nursing Assessment, standards, Observer Variation, Postoperative Care, Predictive Value of Tests, Prospective Studies, Psychiatric Status Rating Scales, standards, ROC Curve, Reproducibility of Results, Sensitivity and Specificity

Serum anticholinergic activity changes with acute illness in elderly medical patients. Flacker JM, Lipsitz LA The journals of gerontology. Series A, Biological sciences and medical sciences 1999

Acute Disease, Aged, Aged, 80 and over, Analysis of Variance, Atropine, blood, Attention, physiology, Cholinergic Antagonists, blood, Cognition, physiology, Confusion, blood, Consciousness, physiology, Cross-Sectional Studies, Delirium, blood, Female, Fever, blood, Follow-Up Studies, Humans, Logistic Models, Male, Muscarinic Antagonists, blood, Quinuclidinyl Benzilate, diagnostic use, Radiopharmaceuticals, diagnostic use, Thinking, physiology, Tritium, diagnostic use

Importance of serum anticholinergic activity in the assessment of elderly patients with delirium. Mussi C, Ferrari R, Ascari S, Salvioli G Journal of geriatric psychiatry and neurology 1999

Aged, Aged, 80 and over, Anti-Bacterial Agents, therapeutic use, Antipsychotic Agents, adverse effects, Benzodiazepines, adverse effects, Body Weight, Cholinergic Antagonists, adverse effects, Cross-Sectional Studies, Delirium, etiology, Female, Humans, Male, Risk Factors

Changing clinical practice through research: the case of delirium. Lacko L, Bryan Y, Dellasega C, Salerno F Clinical nursing research 1999

Aged, Aged, 80 and over, Clinical Nursing Research, education, Clinical Protocols, standards, Delirium, diagnosis, Diffusion of Innovation, Female, Geriatric Assessment, Health Knowledge, Attitudes, Practice, Humans, Male, Mass Screening, methods, Nursing Assessment, methods, Nursing Staff, Hospital, education, Nursing Theory

Delirium in the elderly. Optimal management. Flacker JM, Marcantonio ER Drugs & aging 1998

Aged, Antipsychotic Agents, administration & dosage, Behavior Therapy, methods, Combined Modality Therapy, Counseling, Delirium, prevention & control, Guidelines as Topic, Humans, Risk Factors, Syndrome

The time and change test: a simple screening test for dementia. Inouye SK, Robison JT, Froehlich TE, Richardson ED The journals of gerontology. Series A, Biological sciences and medical sciences 1998

Activities of Daily Living, classification, Aged, Aged, 80 and over, Ambulatory Care Facilities, statistics & numerical data, Connecticut, epidemiology, Dementia, diagnosis, Female, Geriatric Assessment, statistics & numerical data, Humans, Incidence, Linear Models, Male, Mental Status Schedule, Primary Health Care, Prospective Studies, Psychometrics, Reproducibility of Results, Sensitivity and Specificity

Prospective individual matching: covariate balance and power in a comparative study. Makuch RW, Zhang Z, Charpentier PA, Inouye SK Statistics in medicine 1998

Analysis of Variance, Clinical Trials, Phase II as Topic, statistics & numerical data, Clinical Trials, Phase IV as Topic, statistics & numerical data, Humans, Matched-Pair Analysis, Randomized Controlled Trials as Topic, statistics & numerical data, Selection Bias

Importance of functional measures in predicting mortality among older hospitalized patients. Inouye SK, Peduzzi PN, Robison JT, Hughes JS, Horwitz RI, Concato J JAMA 1998

Activities of Daily Living, Aged, Connecticut, Cost of Illness, Female, Hospital Bed Capacity, 500 and over, Hospitalization, statistics & numerical data, Hospitals, University, Humans, Male, Mental Status Schedule, Models, Statistical, Mortality, Outcome Assessment (Health Care), statistics & numerical data, Prognosis, Proportional Hazards Models, Prospective Studies, Risk Assessment, Severity of Illness Index, Survival Analysis

Delirium: comparison of four predictive models in hospitalized critically ill elderly patients. Eden BM, Foreman MD, Sisk R Applied nursing research : ANR 1998

Aged, Aged, 80 and over, Algorithms, Case-Control Studies, Critical Care, Delirium, diagnosis, Discriminant Analysis, Female, Humans, Male, Middle Aged, Nursing Diagnosis, methods, Sensitivity and Specificity

A case control study of falls in the hospital setting. Ash KL, MacLeod P, Clark L Journal of gerontological nursing 1998

Accidental Falls, prevention & control, Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Child, Discriminant Analysis, Female, Hospitals, University, Humans, Male, Middle Aged, Nursing Records, Risk Factors, Risk Management, Saskatchewan, Wounds and Injuries, etiology

Delirium risk factors in elderly hospitalized patients. Elie M, Cole MG, Primeau FJ, Bellavance F Journal of general internal medicine 1998

Age Factors, Aged, Delirium, epidemiology, Female, Humans, Inpatients, Male, Risk Factors

Delirium in hospitalized older patients: recognition and risk factors. Inouye SK Journal of geriatric psychiatry and neurology 1998

Aged, Aged, 80 and over, Cohort Studies, Delirium, diagnosis, Female, Humans, Inpatients, Nutrition Disorders, physiopathology, Polypharmacy, Predictive Value of Tests, Primary Prevention, methods, Psychiatric Status Rating Scales, standards, Restraint, Physical, adverse effects, Risk Assessment, Risk Factors, Urinary Catheterization, adverse effects

Immobility and falls. Mahoney JE Clinics in geriatric medicine 1998

Accidental Falls, Aged, Aged, 80 and over, Hospitalization, Humans, Immobilization, adverse effects

A nonpharmacologic sleep protocol for hospitalized older patients. McDowell JA, Mion LC, Lydon TJ, Inouye SK Journal of the American Geriatrics Society 1998

Aged, Aged, 80 and over, Cohort Studies, Connecticut, Female, Geriatric Assessment, Hospitalization, Humans, Hypnotics and Sedatives, administration & dosage, Male, Prospective Studies, Sleep Initiation and Maintenance Disorders, nursing, Treatment Outcome

Detection and diagnosis of delirium in the elderly: psychiatrist diagnosis, confusion assessment method, or consensus diagnosis? Zou Y, Cole MG, Primeau FJ, McCusker J, Bellavance F, Laplante J International psychogeriatrics / IPA 1998

Aged, Aged, 80 and over, Confusion, diagnosis, Delirium, diagnosis, Female, Geriatric Assessment, Humans, Male, Mental Status Schedule, standards, Nurse Clinicians, Nursing Assessment, standards, Observer Variation, Psychiatry, Reproducibility of Results, Sensitivity and Specificity

Reliability and validity of a new measure of severity of delirium. McCusker J, Cole M, Bellavance F, Primeau F International psychogeriatrics / IPA 1998

Aged, Aged, 80 and over, Confidence Intervals, Delirium, diagnosis, Female, Geriatric Assessment, Humans, Male, Observer Variation, Prospective Studies, Psychiatric Status Rating Scales, standards, Psychometrics, standards, Reproducibility of Results, Severity of Illness Index

Does delirium contribute to poor hospital outcomes? A three-site epidemiologic study. Inouye SK, Rushing JT, Foreman MD, Palmer RM, Pompei P Journal of general internal medicine 1998

Activities of Daily Living, Aged, Delirium, Female, Hospital Mortality, Hospitalization, Humans, Male, Prognosis, Prospective Studies

The impact of postoperative pain on the development of postoperative delirium. Lynch EP, Lazor MA, Gellis JE, Orav J, Goldman L, Marcantonio ER Anesthesia and analgesia 1998

Activities of Daily Living, Age Factors, Aged, Alcoholism, complications, Analgesia, Analgesics, Opioid, administration & dosage, Blood Chemical Analysis, Cognition, Confusion, diagnosis, Delirium, diagnosis, Female, Humans, Incidence, Male, Medical Records, Middle Aged, Movement, Nursing Assessment, Odds Ratio, Pain Measurement, Pain, Postoperative, complications, Postoperative Complications, diagnosis, Prospective Studies, Rest, Risk Factors, Surgical Procedures, Operative

The association of serum anticholinergic activity with delirium in elderly medical patients. Flacker JM, Cummings V, Mach JR, Bettin K, Kiely DK, Wei J The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 1998

Aged, Aged, 80 and over, Boston, Cholinergic Antagonists, adverse effects, Cross-Sectional Studies, Delirium, blood, Female, Humans, Logistic Models, Male, Multivariate Analysis, Odds Ratio

The association of intraoperative factors with the development of postoperative delirium. Marcantonio ER, Goldman L, Orav EJ, Cook EF, Lee TH The American journal of medicine 1998

Aged, Anesthesia, adverse effects, Blood Loss, Surgical, Delirium, epidemiology, Female, Humans, Incidence, Intraoperative Care, Intraoperative Complications, Male, Middle Aged, Postoperative Complications, epidemiology, Prospective Studies

Diagnosing delirium by telephone. Marcantonio ER, Michaels M, Resnick NM Journal of general internal medicine 1998

Aged, Aged, 80 and over, Delirium, diagnosis, Diagnostic Errors, Female, Frail Elderly, Humans, Interviews as Topic, Male, Massachusetts, Remote Consultation, Sensitivity and Specificity, Telephone

Measuring delirium severity in older general hospital inpatients without dementia. The Delirium Severity Scale. Bettin KM, Maletta GJ, Dysken MW, Jilk KM, Weldon DT, Kuskowski M, Mach JR The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 1998

Age Factors, Aged, Cognition Disorders, diagnosis, Delirium, diagnosis, Dementia, diagnosis, Female, Hospitalization, Hospitals, General, Humans, Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index

Screening for dementia in the outpatient setting: the time and change test. Froehlich TE, Robison JT, Inouye SK Journal of the American Geriatrics Society 1998

Activities of Daily Living, classification, Aged, Aged, 80 and over, Ambulatory Care Facilities, statistics & numerical data, Cohort Studies, Connecticut, epidemiology, Cross-Sectional Studies, Dementia, diagnosis, Female, Geriatric Assessment, statistics & numerical data, Humans, Incidence, Male, Mental Status Schedule, statistics & numerical data, Primary Health Care, statistics & numerical data, Prospective Studies, Psychometrics, Reproducibility of Results

Behavioral and pharmacologic treatment of delirium. Jacobson S, Schreibman B American family physician 1997

Cognitive Therapy, Delirium, drug therapy, Humans

Delirium in geropsychiatric patients: patient characteristics and treatment outcomes. McGee SB, Orengo CA, Kunik ME, Molinari VA, Workman RH Journal of geriatric psychiatry and neurology 1997

Activities of Daily Living, psychology, Aged, Aged, 80 and over, Antipsychotic Agents, administration & dosage, Cohort Studies, Combined Modality Therapy, Delirium, diagnosis, Delirium, Dementia, Amnestic, Cognitive Disorders, diagnosis, Dementia, diagnosis, Depressive Disorder, diagnosis, Female, Hospitalization, Humans, Length of Stay, Male, Mental Status Schedule, Neuropsychological Tests, Patient Care Team, Psychiatric Status Rating Scales, Retrospective Studies, Social Environment

Assessing attentiveness in older hospital patients: global assessment versus tests of attention. O'Keeffe ST, Gosney MA Journal of the American Geriatrics Society 1997

Aged, Aged, 80 and over, Attention, Delirium, diagnosis, Dementia, diagnosis, Hospitalization, Humans, Interview, Psychological, Likelihood Functions, Psychological Tests, Sensitivity and Specificity

Development and evaluation of evidence based risk assessment tool (STRATIFY) to predict which elderly inpatients will fall: case-control and cohort studies. Oliver D, Britton M, Seed P, Martin FC, Hopper AH BMJ (Clinical research ed.) 1997

Accidental Falls, prevention & control, Aged, Aged, 80 and over, Case-Control Studies, Cohort Studies, Evidence-Based Medicine, Geriatric Assessment, Hospitals, Urban, Humans, Inpatients, classification, Length of Stay, London, Prospective Studies, Risk Assessment, Sensitivity and Specificity, State Medicine

The natural history of delirium in older hospitalized patients: a syndrome of heterogeneity. Rudberg MA, Pompei P, Foreman MD, Ross RE, Cassel CK Age and ageing 1997

Aged, Aged, 80 and over, Cohort Studies, Delirium, classification, Female, Geriatric Assessment, Humans, Length of Stay, Male, Patient Admission, Prospective Studies, Psychiatric Status Rating Scales, Risk Factors

The informed consent process in older patients who developed delirium: a clinical epidemiologic study. Auerswald KB, Charpentier PA, Inouye SK The American journal of medicine 1997

Aged, Aged, 80 and over, Cognition, Delirium, psychology, Female, Hospitalization, Humans, Informed Consent, Male, Multivariate Analysis, Odds Ratio, Predictive Value of Tests, Severity of Illness Index

The incidence of delirium in psychiatric inpatient units. Patten SB, Williams JV, Haynes L, McCruden J, Arboleda-Flórez J Canadian journal of psychiatry. Revue canadienne de psychiatrie 1997

Adolescent, Adult, Aged, Aged, 80 and over, Alberta, epidemiology, Cross-Sectional Studies, Delirium, diagnosis, Female, Humans, Incidence, Length of Stay, statistics & numerical data, Male, Middle Aged, Neuropsychological Tests, Patient Admission, statistics & numerical data, Psychiatric Department, Hospital, statistics & numerical data, Risk Factors, Selection Bias

Impact of age on the severity, course, and complications of alcohol withdrawal. Kraemer KL, Mayo-Smith MF, Calkins DR Archives of internal medicine 1997

Adult, Age Factors, Aged, Alcohol Withdrawal Delirium, complications, Anti-Anxiety Agents, therapeutic use, Benzodiazepines, Female, Humans, Length of Stay, Male, Middle Aged, Odds Ratio, Severity of Illness Index

Delirium in AIDS patients: recognition and medication factors. Uldall KK, Berghuis JP AIDS patient care and STDs 1997

Acquired Immunodeficiency Syndrome, complications, Adult, Aged, Delirium, classification, Drug-Related Side Effects and Adverse Reactions, Female, Humans, Length of Stay, Logistic Models, Male, Middle Aged, Models, Biological, Retrospective Studies, Skilled Nursing Facilities

Screening for acute confusion in elderly long-term care residents. Culp K, Tripp-Reimer T, Wadle K, Wakefield B, Akins J, Mobily P, Kundradt M The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses 1997

Acute Disease, Aged, Aged, 80 and over, Alzheimer Disease, diagnosis, Confusion, diagnosis, Cross-Sectional Studies, Diagnosis, Differential, Female, Humans, Incidence, Iowa, Long-Term Care, statistics & numerical data, Male, Mass Screening, Middle Aged

Cognitive impairment in medical inpatients. I: Screening for dementia--is history better than mental state? Harwood DM, Hope T, Jacoby R Age and ageing 1997

Aged, Aged, 80 and over, Cognition Disorders, diagnosis, Dementia, diagnosis, Female, Geriatric Assessment, Humans, Male, Mass Screening, Medical History Taking, Mental Status Schedule, statistics & numerical data, Neuropsychological Tests, statistics & numerical data, Patient Admission, Psychometrics, Reproducibility of Results

Computed tomography scanning and delirium in elder patients. Naughton BJ, Moran M, Ghaly Y, Michalakes C Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 1997

Acute Disease, Aged, Aged, 80 and over, Cognition Disorders, classification, Delirium, classification, Emergency Medicine, Emergency Service, Hospital, Female, Humans, Male, Neurologic Examination, Physician’s Practice Patterns, Prospective Studies, Retrospective Studies, Tomography, X-Ray Computed

Ascertaining dementia by expert panel in epidemiologic studies of nursing home residents. Magaziner J, Zimmerman SI, German PS, Kuhn K, May C, Hooper F, Cox D, Hebel JR, Kittner S, Burton L, Fishman P, Kaup B, Rosario J, Cody M Annals of epidemiology 1996

Aged, Aged, 80 and over, Dementia, diagnosis, Epidemiologic Methods, Female, Geriatric Assessment, Homes for the Aged, Humans, Male, Maryland, epidemiology, Nursing Homes, Prevalence

Effectiveness of interventions to prevent delirium in hospitalized patients: a systematic review. Cole MG, Primeau F, McCusker J CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 1996

Delirium, prevention & control, Hospitalization, Humans, Postoperative Care, Preoperative Care, Randomized Controlled Trials as Topic

Precipitating factors for delirium in hospitalized elderly persons. Predictive model and interrelationship with baseline vulnerability. Inouye SK, Charpentier PA JAMA : the journal of the American Medical Association 1996

Aged, Aged, 80 and over, Algorithms, Cohort Studies, Confusion, diagnosis, Delirium, diagnosis, Female, Geriatric Assessment, Hospitalization, Humans, Male, Models, Theoretical, Precipitating Factors, Probability, Prospective Studies, Psychiatric Status Rating Scales, Reproducibility of Results, Risk

A clinical project to reduce confusion in hospitalized, older adults. Miller J Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses 1996

Activities of Daily Living, Aged, Clinical Nursing Research, Confusion, nursing, Geriatric Assessment, Health Facility Environment, Hospitalization, Humans, Nursing Assessment, Patient Care Planning, Pilot Projects, Risk Factors

Acute cognitive impairment in elderly ED patients: etiologies and outcomes. Wofford JL, Loehr LR, Schwartz E The American journal of emergency medicine 1996

Acute Disease, Aged, Cognition Disorders, diagnosis, Emergency Service, Hospital, Female, Geriatric Assessment, Hospitalization, Humans, Male, Retrospective Studies, Treatment Outcome

Development of postoperative delirium in relation to a room change in the general surgical unit. Tsutsui S, Kitamura M, Higashi H, Matsuura H, Hirashima S Surgery today 1996

Adult, Aged, Aged, 80 and over, Anesthesia, General, Confusion, etiology, Delirium, etiology, Female, Hallucinations, etiology, Humans, Male, Middle Aged, Patient Transfer, Postoperative Complications, etiology, Risk Factors, Social Environment, Social Isolation

Functional outcomes of acute medical illness and hospitalization in older persons. Sager MA, Franke T, Inouye SK, Landefeld CS, Morgan TM, Rudberg MA, Sebens H, Winograd CH Archives of internal medicine 1996

Activities of Daily Living, Acute Disease, Aged, Aged, 80 and over, Female, Hospitalization, Humans, Logistic Models, Male, Motor Activity, Prospective Studies

Hospital admission risk profile (HARP): identifying older patients at risk for functional decline following acute medical illness and hospitalization. Sager MA, Rudberg MA, Jalaluddin M, Franke T, Inouye SK, Landefeld CS, Siebens H, Winograd CH Journal of the American Geriatrics Society 1996

Activities of Daily Living, Acute Disease, Aged, Aged, 80 and over, Female, Frail Elderly, Geriatric Assessment, Hospitals, utilization, Humans, Length of Stay, Logistic Models, Male, Patient Admission, Patient Discharge, Patient Readmission, Predictive Value of Tests, Prospective Studies, Reproducibility of Results, Risk Factors, United States

Delirium in AIDS patients: discrepancy between occurrence and health care provider identification. Lalonde B, Uldall KK, Berghuis JP AIDS patient care and STDs 1996

Acquired Immunodeficiency Syndrome, complications, Adult, Aged, Algorithms, Delirium, diagnosis, Health Knowledge, Attitudes, Practice, Health Personnel, education, Humans, Male, Medical Records, Middle Aged, Questionnaires, Referral and Consultation, Retrospective Studies, Skilled Nursing Facilities, Terminal Care

Controlled trial of a geriatric case-finding and liaison service in an emergency department. Miller DK, Lewis LM, Nork MJ, Morley JE Journal of the American Geriatrics Society 1996

Aged, Aged, 80 and over, Case Management, Cohort Studies, Emergency Service, Hospital, economics, Female, Geriatric Assessment, Health Services for the Aged, economics, Health Status, Hospitals, Urban, Humans, Male, Missouri

Shared risk factors for falls, incontinence, and functional dependence. Unifying the approach to geriatric syndromes. Tinetti ME, Inouye SK, Gill TM, Doucette JT JAMA 1995

Accidental Falls, statistics & numerical data, Activities of Daily Living, Aged, Aged, 80 and over, Anxiety, Causality, Cognition, Cohort Studies, Geriatric Assessment, Hearing, Humans, Logistic Models, Multivariate Analysis, Neuropsychological Tests, Nutritional Physiological Phenomena, Physical Fitness, Psychomotor Performance, Risk Factors, Urinary Incontinence, epidemiology, Vision, Ocular

Documentation and evaluation of cognitive impairment in elderly primary care patients. Callahan CM, Hendrie HC, Tierney WM Annals of internal medicine 1995

Age Factors, Aged, Aged, 80 and over, Cognition Disorders, diagnosis, Comorbidity, Documentation, Educational Status, Female, Geriatric Assessment, Humans, Male, Middle Aged, Nutritional Status, Physician’s Practice Patterns, Prevalence, Primary Health Care, utilization, Prospective Studies, Questionnaires

Benzodiazepine use as a cause of cognitive impairment in elderly hospital inpatients. Foy A, O'Connell D, Henry D, Kelly J, Cocking S, Halliday J The journals of gerontology. Series A, Biological sciences and medical sciences 1995

Aged, Aged, 80 and over, Alcoholism, complications, Anoxia, complications, Anti-Anxiety Agents, administration & dosage, Benzodiazepines, Central Nervous System Diseases, complications, Cognition, drug effects, Cognition Disorders, chemically induced, Cohort Studies, Dehydration, complications, Delirium, chemically induced, Drug-Related Side Effects and Adverse Reactions, Female, Follow-Up Studies, Hospitalization, Humans, Male, Middle Aged, Neoplasms, complications, Patient Admission, Prospective Studies, Risk Factors, Urinary Retention, complications

Delirium in critical care unit patients admitted through an emergency room. Kishi Y, Iwasaki Y, Takezawa K, Kurosawa H, Endo S General hospital psychiatry 1995

Adult, Aged, Causality, Comorbidity, Delirium, diagnosis, Emergency Service, Hospital, Female, Humans, Intensive Care Units, Length of Stay, Male, Middle Aged, Outcome Assessment (Health Care), Patient Admission, Predictive Value of Tests, Prevalence, Prospective Studies, Time Factors

Detecting delirium among hospitalized older patients. Pompei P, Foreman M, Cassel CK, Alessi C, Cox D Archives of internal medicine 1995

Aged, Delirium, diagnosis, Diagnosis, Differential, Female, Hospitalization, Humans, Male, Neuropsychological Tests, Prospective Studies, Sensitivity and Specificity

Acute hospital care of the elderly: minimizing the risk of functional decline. Palmer RM Cleveland Clinic journal of medicine 1995

Acute Disease, Aged, Aged, 80 and over, Frail Elderly, Geriatric Assessment, Hospitalization, Humans, Iatrogenic Disease, prevention & control, Nutrition Disorders, Patient Care Team, Physical Therapy Modalities, Risk

A randomized trial of comprehensive geriatric assessment in the care of hospitalized patients. Reuben DB, Borok GM, Wolde-Tsadik G, Ershoff DH, Fishman LK, Ambrosini VL, Liu Y, Rubenstein LZ, Beck JC The New England journal of medicine 1995

Activities of Daily Living, Aged, Aged, 80 and over, California, Critical Care, Female, Follow-Up Studies, Geriatric Assessment, Health Maintenance Organizations, Health Status, Hospitalization, Humans, Male, Patient Care Team, Referral and Consultation, organization & administration, Treatment Outcome

Delirium in elderly patients: evaluation and management. Rummans TA, Evans JM, Krahn LE, Fleming KC Mayo Clinic proceedings 1995

Aged, Causality, Delirium, diagnosis, Diagnosis, Differential, Humans

Confused patients in the acute care setting: prevalence, interventions, and outcomes. Shedd PP, Kobokovich LJ, Slattery MJ Journal of gerontological nursing 1995

Acute Disease, Adolescent, Adult, Child, Confusion, epidemiology, Cross-Sectional Studies, Female, Health Facility Environment, Hospitals, Rural, Humans, Middle Aged, Nursing Assessment, Prevalence

Serious falls in hospitalized patients: correlates and resource utilization. Bates DW, Pruess K, Souney P, Platt R The American journal of medicine 1995

Accidental Falls, economics, Aged, Aged, 80 and over, Case-Control Studies, Female, Hospitalization, Humans, Length of Stay, Logistic Models, Male, Medical Records, Middle Aged, Multivariate Analysis, Odds Ratio, Predictive Value of Tests, Retrospective Studies, Risk Factors, Single-Blind Method

Misdiagnosing delirium as depression in medically ill elderly patients. Farrell KR, Ganzini L Archives of internal medicine 1995

Activities of Daily Living, Age Distribution, Aged, Delirium, diagnosis, Depressive Disorder, diagnosis, Diagnosis, Differential, Diagnostic Errors, Female, Geriatric Assessment, Humans, Interview, Psychological, Male, Mental Status Schedule, Middle Aged, Prospective Studies, Referral and Consultation, Sensitivity and Specificity

Delirium and other cognitive impairment in older adults in an emergency department. Naughton BJ, Moran MB, Kadah H, Heman-Ackah Y, Longano J Annals of emergency medicine 1995

APACHE, Academic Medical Centers, Aged, Aged, 80 and over, Analysis of Variance, Chi-Square Distribution, Cognition Disorders, classification, Cross-Sectional Studies, Delirium, diagnosis, Emergency Service, Hospital, Female, Geriatric Assessment, Humans, Institutionalization, Male, Mental Status Schedule, Prospective Studies

A simple model for predicting postoperative delirium in older patients undergoing elective orthopedic surgery. Fisher BW, Flowerdew G Journal of the American Geriatrics Society 1995

Aged, Cohort Studies, Delirium, diagnosis, Female, Geriatric Assessment, Humans, Interview, Psychological, Male, Odds Ratio, Orthopedics, Postoperative Complications, diagnosis, Predictive Value of Tests, Prospective Studies, Psychological Tests, Risk Factors, Sensitivity and Specificity, Surgical Procedures, Elective

Unrecognized delirium in ED geriatric patients. Lewis LM, Miller DK, Morley JE, Nork MJ, Lasater LC The American journal of emergency medicine 1995

Aged, Cohort Studies, Delirium, classification, Emergency Service, Hospital, Geriatric Assessment, Humans, Neuropsychological Tests, Nursing Assessment, Patient Admission, Patient Discharge, Sensitivity and Specificity

Delirium: a major diagnostic and therapeutic challenge for clinicians caring for the elderly. Levkoff SE, Marcantonio ER Comprehensive therapy 1994

Aged, Delirium, diagnosis, Humans, Patient Care Planning

The dilemma of delirium: clinical and research controversies regarding diagnosis and evaluation of delirium in hospitalized elderly medical patients. Inouye SK The American journal of medicine 1994

Aged, psychology, Delirium, diagnosis, Humans, Inpatients, psychology, Psychiatric Status Rating Scales

A clinical prediction rule for delirium after elective noncardiac surgery. Marcantonio ER, Goldman L, Mangione CM, Ludwig LE, Muraca B, Haslauer CM, Donaldson MC, Whittemore AD, Sugarbaker DJ, Poss R JAMA 1994

Aged, Delirium, diagnosis, Female, Humans, Incidence, Male, Mental Status Schedule, Middle Aged, Outcome Assessment (Health Care), Postoperative Complications, diagnosis, Predictive Value of Tests, Prospective Studies, Reproducibility of Results, Risk Factors, Surgical Procedures, Elective, adverse effects

Systematic intervention for elderly inpatients with delirium: a randomized trial. Cole MG, Primeau FJ, Bailey RF, Bonnycastle MJ, Masciarelli F, Engelsmann F, Pepin MJ, Ducic D CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 1994

Aged, Aged, 80 and over, Combined Modality Therapy, Delirium, diagnosis, Drug Therapy, Combination, Female, Follow-Up Studies, Geriatric Psychiatry, methods, Humans, Inpatients, Intelligence Tests, Length of Stay, Male, Multivariate Analysis, Psychiatric Status Rating Scales, Psychotherapy, Referral and Consultation, Restraint, Physical, Time Factors, Treatment Outcome

Acute confusion: nursing intervention in older patients. Matthiesen V, Sivertsen L, Foreman MD, Cronin-Stubbs D Orthopedic nursing 1994

Acute Disease, Aged, Confusion, diagnosis, Diagnosis, Differential, Geriatric Nursing, methods, Humans, Nursing Assessment, Risk Factors

Delirium in hospitalized older persons: outcomes and predictors. Pompei P, Foreman M, Rudberg MA, Inouye SK, Braund V, Cassel CK Journal of the American Geriatrics Society 1994

Aged, Aging, physiology, Delirium, epidemiology, Female, Hospital Mortality, Hospitalization, Humans, Male, Models, Psychological, Predictive Value of Tests, Prognosis, Prospective Studies, Risk Factors

Methodologic issues in conducting research on hospitalized older people. Berkman CS, Leipzig RM, Greenberg SA, Inouye SK Journal of the American Geriatrics Society 2001

Acute Disease, Aged, Aged, 80 and over, Attitude to Health, Data Collection, methods, Evaluation Studies as Topic, Geriatrics, standards, Guidelines as Topic, Health Services Research, methods, Hospitalization, Humans, Inpatients, Interviews as Topic, methods, Length of Stay, Longitudinal Studies, New York City, Outcome Assessment (Health Care), organization & administration, Patient Selection, Quality of Health Care, Questionnaires, Research Design, standards, Severity of Illness Index

Goals for the care of frail older adults: do caregivers and clinicians agree? Bogardus ST, Bradley EH, Williams CS, Maciejewski PK, van Doorn C, Inouye SK The American journal of medicine 2001

Activities of Daily Living, Adult, Aged, Aged, 80 and over, Caregivers, statistics & numerical data, Female, Frail Elderly, Geriatric Assessment, Goals, Health Knowledge, Attitudes, Practice, Humans, Male, Mental Health, Middle Aged, Physicians, statistics & numerical data, Questionnaires, Safety, Social Support, Stress, Psychological, United States

Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). Ely EW, Inouye SK, Bernard GR, Gordon S, Francis J, May L, Truman B, Speroff T, Gautam S, Margolin R, Hart RP, Dittus R JAMA : the journal of the American Medical Association 2001

APACHE, Aged, Critical Illness, Delirium, diagnosis, Female, Humans, Intensive Care Units, statistics & numerical data, Male, Middle Aged, Prospective Studies, Reference Standards, Reproducibility of Results, Respiration, Artificial, statistics & numerical data, Sensitivity and Specificity, Severity of Illness Index

Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Ely EW, Margolin R, Francis J, May L, Truman B, Dittus R, Speroff T, Gautam S, Bernard GR, Inouye SK Critical care medicine 2001

Aged, Delirium, diagnosis, Dementia, complications, Female, Humans, Intensive Care Units, Male, Middle Aged, Neuropsychological Tests, Observer Variation, Prospective Studies, Reference Standards, Reproducibility of Results, Respiration, Artificial, Sensitivity and Specificity

The cost of delirium in the surgical patient. Franco K, Litaker D, Locala J, Bronson D Psychosomatics 2001

Aged, Cost of Illness, Delirium, diagnosis, Female, Humans, Length of Stay, statistics & numerical data, Male, Middle Aged, Postoperative Complications, diagnosis, Regression Analysis, Statistics, Nonparametric, Surgical Procedures, Operative, psychology

Assessing delirium in cancer patients: the Italian versions of the Delirium Rating Scale and the Memorial Delirium Assessment Scale. Grassi L, Caraceni A, Beltrami E, Borreani C, Zamorani M, Maltoni M, Monti M, Luzzani M, Mercadante S, De Conno F Journal of pain and symptom management 2001

Aged, Delirium, diagnosis, Female, Humans, Male, Middle Aged, Neoplasms, psychology, Psychiatric Status Rating Scales, Severity of Illness Index

Delirium: a barometer for quality of hospital care. Inouye SK Hospital practice (1995) 2001

Aged, Delirium, diagnosis, Geriatric Assessment, Hospitalization, Humans, Quality of Health Care

Nurses' recognition of delirium and its symptoms: comparison of nurse and researcher ratings. Inouye SK, Foreman MD, Mion LC, Katz KH, Cooney LM Archives of internal medicine 2001

Activities of Daily Living, Age Factors, Aged, Aged, 80 and over, Analysis of Variance, Clinical Competence, standards, Delirium, diagnosis, Dementia, complications, Factor Analysis, Statistical, Female, Geriatric Assessment, Humans, Male, Mental Status Schedule, standards, Nursing Assessment, methods, Nursing Evaluation Research, Observer Variation, Prospective Studies, Psychiatric Status Rating Scales, standards, Risk Factors, Sensitivity and Specificity, Vision Disorders, complications

Delirium after hip fracture: to be or not to be? Inouye SK Journal of the American Geriatrics Society 2001

Age Factors, Bias (Epidemiology), Delirium, etiology, Effect Modifier, Epidemiologic, Geriatrics, methods, Hip Fractures, surgery, Humans, Length of Stay, statistics & numerical data, Postoperative Complications, etiology, Referral and Consultation, Research Design, Risk Factors

Multicomponent targeted intervention to prevent delirium in hospitalized older patients: what is the economic value? Rizzo JA, Bogardus ST, Leo-Summers L, Williams CS, Acampora D, Inouye SK Medical care 2001

Aged, Connecticut, Cost-Benefit Analysis, Delirium, economics, Female, Geriatric Assessment, Health Care Costs, Health Services for the Aged, economics, Hospital Costs, Humans, Length of Stay, Male, Models, Econometric, Multivariate Analysis, Outcome Assessment (Health Care), economics, Patient Care Planning, economics, Prospective Studies, Regression Analysis

Intensive Care Delirium Screening Checklist: evaluation of a new screening tool. Bergeron N, Dubois MJ, Dumont M, Dial S, Skrobik Y Intensive care medicine 2001

APACHE, Adult, Aged, Aged, 80 and over, Critical Illness, Delirium, diagnosis, Female, Humans, Intensive Care, methods, Male, Middle Aged, Prospective Studies, Questionnaires, standards, ROC Curve, Sensitivity and Specificity

Immunology of delirium: new opportunities for treatment and research. Broadhurst C, Wilson K The British journal of psychiatry : the journal of mental science 2001

Aged, Animals, Central Nervous System, immunology, Cytokines, immunology, Delirium, immunology, Exercise, physiology, Humans, Insulin-Like Growth Factor I, immunology, Neurodegenerative Diseases, immunology, Research, Somatostatin, physiology, Tumor Necrosis Factor-alpha, immunology

Delirium in the terminally-ill cancer patient: aetiology, symptoms and management. Brown S, Degner LF International journal of palliative nursing 2001

Delirium, diagnosis, Humans, Hypnotics and Sedatives, therapeutic use, Neoplasms, complications, Neuropsychological Tests, Nursing Assessment, methods, Palliative Care, methods, Social Support