NIDUS Delirium Bibliography

Delirium Bibliography books graphic What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!

How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.

Reference Information

Title: The effect of perioperative dexmedetomidine on postoperative delirium in adult patients undergoing cardiac surgery with cardiopulmonary bypass: a systematic review and meta-analysis of randomized controlled trials

Authors: Zhuang, X. Fu, L. Luo, L. Dong, Z. Jiang, Y. Zhao, J. Yang, X. Hei, F.

Year: 2024

Journal: BMC Anesthesiol

Abstract: BACKGROUND: Dexmedetomidine is considered to have neuroprotective effects and may reduce postoperative delirium in both cardiac and major non-cardiac surgeries. Compared with non-cardiac surgery, the delirium incidence is extremely high after cardiac surgery, which could be caused by neuroinflammation induced by surgical stress and CPB. Thus, it is essential to explore the potential benefits of dexmedetomidine on the incidence of delirium in cardiac surgery under CPB. METHODS: Randomized controlled trials studying the effect of perioperative dexmedetomidine on the delirium incidence in adult patients undergoing cardiac surgery with CPB were considered to be eligible. Data collection was conducted by two reviewers independently. The pre-specified outcome of interest is delirium incidence. RoB 2 was used to perform risk of bias assessment by two reviewers independently. The random effects model and Mantel-Haenszel statistical method were selected to pool effect sizes for each study. RESULTS: PubMed, Embase, Cochrane Library, and Web of Science were systematically searched from inception to June 28, 2023. Sixteen studies including 3381 participants were included in our systematic review and meta-analysis. Perioperative dexmedetomidine reduced the incidence of postoperative delirium in patients undergoing cardiac surgery with CPB compared with the other sedatives, placebo, or normal saline (RR 0.57; 95% CI 0.41-0.79; P = 0.0009; I(2) = 61%). CONCLUSIONS: Perioperative administration of dexmedetomidine could reduce the postoperative delirium occurrence in adult patients undergoing cardiac surgery with CPB. However, there is relatively significant heterogeneity among the studies. And the included studies comprise many early-stage small sample trials, which may lead to an overestimation of the beneficial effects. It is necessary to design the large-scale RCTs to further confirm the potential benefits of dexmedetomidine in cardiac surgery with CPB. REGISTRATION NUMBER: CRD42023452410.

PMID: PMID: 39289619

PMCID: PMC11406813

Keywords: Adult
Humans
*Cardiac Surgical Procedures/adverse effects
*Cardiopulmonary Bypass/adverse effects
*Dexmedetomidine/administration & dosage
*Emergence Delirium/prevention & control/epidemiology
*Hypnotics and Sedatives/administration & dosage
Perioperative Care/methods
Randomized Controlled Trials as Topic
Cardiac surgery
Cardiopulmonary bypass
Delirium
Dexmedetomidine
Neurocognitive function

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Total Records Found: 6272, showing 100 per page
Title	Authors	Journal	Year	Keywords
Intraoperative Oxidative Damage and Delirium after Cardiac Surgery	Lopez, M. G. Hughes, C. G. DeMatteo, A. O'Neal, J. B. McNeil, J. B. Shotwell, M. S. Morse, J. Petracek, M. R. Shah, A. S. Brown, N. J. Billings, F. T. th	Anesthesiology	2019
Postoperative delirium after hip surgery is a potential risk factor for incident dementia: A systematic review and meta-analysis of prospective studies	Lee, S. J. Jung, S. H. Lee, S. U. Lim, J. Y. Yoon, K. S. Lee, S. Y.	Arch Gerontol Geriatr	2019	Delirium Dementia Hip fractures Hip replacement Meta-analysis
Evaluation of emergency department derived delirium prediction models using a hospital-wide cohort	Lee, S. Harland, K. Mohr, N. M. Matthews, G. Hess, E. P. Bellolio, M. F. Han, J. H. Weckmann, M. Carnahan, R.	Journal of Psychosomatic Research	2019	aged article cohort analysis controlled study delirium delirium observation screening scale diagnostic test accuracy study emergency ward female hospitalization human ICD-10 ICD-9 major clinical study male model nurse observational study predictive value psychological rating scale retrospective study risk assessment sensitivity and specificity university hospital very elderly
The Practical Use of White Cell Inflammatory Biomarkers in Prediction of Postoperative Delirium after Cardiac Surgery	Kotfis, K. Slozowska, J. Safranow, K. Szylinska, A. Listewnik, M.	Brain Sci	2019	Nlr Plr Pod Pwr biomarkers cardiac surgery delirium prediction index
Characteristics, risk factors and outcome of early-onset delirium in elderly patients with first ever acute ischemic stroke-A prospective observational cohort study	Kotfis, K. Bott-Olejnik, M. Szylińska, A. Listewnik, M. Rotter, I.	Clinical Interventions in Aging	2019	NCT03944694 C reactive protein troponin T aged article atrial fibrillation blood cell ratio brain ischemia clinical feature cohort analysis controlled study delirium disease association female hemianopia hospital admission human incidence major clinical study male mortality neutrophil lymphocyte ratio observational study outcome assessment platelet white blood cell count ratio retrospective study risk factor
Biomarkers of Delirium Duration and Delirium Severity in the ICU	Khan, B. A. Perkins, A. J. Prasad, N. K. Shekhar, A. Campbell, N. L. Gao, S. Wang, S. Khan, S. H. Marcantonio, E. R. Twigg, H. L., 3rd Boustani, M. A.	Crit Care Med	2019
The Role of Inflammation after Surgery for Elders (RISE) study: Study design, procedures, and cohort profile	Hshieh, T. T. Vasunilashorn, S. M. D'Aquila, M. L. Arnold, S. E. Dickerson, B. C. Fong, T. G. Jones, R. N. Marcantonio, E. R. Schmitt, E. M. Xu, G. Gou, Y. Chen, F. Kunze, L. J. Vlassakov, K. V. Abdeen, A. R. Lange, J. K. Earp, B. E. Touroutoglou, A. Carl	Alzheimers Dement	2019	Biomarkers Cerebrospinal fluid Delirium Inflammation Methods Plasma Positron emission tomography Surgery
Clock Drawing Performance Slows for Older Adults after Total Knee Replacement Surgery	Hizel, L. P. Warner, E. D. Wiggins, M. E. Tanner, J. J. Parvataneni, H. Davis, R. Penney, D. L. Libon, D. J. Tighe, P. Garvan, C. W. Price, C. C.	Anesthesia and Analgesia	2019	nct01786577 aged article clock drawing test cognition controlled clinical trial controlled study delirium female human latent period major clinical study male observational study priority journal prospective study total knee arthroplasty
Postoperative delirium after lung resection for primary lung cancer: Risk factors, risk scoring system, and prognosis	Hayashi, K. Motoishi, M. Sawai, S. Horimoto, K. Hanaoka, J.	PLoS One	2019
Intraoperative Low Alpha Power in the Electroencephalogram Is Associated With Postoperative Subsyndromal Delirium	Gutierrez, R. Egaña, J. I. Saez, I. Reyes, F. Briceño, C. Venegas, M. Lavado, I. Penna, A.	Frontiers in Systems Neuroscience	2019	electroencephalograph age aged alpha rhythm anesthesia article assessment of humans clinical article cohort analysis Confusion Assessment Method controlled study delirium delta rhythm electroencephalography female human intraoperative period male minimum lung alveolus concentration Montreal cognitive assessment observational study postoperative delirium power spectrum receiver operating characteristic sensitivity and specificity subsyndromal delirium
Post-operative delirium associated with metabolic alterations following hemi-arthroplasty in older patients	Guo, Y. Li, Y. Zhang, Y. Fang, S. Xu, X. Zhao, A. Zhang, J. Li, J. V. Ma, D. Jia, W. Jiang, W.	Age Ageing	2019	hip fracture metabolomics older patients post-operative delirium
Validation of the Delirium Diagnostic Tool-Provisional (DDT-Pro) With Medical Inpatients and Comparison With the Confusion Assessment Method Algorithm	Franco, J. G. Ocampo, M. V. Velásquez-Tirado, J. D. Zaraza, D. R. Giraldo, A. M. Serna, P. A. López, C. Zuluaga, A. Sepúlveda, E. Kean, J. Trzepacz, P. T.	Journal of Neuropsychiatry and Clinical Neurosciences	2019	administrative personnel adult algorithm article consultation content validity controlled study delirium dementia diagnosis diagnostic accuracy diagnostic test accuracy study disease course DSM-5 female hospital patient human internal consistency interrater reliability major clinical study male neuropsychiatry nurse nursing assessment physician psychological rating scale receiver operating characteristic sensitivity and specificity standard traumatic brain injury
Efficacy and safety of haloperidol for delirium prevention in adult patients: An updated meta-analysis with trial sequential analysis of randomized controlled trials	Chen, Z. Chen, R. Zheng, D. Su, Y. Wen, S. Guo, H. Ye, Z. Deng, Y. Liu, G. Zuo, L. Wei, X. Hou, Y.	Journal of Clinical Anesthesia	2019	adult artificial ventilation Cochrane Library controlled study delirium drug safety drug therapy Embase extrapyramidal symptom female hospitalization human incidence intensive care unit male Medline meta analysis mortality outcome assessment pharmacokinetics prevention prophylaxis QT prolongation quality control randomized controlled trial (topic) review risk factor sequential analysis systematic review Web of Science haloperidol placebo sodium chloride
Change in Serum Level of Interleukin 6 and Delirium After Coronary Artery Bypass Graft	Chen, Y. Lu, S. Wu, Y. Shen, Y. Zhao, H. Ding, S. Feng, X. Sun, L. Tao, X. Li, J. Ma, R. Liu, W. Wu, F. Feng, Y.	Am J Crit Care	2019
Preoperative cardiac function parameters as valuable predictors for nurses to recognise delirium after cardiac surgery: a prospective cohort study	Cai, S. Latour, J. M. Lin, Y. Pan, W. Zheng, J. Xue, Y. Gao, J. Lv, M. Zhang, X. Luo, Z. Wang, C. Zhang, Y.	Eur J Cardiovasc Nurs	2019	Cardiac surgery cardiac function delirium intensive care units predictors
Bedside mental status and outcome in elderly patients admitted for acute coronary syndromes	Briet, C. Blanchart, K. Lemaitre, A. Roux, I. Lavergne, K. Rocamora, A. Bignon, M. Ardouin, P. Sabatier, R. Roule, V. Beygui, F.	Heart	2019	acute coronary syndrome cognitive impairment death delirium elderly outcome grants from Biosensors, Medtronic and Boston Scientific.
Delirium Screening in Aphasic Patients With the Intensive Care Delirium Screening Checklist (ICDSC): A Prospective Cohort Study	Bosselmann, C. Zurloh, J. Stefanou, M. I. Stadler, V. Weber, Y. Lerche, H. Poli, S. Ziemann, U. Mengel, A.	Front Neurol	2019	intensive care delirium screening checklist intracerebral hemorrhage post-stroke aphasia post-stroke delirium stroke
Impact of Frailty on 30-Day Morbidity and Mortality of Patients With Intertrochanteric Femur Fractures	Boissonneault, A. Mener, A. Schwartz, A. Wilson, J. Staley, C. Schenker, M.	Orthopedics	2019
The utility of nursing instruments for daily screening for delirium: Delirium causes substantial functional impairment	Bode, L. Isler, F. Fuchs, S. Marquetand, J. Petry, H. Ernst, J. Schubert, M. Garcia Nunez, D. von Kanel, R. Boettger, S.	Palliat Support Care	2019	Assessment Delirium Electronic Patient Assessment-Acute Care (ePA-AC) Functional impairment Nursing
The short IQCODE as a predictor for delirium in hospitalized geriatric patients	Blandfort, S. Gregersen, M. Rahbek, K. Juul, S. Damsgaard, E. M.	Aging Clin Exp Res	2019	Delirium predictor Geriatrics Iqcode Older patient
The relationship among frailty, delirium and attentional tests to detect delirium: a cohort study	Bellelli, P. G. Biotto, M. Morandi, A. Meagher, D. Cesari, M. Mazzola, P. Annoni, G. Zambon, A.	Eur J Intern Med	2019	Attention Delirium Frailty Geriatric Older patients
Haloperidol for the treatment of delirium in critically ill patients: A systematic review with meta-analysis and Trial Sequential Analysis	Barbateskovic, M. Krauss, S. R. Collet, M. O. Andersen-Ranberg, N. C. Mathiesen, O. Jakobsen, J. C. Perner, A. Wetterslev, J.	Acta Anaesthesiologica Scandinavica	2019	adult all cause mortality cognition controlled study critically ill patient delirium drug therapy extrapyramidal symptom female human male meta analysis QT prolongation quality of life randomized controlled trial (topic) review sensitivity analysis sequential analysis systematic review haloperidol
The Volunteer Dementia and Delirium Care (VDDC) © Program: An Exploration of Perceived Barriers and Enablers to Implementation in an Acute and Subacute Metropolitan Hospital	Ayton, D. Moran, C. Berkovic, D. Bateman, C. Anderson, K. Blair, A. Soh, S. E. Morello, R. Ying Lim, Y. Liew, D.	Australas J Ageing	2019	delirium dementia hospital volunteers
Comorbidities rather than age affect medium-term outcome in octogenarian patients after total knee arthroplasty	Andreozzi, V. Conteduca, F. Iorio, R. Di Stasio, E. Mazza, D. Drogo, P. Annibaldi, A. Ferretti, A.	Knee Surg Sports Traumatol Arthrosc	2019	Comorbidity Complication Elderly Octogenarian Total knee arthroplasty Total knee replacement
Effect of the Tailored, Family-Involved Hospital Elder Life Program on Postoperative Delirium and Function in Older Adults: A Randomized Clinical Trial	Wang, Y. Y. Yue, J. R. Xie, D. M. Carter, P. Li, Q. L. Gartaganis, S. L. Chen, J. Inouye, S. K.	JAMA Intern Med	2019
Nomogram for Predicting Postoperative Delirium After Deep Brain Stimulation Surgery for Parkinson's Disease	Wang, X. Q. Zhuang, H. X. Zhang, L. X. Chen, X. Niu, C. S. Zhao, M.	World Neurosurg	2019	Deep brain stimulation Nomograms Parkinson’s disease Postoperative delirium
Automated tracking of level of consciousness and delirium in critical illness using deep learning	Sun, H. Kimchi, E. Akeju, O. Nagaraj, S. B. McClain, L. M. Zhou, D. W. Boyle, E. Zheng, W. L. Ge, W. Westover, M. B.	NPJ Digital Medicine	2019	propofol adult aged APACHE article artificial ventilation body mass brain function clinical research consciousness level convolutional neural network critical illness deep learning delirium elective surgery electroencephalography eye movement female human intensive care unit long short term memory network major clinical study male neuromonitoring observational study priority journal prospective study recurrent neural network Richmond Agitation Sedation Scale sedation sensitivity and specificity
Impact of natural light exposure on delirium burden in adult patients receiving invasive mechanical ventilation in the ICU: a prospective study	Smonig, R. Magalhaes, E. Bouadma, L. Andremont, O. de Montmollin, E. Essardy, F. Mourvillier, B. Lebut, J. Dupuis, C. Neuville, M. Lermuzeaux, M. Timsit, J. F. Sonneville, R.	Ann Intensive Care	2019	Agitation Antipsychotics Delirium Hallucinations Light
Differences in 90-day mortality of delirium subtypes in the intensive care unit: A retrospective cohort study	Rood, P. J. T. van de Schoor, F. van Tertholen, K. Pickkers, P. van den Boogaard, M.	J Crit Care	2019	Critical care Delirium Icu Mortality Subtypes
The Role of Delirium and Other Risk Factors on Mortality in Elderly Patients with Critical Limb Ischemia Undergoing Major Lower Limb Amputation	Roijers, J. P. Hopmans, C. J. Janssen, T. L. Mulder, P. G. H. Buimer, M. G. Ho, G. H. de Groot, H. G. W. Veen, E. J. van der Laan, L.	Ann Vasc Surg	2019
Antipsychotics for preventing delirium in hospitalized adults a systematic review	Oh, E. S. Needham, D. M. Nikooie, R. Wilson, L. M. Zhang, A. Robinson, K. A. Neufeld, K. J.	Annals of Internal Medicine	2019	neuroleptic agent adult adverse event cognition delirium delirium rating scale revised 98 Diagnostic and Statistical Manual of Mental Disorders disease duration drug safety extrapyramidal symptom heart arrhythmia hospital patient human incidence length of stay mental disease assessment meta analysis mortality neuroleptic malignant syndrome priority journal prophylaxis review sedation systematic review
Antipsychotics for treating delirium in hospitalized adults a systematic review	Nikooie, R. Neufeld, K. J. Oh, E. S. Wilson, L. M. Zhang, A. Robinson, K. A. Needham, D. M.	Annals of Internal Medicine	2019	amisulpride aripiprazole haloperidol neuroleptic agent olanzapine placebo quetiapine risperidone ziprasidone adult Clinical Global Impression scale critical illness critically ill patient delirium drug withdrawal extrapyramidal symptom heart disease hospital mortality hospital patient human length of stay meta analysis neurologic disease palliative therapy priority journal psychopharmacotherapy QTc interval randomized controlled trial (topic) review sedation systematic review
Exploiting Machine Learning Algorithms and Methods for the Prediction of Agitated Delirium After Cardiac Surgery: Models Development and Validation Study	Mufti, H. N. Hirsch, G. M. Abidi, S. R. Abidi, S. S. R.	JMIR Med Inform	2019	cardiac surgery delirium machine learning predictive modeling
Predictors and prognosis of delirium among older subjects in cardiac intensive care unit: focus on potentially preventable forms	Mossello, E. Baroncini, C. Pecorella, L. Giulietti, C. Chiti, M. Caldi, F. Cavallini, M. C. Simoni, D. Baldasseroni, S. Fumagalli, S. Valoti, P. Stroppa, S. Parenti, K. Ungar, A. Masotti, G. Marchionni, N. Di Bari, M.	Eur Heart J Acute Cardiovasc Care	2019	Delirium acute coronary syndrome aged intensive care unit
Dysfunction of the blood-brain barrier in postoperative delirium patients, referring to the axonal damage biomarker phosphorylated neurofilament heavy subunit	Mietani, K. Sumitani, M. Ogata, T. Shimojo, N. Inoue, R. Abe, H. Kawamura, G. Yamada, Y.	PLoS One	2019
The 4 ‘a’s test for detecting delirium in acute medical patients: A diagnostic accuracy study	Maclullich, A. M. J. Shenkin, S. D. Goodacre, S. Godfrey, M. Hanley, J. Stíobhairt, A. Lavender, E. Boyd, J. Stephen, J. Weir, C. Macraild, A. Steven, J. Black, P. Diernberger, K. Hall, P. Tieges, Z. Fox, C. Anand, A. Young, J. Siddiqi, N. Gray, A.	Health Technology Assessment	2019	ISRCTN53388093 age Arousal Attention Abbreviated Mental Test 4 article awareness biomedical technology assessment clinical practice community care confidence interval cost benefit analysis cost effectiveness analysis delirium diagnostic accuracy diagnostic test accuracy study diagnostic value documentation emergency ward England false negative result false positive result frailty health care policy health economics health status hospital cost hospitalization human information processing interview length of stay long term care medical education mortality rate national health organization national health service practice guideline probability psychologic assessment qualitative research receiver operating characteristic scoring system sensitivity and specificity statistics surgery systematic review United Kingdom ward
Initiation and continuation of antipsychotic medicines in older people following non-psychiatric hospital admission	Kalisch Ellett, L. M. Pratt, N. L. Apajee, J. Roughead, E. E.	Int J Clin Pharm	2019	Antipsychotic Australia Delirium Dementia Elderly Hospital admission
Staged Implementation of Awakening and Breathing, Coordination, Delirium Monitoring and Management, and Early Mobilization Bundle Improves Patient Outcomes and Reduces Hospital Costs	Hsieh, S. J. Otusanya, O. Gershengorn, H. B. Hope, A. A. Dayton, C. Levi, D. Garcia, M. Prince, D. Mills, M. Fein, D. Colman, S. Gong, M. N.	Critical Care Medicine	2019	adult arousal article artificial ventilation clinical practice cohort analysis controlled study decubitus delirium female hospital cost human length of stay major clinical study male medical intensive care unit mobilization prospective study ventilated patient
The Prevalence of Delirium in An Older Acute Surgical Population and Its Effect on Outcome	Hewitt, J. Owen, S. Carter, B. R. Stechman, M. J. Tay, H. S. Greig, M. McCormack, C. Pearce, L. McCarthy, K. Myint, P. K. Moug, S. J.	Geriatrics	2019	Cognitive impairment delirium older surgical patients
Care challenges in older general hospital patients : Impact of cognitive impairment and other patient-related factors	Hendlmeier, I. Bickel, H. Hessler-Kaufmann, J. B. Schaufele, M.	Z Gerontol Geriatr	2019	Adverse events Cognitive impairment Cross-sectional studies Dementia Nursing
Efficacy of music on sedation, analgesia and delirium in critically ill patients. A systematic review of randomized controlled trials	Garcia Guerra, G. Almeida, L. Zorzela, L. King-Jones, S. Joffe, A. R. Hartling, L. Jou, H. Vohra, S.	J Crit Care	2019	Analgesia Delirium Music Sedation Systematic review
Postoperative Pressure Ulcers After Geriatric Hip Fracture Surgery Are Predicted by Defined Preoperative Comorbidities and Postoperative Complications	Galivanche, A. R. Kebaish, K. J. Adrados, M. Ottesen, T. D. Varthi, A. G. Rubin, L. E. Grauer, J. N.	The Journal of the American Academy of Orthopaedic Surgeons	2019	adult article cohort analysis comorbidity complication decubitus female hip fracture human insulin dependent diabetes mellitus major clinical study male multicenter study platelet count pneumonia postoperative delirium preoperative evaluation risk factor sepsis surgeon surgery total quality management urinary tract infection
The Healthy Heart-Mind Trial: Randomized Controlled Trial of Melatonin for Prevention of Delirium	Ford, A. H. Flicker, L. Kelly, R. Patel, H. Passage, J. Wibrow, B. Anstey, M. Edwards, M. Almeida, O. P.	J Am Geriatr Soc	2019	cardiothoracic delirium melatonin prevention surgery
The Caregiver Burden of Delirium in Older Adults With Alzheimer Disease and Related Disorders	Fong, T. G. Racine, A. M. Fick, D. M. Tabloski, P. Gou, Y. Schmitt, E. M. Hshieh, T. T. Metzger, E. Bertrand, S. E. Marcantonio, E. R. Jones, R. N. Inouye, S. K.	J Am Geriatr Soc	2019	Alzheimer disease Alzheimer disease or related disorder caregiver burden delirium burden dementia patient burden
Geriatric Events Among Older Adults Undergoing Nonelective Surgery Are Associated with Poor Outcomes	Dworsky, J. Q. Childers, C. P. Copeland, T. Maggard-Gibbons, M. Tan, H. J. Saliba, D. Russell, M. M.	Am Surg	2019
Shifting the focus: A QI project to improve the management of delirium in patients with hip fracture	Dormandy, L. Mufti, S. Higgins, E. Bailey, C. Dixon, M.	Future Healthc J	2019	Neck of femur fracture delirium perioperative medicine
Impact of a delirium prevention project among older hospitalized patients who underwent orthopedic surgery: a retrospective cohort study	Choi, J. Y. Kim, K. I. Kang, M. G. Lee, Y. K. Koo, K. H. Oh, J. H. Park, Y. H. Suh, J. Kim, N. H. Yoo, H. J. Koo, J. Moon, H. M. Kim, E. H. Park, K. Kim, C. H.	BMC Geriatr	2019	Delirium Multidisciplinary geriatric intervention Quality improvement project
Melatonin for the prevention of postoperative delirium in older adults: a systematic review and meta-analysis	Campbell, A. M. Axon, D. R. Martin, J. R. Slack, M. K. Mollon, L. Lee, J. K.	BMC Geriatr	2019	Delirium Geriatric Melatonin Postoperative Ramelteon
Assessment of a Geriatric Hip Fracture Program: Analysis of Harmful Adverse Events Using the Global Trigger Tool	Blood, T. D. Deren, M. E. Goodman, A. D. Hayda, R. A. Trafton, P. G.	Journal of Bone and Joint Surgery - American Volume	2019	acute blood loss anemia age aged anemia article Charlson Comorbidity Index clinical effectiveness controlled study death disease severity female femoral neck fracture femur intertrochanteric fracture frequency geriatric care Geriatric Hip Fracture Program Global Trigger Tool health program hip fracture hospital admission hospital patient hospital readmission human length of stay major clinical study male musculoskeletal disease assessment postoperative delirium predictor variable priority journal risk factor trend study urinary tract infection very elderly
Clinical management of delirium: The response depends on the subtypes. An observational cohort study in 602 patients	Zipser, C. M. Knoepfel, S. Hayoz, P. Schubert, M. Ernst, J. von Kanel, R. Boettger, S.	Palliat Support Care	2019	Antipsychotics Delirium Hyperactive Hypoactive Management of delirium Psychotropics Subtypes
Predisposing and precipitating factors for delirium in neurology: a prospective cohort study of 1487 patients	Zipser, C. M. Deuel, J. Ernst, J. Schubert, M. Weller, M. von Kanel, R. Boettger, S.	J Neurol	2019	Delirium Neurology Neuropsychiatry Risk factor
Risk factors for postoperative delirium after spinal surgery: a systematic review and meta-analysis	Zhu, C. Wang, B. Yin, J. Xue, Q. Gao, S. Xing, L. Wang, H. Liu, W. Liu, X.	Aging Clin Exp Res	2019	Delirium Postoperative Risk factors Spinal surgery
Dexmedetomidine for the prevention of postoperative delirium in elderly patients undergoing noncardiac surgery: A meta-analysis of randomized controlled trials	Zeng, H. Li, Z. He, J. Fu, W.	PLoS One	2019
Risk factors for delirium: Are therapeutic interventions part of it?	Xing, J. Yuan, Z. Jie, Y. Liu, Y. Wang, M. Sun, Y.	Neuropsychiatric Disease and Treatment	2019	arterial line stomach tube sedative agent vasoactive agent adult aged APACHE article artificial ventilation bladder catheterization catheter removal clinical evaluation clinical feature clinical study cohort analysis controlled study critically ill patient delirium disease association early intervention female human intensive care intensive care unit length of stay major clinical study male observational study prospective study risk assessment risk factor treatment duration tube removal vein catheterization
Intraoperative hyperglycemia increases the incidence of postoperative delirium	Windmann, V. Spies, C. Knaak, C. Wollersheim, T. Piper, S. K. Vorderwulbecke, G. Kurpanik, M. Kuenz, S. Lachmann, G.	Minerva Anestesiol	2019
External Validation of Two Models to Predict Delirium in Critically Ill Adults Using Either the Confusion Assessment Method-ICU or the Intensive Care Delirium Screening Checklist for Delirium Assessment	Wassenaar, A. Schoonhoven, L. Devlin, J. W. van Haren, F. M. P. Slooter, A. J. C. Jorens, P. G. van der Jagt, M. Simons, K. S. Egerod, I. Burry, L. D. Beishuizen, A. Matos, J. Donders, A. R. T. Pickkers, P. van den Boogaard, M.	Crit Care Med	2019	adult animal experiment animal model article checklist cohort analysis controlled study critically ill patient female intensive care psychosis intensive care unit male nonhuman prediction prospective study receiver operating characteristic validation process
Risk Factors and Incidence of Postoperative Delirium in Patients Undergoing Laryngectomy	Wang, Y. Yu, H. Qiao, H. Li, C. Chen, K. Shen, X.	Otolaryngol Head Neck Surg	2019	head and neck cancer laryngeal cancer outcome postoperative delirium
Regional cerebral oxygen saturation and postoperative delirium in endovascular surgery: a prospective cohort study	Wang, X. Feng, K. Liu, H. Liu, Y. Ye, M. Zhao, G. Wang, T.	Trials	2019	Delirium Regional cerebral oxygen saturation rSO2
The impact of analgosedation on mortality and delirium in critically ill patients: A systematic review and meta-analysis	Wang, C. T. Mao, Y. Zhao, L. Ma, B.	Intensive Crit Care Nurs	2019	Analgesia-based sedation Analgesia-first sedation Analogsedation Critically ill patients Delirium Meta-analysis Mortality No sedation Systematic review
Incidence and risk factors of postoperative delirium in patients admitted to the ICU after elective intracranial surgery: A prospective cohort study	Wang, C. M. Huang, H. W. Wang, Y. M. He, X. Sun, X. M. Zhou, Y. M. Zhang, G. B. Gu, H. Q. Zhou, J. X.	Eur J Anaesthesiol	2019
Association between preoperative nutritional status and postoperative delirium in individuals with coronary artery bypass graft surgery: A prospective cohort study	Velayati, A. Vahdat Shariatpanahi, M. Shahbazi, E. Vahdat Shariatpanahi, Z.	Nutrition	2019	adductor pollicis muscle adult arm circumference article body mass cohort analysis confusion assessment controlled study coronary artery bypass graft coronary artery bypass surgery disease association disease severity female general health status assessment high risk population human intensive care unit major clinical study male malnutrition mental disease assessment muscle thickness nutritional assessment Nutritional Risk Screening 2002 nutritional status observational study postoperative delirium preoperative period prevalence priority journal prospective study risk reduction skeletal muscle skinfold thickness subjective global assessment triceps brachii muscle
Prevalence and risk factors for delirium in elderly patients with severe burns: a retrospective cohort study	van Yperen, D. T. Raats, J. W. Dokter, J. Ziere, G. Roukema, G. R. van Baar, M. E. van der Vlies, C. H.	J Burn Care Res	2019	Elderly burns delirium prevalence risk factors
Delirium After Transcatheter Aortic Valve Implantation Under General Anesthesia: Incidence, Predictors, and Relation to Long-Term Survival	van der Wulp, K. van Wely, M. van Heijningen, L. van Bakel, B. Schoon, Y. Verkroost, M. Gehlmann, H. Van Garsse, L. Vart, P. Kievit, P. Rikkert, M. O. Morshuis, W. van Royen, N.	J Am Geriatr Soc	2019	general anesthesia postoperative delirium survival transcatheter aortic valve implantation
Impact of a Premorbid Psychiatric Disorder on the Incidence of Delirium during ICU Stay, Morbidity, and Long-Term Mortality	van der Kuur, A. Bethlehem, C. Bruins, N. de Jager, C. van Alst, C. Haagsma, O. G. Keijzers, A. Boerma, E. C.	Crit Care Res Pract	2019
Identifying determinants for the application of physical or chemical restraint in the management of psychomotor agitation on the critical care unit	Teece, A. Baker, J. Smith, H.	J Clin Nurs	2019	agitation critical care decision-making delirium intensive care nursing restraint
Impact of a nurse engagement intervention on pain, agitation and delirium assessment in a community intensive care unit	Tan, C. M. Camargo, M. Miller, F. Ross, K. Maximous, R. Yung, P. Marshall, C. Fleming, D. Law, M. Tsang, J. L.	BMJ Open Qual	2019	critical care healthcare quality improvement nurses performance measures quality improvement
Predictors of delirium after cardiac surgery in patients with sleep disordered breathing	Tafelmeier, M. Knapp, M. Lebek, S. Floerchinger, B. Camboni, D. Creutzenberg, M. Wittmann, S. Zeman, F. Schmid, C. Maier, L. S. Wagner, S. Arzt, M.	Eur Respir J	2019
The relationship between obstructive sleep apnoea and postoperative delirium and pain: an observational study of a surgical cohort	Strutz, P. K. Kronzer, V. Tzeng, W. Arrington, B. McKinnon, S. L. Ben Abdallah, A. Haroutounian, S. Avidan, M. S.	Anaesthesia	2019	delirium pain, postoperative sleep apnoea, obstructive
Ultra-brief Screeners for Detecting Delirium Superimposed on Dementia	Steensma, E. Zhou, W. Ngo, L. Gallagher, J. Inouye, S. Leslie, D. Boltz, M. Kolanowski, A. Mion, L. Marcantonio, E. R. Fick, D.	J Am Med Dir Assoc	2019	Delirium dementia screening tools
Etiology and Related Factors of Postoperative Delirium in Orthopedic Surgery	Song, K. J. Ko, J. H. Kwon, T. Y. Choi, B. W.	Clin Orthop Surg	2019	Delirium Etiology Orthopedic surgery Risk factor was reported.
Preoperative transcranial Doppler and cerebral oximetry as predictors of delirium following valvular heart surgery: a case-control study	Soh, S. Shim, J. K. Song, J. W. Choi, N. Kwak, Y. L.	J Clin Monit Comput	2019	Cardiac surgical procedures Delirium Heart valve diseases Spectroscopy, Near-infrared Ultrasonography, Doppler, Transcranial
Identification of Patients With High Mortality Risk and Prediction of Outcomes in Delirium by Bispectral EEG	Shinozaki, G. Bormann, N. L. Chan, A. C. Zarei, K. Sparr, N. A. Klisares, M. J. Jellison, S. S. Heinzman, J. T. Dahlstrom, E. B. Duncan, G. N. Gaul, L. N. Wanzek, R. J. Cramer, E. M. Wimmel, C. G. Sabbagh, S. Yuki, K. Weckmann, M. T. Yamada, T. Karam, M.	J Clin Psychiatry	2019
Postoperative Delirium Is Associated with Long-term Decline in Activities of Daily Living	Shi, Z. Mei, X. Li, C. Chen, Y. Zheng, H. Wu, Y. Zheng, H. Liu, L. Marcantonio, E. R. Xie, Z. Shen, Y.	Anesthesiology	2019
Managing Delirium and Agitation in the Older Emergency Department Patient: The ADEPT Tool	Shenvi, C. Kennedy, M. Austin, C. A. Wilson, M. P. Gerardi, M. Schneider, S.	Ann Emerg Med	2019
Delirium detection in older acute medical inpatients: a multicentre prospective comparative diagnostic test accuracy study of the 4AT and the confusion assessment method	Shenkin, S. D. Fox, C. Godfrey, M. Siddiqi, N. Goodacre, S. Young, J. Anand, A. Gray, A. Hanley, J. MacRaild, A. Steven, J. Black, P. L. Tieges, Z. Boyd, J. Stephen, J. Weir, C. J. MacLullich, A. M. J.	BMC Med	2019	4at Confusion assessment method (CAM) Delirium Diagnostic test accuracy Hospital Sensitivity *Specificity
Occurrence Rate of Delirium in Acute Stroke Settings: Systematic Review and Meta-Analysis	Shaw, R. C. Walker, G. Elliott, E. Quinn, T. J.	Stroke	2019	delirium humans risk stroke systematic review
Delirium in an Acute Stroke Setting, Occurrence, and Risk Factors	Shaw, R. Drozdowska, B. Taylor-Rowan, M. Elliott, E. Cuthbertson, G. Stott, D. J. Quinn, T. J.	Stroke	2019	cognitive dysfunction delirium humans odds ratio stroke
The relationship between serum cobalamin, folic acid, and homocysteine and the risk of post-cardiac surgery delirium	Shariatpanahi, M. V. Velayati, A. Jamalian, S. A. Babevaynejad, M. Shariatpanahi, Z. V.	Neuropsychiatric Disease and Treatment	2019	cobalamin folic acid homocysteine adult aged amino acid blood level article cardiopulmonary bypass cohort analysis controlled study coronary artery bypass graft enzyme immunoassay female folic acid blood level hospital admission human intensive care unit major clinical study male pathophysiology population research postoperative delirium postoperative period prospective study surgical risk vitamin blood level
The effect of volunteers' care and support on the health outcomes of older adults in acute care: A systematic scoping review	Saunders, R. Seaman, K. Graham, R. Christiansen, A.	J Clin Nurs	2019	Volunteers clinical outcomes confusion frailty hospital nursing older adults
Mitochondrial DNA Haplogroups and Delirium During Sepsis	Samuels, D. C. Hulgan, T. Fessel, J. P. Billings, F. T. th Thompson, J. L. Chandrasekhar, R. Girard, T. D.	Crit Care Med	2019
Effect of Flexible Family Visitation on Delirium Among Patients in the Intensive Care Unit: The ICU Visits Randomized Clinical Trial	Rosa, R. G. Falavigna, M. da Silva, D. B. Sganzerla, D. Santos, M. M. S. Kochhann, R. de Moura, R. M. Eugenio, C. S. Haack, Tdsr Barbosa, M. G. Robinson, C. C. Schneider, D. de Oliveira, D. M. Jeffman, R. W. Cavalcanti, A. B. Machado, F. R. Azevedo, L. C.	JAMA	2019	Anxiety Brazil Burnout, Professional Critical Care/psychology Cross-Over Studies Delirium/prevention & control Depression Family/psychology Female Health Education Hospitalization Humans Incidence Intensive Care Units/organization & administration Male Middle Aged Time Factors Visitors to Patients
Deconstructing Poststroke Delirium in a Prospective Cohort of Patients With Intracerebral Hemorrhage	Reznik, M. E. Drake, J. Margolis, S. A. Moody, S. Murray, K. Costa, S. Mahta, A. Wendell, L. C. Thompson, B. B. Rao, S. S. Barrett, A. M. Boukrina, O. Daiello, L. A. Asaad, W. F. Furie, K. L. Jones, R. N.	Crit Care Med	2019
Impact of intraoperative blood pressure, blood pressure fluctuation, and pulse pressure on postoperative delirium in elderly patients with hip fracture: A prospective cohort study	Radinovic, K. Markovic Denic, L. Milan, Z. Cirkovic, A. Baralic, M. Bumbasirevic, V.	Injury	2019	Blood pressure Clinical outcomes Hip fracture Postoperative delirium Pulse pressure
Economic impact of delirium in Australia: a cost of illness study	Pezzullo, L. Streatfeild, J. Hickson, J. Teodorczuk, A. Agar, M. R. Caplan, G. A.	BMJ Open	2019	delirium & cognitive disorders dementia health economics
Delirium Predisposing and Triggering Factors in Nursing Home Residents: A Cohort Trial-Nested Case-Control Study	Pérez-Ros, P. Martínez-Arnau, F. M. Baixauli-Alacreu, S. Caballero-Pérez, M. García-Gollarte, J. F. Tarazona-Santabalbina, F.	Journal of Alzheimer's Disease	2019	urinary catheter antidepressant agent anxiolytic agent cholinergic receptor blocking agent neuroleptic agent aged anemia article autoimmune disease Barthel index case control study cerebrovascular accident cognitive defect cohort analysis controlled study daily life activity delirium dementia dependent personality disorder depression diabetes mellitus disease predisposition dysphagia epilepsy female follow up geriatric assessment Geriatric Depression Scale glomerulus filtration rate hearing impairment hospital admission human hypoglycemia kidney failure major clinical study male Mini Mental State Examination nursing home patient pain Parkinson disease pneumonia predictive value priority journal urinary tract infection urine incontinence very elderly visual impairment
Preoperative C-Reactive Protein/Albumin Ratio, a Risk Factor for Postoperative Delirium in Elderly Patients After Total Joint Arthroplasty	Peng, J. Wu, G. Chen, J. Chen, H.	Journal of Arthroplasty	2019	aged area under the curve arthroplasty article brain dysfunction controlled study diagnosis diagnostic test accuracy study epidural anesthesia female human incidence laboratory test major clinical study male multivariate logistic regression analysis postoperative delirium preoperative evaluation receiver operating characteristic risk factor sensitivity and specificity albumin biological marker C reactive protein endogenous compound
Combination of lithium and electroconvulsive therapy (ECT) is associated with higher odds of delirium and cognitive problems in a large national sample across the United States	Patel, R. S. Bachu, A. Youssef, N. A.	Brain Stimul	2019	Bipolar disorder Cognitive side effects Delirium Depression Electroconvulsive therapy Lithium Major depressive disorder Treatment-resistant depression
The long-term prognosis of patients with delirium in the acute phase of stroke: PRospective Observational POLIsh Study (PROPOLIS)	Pasinska, P. Wilk, A. Kowalska, K. Szyper-Maciejowska, A. Klimkowicz-Mrowiec, A.	J Neurol	2019	Delirium Long-term prognosis Mortality Stroke
Postoperative Delirium is Associated with Negative Outcomes and Long-Term Mortality in Elderly Koreans: A Retrospective Observational Study	Park, E. A. Kim, M. Y.	Medicina (Kaunas)	2019	delirium elderly mortality outcome surgery
Development of a Tool for the Assessment of Nurses' Attitudes Toward Delirium	Papastavrou, E. Papaioannou, M. Evripidou, M. Tsangari, H. Kouta, C. Merkouris, A.	J Nurs Meas	2019	attitude delirium nursing validation
The risk factors associated with delirium after lumbar spine surgery in elderly patients	Pan, Z. Huang, K. Huang, W. Kim, K. H. Wu, H. Yu, Y. Kim, K. N. Yi, S. Shin, D. A. Vora, D. Gragnaniello, C. Phan, K. Tasiou, A. Winder, M. J. Koga, H. Azimi, P. Kang, S. Y. Ha, Y.	Quantitative Imaging in Medicine and Surgery	2019	angiotensin receptor antagonist antihistaminic agent benzodiazepine derivative C reactive protein cholinergic receptor blocking agent dopamine receptor stimulating agent hydroxymethylglutaryl coenzyme A reductase inhibitor hypnotic agent opiate psychotropic agent aged article brain hemorrhage brain infarction cerebrovascular accident controlled study dementia diffusion weighted imaging female human incidence laminectomy lumbar spine magnetic resonance angiography major clinical study male mild cognitive impairment Mini Mental State Examination operation duration operative blood loss parkinsonism postoperative delirium preoperative period prospective study risk factor sex difference spinal cord decompression spine fusion spine surgery susceptibility weighted imaging transient ischemic attack very elderly
Incidence, risk factors, and cumulative risk of delirium among ICU patients: A case-control study	Pan, Y. Yan, J. Jiang, Z. Luo, J. Zhang, J. Yang, K.	International Journal of Nursing Sciences	2019	analgesic agent sedative agent aged APACHE article artificial ventilation case control study controlled study delirium diagnostic accuracy diagnostic test accuracy study female hospitalization human incidence intensive care unit length of stay major clinical study male mental disease assessment receiver operating characteristic retrospective study Richmond Agitation Sedation Scale risk assessment risk factor sensitivity and specificity very elderly
Perioperative dexmedetomidine reduces delirium in elderly patients after non-cardiac surgery: a systematic review and meta-analysis of randomized-controlled trials	Pan, H. Liu, C. Ma, X. Xu, Y. Zhang, M. Wang, Y.	Can J Anaesth	2019
International analgesia, sedation, and delirium practices: A prospective cohort study	Owen, G. D. Stollings, J. L. Rakhit, S. Wang, L. Yu, C. Hosay, M. A. Stewart, J. W. Frutos-Vivar, F. Peñuelas, O. Esteban, A. Anzueto, A. R. Raymondos, K. Rios, F. Thille, A. W. González, M. Du, B. Maggiore, S. M. Matamis, D. Abroug, F. Amin, P. Zeggwag	Journal of Intensive Care	2019	NCT02731898 benzodiazepine dexmedetomidine propofol acute respiratory failure adult aged analgesia article artificial ventilation asthma body mass Canada chronic lung disease chronic obstructive lung disease cohort analysis coma delayed emergence from anesthesia delirium female human major clinical study male multicenter study neuromuscular disease outcome assessment priority journal prospective study retrospective study Richmond Agitation Sedation Scale sedation Simplified Acute Physiology Score United States
Validation of 3-minute diagnostic interview for CAM-defined Delirium to detect postoperative delirium in the recovery room: A prospective diagnostic study	Olbert, M. Eckert, S. Morgeli, R. Kruppa, J. Spies, C. D.	Eur J Anaesthesiol	2019
Antipsychotics for Preventing Delirium in Hospitalized Adults: A Systematic Review	Oh, E. S. Needham, D. M. Nikooie, R. Wilson, L. M. Zhang, A. Robinson, K. A. Neufeld, K. J.	Ann Intern Med	2019
Prevention of Early Postoperative Decline: A Randomized, Controlled Feasibility Trial of Perioperative Cognitive Training	O'Gara, B. P. Mueller, A. Gasangwa, D. V. I. Patxot, M. Shaefi, S. Khabbaz, K. Banner-Goodspeed, V. Pascal-Leone, A. Marcantonio, E. R. Subramaniam, B.	Anesth Analg	2019
Antipsychotics for Treating Delirium in Hospitalized Adults: A Systematic Review	Nikooie, R. Neufeld, K. J. Oh, E. S. Wilson, L. M. Zhang, A. Robinson, K. A. Needham, D. M.	Ann Intern Med	2019
Characteristics of Hospitalized Patients Screening Positive for Delirium	Nguyen, T. H. Atayee, R. S. Derry, K. L. Hirst, J. Biondo, A. Edmonds, K. P.	Am J Hosp Palliative Care	2019	Cam-icu Doss delirium drugs mortality palliative
The effect of melatonin on delirium in hospitalised patients: A systematic review and meta-analyses with trial sequential analysis	Ng, K. T. Teoh, W. Y. Khor, A. J.	J Clin Anesth	2019	Agitation Delirium Length of hospital stay Melatonin Ramelteon