What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Patterns of Potentially Inappropriate Bladder Antimuscarinic Use in People with Dementia: A Retrospective Cohort Study | Green, A. R. Segal, J. Boyd, C. M. Huang, J. Roth, D. L. | Drugs Real World Outcomes | 2020 | |
| Incidence, determinants and consequences of delirium in older patients after transcatheter aortic valve implantation | Goudzwaard, J. A. de Ronde-Tillmans, Mjag de Jager, T. A. J. Lenzen, M. J. Nuis, R. J. van Mieghem, N. M. Daemen, J. de Jaegere, P. P. T. Mattace-Raso, F. U. S. | Age Ageing | 2020 |
aortic stenosis |
| Neuromonitoring of delirium with quantitative pupillometry in sedated mechanically ventilated critically ill patients | Favre, E. Bernini, A. Morelli, P. Pasquier, J. Miroz, J. P. Abed-Maillard, S. Ben-Hamouda, N. Oddo, M. | Crit Care | 2020 |
Cholinergic |
| Cognitive Outcomes of Long-term Benzodiazepine and Related Drug (BDZR) Use in People Living With Mild to Moderate Alzheimer's Disease: Results From NILVAD | Dyer, A. H. Murphy, C. Lawlor, B. Kennelly, S. P. | J Am Med Dir Assoc | 2020 |
Dementia |
| 'Nonagenarians' with a hip fracture: is a different orthogeriatric treatment strategy necessary? | de Groot, R. Nijmeijer, W. S. Folbert, E. C. Vollenbroek-Hutten, M. M. R. Hegeman, J. H. | Arch Osteoporos | 2020 |
Frail elderly |
| Comparison of single minimum dose administration of dexmedetomidine and midazolam for prevention of emergence delirium in children: a randomized controlled trial | Cho, E. A. Cha, Y. B. Shim, J. G. Ahn, J. H. Lee, S. H. Ryu, K. H. | J Anesth | 2020 |
Dexmedetomidine |
| Innovative care models across settings: Providing nursing care to older adults | Cacchione, P. Z. | Geriatr Nurs | 2020 |
Evercare/Optum |
| Is the bispectral index monitoring protective against postoperative cognitive decline? A systematic review with meta-analysis | Bocskai, T. Kovacs, M. Szakacs, Z. Gede, N. Hegyi, P. Varga, G. Pap, I. Toth, I. Revesz, P. Szanyi, I. Nemeth, A. Gerlinger, I. Karadi, K. Lujber, L. | PLoS One | 2020 |
Anesthesia |
| Postanesthesia care unit delirium following robot-assisted vs open retropubic radical prostatectomy: A prospective observational study | Beck, S. Hoop, D. Ragab, H. Rademacher, C. Messner-Schmitt, A. von Breunig, F. Haese, A. Graefen, M. Zollner, C. Fischer, M. | Int J Med Robot | 2020 |
Trendelenburg position |
| The impact of Hospital Elder Life Program interventions, on 30-day readmission Rates of older hospitalized patients | Zachary, W. Kirupananthan, A. Cotter, S. Barbara, G. H. Cooke, R. C., 3rd Sipho, M. | Arch Gerontol Geriatr | 2020 |
Cost savings |
| Prevalence and risk factors for postoperative delirium in patients with colorectal carcinoma: a systematic review and meta-analysis | Yang, Z. Wang, X. F. Yang, L. F. Fang, C. Gu, X. K. Guo, H. W. | Int J Colorectal Dis | 2020 |
Coloretal cancer |
| Incidence, risk factors, and outcomes for sepsis-associated delirium in patients with mechanical ventilation: A sub-analysis of a multicenter randomized controlled trial | Yamamoto, T. Mizobata, Y. Kawazoe, Y. Miyamoto, K. Ohta, Y. Morimoto, T. Yamamura, H. | Journal of Critical Care | 2020 |
fentanyl |
| Effects of different BP management strategies on postoperative delirium in elderly patients undergoing hip replacement: A single center randomized controlled trial | Xu, X. Hu, X. Wu, Y. Li, Y. Zhang, Y. Zhang, M. Yang, Q. | J Clin Anesth | 2020 |
Blood pressure |
| Preoperative prognostic nutritional index predicts postoperative delirium in elderly patients after hip fracture surgery | Xing, H. Xiang, D. Li, Y. Ji, X. Xie, G. | Psychogeriatrics | 2020 |
elderly |
| The effects of early femoral nerve block intervention on preoperative pain management and incidence of postoperative delirium geriatric patients undergoing trochanteric femur fracture surgery: A randomized controlled trial | Uysal, A. I. Altiparmak, B. Yasar, E. Turan, M. Canbek, U. Yilmaz, N. Gumus Demirbilek, S. | Ulus Travma Acil Cerrahi Derg | 2020 | |
| A smartphone-based test for the assessment of attention deficits in delirium: A case-control diagnostic test accuracy study in older hospitalised patients | Tieges, Z. Stott, D. J. Shaw, R. Tang, E. Rutter, L. M. Nouzova, E. Duncan, N. Clarke, C. Weir, C. J. Assi, V. Ensor, H. Barnett, J. H. Evans, J. Green, S. Hendry, K. Thomson, M. McKeever, J. Middleton, D. G. Parks, S. Walsh, T. Weir, A. J. Wilson, E. Qua | PLoS One | 2020 | |
| A 'real-world' analysis of risk factors for post liver transplant delirium and the effect on length of stay | Tavabie, O. D. Colwill, M. Adamson, R. McPhail, M. J. W. Bernal, W. Jassem, W. Prachialias, A. Heneghan, M. Aluvihare, V. R. Agarwal, K. | Eur J Gastroenterol Hepatol | 2020 | |
| Intraoperative hypotension and delirium in patients with hip fracture | Tantardini, V. Roca, F. Bahri, O. Compere, V. Dujardin, F. Chassagne, P. | Geriatr Psychol Neuropsychiatr Vieil | 2020 |
anaesthesia |
| Evaluation of emergence agitation after general anaesthesia in rhinoplasty patients: Inhalation anaesthesia versus total intravenous anaesthesia | Talih, G. Yüksek, A. Şahin, E. | American Journal of Otolaryngology - Head and Neck Medicine and Surgery | 2020 |
adult |
| Implementation of a multiprofessional, multicomponent delirium management guideline in two intensive care units, and its effect on patient outcomes and nurse workload: a pre-post design retrospective cohort study | Schubert, M. Bettex, D. Steiger, P. Schurch, R. Haller, A. Bogdanovic, J. Garcia Nunez, D. Schwarz, U. Siegemund, M. | Swiss Med Wkly | 2020 | |
| Cerebrospinal Fluid Levels of Interleukin-8 in Delirium, Dementia, and Cognitively Healthy Patients | Sajjad, M. U. Blennow, K. Knapskog, A. B. Idland, A. V. Chaudhry, F. A. Wyller, T. B. Zetterberg, H. Watne, L. O. | J Alzheimers Dis | 2020 |
Alzheimer’s disease |
| Prehospital Anticholinergic Burden Is Associated With Delirium but Not With Mortality in a Population of Acutely Ill Medical Patients | Rigor, J. Rueff Rato, I. Ferreira, P. M. Pereira, R. Ribeiro, C. Teixeira, D. Mesquita Oliveira, P. Silva, A. M. Pereira, S. Costa, I. Ferreira, P. Sequeira, M. Monteiro-Soares, M. Martins-Mendes, D. | J Am Med Dir Assoc | 2020 |
Anticholinergic |
| Impact of Vitamin C and Thiamine Administration on Delirium-Free Days in Patients with Septic Shock | Park, J. E. Shin, T. G. Jo, I. J. Jeon, K. Suh, G. Y. Park, M. Won, H. Chung, C. R. Hwang, S. Y. | J Clin Med | 2020 |
delirium |
| Evaluation of an updated sedation protocol to reduce benzodiazepines in a pediatric intensive care unit | Michel, J. Hofbeck, M. Peper, A. K. Kumpf, M. Neunhoeffer, F. | Curr Med Res Opin | 2020 |
Cardiac surgery |
| A qualitative exploration of the views of patients and their relatives regarding interventions to minimize the distress related to postoperative delirium | Meilak, C. Biswell, E. Willis, R. Partridge, J. Dhesi, J. | Int J Geriatr Psychiatry | 2020 |
aged |
| Incidence and risk factors of postoperative delirium in elderly patients undergoing urological surgery: A multi-institutional prospective study | Matsuki, M. Tanaka, T. Takahashi, A. Inoue, R. Hotta, H. Itoh, N. Taguchi, K. Kato, R. Kobayashi, K. Masumori, N. | Int J Urol | 2020 |
elderly patients |
| Still Predicting Delirium After All These Years | Marcantonio, ER | Anesth Analg | 2020 | |
| Ketamine sedation in mechanically ventilated patients: A systematic review and meta-analysis | Manasco, A. T. Stephens, R. J. Yaeger, L. H. Roberts, B. W. Fuller, B. M. | Journal of Critical Care | 2020 |
fentanyl |
| A Study of the Psychometric Properties of the “Stanford Proxy Test for Delirium” (S-PTD): A New Screening Tool for the Detection of Delirium | Maldonado, J. R. Sher, Y. I. Benitez-Lopez, M. A. Savant, V. Garcia, R. Ament, A. De Guzman, E. | Psychosomatics | 2020 |
adult |
| Risk factors for postoperative delirium after colorectal surgery: a systematic review and meta-analysis | Lee, S. H. Lim, S. W. | Int J Colorectal Dis | 2020 |
Colorectal surgery |
| Results from a double blinded, randomized, placebo-controlled, feasibility trial of melatonin for the treatment of delirium in older medical inpatients | Lange, P. W. Clayton-Chubb, D. I. Watson, R. Maier, A. B. | Intern Med J | 2020 |
Delirium |
| Risk factors and outcomes among delirium subtypes in adult ICUs: A systematic review | Krewulak, K. D. Stelfox, H. T. Ely, E. W. Fiest, K. M. | J Crit Care | 2020 |
Critical care |
| Survey of analgesia and sedation in pediatric intensive care units in Japan | Koizumi, T. Kurosawa, H. | Pediatr Int | 2020 |
analgesia |
| Association of neuronal repair biomarkers with delirium among survivors of critical illness | Hayhurst, C. J. Patel, M. B. McNeil, J. B. Girard, T. D. Brummel, N. E. Thompson, J. L. Chandrasekhar, R. Ware, L. B. Pandharipande, P. P. Ely, E. W. Hughes, C. G. | Journal of Critical Care | 2020 |
NCT00392795 |
| Dexmedetomidine's Relationship to Delirium in Patients Undergoing Cardiac Surgery: A Systematic Review | Halpin, E. Inch, H. O'Neill, M. | Crit Care Nurs Q | 2020 | |
| Management of delirium at an academic medical center: Plans for antipsychotic prescribing upon discharge | Halavonich, L. Robert, S. McGraw, D. Weeda, E. Mullinax, K. Bass, B. | Ment Health Clin | 2020 |
antipsychotic |
| Association Between Level of Arousal and 30-Day Survival in Acutely Ill Older Adults | Garcez, F. B. Jacob-Filho, W. Avelino-Silva, T. J. | J Am Med Dir Assoc | 2020 |
Delirium |
| Drug therapy for delirium in terminally ill adults | Finucane, A. M. Jones, L. Leurent, B. Sampson, E. L. Stone, P. Tookman, A. Candy, B. | Cochrane Database Syst Rev | 2020 | |
| Delirium in patients with hip fracture is associated with increased heart rate variability | Ernst, G. Watne, L. O. Rostrup, M. Neerland, B. E. | Aging Clin Exp Res | 2020 |
Autonomic nervous system |
| Risk factors for delirium after esophagectomy | Dezube, A. R. Bravo-Iniguez, C. E. Yelamanchili, N. De Leon, L. E. Tarascio, J. Jaklitsch, M. T. Wee, J. O. | J Surg Oncol | 2020 |
delirium |
| Delirium in a Tertiary PICU: Risk Factors and Outcomes | Dervan, L. A. Di Gennaro, J. L. Farris, R. W. D. Watson, R. S. | Pediatr Crit Care Med | 2020 | |
| Validity and Reliability of the Brazilian Portuguese Version of the Pediatric Confusion Assessment Method for the ICU | de Castro, R. E. V. Prata-Barbosa, A. de Magalhaes-Barbosa, M. C. Cunha, Ajlad Cheniaux, E. Smith, H. A. B. | Pediatr Crit Care Med | 2020 | |
| Outcomes for patients with delirium receiving hospital-in-the-home treatment: An Australian perspective | Chia, J. Eeles, E. M. Tattam, K. Yerkovich, S. | Australas J Ageing | 2020 |
delirium |
| A software to prevent delirium in hospitalised older adults: development and feasibility assessment | Alvarez, E. A. Garrido, M. Ponce, D. P. Pizarro, G. Cordova, A. A. Vera, F. Ruiz, R. Fernandez, R. Velasquez, J. D. Tobar, E. Salech, F. | Age Ageing | 2020 |
delirium |
| Cholinesterase alterations in delirium after cardiosurgery: a German monocentric prospective study | Adam, E. H. Haas, V. Lindau, S. Zacharowski, K. Scheller, B. | BMJ Open | 2020 |
acetylcholinesterase |
| Cornell Assessment of Pediatric Delirium: a valid, rapid, observational tool for screening delirium in the PICU* | Traube, C. Silver, G. Kearney, J. Patel, A. Atkinson, T. M. Yoon, M. J. Halpert, S. Augenstein, J. Sickles, L. E. Li, C. Greenwald, B. | Crit Care Med | 2014 |
Adolescent |
| The Preschool Confusion Assessment Method for the ICU: Valid and Reliable Delirium Monitoring for Critically Ill Infants and Children | Smith, H. A. Gangopadhyay, M. Goben, C. M. Jacobowski, N. L. Chestnut, M. H. Savage, S. Rutherford, M. T. Denton, D. Thompson, J. L. Chandrasekhar, R. Acton, M. Newman, J. Noori, H. P. Terrell, M. K. Williams, S. R. Griffith, K. Cooper, T. J. Ely, E. W. F | Crit Care Med | 2016 |
Child, Preschool |
| Diagnosing delirium in critically ill children: Validity and reliability of the Pediatric Confusion Assessment Method for the Intensive Care Unit | Smith, H. A. Boyd, J. Fuchs, D. C. Melvin, K. Berry, P. Shintani, A. Eden, S. K. Terrell, M. K. Boswell, T. Wolfram, K. Sopfe, J. Barr, F. E. Pandharipande, P. P. Ely, E. W. | Crit Care Med | 2011 |
Child |
| Development and psychometric evaluation of the pediatric anesthesia emergence delirium scale | Sikich, N. Lerman, J. | Anesthesiology | 2004 |
*Anesthesia Recovery Period |
| From Pediatrics to Geriatrics: Toward a Unified Standardized Screening Tool for Delirium: A Thought Experiment | Schieveld, J. N. van Zwieten, J. J. | Crit Care Med | 2016 |
Adult |
| Diagnostic considerations regarding pediatric delirium: a review and a proposal for an algorithm for pediatric intensive care units | Schieveld, J. N. van der Valk, J. A. Smeets, I. Berghmans, E. Wassenberg, R. Leroy, P. L. Vos, G. D. van Os, J. | Intensive Care Med | 2009 |
Age Factors |
| On the utility of diagnostic instruments for pediatric delirium in critical illness: an evaluation of the Pediatric Anesthesia Emergence Delirium Scale, the Delirium Rating Scale 88, and the Delirium Rating Scale-Revised R-98 | Janssen, N. J. Tan, E. Y. Staal, M. Janssen, E. P. Leroy, P. L. Lousberg, R. van Os, J. Schieveld, J. N. | Intensive Care Med | 2011 |
*Anesthesia Recovery Period |
| Validation of the SOS-PD scale for assessment of pediatric delirium: a multicenter study | Ista, E. van Beusekom, B. van Rosmalen, J. Kneyber, M. C. J. Lemson, J. Brouwers, A. Dieleman, G. C. Dierckx, B. de Hoog, M. Tibboel, D. van Dijk, M. | Crit Care | 2018 |
Adolescent |
| Sophia Observation withdrawal Symptoms-Paediatric Delirium scale: A tool for early screening of delirium in the PICU | Ista, E. Te Beest, H. van Rosmalen, J. de Hoog, M. Tibboel, D. van Beusekom, B. van Dijk, M. | Aust Crit Care | 2018 |
Adolescent |
| Psychometric evaluation of the Sophia Observation withdrawal symptoms scale in critically ill children | Ista, E. de Hoog, M. Tibboel, D. Duivenvoorden, H. J. van Dijk, M. | Pediatr Crit Care Med | 2013 |
Adolescent |
| Clinical recommendations for pain, sedation, withdrawal and delirium assessment in critically ill infants and children: an ESPNIC position statement for healthcare professionals | Harris, J. Ramelet, A. S. van Dijk, M. Pokorna, P. Wielenga, J. Tume, L. Tibboel, D. Ista, E. | Intensive Care Med | 2016 |
Child |
| Assessment scales for delirium: A review | Grover, S. Kate, N. | World J Psychiatry | 2012 |
Cognition |
| Diagnostic accuracy of delirium diagnosis in pediatric intensive care: a systematic review | Daoud, A. Duff, J. P. Joffe, A. R. Alberta Sepsis, Network | Crit Care | 2014 |
Anesthesia/adverse effects |
| Diagnostic accuracy of delirium diagnosis in pediatric intensive care: a systematic review | Daoud, A. Duff, J. P. Joffe, A. R. Alberta Sepsis, Network | Crit Care | 2014 |
Anesthesia/adverse effects |
| Delirium is prevalent in older hospital inpatients and associated with adverse outcomes: Results of a prospective multi-centre study on World Delirium Awareness Day | Welch, C. McCluskey, L. Wilson, D. Chapman, G. E. Jackson, T. A. Treml, J. Davis, D. Cunningham, E. Copeland, C. Quinn, T. Pinkney, T. Mahida, R. Nightingale, P. Richardson, S. Todd, O. Willott, R. Torsney, K. Ni Lochlainn, M. Giridharan, K. Cox, N. Masol | BMC Medicine | 2019 |
adult |
| Olanzapine Versus Haloperidol for Treatment of Delirium in Patients with Advanced Cancer: A Phase III Randomized Clinical Trial | van der Vorst, Mjdl Neefjes, E. C. W. Boddaert, M. S. A. Verdegaal, Batt Beeker, A. Teunissen, S. C. C. Beekman, A. T. F. Wilschut, J. A. Berkhof, J. Zuurmond, W. W. A. Verheul, H. M. W. | Oncologist | 2019 |
Advanced cancer |
| Diverging Awareness of Postoperative Delirium and Cognitive Dysfunction in German Health Care Providers | Sturm, H. Wildermuth, R. Stolz, R. Bertram, L. Eschweiler, G. W. Thomas, C. Rapp, M. Joos, S. | Clin Interv Aging | 2019 |
Pocd |
| An evaluation of the Danish version of the Pediatric Anesthesia Emergence Delirium scale | Simonsen, B. Y. Skovby, P. Lisby, M. | Acta Anaesthesiol Scand | 2019 | |
| Incidence and Risk Factors for Delirium in Elderly Patients with Critical Limb Ischaemia | Roijers, J. P. Rakke, Y. S. Hopmans, C. J. Buimer, M. G. de Groot, H. G. W. Ho, G. H. Veen, E. J. Mulder, P. G. H. van der Laan, L. | Eur J Vasc Endovasc Surg | 2019 |
Critical limb ischaemia |
| Initiative for Prevention and Early Identification of Delirium in Medical-Surgical Units: Lessons Learned in the Past Five Years | Rohatgi, N. Weng, Y. Bentley, J. Lansberg, M. G. Shepard, J. Mazur, D. Ahuja, N. Hopkins, J. | Am J Med | 2019 |
Delirium |
| Elevation of Preoperative Ammonia Level Is Not Associated With the Incidence of Postoperative Delirium in Patients with Liver Transplantation: A Propensity Score Matching Analysis | Ri, H. S. Choi, Y. J. Park, J. Y. Jin, S. J. Lee, Y. S. Son, J. M. Yoon, S. Z. Shin, H. W. Choi, B. H. Lee, T. B. | Transplant Proc | 2019 | |
| Fluctuations of consciousness after stroke: Associations with the confusion assessment method for the intensive care unit (CAM-ICU) and potential undetected delirium | Reznik, M. E. Daiello, L. A. Thompson, B. B. Wendell, L. C. Mahta, A. Potter, N. S. Yaghi, S. Levy, M. M. Fehnel, C. R. Furie, K. L. Jones, R. N. | J Crit Care | 2019 |
Consciousness |
| Postoperative serum albumin decrease independently predicts delirium in elderly subjects after total joint arthroplasty | Qi, J. Liu, C. Chen, L. Chen, J. | Curr Pharm Des | 2019 |
Postoperative delirium |
| Dexmedetomidine versus propofol sedation in reducing delirium among older adults in the ICU: A systematic review and meta-analysis | Pereira, J. V. Sanjanwala, R. M. Mohammed, M. K. Le, M. L. Arora, R. C. | Eur J Anaesthesiol | 2019 | |
| Delirium Rates in Advanced Cancer Patients Admitted to Different Palliative Care Settings: Does It Make the Difference? | Pallotti, M. C. Lopez-Fidalgo Ph, D. J. Biasco, G. Celin, D. Centeno, C. Paragona, M. Moroni, M. Noguera, A. | J Palliat Med | 2019 |
cancer patients |
| Randomized Controlled Trial of Enhanced Recovery Program Dedicated to Elderly Patients after Colorectal Surgery | Ostermann, S. Morel, P. Chalé, J. J. Bucher, P. Konrad, B. Meier, R. P. H. Ris, F. Schiffer, E. R. C. | Diseases of the Colon and Rectum | 2019 |
NCT01646190 |
| The effect of ketamine on emergence agitation in children: A systematic review and meta-analysis | Ng, K. T. Sarode, D. Lai, Y. S. Teoh, W. Y. Wang, C. Y. | Paediatr Anaesth | 2019 |
emergence agitation |
| BIS index monitoring and perioperative neurocognitive disorders in older adults: a systematic review and meta-analysis | Miao, M. Xu, Y. Sun, M. Chang, E. Cong, X. Zhang, J. | Aging Clin Exp Res | 2019 |
Bispectral index |
| Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients | McNeil, J. B. Hughes, C. G. Girard, T. Ware, L. B. Ely, E. W. Chandrasekhar, R. Han, J. H. | PLoS One | 2019 | |
| Randomized controlled trial of acupuncture to prevent emergence delirium in children undergoing myringotomy tube placement | Martin, C. S. Yanez, N. D. Treggiari, M. M. Piper, L. Cusick, J. Lalwani, K. | Minerva Anestesiol | 2019 | |
| Detecting delirium in patients with acute stroke: a systematic review of test accuracy | Mansutti, I. Saiani, L. Palese, A. | BMC Neurol | 2019 |
Instruments |
| Associations of 4AT with mobility, length of stay and mortality in hospital and discharge destination among patients admitted with hip fractures | Lisk, R. Yeong, K. Enwere, P. Jenkinson, J. Robin, J. Irvin-Sellers, M. Fluck, D. Osmani, A. Sharmin, R. Sharma, P. Fry, C. H. Han, T. S. | Age Ageing | 2019 |
Nhs |
| Effectiveness of an advanced practice nurse-led delirium education and training programme | Lieow, J. L. M. Chen, F. S. M. Song, G. Tang, P. S. Kowitlawakul, Y. Mukhopadhyay, A. | Int Nurs Rev | 2019 |
Advanced Practice Nurses |
| Comparison of emergence agitation between succinylcholine and rocuronium-sugammadex in adults following closed reduction of a nasal bone fracture: A prospective randomized controlled trial | Lee, S. J. Sung, T. Y. Cho, C. K. | BMC Anesthesiology | 2019 |
adult |
| Risk factors for post-intensive care syndrome: A systematic review and meta-analysis | Lee, M. Kang, J. Jeong, Y. J. | Aust Crit Care | 2019 |
Intensive care units |
| Effect of Perioperative Low-Dose Dexmedetomidine on Postoperative Delirium After Living-Donor Liver Transplantation: A Randomized Controlled Trial | Lee, H. Yang, S. M. Chung, J. Oh, H. W. Yi, N. J. Suh, K. S. Oh, S. Y. Ryu, H. G. | Transplant Proc | 2019 | |
| The Association of Perioperative Serum Lactate Levels with Postoperative Delirium in Elderly Trauma Patients | Lee, C. Lee, J. Cho, H. Song, J. Jung, H. Ma, X. Hwang, J. | BioMed Research International | 2019 |
lactic acid |
| Frailty defined by 19 items as a predictor of short-term functional recovery in patients with hip fracture | Inoue, T. Misu, S. Tanaka, T. Kakehi, T. Kakiuchi, M. Chuman, Y. Ono, R. | Injury | 2019 |
aged |
| Using language descriptors to recognise delirium: a survey of clinicians and medical coders to identify delirium-suggestive words | Holmes, N. E. Amjad, S. Young, M. Berlowitz, D. J. Bellomo, R. | Crit Care Resusc | 2019 |
*Clinical Coding |
| Diagnostic test accuracy meta-analysis of PRE-DELIRIC (PREdiction of DELIRium in ICu patients): A delirium prediction model in intensive care practice | Ho, M. H. Chen, K. H. Montayre, J. Liu, M. F. Chang, C. C. Traynor, V. Shen Hsiao, S. T. Chang, H. R. Chiu, H. Y. | Intensive Crit Care Nurs | 2019 |
Delirium |
| Delirium management: Let's get physical? A systematic review and meta-analysis | Haley, M. N. Casey, P. Kane, R. Y. Darzins, P. Lawler, K. | Australas J Ageing | 2019 |
delirium |
| Delirium post-cardiac surgery: Incidence and associated factors | Habeeb-Allah, A. Alshraideh, J. A. | Nurs Crit Care | 2019 |
associated factors |
| EEG Correlates of Delirium in Children and Young Adults With CD19-Directed CAR T Cell Treatment-Related Neurotoxicity | Gust, J. Annesley, C. E. Gardner, R. A. Bozarth, X. | J Clin Neurophysiol | 2019 | |
| Process of implementing and delivering the Prevention of Delirium system of care: a mixed method preliminary study | Godfrey, M. Green, J. Smith, J. Cheater, F. Inouye, S. K. Hurst, K. Young, J. | BMC Geriatr | 2019 |
Delirium prevention |
| Association between postoperative delirium and postoperative cerebral oxygen desaturation in older patients after cardiac surgery | Eertmans, W. De Deyne, C. Genbrugge, C. Marcus, B. Bouneb, S. Beran, M. Fret, T. Gutermann, H. Boer, W. Vander Laenen, M. Heylen, R. Mesotten, D. Vanelderen, P. Jans, F. | Br J Anaesth | 2019 |
cardiac surgery |
| Frailty and hospital outcomes within a low socioeconomic population | Clark, S. Shaw, C. Padayachee, A. Howard, S. Hay, K. Frakking, T. T. | QJM | 2019 | |
| Perioperative outcomes in geriatric patients undergoing hip fracture surgery with different anesthesia techniques: A systematic review and meta-analysis | Chen, D. X. Yang, L. Ding, L. Li, S. Y. Qi, Y. N. Li, Q. | Medicine | 2019 |
Aged |
| Postoperative delirium is associated with increased plasma neurofilament light | Casey, C. P. Lindroth, H. Mohanty, R. Farahbakhsh, Z. Ballweg, T. Twadell, S. Miller, S. Krause, B. Prabhakaran, V. Blennow, K. Zetterberg, H. Sanders, R. D. | Brain | 2019 |
adult |
| Differential clinical characteristics, management and outcome of delirium among ward compared with intensive care unit patients | Canet, E. Amjad, S. Robbins, R. Lewis, J. Matalanis, M. Jones, D. Bellomo, R. | Intern Med J | 2019 |
*agitation |
| An Evaluation of Risperidone Dosing for Pediatric Delirium in Children Less Than or Equal to 2 Years of Age | Campbell, C. T. Grey, E. Munoz-Pareja, J. Manasco, K. B. | Annals of Pharmacotherapy | 2019 |
article |
| Inpatient Rehabilitation Delirium Screening: Impact on Acute Care Transfers and Functional Outcomes | Bushi, S. Barrett, A. M. Oh-Park, M. | PMR | 2019 |
Acute Care Transfer |
| Routine Management of Postoperative Delirium Outside the ICU: Results of an International Survey among Anaesthesiologists | Bilotta, F. Weiss, B. Neuner, B. Kramer, S. Aldecoa, C. Bettelli, G. Sanders, R. D. Delp, S. M. Spies, C. D. | Acta Anaesthesiol Scand | 2019 |
Postoperative delirium |
| Impact of delirium on short-term outcomes in hip fracture patients under a program of approach to delirium | Bielza, R. Zambrana, F. Fernandez de la Puente, E. Sanjurjo, J. Andreu, C. Thuissard, I. J. Gomez Cerezo, J. | Geriatr Gerontol Int | 2019 |
delirium |
| Outcome Differences by Delirium Motor Subtype in Patients with Ischemic Stroke | Yang, H. W. Lee, M. Shin, J. W. Jeong, H. S. Kim, J. Kim, J. L. | Psychiatry Investig | 2019 |
Delirium |
| Serial Ottawa 3DY assessments to detect delirium in older emergency department community dwellers | Yadav, K. Boucher, V. Carmichael, P. H. Voyer, P. Eagles, D. Pelletier, M. Gouin, E. Daoust, R. Vu, T. T. M. Berthelot, S. Emond, M. | Age Ageing | 2019 |
delirium |