Delirium Bibliography

Delirium Bibliography books graphicWhat is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!

How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.

Reference Information

Title
Diurnal variation of postoperative delirium in elderly patients undergoing esketamine anesthesia for elective noncardiac surgery: a randomized clinical trial
Authors
Zhang, Y. Chen, R. Tang, S. Sun, T. Yu, Y. Shi, R. Wang, K. Zeng, Z. Liu, X. Meng, Q. Xia, Z.
Year
2024
Journal
Int J Surg
Abstract

BACKGROUND: Postoperative delirium (POD) is a serious and common complication. The aim of present study is to investigate the diurnal variation of POD and the effects of esketamine in elderly patients. METHODS: A randomized, double-blind, placebo-controlled clinical trial with factorial design was conducted. Patients (aged 65 to 85 years) with normal Mini-Mental State Examination (MMSE) score were stratified by age (≤70 vs. >70) and American Society of Anesthesiologists physical status classification (Ⅱ vs. Ⅲ), then randomly assigned to either morning (08:00-12:00) or afternoon (14:00-18:00) noncardiac operation under general anesthesia with or without esketamine administration (0.2 mg/kg). The primary outcome was the incidence of POD (3-Minute Diagnostic Interview for Confusion Assessment Method-defined Delirium, 3D-CAM) on postoperative days 1, 3, and 7. The secondary outcomes were the scores of MMSE and Hospital Anxiety and Depression Scale. The intention-to-treat analysis of the outcomes were performed by generalized estimating equation. RESULTS: Six patients who did not receive an intervention because of canceled operation were excluded after randomization. The datasets containing 426 cases were analyzed following the intention-to-treat principle after handling missing data via multiple imputation method. The incidence of POD declined from about 55% on postoperative day 1 to 31 and 18% on postoperative days 3 and 7, respectively. Afternoon operation [B=-0.583, OR (95% CI) 0.558 (0.319-0.976); P=0.041], but not esketamine, significantly decreased the incidence of POD. Both esketamine and operation time failed to significantly affect MMSE, HAD, and NRS score. There was no interaction among operation time, esketamine, and follow up time. CONCLUSION: Elderly patients undergoing elective noncardiac surgery in the afternoon displayed lower POD incidence than those operated in the morning. A single low-dose of esketamine before general anesthesia induction failed to significantly decrease the risk of POD but decrease the risk of intraoperative hypotension and emergence agitation.

PMID

PMID: 39275772

PMCID: PMC11392167

Keywords

Humans
*Ketamine/administration & dosage
Aged
Female
Male
Double-Blind Method
Aged, 80 and over
*Elective Surgical Procedures/adverse effects
*Postoperative Complications/prevention & control/epidemiology
Anesthesia, General/adverse effects
Circadian Rhythm
Delirium/prevention & control/epidemiology/diagnosis
Emergence Delirium/prevention & control/epidemiology/diagnosis

Page(s)
Issue

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Total Records Found: 6272, showing 100 per page
TitleAuthorsJournalYearKeywords
Cluster nursing can reduce postoperative delirium and improve the negative emotions and quality of life of elderly ICU patients Di, J. Wang, X. Chen, J. Am J Transl Res 2021

Cluster nursing
delirium
elderly
intensive care unit
quality of life

Cluster nursing can reduce postoperative delirium and improve the negative emotions and quality of life of elderly ICU patients Di, J. Wang, X. Chen, J. Am J Transl Res 2021

Cluster nursing
delirium
elderly
intensive care unit
quality of life

Influence of intraoperative and postoperative factors on the predictive capacity of the delirium risk model for cardiac surgery patients (DELIPRECAS): An observational multicentre study de la Varga-Martínez, O. Gómez-Pesquera, E. Muñoz-Moreno, M. F. Marcos-Vidal, J. M. López-Gómez, A. Rodenas-Gómez, F. Ramasco, F. Álvarez-Refojo, F. Barón, M. S. Tamayo, E. Heredia-Rodríguez, M. Gómez-Sánchez, E. J Clin Anesth 2021

Cardiac Surgical Procedures/adverse effects
Delirium/diagnosis/epidemiology/etiology
Humans
Postoperative Complications/diagnosis/epidemiology/etiology
Risk Factors
Cardiac surgery
Delirium
Prevention

Older trauma patients are at high risk of delirium, especially those with underlying dementia or baseline frailty Ní Chróinín D Francis, N. Wong, P. Kim, Y. D. Nham, S. D'Amours, S. Trauma Surg Acute Care Open 2021

cognition
frailty
geriatrics
patient outcome assessment

The Impact of Monitoring Depth of Anesthesia and Nociception on Postoperative Cognitive Function in Adult Multiple Trauma Patients Cotae, A. M. Ţigliş, M. Cobilinschi, C. Băetu, A. E. Iacob, D. M. Grinţescu, I. M. Medicina (Kaunas) 2021

Adult
Cognition
Delirium
Humans
Middle Aged
Multiple Trauma
Neuropsychological Tests
Nociception
Postoperative Complications
Prospective Studies
Pocd
anesthesia depth
entropy
general emergency surgery

Outcomes of trimodality CROSS regimen in older adults with locally advanced esophageal cancer Cooper, L. Dezube, A. R. De León, L. E. Kucukak, S. Mazzola, E. Dumontier, C. Mamon, H. Enzinger, P. Jaklitsch, M. T. Frain, L. N. Wee, J. O. Eur J Surg Oncol 2021

Cross
Esophageal cancer
Esophagectomy
Neoadjuvant toxicity
Older adults

Nursing intervention to prevent delirium in critically ill adults Contreras, C. C. T. Páez-Esteban, A. N. Rincon-Romero, M. K. Carvajal, R. R. Herrera, M. M. Castillo, Ahdd Rev Esc Enferm USP 2021
Changes in Sedation Practices in Association with Delirium Screening in Infants After Cardiopulmonary Bypass Chomat, M. R. Said, A. S. Mann, J. L. Wallendorf, M. Bickhaus, A. Figueroa, M. Pediatr Cardiol 2021

Cornell Assessment of Pediatric Delirium
Dexmedetomidine
Pediatric cardiac surgery
Pediatric delirium
Sedation
Sedation wean

Risk factors of postoperative delirium after cardiac surgery: a meta-analysis Chen, H. Mo, L. Hu, H. Ou, Y. Luo, J. J Cardiothorac Surg 2021

Age Factors
Cardiac Surgical Procedures/ adverse effects
Carotid Stenosis/epidemiology
Cognitive Dysfunction/epidemiology
Delirium/ etiology
Depression/epidemiology
Diabetes Mellitus/epidemiology
Humans
Intensive Care Units
Length of Stay
Postoperative Complications/etiology
Respiration, Artificial
Risk Factors
Cardiac surgery
Meta-analysis
Postoperative delirium

Diagnosis of overweight or obese malnutrition spells DOOM for hip fracture patients: A prospective audit Bell, J. J. Pulle, R. C. Lee, H. B. Ferrier, R. Crouch, A. Whitehouse, S. L. Clin Nutr 2021

Body mass index
Hip fracture
Malnutrition
Obesity
Overweight

Risk factors for delirium among hospitalized patients in Zambia Mateyo, K. Yan, Y. Liu, D. Zuo, Y. Di Gravio, C. Thome, J. C. Riviello, E. D. Saylor, D. Ely, E. W. Heimburger, D. C. PLoS One 2021
Risk factors associated with treatment of hyperactive postoperative delirium in elderly patients following hip fracture surgery under regional anesthesia: a nationwide population-based study Ahn, E. J. Bang, S. R. Braz J Anesthesiol 2021

Anesthesia
Delirium
Hip fracture

Incidence of delirium in the critical care unit and risk factors in the Central Region, Saudi Arabia Abazid, R. M. Al-Harbi, S. A. Allihimy, A. S. Aldrewesh, D. A. Alkuraydis, S. A. Alhammad, I. M. Elbashir, A. Y. Widyan, A. M. Abohamr, S. I. Saudi Med J 2021

Saudi
critical care
delirium

The risk factors of postoperative delirium in patients with hip fracture: implication for clinical management Xu, W. Ma, H. Li, W. Zhang, C. BMC Musculoskelet Disord 2021

Delirium/diagnosis/epidemiology/etiology
Hip Fractures/epidemiology/surgery
Humans
Incidence
Postoperative Complications/diagnosis/epidemiology/etiology
Risk Factors
Delirium
Hip fracture
Nursing care
Risk
Surgery

Nationwide mortality trends of delirium in Australia and the United States from 2006 to 2016 Wu, H. Mach, J. Le Couteur, D. G. Hilmer, S. N. Australas J Ageing 2021

delirium
geriatrics
mortality
sex differences
trends

The Use of Near-Infrared Spectroscopy and/or Transcranial Doppler as Non-Invasive Markers of Cerebral Perfusion in Adult Sepsis Patients With Delirium: A Systematic Review Wood, M. D. Boyd, J. G. Wood, N. Frank, J. Girard, T. D. Ross-White, A. Chopra, A. Foster, D. Griesdale, D. E. G. J Intensive Care Med 2021

cerebral autoregulation
delirium
near-infrared spectroscopy
pulsatility index
sepsis
transcranial Doppler

Midazolam Premedication Immediately Before Surgery Is Not Associated With Early Postoperative Delirium Wang, M. L. Min, J. Sands, L. P. Leung, J. M. Anesth Analg 2021
The Effect of a Quality Improvement Intervention on Sleep and Delirium in Critically Ill Patients in a Surgical ICU Tonna, J. E. Dalton, A. Presson, A. P. Zhang, C. Colantuoni, E. Lander, K. Howard, S. Beynon, J. Kamdar, B. B. Chest 2021

critical care
delirium
sleep
sleep hygiene
wakefulness

Association between components of the delirium syndrome and outcomes in hospitalised adults: a systematic review and meta-analysis Tieges, Z. Quinn, T. MacKenzie, L. Davis, D. Muniz-Terrera, G. MacLullich, A. M. J. Shenkin, S. D. BMC Geriatr 2021

Cognition
Cognitive Dysfunction
Delirium/diagnosis
Humans
Altered mental status
Arousal
Attention
Delirium
Mortality
Systematic review

The Prognostic Performance of Frailty for Delirium and Functional Decline in Vascular Surgery Patients Thillainadesan, J. Mudge, A. M. Aitken, S. J. Hilmer, S. N. Cullen, J. S. Yumol, M. F. Close, J. C. T. Norris, C. M. Kerdic, R. Naganathan, V. J Am Geriatr Soc 2021

delirium
frailty
function
geriatric surgery

Efficacy of quetiapine for delirium prevention in hospitalized older medical patients: a randomized double-blind controlled trial Thanapluetiwong, S. Ruangritchankul, S. Sriwannopas, O. Chansirikarnjana, S. Ittasakul, P. Ngamkala, T. Sukumalin, L. Charernwat, P. Saranburut, K. Assavapokee, T. BMC Geriatr 2021

Aged
Antipsychotic Agents/adverse effects
Delirium/diagnosis/drug therapy/prevention & control
Double-Blind Method
Haloperidol/therapeutic use
Humans
Quetiapine Fumarate/adverse effects
Thailand
Delirium
Hospitalized
Older
Prevention
Quetiapine

Effects of Slowness, Frailty, Insufficient Intake, and Delirium in Patients Following Cardiac Surgery: A Cohort Study Teng, C. H. Hsu, R. B. Chi, N. H. Wang, S. S. Chen, Y. S. Chen, S. Y. Chen, C. C. J Cardiovasc Nurs 2021
Factors associated with the severity of delirium Tachibana, M. Inada, T. Ichida, M. Kojima, S. Shioya, M. Wakayama, K. Ozaki, N. Hum Psychopharmacol 2021

Drs-r98
benzodiazepine
delirium
severity
β-blocker

Screening for delirium in the intensive care unit using eDIS-ICU - A purpose-designed app: A pilot study Sutt, A. L. Flaws, D. Gunn, H. Eeles, E. Lye, I. Irvine, L. Patterson, S. Bagshaw, T. O'Luanaigh, C. Tronstad, O. Fraser, J. Aust Crit Care 2021

Delirium
Icu
Screening tools
Technology

Association Among Preoperative Cognitive Performance, Regional Cerebral Oxygen Saturation, and Postoperative Delirium in Older Portuguese Patients Susano, M. J. Dias, M. Seixas, F. S. Vide, S. Grasfield, R. Abelha, F. J. Crosby, G. Culley, D. J. Amorim, P. Anesth Analg 2021

Age Factors
Aged
Aged, 80 and over
Blood Gas Monitoring, Transcutaneous
Cerebrovascular Circulation
Cognition
Cognitive Dysfunction/ complications/diagnosis/psychology
Delirium/diagnosis/ etiology/psychology
Elective Surgical Procedures/ adverse effects
Female
Humans
Male
Neuropsychological Tests
Oxygen/ blood
Portugal
Postoperative Complications/diagnosis/ etiology/psychology
Prospective Studies
Risk Assessment
Risk Factors
Spectroscopy, Near-Infrared
Treatment Outcome

Sleep and circadian rhythm disturbances in intensive care unit (ICU)-acquired delirium: a case-control study Sun, T. Sun, Y. Huang, X. Liu, J. Yang, J. Zhang, K. Kong, G. Han, F. Hao, D. Wang, X. J Int Med Res 2021

Adolescent
Adult
Aged
Case-Control Studies
Circadian Rhythm
Delirium/diagnosis
Humans
Intensive Care Units
Middle Aged
Sleep
Young Adult
Delirium
cortisol
critical care
melatonin
polysomnography
sleep

Terminal Delirium in Hospice: The Experiences and Perspectives of Caregivers Providing Care to Terminally Ill Patients in Home Settings Soroka, J. T. Fling, K. J. Heibel, J. M. Kutcher, G. R. Ward, S. J. Am J Hosp Palliat Care 2021

caregivers
delirium experiences
end-of-life care
hospice home care
interventions
terminal delirium

Estimates of Geriatric Delirium Frequency in Noncardiac Surgeries and Its Evaluation Across the Years: A Systematic Review and Meta-analysis Silva, A. R. Regueira, P. Albuquerque, E. Baldeiras, I. Cardoso, A. L. Santana, I. Cerejeira, J. J Am Med Dir Assoc 2021

Delirium
anesthesia
frequency
incidence
noncardiac surgery
old age

The Effects of Bispectral Index-Guided Anesthesia on Postoperative Delirium in Elderly Patients: A Systematic Review and Meta-Analysis Shan, W. Chen, B. Huang, L. Zhou, Y. World Neurosurg 2021

Bispectral index
Elderly patients
Major surgery
Postoperative delirium

Validation of the Delirium Diagnostic Tool-Provisional (DDT-Pro) in a skilled nursing facility and comparison to the 4 'A's test (4AT) Sepúlveda, E. Bermúdez, E. González, D. Cotino, P. Viñuelas, E. Palma, J. Ciutat, M. Grau, I. Vilella, E. Trzepacz, P. T. Franco, J. G. Gen Hosp Psychiatry 2021

Delirium diagnosis
Diagnostic tests comparison.
Geriatric assessment.
Psychiatric status rating scales.
Skilled nursing.

Evaluation of Delirium in Critically Ill Patients Prescribed Melatonin or Ramelteon Romero, N. Dube, K. M. Lupi, K. E. DeGrado, J. R. Ann Pharmacother 2021

agitation
delirium
intensive care unit
melatonin
ramelteon
sedation

Delirium and delirium severity predict the trajectory of the Hierarchical Assessment of Balance and Mobility (HABAM) in hospitalised older people: findings from the DECIDE Study Richardson, S. Murray, J. Davis, D. Stephan, B. C. M. Robinson, L. Brayne, C. Barnes, L. Parker, S. Sayer, A. Dodds, R. Allan, L. J Gerontol A Biol Sci Med Sci 2021

Epidemiology
Hospital related
Physical function

Common biomarkers of physiologic stress and associations with delirium in patients with intracerebral hemorrhage Reznik, M. E. Kalagara, R. Moody, S. Drake, J. Margolis, S. A. Cizginer, S. Mahta, A. Rao, S. S. Stretz, C. Wendell, L. C. Thompson, B. B. Asaad, W. F. Furie, K. L. Jones, R. N. Daiello, L. A. J Crit Care 2021

Biomarkers
Delirium
Intracerebral hemorrhage

Effects of Preoperative Anxiety on Postoperative Delirium in Elderly Patients Undergoing Elective Orthopedic Surgery: A Prospective Observational Cohort Study Ren, A. Zhang, N. Zhu, H. Zhou, K. Cao, Y. Liu, J. Clin Interv Aging 2021

Aged
Aged, 80 and over
Anxiety/ epidemiology
Cohort Studies
Delirium/ epidemiology
Elective Surgical Procedures/ adverse effects
Female
Humans
Logistic Models
Male
Mental Status and Dementia Tests
Odds Ratio
Orthopedic Procedures/ adverse effects
Postoperative Complications/ epidemiology
Prospective Studies
Risk Factors
anxiety
delirium
orthopedic

Hyperactive delirium in patients after non-traumatic subarachnoid hemorrhage Reimann, F. Rinner, T. Lindner, A. Kofler, M. Ianosi, B. A. Schiefecker, A. J. Beer, R. Schmutzhard, E. Pfausler, B. Helbok, R. Rass, V. J Crit Care 2021

Critical care
Delirium
Intensive care delirium screening checklist
Subarachnoid hemorrhage

Prescribing Practices of Valproic Acid for Agitation and Delirium in the Intensive Care Unit Quinn, N. J. Hohlfelder, B. Wanek, M. R. Duggal, A. Torbic, H. Ann Pharmacother 2021

Aged
Anticonvulsants/pharmacology/ therapeutic use
Antipsychotic Agents/ therapeutic use
Cohort Studies
Female
Humans
Incidence
Intensive Care Units/ standards
Male
Middle Aged
Psychomotor Agitation/ drug therapy
Retrospective Studies
Valproic Acid/pharmacology/ therapeutic use
agitation
critical illness
delirium
sedation
valproic acid

Delirium and Mortality in Coronavirus Disease 2019 (COVID-19) - A Systematic Review and Meta-analysis Pranata, R. Huang, I. Lim, M. A. Yonas, E. Vania, R. Kuswardhani, R. A. T. Arch Gerontol Geriatr 2021

Aged

Covid-19
Delirium/diagnosis/epidemiology
Humans
Hypertension/epidemiology
Male
Pandemics
SARS-CoV-2
Confusion
Delirium
Geriatric
Severe

Dexmedetomidine vs. total intravenous anaesthesia in paediatric emergence delirium: A network meta-analysis Petre, M. A. Levin, D. N. Englesakis, M. Maynes, J. T. Pechlivanoglou, P. Aoyama, K. Eur J Anaesthesiol 2021
Delirium prevalence in a Colombian hospital, association with geriatric syndromes and complications during hospitalization Peralta-Cuervo, A. F. Garcia-Cifuentes, E. Castellanos-Perilla, N. Chavarro-Carvajal, D. A. Venegas-Sanabria, L. C. Cano-Gutiérrez, C. A. Rev Esp Geriatr Gerontol 2021

Aged
Delirio
Delirium
Envejecido
Factores de riesgo
Funcionalidad
Functionality
Mortalidad
Mortality
Risk factors

Anticholinergic load and delirium in end-of-life patients Pasina, L. Rizzi, B. Nobili, A. Recchia, A. Eur J Clin Pharmacol 2021

Anticholinergic drugs
Delirium
Elderly
End-of-life

Patients, family members and providers perceive family-administered delirium detection tools in the adult ICU as feasible and of value to patient care and family member coping: a qualitative focus group study Parsons Leigh, J. Krewulak, K. D. Zepeda, N. Farrier, C. E. Spence, K. L. Davidson, J. E. Stelfox, H. T. Fiest, K. M. Can J Anaesth 2021

Adaptation, Psychological
Adult
Alberta
Delirium/diagnosis
Family
Focus Groups
Humans
Intensive Care Units
Icu
critical care
delirium

Serum melatonin concentration in critically ill patients randomized to sedation or non-sedation Oxlund, J. Knudsen, T. Strøm, T. Lauridsen, J. T. Jennum, P. J. Toft, P. Ann Intensive Care 2021

Circadian
Delirium
Melatonin
Non-sedation
Rhythm
Sedation

Depression predicts cognitive and functional decline one month after coronary artery bypass graft surgery (Neuropsychiatric Outcomes After Heart Surgery study) Oldham, M. A. Lin, I. H. Hawkins, K. A. Li, F. Y. Yuh, D. D. Lee, H. B. Int J Geriatr Psychiatry 2021

Aged
Cardiac Surgical Procedures
Cognition
Coronary Artery Bypass
Depression
Female
Humans
Neuropsychological Tests
Prospective Studies
CABGsurgery
cognitive decline
functional status
neuropsychological testing

Effect of deep neuromuscular blockade on serum cytokines and postoperative delirium in elderly patients undergoing total hip replacement: A prospective single-blind randomised controlled trial Oh, C. S. Lim, H. Y. Jeon, H. J. Kim, T. H. Park, H. J. Piao, L. Kim, S. H. Eur J Anaesthesiol 2021

Aged
Arthroplasty, Replacement, Hip/adverse effects
Cytokines
Delirium/diagnosis/epidemiology/etiology
Double-Blind Method
Humans
Neuromuscular Blockade
Prospective Studies
Single-Blind Method

Cerebral autoregulation in the operating room and intensive care unit after cardiac surgery Nakano, M. Nomura, Y. Whitman, G. Sussman, M. Schena, S. Kilic, A. Choi, C. W. Akiyoshi, K. Neufeld, K. J. Lawton, J. Colantuoni, E. Yamaguchi, A. Wen, M. Smielewski, P. Brady, K. Bush, B. Hogue, C. W. Brown, C. H. th Br J Anaesth 2021

Aged
Arterial Pressure/ physiology
Cardiac Surgical Procedures/ methods
Cerebrovascular Circulation/ physiology
Delirium/ physiopathology
Female
Homeostasis/physiology
Humans
Intensive Care Units
Male
Middle Aged
Monitoring, Intraoperative/methods
Operating Rooms
Oximetry
cardiac surgery
cerebral autoregulation
delirium
geriatrics
intensive care unit

Propofol plus low-dose dexmedetomidine infusion and postoperative delirium in older patients undergoing cardiac surgery Momeni, M. Khalifa, C. Lemaire, G. Watremez, C. Tircoveanu, R. Van Dyck, M. Kahn, D. Rosal Martins, M. Mastrobuoni, S. De Kerchove, L. Zango, S. H. Jacquet, L. M. Br J Anaesth 2021

Aged
Cardiac Surgical Procedures
Delirium/ prevention & control
Dexmedetomidine/ administration & dosage/therapeutic use
Dose-Response Relationship, Drug
Double-Blind Method
Drug Therapy, Combination
Female
Humans
Hypnotics and Sedatives/administration & dosage/ therapeutic use
Infusions, Intravenous
Male
Postoperative Complications/ prevention & control
Propofol/ administration & dosage/therapeutic use
Treatment Outcome
Confusion Assessment Method
cardiac surgery
dexmedetomidine
older patients
postoperative delirium

Delirium REduction after administration of melatonin in acute ischemic stroke (DREAMS): A propensity score-matched analysis Mengel, A. Zurloh, J. Boßelmann, C. Brendel, B. Stadler, V. Sartor-Pfeiffer, J. Meisel, A. Fleischmann, R. Ziemann, U. Poli, S. Stefanou, M. I. Eur J Neurol 2021

delirium
delirium prevention
ischemic stroke
melatonin
poststroke delirium

Incidence, Risk Factors and Impact on Long-Term Outcome of Postoperative Delirium After Transcatheter Aortic Valve Replacement Mauri, V. Reuter, K. Körber, M. I. Wienemann, H. Lee, S. Eghbalzadeh, K. Kuhn, E. Baldus, S. Kelm, M. Nickenig, G. Veulemans, V. Jansen, F. Adam, M. Rudolph, T. K. Front Cardiovasc Med 2021

Tavr
delirium
frailty
survival
transcatheter aortic valve implantation

Predisposing and Precipitating Factors for Delirium in the Very Old (≥80 Years): A Prospective Cohort Study of 3,076 Patients Marquetand, J. Bode, L. Fuchs, S. Ernst, J. von Känel, R. Boettger, S. Gerontology 2021

80 years
Delirium
Disorders
Risk factors
Very old

Delirium and Functional Recovery in Patients Discharged to Skilled Nursing Facilities After Hospitalization for Heart Failure Madrigal, C. Kim, J. Jiang, L. Lafo, J. Bozzay, M. Primack, J. Correia, S. Erqou, S. Wu, W. C. Rudolph, J. L. JAMA Netw Open 2021

Activities of Daily Living
Aged
Aged, 80 and over
Delirium
Dementia
Female
Heart Failure/psychology/ rehabilitation/therapy
Hospitalization
Humans
Male
Patient Discharge
Patient Readmission
Recovery of Function
Retrospective Studies
Skilled Nursing Facilities
United States

Prevalence of high-risk medications in patients enrolled in the Hospital Elder Life Program Macias Tejada, J. A. Klumph, M. Heslin, K. Khan, A. Malone, M. L. J Am Geriatr Soc 2021

antipsychotics
benzodiazepines
delirium
high-risk medications
hospital elder life program

Acupuncture Treatment of Delirium in Older Adults Hospitalized in Internal Medicine Departments: An Open-Label Pragmatic Randomized-Controlled Trial Levy, I. Gavrieli, S. Hefer, T. Attias, S. Schiff, A. Oliven, R. Wisberg-Levi, S. Hanchinsky, R. Schiff, E. J Geriatr Psychiatry Neurol 2021

acupuncture
delirium
hospitalization
internal medicine
older adults
traditional Chinese medicine

Impact of an orthogeriatric collaborative care model for older adults with hip fracture in a community hospital setting Lee, J. C. Koo, K. Wong, E. K. C. Naqvi, R. Wong, C. L. Can J Surg 2021
Cardiac Delirium Index for Predicting the Occurrence of Postoperative Delirium in Adult Patients After Coronary Artery Bypass Grafting Lechowicz, K. Szylińska, A. Listewnik, M. Drożdżal, S. Tomska, N. Rotter, I. Kotfis, K. Clin Interv Aging 2021

Aged
Biomarkers/blood
C-Reactive Protein/analysis
Coronary Artery Bypass/ adverse effects
Delirium/ blood/ etiology
Female
Humans
Male
Middle Aged
Postoperative Complications/epidemiology
Retrospective Studies
Risk Assessment
Risk Factors
Cabg
Cam-icu
Pod
cardiac surgery
coronary artery bypass grafting
delirium

Delirium documentation in hospitalized pediatric patients with cancer Lastrapes, K. Dang, M. Cassel, J. B. Orr, T. Proffitt, T. Del Fabbro, E. Palliat Support Care 2021

Delirium
Documentation and ICD coding for delirium
Pediatric oncology

Efficacy of two integrated geriatric care pathways for the treatment of hip fractures: a cross-cultural comparison Kusen, J. Q. van der Vet, P. C. R. Wijdicks, F. J. G. Verleisdonk, Ejjm Link, B. C. Houwert, R. M. Knobe, M. van der Velde, D. Babst, R. Beeres, F. J. P. Eur J Trauma Emerg Surg 2021

Clinical pathway
Cross-cultural comparison
Geriatrician
Hip fracture
Trauma surgeon

Depressed mood, associated factors, and understanding of delirium among caregivers of patients with delirium Kim, S. Y. Jhon, M. Kang, H. J. Lee, J. Y. Kim, S. W. Kim, J. M. Shin, I. S. Int J Psychiatry Med 2021

caregiver
delirium
depression
education
information
misinterpretation

Scheduled Prophylactic 6-Hourly IV AcetaminopheN to Prevent Postoperative Delirium in Older CaRdiac SurgicAl Patients (PANDORA): protocol for a multicentre randomised controlled trial Khera, T. Mathur, P. A. Banner-Goodspeed, V. M. Narayanan, S. McGourty, M. Kelly, L. Palihnich, K. Novack, L. Davis, R. Talmor, D. Marcantonio, E. R. Subramaniam, B. BMJ Open 2021

Acetaminophen
Aged
Boston
Cardiac Surgical Procedures/adverse effects
Cerebrovascular Circulation
Delirium/prevention & control
Double-Blind Method
Humans
Multicenter Studies as Topic
Oximetry
Randomized Controlled Trials as Topic
adult intensive & critical care
anaesthesia in cardiology
cardiac surgery
delirium & cognitive disorders

Serum Biomarkers in Postoperative Delirium after Esophagectomy Khan, S. H. Lindroth, H. Jawed, Y. Wang, S. Nasser, J. Seyffert, S. Naqvi, K. Perkins, A. J. Gao, S. Kesler, K. Khan, B. Ann Thorac Surg 2021

biomarkers
c-reactive protein
delirium
esophagectomy
postoperative delirium

Drug-related problems of antipsychotics in treating delirium among elderly patients: A real-world observational study Jenraumjit, R. Somboon, J. Chainan, S. Chuenchom, P. Wongpakaran, N. Wongpakaran, T. J Clin Pharm Ther 2021

antipsychotics
delirium
drug-related problems
elderly

Effect of Melatonin on Delirium After on-Pump Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial Javaherforoosh Zadeh, F. Janatmakan, F. Shafaeebejestan, E. Jorairahmadi, S Iran J Med Sci 2021

Delirium
Melatonin
Thoracic surgery

A polysomnography study examining the association between sleep and postoperative delirium in older hospitalized cardiac surgical patients Ibala, R. Mekonnen, J. Gitlin, J. Hahm, E. Y. Ethridge, B. R. Colon, K. M. Marota, S. Ortega, C. Pedemonte, J. C. Cobanaj, M. Chamadia, S. Qu, J. Gao, L. Barbieri, R. Akeju, O. J Sleep Res 2021

cardiac surgery
delirium
hospitalization
older
polysomnography
sleep

Delirium in older patients undergoing aortic valve replacement: incidence, predictors, and cognitive prognosis Humbert, M. Büla, C. J. Muller, O. Krief, H. Monney, P. BMC Geriatr 2021

Activities of Daily Living
Aged
Aged, 80 and over
Aortic Valve/surgery
Cognition
Delirium/diagnosis/epidemiology/etiology
Heart Valve Prosthesis Implantation/adverse effects
Humans
Incidence
Prognosis
Prospective Studies
Risk Assessment
Risk Factors
Treatment Outcome
Aortic stenosis
Delirium
Society of thoracic surgeons risk score
Surgical aortic valve replacement
Transcatheter aortic valve replacement

A clinical risk analysis of early post-operative delirium after laparoscopic colorectal cancer surgery in elderly patients: a retrospective study Hiraki, M. Tanaka, T. Ishii, H. Sadashima, E. Miura, D. Sunami, T. Hanafusa, K. Sato, H. Kitahara, K. Int J Colorectal Dis 2021

Aged
Aged, 80 and over
Colorectal Neoplasms/surgery
Delirium
Humans
Laparoscopy/adverse effects
Postoperative Complications/etiology
Retrospective Studies
Risk Assessment
Risk Factors
Colorectal cancer
Elderly patient
Laparoscopic surgery
Post-operative delirium

Nurses' experiences of delirium and how to identify delirium-A qualitative study Helgesen, A. K. Adan, Y. H. Dybvik Bjørglund, C. Weberg-Haugen, C. Johannessen, M. Åsmul Kristiansen, K. Vasskog Risan, E. Relusco, M. L. Skaarer-Heen, H. M. Sørensen, T. S. Vedå, L. Abrahamsen Grøndahl, V. Nurs Open 2021

Delirium/diagnosis
Female
Focus Groups
Humans
Nurses
Nursing Care
Qualitative Research
community care
delirium
identification
knowledge
qualitative

Preoperative Comparison of Three Anticholinergic Drug Scales in Older Adult Patients and Development of Postoperative Delirium: A Prospective Observational Study Heinrich, M. Müller, A. Cvijan, A. Mörgeli, R. Kruppa, J. Winterer, G. Slooter, A. J. C. Spies, C. D. Drugs Aging 2021
Characterization of Nocturnal Neuroactive Medication Use and Related Sleep Documentation in Critically Ill Adults Hamidi, A. Roberts, R. J. Weinhouse, G. L. Szumita, P. M. Degrado, J. R. Dube, K. M. Kovacevic, M. P. Choi, M. Sevinsky, R. Duprey, M. S. Devlin, J. W. Crit Care Explor 2021

antipsychotics
delirium
intensive care
melatonin
ramelteon
sleep

Optimal interval and duration of CAM-ICU assessments for delirium detection after cardiac surgery Hamadnalla, H. Sessler, D. I. Troianos, C. A. Fang, J. Rivas, E. Ma, C. Mascha, E. J. Turan, A. J Clin Anesth 2021

Anesthesia
Cam-icu
Cognitive impairment
Delirium
Surgery

Is there evidence for using anticonvulsants in the prevention and/or treatment of delirium among older adults? Gupta, A. Joshi, P. Bhattacharya, G. Lehman, M. Funaro, M. Tampi, D. J. Tampi, R. R. Int Psychogeriatr 2021

anticonvulsants
delirium
gabapentin
older adults
pregabalin
prevention
treatment

Is there evidence for using anticonvulsants in the prevention and/or treatment of delirium among older adults? Gupta, A. Joshi, P. Bhattacharya, G. Lehman, M. Funaro, M. Tampi, D. J. Tampi, R. R. Int Psychogeriatr 2021

anticonvulsants
delirium
gabapentin
older adults
pregabalin
prevention
treatment

Association of CSF Alzheimer's disease biomarkers with postoperative delirium in older adults Fong, T. G. Vasunilashorn, S. M. Gou, Y. Libermann, T. A. Dillon, S. Schmitt, E. Arnold, S. E. Kivisäkk, P. Carlyle, B. Oh, E. S. Vlassakov, K. Kunze, L. Hshieh, T. Jones, R. N. Marcantonio, E. R. Inouye, S. K. Alzheimers Dement (N Y) 2021

AD biomarkers
delirium

Impact of Delirium and Its Motor Subtypes on Stroke Outcomes Fialho Silva, I. T. Assis Lopes, P. Timotio Almeida, T. Ramos, S. C. Caliman Fontes, A. T. Guimarães Silva, D. Martins Soares, C. Oliveira Carneiro, L. Souza, I. F. B. Ferreira Abreu, F. Nascimento Silva, G. Mascarenhas de Souza, L. Brito Pinheiro, T. de Stroke 2021

cognition
death
delirium
intensive care unit
prognosis
stroke

The experience of delirium in palliative care settings for patients, family, clinicians and volunteers: A qualitative systematic review and thematic synthesis Featherstone, I. Hosie, A. Siddiqi, N. Grassau, P. Bush, S. H. Taylor, J. Sheldon, T. Johnson, M. J. Palliat Med 2021

Delirium
palliative care
qualitative research
systematic review

The association of post-operative delirium with patient-reported outcomes and mortality after lung transplantation DeBolt, C. L. Gao, Y. Sutter, N. Soong, A. Leard, L. Jeffrey, G. Kleinhenz, M. E. Calabrese, D. Greenland, J. Venado, A. Hays, S. R. Shah, R. Kukreja, J. Trinh, B. Kolaitis, N. A. Douglas, V. Diamond, J. M. Smith, P. Singer, J. Clin Transplant 2021

Critical care medicine
delirium
delirium outcomes
lung transplant
lung transplantation

Does rocking motion calm delirious patients in ICU? A multicentre randomised clinical trial protocol (RockingICU) Collet, M. O. Nielsen, G. M. Bang, B. Laerkner, E. Fischer, S. Langvad, A. Thorn, L. Lange, T. Egerod, I. Acta Anaesthesiol Scand 2021

delirium
intensive care
mobilisation

Do specific delirium aetiologies have different associations with death? A longitudinal cohort of hospitalised patients Chalmers, L. A. Searle, S. D. Whitby, J. Tsui, A. Davis, D. Eur Geriatr Med 2021

Aetiology
Ageing
Delirium
Hospital
Mortality
Survival

Development and External Validation of a Delirium Prediction Model for Hospitalized Patients With Coronavirus Disease 2019 Castro, V. M. Sacks, C. A. Perlis, R. H. McCoy, T. H. J Acad Consult Liaison Psychiatry 2021

Covid-19
cohort study
crisis standard of care
delirium
electronic health records
machine learning
predictive modeling

Incidence and risk factors of delirium in surgical intensive care unit Ali, M. A. Hashmi, M. Ahmed, W. Raza, S. A. Khan, M. F. Salim, B. Trauma Surg Acute Care Open 2021

brain
morbidity
observational study
risk factor

Economic Impact of Poststroke Delirium and Associated Risk Factors: Findings From a Prospective Cohort Study Zipser, C. M. Deuel, J. W. Held, J. P. O. Ernst, J. Schubert, M. Weller, M. Luft, A. R. von Känel, R. Boettger, S. Stroke 2021

costs
delirium
dementia
odds ratio
risk factor

Development and validation of a delirium risk assessment tool in older patients admitted to the Emergency Department Observation Unit Zucchelli, A. Apuzzo, R. Paolillo, C. Prestipino, V. De Bianchi, S. Romanelli, G. Padovani, A. Marengoni, A. Bellelli, G. Aging Clin Exp Res 2021

Delirium
Emergency department
Older persons
Prediction score

Differences in efficacy and safety of midazolam vs. dexmedetomidine in critically ill patients: A meta-analysis of randomized controlled trial Zhou, W. J. Liu, M. Fan, X. P. Exp Ther Med 2021

critically ill
dexmedetomidine
midazolam

Risk factors of postoperative delirium after liver transplantation: a systematic review and meta-analysis Zhou, J. Xu, X. Liang, Y. Zhang, X. Tu, H. Chu, H. Minerva Anestesiol 2021
Derivation and validation of a novel comorbidity-based delirium risk index to predict postoperative delirium using national administrative healthcare database Zhong, X. Lin, J. Y. Li, L. Barrett, A. M. Poeran, J. Mazumdar, M. Health Serv Res 2021

Lasso
comorbidity
covariate adjustment
delirium
index
prediction

The Association Between Frailty and Delirium Among Hospitalized Patients: An Updated Meta-Analysis Zhang, X. M. Jiao, J. Xie, X. H. Wu, X. J. J Am Med Dir Assoc 2021

Frailty
delirium
hospitalized patients
meta-analysis
mortality

Effectiveness of Bundle Interventions on ICU Delirium: A Meta-Analysis Zhang, S. Han, Y. Xiao, Q. Li, H. Wu, Y. Crit Care Med 2021
Development and validation of a predictive score for ICU delirium in critically ill patients Zhang, H. Yuan, J. Chen, Q. Cao, Y. Wang, Z. Lu, W. Bao, J. BMC Anesthesiol 2021

Delirium
Incidence
Intensive care unit
Prediction
Risk factors

Comparison of the '4-item assessment test' and 'nursing delirium screening scale' delirium screening tools on nonintensive care unit wards: A prospective mixed-method approach Zastrow, I. Tohsche, P. Loewen, T. Vogt, B. Feige, M. Behnke, M. Wolff, A. Kiefmann, R. Olotu, C. Eur J Anaesthesiol 2021
Effects of general versus regional anaesthesia on circadian melatonin rhythm and its association with postoperative delirium in elderly patients undergoing hip fracture surgery: study protocol for a prospective cohort clinical trial Yuan, Y. Song, Y. Wang, G. Jia, Y. Zhou, Y. Mi, X. Jia, X. Wang, X. Liu, C. Li, Y. Shi, C. Han, Y. Guo, X. Zhang, W. Li, Z. BMJ Open 2021

Aged
Anesthesia, Conduction
Circadian Rhythm
Delirium/epidemiology/etiology/prevention & control
Hip Fractures/surgery
Humans
Melatonin
Postoperative Complications
Prospective Studies
adult anaesthesia
anaesthesia in orthopaedics
delirium & cognitive disorders

Association Between Dexamethasone and Delirium in Critically Ill Patients: A Retrospective Cohort Study of a Large Clinical Database Wu, Z. Li, H. Liao, K. Wang, Y. J Surg Res 2021

Delirium
Dexamethasone
Intensive care unit (ICU)
Mortality
Propensity score matching (PSM)

Perioperative risk factors for recovery room delirium after elective non-cardiovascular surgery under general anaesthesia Wu, J. Gao, S. Zhang, S. Yu, Y. Liu, S. Zhang, Z. Mei, W. Perioper Med (Lond) 2021

Delirium
General anaesthesia
Non-cardiac surgery
Postoperative recovery
Risk factors

Management of delirium within intraoperative settings for older adults with hip fracture: a scoping review White, L. B. Coyne, E. Grealish, L. J Clin Nurs 2021

Anaesthesia
delirium
hip fracture
intraoperative

Delirium screening tools validated in the context of palliative care: A systematic review Watt, C. L. Scott, M. Webber, C. Sikora, L. Bush, S. H. Kabir, M. Boland, J. W. Woodhouse, R. Sands, M. B. Lawlor, P. G. Palliat Med 2021

Adult
Delirium/diagnosis
Hospice and Palliative Care Nursing
Humans
Mass Screening
Palliative Care
Delirium
cognitive assessment screening instrument
screening
systematic review

The Relationship of Postoperative Delirium and Unplanned Perioperative Hypothermia in Surgical Patients Wagner, D. Hooper, V. Bankieris, K. Johnson, A. J Perianesth Nurs 2021

noncardiac surgery
postoperative delirium
unplanned hypothermia

Proteome-Wide Analysis using SOMAscan Identifies and Validates Chitinase-3-Like Protein 1 as a Risk and Disease Marker of Delirium Among Older Adults Undergoing Major Elective Surgery Vasunilashorn, S. M. Dillon, S. T. Chan, N. Y. Fong, T. G. Joseph, M. Tripp, B. Xie, Z. Ngo, L. H. Lee, C. G. Elias, J. A. Otu, H. H. Inouye, S. Marcantonio, E. R. Libermann, T. A. J Gerontol A Biol Sci Med Sci 2021

inflammation
postoperative
proteomics

Delirium in your house: a survey during General Practitioner-programmed home visits Tremolizzo, L. Bargossi, L. Storti, B. Ferrarese, C. Bellelli, G. Appollonio, I. Aging Clin Exp Res 2021

4at
Delirium
Dementia
General practitioner
Home visits

Dexmedetomidine for hyperactive delirium at the end of life: An open-label single arm pilot study with dose escalation in adult patients admitted to an inpatient palliative care unit Thomas, B. Lo, W. A. Nangati, Z. Barclay, G. Palliat Med 2021

Adult
Death
Delirium/drug therapy
Dexmedetomidine/therapeutic use
Humans
Hypnotics and Sedatives/therapeutic use
Inpatients
Intensive Care Units
Palliative Care
Pilot Projects
Prospective Studies
Delirium
conscious sedation
dexmedetomidine
hypnotics and sedatives
terminal care

Significant decrease in delirium referrals after changing hypnotic from benzodiazepine to suvorexant Tachibana, M. Inada, T. Ichida, M. Kojima, S. Arai, T. Naito, K. Ozaki, N. Psychogeriatrics 2021

Aged
Azepines
Benzodiazepines/therapeutic use
Delirium/chemically induced/drug therapy
Humans
Hypnotics and Sedatives/adverse effects
Referral and Consultation
Sleep Initiation and Maintenance Disorders/drug therapy
Triazoles
benzodiazepine
delirium
general hospital
hypnotic
psychiatry
suvorexant

Haloperidol, clonidine and resolution of delirium in critically ill patients: a prospective cohort study Smit, L. Dijkstra-Kersten, S. M. A. Zaal, I. J. van der Jagt, M. Slooter, A. J. C. Intensive Care Med 2021

Clonidine/therapeutic use
Cohort Studies
Critical Illness
Delirium/drug therapy
Haloperidol/therapeutic use
Humans
Intensive Care Units
Prospective Studies
Clonidine
Critical care
Delirium
Haloperidol
Intensive care unit

Acute-onset delirium in intensive care COVID patients: association of imperfect brain repair with foodborne micro-pollutants Schneider, F. Agin, A. Baldacini, M. Maurer, L. Schenck, M. Alemann, M. Solis, M. Helms, J. Villette, C. Artzner, T. Kremer, S. Heintz, D. Eur J Neurol 2021

Covid
brain
delirium
erythropoietin
hypoxia
metabolomics

Delirium in acute stroke: A prospective, cross-sectional, cohort study Rollo, E. Callea, A. Brunetti, V. Vollono, C. Marotta, J. Imperatori, C. Frisullo, G. Broccolini, A. Della Marca, G. Eur J Neurol 2021

Cam-icu
delirium
physical restraint
risk factors
stroke
stroke unit