What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Six-Year Cognitive Trajectory in Older Adults Following Major Surgery and Delirium
- Authors
- Kunicki, Z. J. Ngo, L. H. Marcantonio, E. R. Tommet, D. Feng, Y. Fong, T. G. Schmitt, E. M. Travison, T. G. Jones, R. N. Inouye, S. K.
- Year
- 2023
- Journal
- JAMA Intern Med
- Abstract
IMPORTANCE: The study results suggest that delirium is the most common postoperative complication in older adults and is associated with poor outcomes, including long-term cognitive decline and incident dementia. OBJECTIVE: To examine the patterns and pace of cognitive decline up to 72 months (6 years) in a cohort of older adults following delirium. DESIGN, SETTING, AND PARTICIPANTS: This was a prospective, observational cohort study with long-term follow-up including 560 community-dwelling older adults (older than 70 years) in the ongoing Successful Aging after Elective Surgery study that began in 2010. The data were analyzed from 2021 to 2022. EXPOSURE: Development of incident delirium following major elective surgery. MAIN OUTCOMES AND MEASURES: Delirium was assessed daily during hospitalization using the Confusion Assessment Method, which was supplemented with medical record review. Cognitive performance using a comprehensive battery of neuropsychological tests was assessed preoperatively and across multiple points postoperatively to 72 months of follow-up. We evaluated longitudinal cognitive change using a composite measure of neuropsychological performance called the general cognitive performance (GCP), which is scaled so that 10 points on the GCP is equivalent to 1 population SD. Retest effects were adjusted using cognitive test results in a nonsurgical comparison group. RESULTS: The 560 participants (326 women [58%]; mean [SD] age, 76.7 [5.2] years) provided a total of 2637 person-years of follow-up. One hundred thirty-four participants (24%) developed postoperative delirium. Cognitive change following surgery was complex: we found evidence for differences in acute, post-short-term, intermediate, and longer-term change from the time of surgery that were associated with the development of postoperative delirium. Long-term cognitive change, which was adjusted for practice and recovery effects, occurred at a pace of about -1.0 GCP units (95% CI, -1.1 to -0.9) per year (about 0.10 population SD units per year). Participants with delirium showed significantly faster long-term cognitive change with an additional -0.4 GCP units (95% CI, -0.1 to -0.7) or -1.4 units per year (about 0.14 population SD units per year). CONCLUSIONS AND RELEVANCE: This cohort study found that delirium was associated with a 40% acceleration in the slope of cognitive decline out to 72 months following elective surgery. Because this is an observational study, we cannot be sure whether delirium directly causes subsequent cognitive decline, or whether patients with preclinical brain disease are more likely to develop delirium. Future research is needed to understand the causal pathway between delirium and cognitive decline.
- PMID
PMID: 36939716
PMCID: PMC10028541
- Keywords
dementia, delirium, older adults, prospective study, Cognitive Trajectory, follow-up, surgical
- Page(s)
- Volume
- Issue
Title | Authors | Journal | Year | Keywords |
---|---|---|---|---|
Developing a machine learning model to identify delirium risk in geriatric internal medicine inpatients | Li, Q. Zhao, Y. Chen, Y. Yue, J. Xiong, Y. | Eur Geriatr Med | 2021 |
Delirium |
Development and validation of a risk score for predicting postoperative delirium after major abdominal surgery by incorporating preoperative risk factors and surgical Apgar score | Li, G. H. Zhao, L. Lu, Y. Wang, W. Ma, T. Zhang, Y. X. Zhang, H. | J Clin Anesth | 2021 |
Bootstrapping |
Non-Pharmacological Nursing Interventions for Prevention and Treatment of Delirium in Hospitalized Adult Patients: Systematic Review of Randomized Controlled Trials | Lee, Y. Lee, J. Kim, J. Jung, Y. | Int J Environ Res Public Health | 2021 |
Adult |
Association of natural light exposure and delirium according to the presence or absence of windows in the intensive care unit | Lee, H. J. Bae, E. Lee, H. Y. Lee, S. M. Lee, J. | Acute Crit Care | 2021 |
delirium |
Knowledge, barriers, and training needs of nurses working in delirium care | Lee, G. Roh, Y. S | Nurs Crit Care | 2021 |
barrier |
Causes and Predictors of 30-Day Readmission in Elderly Patients With Delirium | Lau, H. L. Patel, S. D. Garg, N. | Neurol Clin Pract | 2021 |
Readmission rate, Delirium, Hospitalization, Length of stay, Post discharge care |
Comparison of Antipsychotics for the Treatment of Patients With Delirium and QTc Interval Prolongation: A Clinical Decision Analysis | Kurisu, K. Yoshiuchi, K. | Front Psychiatry | 2021 |
QTc prolongation |
The Polish Version of the Nursing Delirium Screening Scale (NuDESC PL)-Experience of Using in Nursing Practice in Cardiac Surgery Intensive Care Unit | Krupa, S. Dorota, O. Friganovic, A. Mędrzycka-Dąbrowska, W. Jurek, K. | Int J Environ Res Public Health | 2021 |
Cardiac Surgical Procedures/adverse effects |
Associations of delirium with urinary tract infections and asymptomatic bacteriuria in adults aged 65 and older: A systematic review and meta-analysis | Krinitski, D. Kasina, R. Klöppel, S. Lenouvel, E. | J Am Geriatr Soc | 2021 |
asymptomatic bacteriuria |
Prevalence and Factors Affecting Postoperative Delirium in a Neurosurgical Intensive Care Unit | Kose, G. Şirin, K. Inel, M. B. Mertoglu, S. Aksakal, R. Kurucu, Ş | J Neurosci Nurs | 2021 |
Cross-Sectional Studies |
Effect of hypertension and medication use regularity on postoperative delirium after maxillofacial tumors radical surgery | Kong, S. Wang, J. Xu, H. Wang, K. | Oncotarget | 2021 |
hypertension |
Perioperative Electroencephalogram Spectral Dynamics Related to Postoperative Delirium in Older Patients | Koch, S. Windmann, V. Chakravarty, S. Kruppa, J. Yürek, F. Brown, E. N. Winterer, G. Spies, C. | Anesth Analg | 2021 |
Electroencephalography, Postoperative delirium, Surgery, Spectral edge frequency |
Is dislocation following total hip arthroplasty caused while suffering from delirium? | Kobayashi, T. Morimoto, T. Sonohata, M. Mawatari, M. | Nagoya J Med Sci | 2021 |
dislocation |
Availability of preoperative neutrophil-lymphocyte ratio to predict postoperative delirium after head and neck free-flap reconstruction: A retrospective study | Kinoshita, H. Saito, J. Takekawa, D. Ohyama, T. Kushikata, T. Hirota, K. | PLoS One | 2021 |
Postoperative delirium, ICU delirium, Neutrophil-lymphocyte ratio, Surgery, Length of Stay |
Delirium risk of histamine-2 receptor antagonists and proton pump inhibitors: A study based on the adverse drug event reporting database in Japan | Kikkawa, N. Sogawa, R. Monji, A. Sumi, S. Murakawa-Hirachi, T. Kubo, T. Eguchi, Y. Miyamoto, Y. Kamo, M. Tobita, S. Yukawa, M. Uchida, R. Egoshi, M. Shimanoe, C. | Gen Hosp Psychiatry | 2021 |
Delirium |
Delirium in neurosurgery: a systematic review and meta-analysis | Kappen, P. R. Kakar, E. Dirven, C. M. F. van der Jagt, M. Klimek, M. Osse, R. J. Vincent, Apje | Neurosurg Rev | 2021 |
Delirium |
Risk factors for postoperative delirium and subsyndromal delirium in older patients in the surgical ward: A prospective observational study | Kanno, M. Doi, M. Kubota, K. Kanoya, Y. | PLoS One | 2021 |
Postoperative delirium, Subsyndromal delirium, Surgery, CAM |
Diagnostic accuracy and clinical applicability of the Swedish version of the 4AT assessment test for delirium detection, in a mixed patient population and setting | Johansson, Y. A. Tsevis, T. Nasic, S. Gillsjö, C. Johansson, L. Bogdanovic, N. Kenne Sarenmalm, E | BMC Geriatr | 2021 |
Aged |
In-Hospital Delirium as a Prognostic Factor for New Cognitive Disorder in a 1-Year Post-Hip Fracture Follow-Up | Jaatinen, R. Luukkaala, T. Hongisto, M. T. Helminen, H. Nuotio, M. S. | Dement Geriatr Cogn Disord | 2021 |
Cognition |
Italian version of the short 10/66 dementia diagnostic schedule: a validation study | Ibnidris, A. Piumatti, G. Carlevaro, F. Fadda, M. Magno, F. Magistro, D. Albanese, E. | BMJ Open | 2021 |
Aged |
A Machine Learning-Based Algorithm for the Prediction of Intensive Care Unit Delirium (PRIDE): Retrospective Study | Hur, S. Ko, R. E. Yoo, J. Ha, J. Cha, W. C. Chung, C. R. | JMIR Med Inform | 2021 |
clinical prediction |
The effect of evidence-based cluster nursing intervention on the incidences of delirium and the prognoses of ICU patients | Huang, S. Xu, J. Du, Y. Wang, Y. Wei, H. Wei, G. Hu, M. | Am J Transl Res | 2021 |
Evidence-based medicine |
Impact of dexmedetomidine supplemented analgesia on delirium in patients recovering from orthopedic surgery: A randomized controlled tria | Hong, H. Zhang, D. Z. Li, M. Wang, G. Zhu, S. N. Zhang, Y. Wang, D. X. Sessler, D. I. | BMC Anesthesiol | 2021 |
Delirium |
Effects of a simulation-based education programme on delirium care for critical care nurses: A randomized controlled trial | Ho, M. H. Yu, L. F. Lin, P. H. Chang, H. R. Traynor, V. Huang, W. C. Montayre, J. Chen, K. H. | J Adv Nurs | 2021 |
Clinical Competence |
Postoperative Delirium in Older Patients: A Systematic Review of Assessment and Incidence of Postoperative Delirium | Ho, M. H. Nealon, J. Igwe, E. Traynor, V. Chang, H. R. Chen, K. H. Montayre, J. | Worldviews Evid Based Nurs | 2021 |
Aged |
Harmonization of Four Delirium Instruments: Creating Crosswalks and the Delirium Item-Bank (DEL-IB) | Helfand, B. K. I. Detroyer, E. Milisen, K. Adamis, D. Metzger, E. D. Boudreaux, E. D. Inouye, S. K. Jones, R. N. | Am J Geriatr Psychiatry | 2021 | |
Association between genetic variants of the cholinergic system and postoperative delirium and cognitive dysfunction in elderly patients | Heinrich, M. Sieg, M. Kruppa, J. Nürnberg, P. Schreier, P. H. Heilmann-Heimbach, S. Hoffmann, P. Nöthen, M. M. Janke, J. Pischon, T. Slooter, A. J. C. Winterer, G. Spies, C. D. | BMC Med Genomics | 2021 |
Chrm2 |
Risk of delirium and impaired neurological outcome associated with delay in neurorehabilitation after acquired brain injury | Hansen, P. M. Lauridsen, J. T. Frandsen, N. S. | Dan Med J | 2021 |
*Brain Injuries |
Prevalence, Risk Factors, and Impact of Delirium on Hospitalized Older Adults With Dementia: A Systematic Review and Meta-Analysis | Han, Q. Y. C. Rodrigues, N. G. Klainin-Yobas, P. Haugan, G. Wu, X. | J Am Med Dir Assoc | 2021 |
Dementia |
Urinary albumin creatinine ratio associated with postoperative delirium in elderly patients undergoing elective non-cardiac surgery: A prospective observational study | Guan, H. L. Liu, H. Hu, X. Y. Abdul, M. Dai, M. S. Gao, X. Chen, X. F. Zhou, Y. Sun, X. Zhou, J. Li, X. Zhao, Q. Zhang, Q. Q. Wang, J. Han, Y. Cao, J. L. | CNS Neurosci Ther | 2021 |
delirium |
Cognitive Impairment and Delirium in Older Patients Undergoing Major Head and Neck Surgery | Goldstein, D. P. Blasco, M. de Almeida, J. Su, J. Xu, W. Cohen, M. Sklar, M. Alibhai, S | Otolaryngol Head Neck Surg | 2021 |
clock draw test |
What prompts patients to present with delirium? | Gibb, K. Krywonos, A. Shah, R. Jha, A. Davis, D. | Eur Geriatr Med | 2021 |
Adult |
Admission Systolic Blood Pressure Predicts Post-Operative Delirium of Acute Aortic Dissection Patients in the Intensive Care Unit | Fu, Z. Xu, Q. Zhang, C. Bai, H. Chen, X. Zhang, Y. Luo, W. Lin, G. | Int J Gen Med | 2021 |
acute Stanford type A aortic dissection |
Postoperative Delirium in Patients After Brain Tumor Surgery | French, J. Weber, T. Ge, B. Litofsky, N. S. | World Neurosurg | 2021 |
Confusion assessment method |
Physical Restraints and Post-Traumatic Stress Disorder in Survivors of Critical Illness. A Systematic Review and Meta-analysis | Franks, Z. M. Alcock, J. A. Lam, T. Haines, K. J. Arora, N. Ramanan, M. | Ann Am Thorac Soc | 2021 |
Adult |
Long-Term Outcomes in ICU Patients with Delirium: A Population-based Cohort Study | Fiest, K. M. Soo, A. Hee Lee, C. Niven, D. J. Ely, E. W. Doig, C. J. Stelfox, H. T. | Am J Respir Crit Care Med | 2021 |
Adolescent |
The effect of foot reflexology massage on delirium and sleep quality following cardiac surgery: A randomized clinical trial | Fazlollah, A. Babatabar Darzi, H. Heidaranlu, E. Moradian, S. T. | Complement Ther Med | 2021 |
*Cardiac Surgical Procedures/adverse effects |
A delirium prevalence audit and a pre and post evaluation of an interprofessional education intervention to increase staff knowledge about delirium in older adults | Ewens, B. Seaman, K. Whitehead, L. Towell-Barnard, A. Young, M. | BMC Nurs | 2021 |
Delirium |
Anaesthetic depth and delirium after major surgery: a randomised clinical trial | Evered, L. A. Chan, M. T. V. Han, R. Chu, M. H. M. Cheng, B. P. Scott, D. A. Pryor, K. O. Sessler, D. I. Veselis, R. Frampton, C. Sumner, M. Ayeni, A. Myles, P. S. Campbell, D. Leslie, K. Short, T. G. | Br J Anaesth | 2021 |
anaesthesia |
Association of preoperative frailty with postoperative delirium in elderly orthopedic trauma patients | Esmaeeli, S. Franco-Garcia, E. Akeju, O. Heng, M. Zhou, C. Azocar, R. J. Quraishi, S. A. | Aging Clin Exp Res | 2021 |
Cognition |
Prevention of postoperative delirium after cardiovascular surgery: A team-based approach | Enomoto, K. Kosaka, S. Kimura, T. Matsubara, M. Kitada, Y. Mieno, M. Okamura, H. | J Thorac Cardiovasc Surg | 2021 |
Delirium Team Approach program |
Serum Levels of S100β, Neuron-Specific Enolase, Glial Fibrillary Acidic Protein in Kidney Transplant Recipients and Donors: A Prospective Cohort Study | Dinc, B. Yılmaz, V. T. Aslan, M. Aycan, I. O. Kiraz, N. Kisaoglu, A. Dandin, O. Hadimioglu, N. Ertug, Z. | Transplant Proc | 2021 |
Nephrectomy, Kidney transplant, Neuromarkers, Postoperative delirium |
Delirium and Its Pharmacological Causes in Older People, Part 1 | DeMaagd, G. A. DeMaagd, D. R. Philip, A. Coalter, C. F. | Sr Care Pharm | 2021 |
Aged |
Potentially inappropriate prescribing in dementia, multi-morbidity and incidence of adverse health outcomes | Delgado, J. Jones, L. Bradley, M. C. Allan, L. M. Ballard, C. Clare, L. Fortinsky, R. H. Hughes, C. M. Melzer, D. | Age Ageing | 2021 |
Aged |
The Nexus Between Sleep Disturbance and Delirium Among Intensive Care Patients | Delaney, L. J. Litton, E. Van Haren, F. | Crit Care Nurs Clin North Am | 2021 |
Critical Care |
Opportunities for quality improvement in the morbidity pattern of older adults undergoing pulmonary lobectomy for cancer | De León, L. E. Rochefort, M. M. Bravo-Iñiguez, C. E. Fox, S. W. Tarascio, J. N. Cardin, K. DuMontier, C. Frain, L. N. Jaklitsch, M. T. | J Geriatr Oncol | 2021 |
Aged |
Palliative sedation in patients with advanced cancer in a specialized unit in a middle-income country: A retrospective cohort study | de Araujo, C. Z. S. de Araújo, L. Z. S. Nassar Junior, A. P. | Palliat Support Care | 2021 |
Cancer |
Development and Implementation of a Multicomponent Protocol to Promote Sleep and Reduce Delirium in a Medical Intensive Care Unit | Darby, A. Northam, K. Austin, C. A. Chang, L. Campbell-Bright, S | Ann Pharmacother | 2021 |
critical care |
Effect of Interventions With a Clinical Decision Support System for Hospitalized Older Patients: Systematic Review Mapping Implementation and Design Factors | Damoiseaux-Volman, B. A. van der Velde, N. Ruige, S. G. Romijn, J. A. Abu-Hanna, A. Medlock, S. | JMIR Med Inform | 2021 |
aged |
Sevoflurane-Remifentanil Versus Propofol-Remifentanil Anesthesia During Noncardiac Surgery for Patients with Coronary Artery Disease - A Prospective Study Between 2016 and 2017 at a Single Center | Dai, Z. Lin, M. Li, Y. Gao, W. Wang, P. Lin, J. Wan, Z. Jiang, Y. | Med Sci Monit | 2021 |
Acute Coronary Syndrome, Coronary Artery Disease, Propofol |
Symptom trajectories for palliative care inpatients with and without hyperactive delirium in the last week of life | Dai, Y. Walpole, G. Ding, J. Scanlon, C. Ho, L. Khoo, R. H. Huang, C. Cook, A. William, L. Johnson, C. E. | J Adv Nurs | 2021 |
end of life |
Subtypes of delirium after ischaemic stroke-predisposing factors and outcomes: a prospective observational study (PROPOLIS) | Czyzycki, M. Klimiec-Moskal, E. Chrobak, A. A. Pera, J. Slowik, A. Dziedzic, T. | Eur J Neurol | 2021 |
delirium |
Effectiveness of a Delirium Prevention Initiative on an Inpatient Neuroscience Unit | Cyrus, T. Wenthold, R. Hall, B. Tu, L. Hedquist, K. Omodt, J. Kozub, E. Guthrie, P. F. | J Neurosci Nurs | 2021 |
Clinical Competence |
Association Between Cerebral Desaturation and Postoperative Delirium in Thoracotomy With One-Lung Ventilation: A Prospective Cohort Study | Cui, F. Zhao, W. Mu, D. L. Zhao, X. Li, X. Y. Wang, D. X. Jia, H. Q. Dai, F. Meng, L. | Anesth Analg | 2021 |
Aged |
Factors for Timely Identification of Possible Occurrence of Delirium in Palliative Care: A Prospective Observational Study | Corli, O. Santucci, C. Uggeri, S. Bosetti, C. Cattaneo, M. Ermolli, D. Varrassi, G. Myrcik, D. Paladini, A. Rekatsina, M. Gerosa, C. Ornaghi, M. Roccasalva, A. Santambrogio, P. Beretta, M. | Adv Ther | 2021 |
*Delirium/chemically induced/diagnosis/epidemiology |
A Processed Electroencephalogram-Based Brain Anesthetic Resistance Index Is Associated With Postoperative Delirium in Older Adults: A Dual Center Study | Cooter Wright, M. Bunning, T. Eleswarpu, S. S. Heflin, M. T. McDonald, S. R. Lagoo-Deenadalayan, S. Whitson, H. E. Martinez-Camblor, P. Deiner, S. G. Berger, M. | Anesth Analg | 2021 |
age factors, anesthesia, methods, delirium, surgery/prevention & control, Electroencephalography, drug effects |
Implementation and Routinization of the ABCDE Bundle: A Mixed Methods Evaluation | Collinsworth, A. W. Brown, R. Cole, L. Jungeblut, C. Kouznetsova, M. Qiu, T. Richter, K. M. Smith, S. Masica, A. L. | Dimens Crit Care Nurs | 2021 |
Adult |
Prediction of delirium using data mining: A systematic review | Chua, S. J. Wrigley, S. Hair, C. Sahathevan, R | J Clin Neurosci | 2021 |
Area Under Curve |
Determinants of Non-emergency Use of Control Interventions in Older Canadian Psychiatric Inpatients: Analysizing the InterRAI Mental Health Electronic Health Records | Cheung, G. Mah, T. M. Barak, Y. Hirdes, J. P. | Front Psychiatry | 2021 |
aggression |
Assessment of preoperative frailty and identification of patients at risk for postoperative delirium in cardiac intensive care units: a prospective observational study | Cheng, H. W. Liu, C. Y. Chen, Y. S. Shih, C. C. Chen, W. Y. Chiou, A. F. | Eur J Cardiovasc Nurs | 2021 |
Anxiety |
Preoperative prognostic nutritional index is useful factor for predicting postoperative delirium after primary total joint arthroplasty | Chen, J. Zheng, C. Zhong, J. Zhao, G. Shi, J. Huang, G. Wei, Y. Wang, S. Yu, J. Xia, J. | BMC Musculoskelet Disord | 2021 |
Aged |
Case-control study on the interplay between immunoparalysis and delirium after cardiac surgery | CheheiliSobbi, S. Peters van Ton, A. M. Wesselink, E. M. Looije, M. F. Gerretsen, J. Morshuis, W. J. Slooter, A. J. C. Abdo, W. F. Pickkers, P. van den Boogaard, M. | J Cardiothorac Surg | 2021 |
*Cardiac Surgical Procedures/adverse effects |
Diagnostic accuracy of the "4 A's Test" delirium screening tool for the postoperative cardiac surgery ward | Chang, Y. Ragheb, S. M. Oravec, N. Kent, D. Nugent, K. Cornick, A. Hiebert, B. Rudolph, J. L. MacLullich, A. M. J. Arora, R. C. | J Thorac Cardiovasc Surg | 2021 |
4at |
Meta-analysis of ICU Delirium Biomarkers and Their Alignment With the NIA-AA Research Framework | Chan, C. K. Song, Y. Greene, R. Lindroth, H. Khan, S. Rios, G. Khan, B. Wang, S | Am J Crit Care | 2021 |
Alzheimer Disease |
Sedation strategy and ICU delirium: a multicentre, population-based propensity score-matched cohort study | Casault, C. Soo, A. Lee, C. H. Couillard, P. Niven, D. Stelfox, T. Fiest, K. | BMJ Open | 2021 |
Adult |
Health outcomes after the implementation of multidisciplinary clinical guidelines for the care of hip fractures | Casanova Querol, T. Santiago Bautista, J. M. Lafuente Salinas, M. Güell Farré, E. Girós Torres, J. Martín-Baranera, M. Miralles Basseda, R. | Rev Clin Esp (Barc) | 2021 |
Atención continuada |
Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis | Burry, L. D. Cheng, W. Williamson, D. R. Adhikari, N. K. Egerod, I. Kanji, S. Martin, C. M. Hutton, B. Rose, L. | Intensive Care Med | 2021 |
Adult |
Dexmedetomidine for Facilitating Mechanical Ventilation Extubation in Difficult-to-Wean ICU Patients: Systematic Review and Meta-Analysis of Clinical Trials | Buckley, M. S. Smithburger, P. L. Wong, A. Fraser, G. L. Reade, M. C. Klein-Fedyshin, M. Ardiles, T. Kane-Gill, S. L. | J Intensive Care Med | 2021 |
Adult |
Risk factors for postoperative delirium: An umbrella review of systematic reviews | Bramley, P. McArthur, K. Blayney, A. McCullagh, I. | Int J Surg | 2021 |
*Cognitive Dysfunction |
Inadequate emergence after anesthesia for elective cancer surgery: a single-center cohort study | Braga, A. Abelha, F. | Braz J Anesthesiol | 2021 |
Cancer surgeries |
Asthma and delirium episodes during hospitalization | Bozek, A. Fiolka, R. Zajac, M. | Aging Med (Milton) | 2021 |
asthma |
A pragmatic assessment of proton pump inhibitors vs. histamine type 2 receptor antagonists on clinically important gastrointestinal bleeding and mortality when used for stress ulcer prophylaxis in the ICU | Boyd, C. Hassig, T. MacLaren, R. | Pharmacotherapy | 2021 |
critical illness |
Brain Network Dysfunction in Poststroke Delirium and Spatial Neglect: An fMRI Study | Boukrina, O. Kowalczyk, M. Koush, Y. Kong, Y. Barrett, A. M. | Stroke | 2021 |
MRI, functional |
Preventing Delirium and Promoting Long-Term Brain Health: A Clinical Trial Design for the Perioperative Cognitive Enhancement (PROTECT) Trial | Atkins, K. J. Scott, D. A. Silbert, B. Pike, K. E. Evered, L. | J Alzheimers Dis | 2021 |
Anesthesia and analgesia |
Prevalence of Severe Neurocognitive Impairment and Its Association with Socio-Demographics and Functionality Among Ugandan Older Persons: A Hospital-Based Study | Atim, L. M. Kaggwa, M. M. Mamun, M. A. Ashaba, S. Maling, S. | Clin Interv Aging | 2021 |
Aged |
Clinical Aspects of Palliative Sedation in Prospective Studies. A Systematic Review | Arantzamendi, M. Belar, A. Payne, S. Rijpstra, M. Preston, N. Menten, J. Van der Elst, M. Radbruch, L. Hasselaar, J. Centeno, C. | J Pain Symptom Manage | 2021 |
*Hospice and Palliative Care Nursing |
Psychometric Properties of Nursing Delirium Screening Scale in Patients Admitted to Intensive Care Units | Amirajam, Z. Asadi-Noran, E. Molaei, B. Adiban, V. Heidarzadeh, M. Hassanpour-Darghah, M. | Indian J Crit Care Med | 2021 |
Delirium |
Delirium researchers' perspectives of the challenges in delirium biomarker research: A qualitative study | Amgarth-Duff, I. Hosie, A. Caplan, G. A. Agar, M. | PLoS One | 2021 |
Biomarkers/blood |
Addition of Valerian and Lemon Balm Extract to Quetiapine Reduces Agitation in Critically Ill Patients with Delirium: A Pilot Randomized Clinical Trial | Alikiaie, B. Shahmoradi, E. Yekdaneh, A. Mousavi, S. | Indian J Crit Care Med | 2021 |
Delirium |
Spinal block and delirium in oncologic patients after laparoscopic surgery in the Trendelenburg position: A randomized controlled trial | Mitsunaga, J. K. Junior Calsavara, V. F. Onari, E. S. Arantes, V. M. Akamine, C. P. Handa, A. M. Quezada, M. M. C. Ito, F. Y. Porto, A. C. S. Giroud Joaquim, E. H. Nakamura, G. | PLoS One | 2021 | |
Perioperative Vascular Biomarker Profiling in Elective Surgery Patients Developing Postoperative Delirium: A Prospective Cohort Study | Menzenbach, J. Frede, S. Petras, J. Guttenthaler, V. Kirfel, A. Neumann, C. Mayr, A. Wittmann, M. Coburn, M. Klaschik, S. Hilbert, T. | Biomedicines | 2021 |
Ccl2 |
Preliminary Study of Serum Biomarkers Associated With Delirium After Major Cardiac Surgery | McKay, T. B. Rhee, J. Colon, K. Adelsberger, K. Turco, I. Mueller, A. Qu, J. Akeju, O. | J Cardiothorac Vasc Anesth | 2021 |
Fgf |
Stratified delirium risk using prescription medication data in a state-wide cohort | McCoy, T. H., Jr. Castro, V. M. Hart, K. L. Perlis, R. H. | Gen Hosp Psychiatry | 2021 |
Cohort study |
Nutritional Risk at intensive care unit admission and outcomes in survivors of critical illness | Mart, M. F. Girard, T. D. Thompson, J. L. Whitten-Vile, H. Raman, R. Pandharipande, P. P. Heyland, D. K. Ely, E. W. Brummel, N. E. | Clin Nutr | 2021 |
Activities of daily living |
Risk Factors for Delirium Are Different in the Very Old: A Comparative One-Year Prospective Cohort Study of 5,831 Patients | Marquetand, J. Bode, L. Fuchs, S. Hildenbrand, F. Ernst, J. von Kaenel, R. Boettger, S. | Front Psychiatry | 2021 |
comparison |
Plasma interleukin-6 is a potential predictive biomarker for postoperative delirium among acute type a aortic dissection patients treated with open surgical repair | Lv, X. C. Lin, Y. Wu, Q. S. Wang, L. Hou, Y. T. Dong, Y. Chen, L. W. | J Cardiothorac Surg | 2021 |
Adult |
Association of early and later depressive symptoms with functional outcome after ischemic stroke | Lopatkiewicz, A. M. Pera, J. Slowik, A. Dziedzic, T. | J Neural Transm (Vienna) | 2021 |
Cognitive decline |
Development and validation of a postoperative delirium prediction model for pediatric patients: A prospective, observational, single-center study | Lin, N. Liu, K. Feng, J. Chen, R. Ying, Y. Lv, D. Zhou, Y. Xu, H. | Medicine (Baltimore) | 2021 |
Adolescent |
Patients' experiences of delirium: A systematic review and meta-summary of qualitative research | Kuusisto-Gussmann, E. Höckelmann, C. von der Lühe, V. Schmädig, R. Baltes, M. Stephan, A. | J Adv Nurs | 2021 |
delirium |
Effects of case-based confusion assessment methods for intensive care unit training on delirium knowledge and delirium assessment accuracy of intensive care units: A quasi-experimental study | Kim, Y. N. Kim, D. H. | Nurse Educ Today | 2021 |
Critical Illness |
Bridging the Gap Between the Intensive Care Unit and the Acute Medical Care Unit | Kim, E. Kast, C. Afroz-Hossain, A. Qiu, M. Pappas, K. Sinvani, L. | Am J Crit Care | 2021 | |
Preoperative MRI brain phenotypes are related to postoperative delirium in older individuals | Kant, I. M. J. Slooter, A. J. C. Jaarsma-Coes, M. van Montfort, S. J. T. Witkamp, T. D. Pasma, W. Hendrikse, J. de Bresser, J. | Neurobiol Aging | 2021 |
Brain phenotypes |
Pre-Existing Psychiatric Illness Is Associated With an Increased Risk of Delirium in Patients With Acute Respiratory Distress Syndrome | Kalra, S. S. Jaber, J. Alzghoul, B. N. Hyde, R. Parikh, S. Urbine, D. Reddy, R. | J Intensive Care Med | 2021 |
Ards |
Development and internal validation of a predictive model of cognitive decline 36 months following elective surgery | Jones, R. N. Tommet, D. Steingrimsson, J. Racine, A. M. Fong, T. G. Gou, Y. Hshieh, T. T. Metzger, E. D. Schmitt, E. M. Tabloski, P. A. Travison, T. G. Vasunilashorn, S. M. Abdeen, A. Earp, B. Kunze, L. Lange, J. Vlassakov, K. Dickerson, B. C. Marcantonio | Alzheimers Dement (Amst) | 2021 |
cognitive decline |
The performance of the Dutch Safety Management System frailty tool to predict the risk of readmission or mortality in older hospitalised cardiac patients | Jepma, P. Verweij, L. Tijssen, A. Heymans, M. W. Flierman, I. Latour, C. H. M. Peters, R. J. G. Scholte Op Reimer, W. J. M. Buurman, B. M. Ter Riet, G. | BMC Geriatr | 2021 |
Aged |
Outcomes of transcatheter aortic valve replacement in patients with cognitive dysfunction | Jain, V. Kalra, A. Panhwar, M. S. Bansal, A. Nowacki, A. Bhatia, K. Gupta, T. Ineman, N. L. Khan, S. U. Krishnaswamy, A. Reed, G. W. Puri, R. Kapadia, S. R. Svensson, L. G. Kanaa, N. A. Lahorra, J. A. | J Am Geriatr Soc | 2021 |
cognitive impairment |
The Importance of Delirium and Delirium Prevention in Older Adults During Lockdowns | Inouye, S. K. | JAMA | 2021 |
Aged |
Association of Pain With Atrial Fibrillation and Delirium After Cardiac Surgery: A DECADE Sub-Study | Ince, I. Chiu, A. Sagir, A. Chahar, P. Lin, J. Douglas, A. Adi, A. Fang, J. Mao, G. Turan, A. | J Cardiothorac Vasc Anesth | 2021 |
atrial fibrillation |
Higher versus lower mean arterial pressure target management in older patients having non-cardiothoracic surgery: A prospective randomized controlled trial | Hu, A. M. Qiu, Y. Zhang, P. Zhao, R. Li, S. T. Zhang, Y. X. Zheng, Z. H. Hu, B. L. Yang, Y. L. Zhang, Z. J. | J Clin Anesth | 2021 |
Aged |
Are Patients Taking Benzodiazepines at Increased Risk for Complications Following Primary Total Knee Arthroplasty? | Hernandez, N. M. Cunningham, D. J. Hinton, Z. W. Wu, C. J. Seyler, T. M. | J Arthroplasty | 2021 |
Arthroplasty, Replacement, Knee/adverse effects |