What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia.
- Authors
- Van Leeuwen, E. Petrovic, M. van Driel, M. L. De Sutter, A. I. M. Vander Stichele, R. Declercq, T. Christiaens, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Antipsychotic agents are often used to treat neuropsychiatric symptoms (NPS) in people with dementia although there is uncertainty about the effectiveness of their long-term use for this indication and concern that they may cause harm, including higher mortality. When behavioural strategies have failed and treatment with antipsychotic drugs is instituted, regular attempts to withdraw them have been recommended in guidelines. Physicians, nurses and families of older people with dementia may be reluctant to stop antipsychotics, fearing deterioration of NPS. This is an update of a Cochrane Review published in 2013. Objectives: To evaluate whether withdrawal of antipsychotic agents is successful in older people with dementia and NPS in primary care or nursing home settings, to list the different strategies for withdrawal of antipsychotic agents in older participants with dementia and NPS, and to measure the effects of withdrawal of antipsychotic agents on participants’ behaviour and assess safety. Search methods: We searched the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (ALOIS), theCochrane Library, MEDLINE, Embase, PsycINFO, CINAHL, LILACS, clinical trials registries and grey literature sources up to 11 January 2018. Selection criteria: We included all randomised, controlled trials comparing an antipsychotic withdrawal strategy to continuation of antipsychotics in people with dementia who had been treated with an antipsychotic drug for at least three months. Data collection and analysis: We used standard methodological procedures according to the Cochrane Handbook for Systematic Reviews of Interventions. We rated the quality of evidence for each outcome using the GRADE approach. Main results: We included 10 studies involving 632 participants. One new trial (19 participants) was added for this update. One trial was conducted in a community setting, eight in nursing homes and one in both settings. Different types of antipsychotics at varying doses were discontinued in the studies. Both abrupt and gradual withdrawal schedules were used. Reported data were predominantly from studies at low or unclear risk of bias. We included nine trials with 575 randomised participants that used a proxy outcome for overall success of antipsychotic withdrawal. Pooling data was not possible due to heterogeneity of outcome measures used. Based on assessment of seven studies, discontinuation may make little or no difference to whether or not participants complete the study (low-quality evidence). Two trials included only participants with psychosis, agitation or aggression who had responded to antipsychotic treatment. In these two trials, stopping antipsychotics was associated with a higher risk of leaving the study early due to symptomatic relapse or a shorter time to symptomatic relapse. We found low-quality evidence that discontinuation may make little or no difference to overall NPS, measured using various scales (7 trials, 519 participants). There was some evidence from subgroup analyses in two trials that discontinuation may reduce agitation for participants with less severe NPS at baseline, but may be associated with a worsening of NPS in participants with more severe NPS at baseline. None of the studies assessed withdrawal symptoms. Adverse effects of antipsychotics (such as falls) were not systematically assessed. Low-quality evidence showed that discontinuation may have little or no effect on adverse events (5 trials, 381 participants), quality of life (2 trials, 119 participants), or cognitive function (5 trials, 365 participants). There were insufficient data to determine whether discontinuation of antipsychotics has any effect on mortality (very low-quality evidence). Authors’ conclusions: There is low-quality evidence that antipsychotics may be successfully discontinued in older people with dementia and NPS who have been taking antipsychotics for at least three months, and that discontinuation may have little or no important effect on behavioural and psychological symptoms. This i consistent with the observation that most behavioural complications of dementia are intermittent and often do not persist for longer than three months. Discontinuation may have little or no effect on overall cognitive function. Discontinuation may make no difference to adverse events and quality of life. Based on the trials in this review, we are uncertain whether discontinuation of antipsychotics leads to a decrease in mortality. People with psychosis, aggression or agitation who responded well to long-term antipsychotic drug use, or those with more severe NPS at baseline, may benefit behaviourally from continuation of antipsychotics. Discontinuation may reduce agitation for people with mild NPS at baseline. However, these conclusions are based on few studies or small subgroups and further evidence of benefits and harms associated with withdrawal of antipsychotic is required in people with dementia and mild and severe NPS. The overall conclusions of the review have not changed since 2013 and the number of available trials remains low.
- PMID
- Keywords
chlorpromazine
haloperidol
levomepromazine
lorazepam
loxapine
mesoridazine
neuroleptic agent
olanzapine
perphenazine
placebo
risperidone
thioridazine
tiotixene
trifluoperazine
aggression
agitation
akathisia
behavior disorder
blood pressure
body equilibrium
cardiovascular disease
cognition
confusion
dementia
drug fatality
drug megadose
drug response
drug safety
drug withdrawal
extrapyramidal symptom
falling
fracture
heart rate
human
insomnia
long term care
low drug dose
lung disease
mental disease
motor dysfunction
nausea
neurologic disease
nursing home
parkinsonism
physical mobility
primary medical care
priority journal
psychosis
quality of life
relapse
restlessness
review
sedation
side effect
systematic review
tardive dyskinesia
treatment outcome
vomiting
- Page(s)
- Volume
- Issue
- 3
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| DNA methylation in the inflammatory genes after neurosurgery and diagnostic ability of post-operative delirium | Yamanashi, T. Nagao, T. Wahba, N. E. Marra, P. S. Crutchley, K. J. Meyer, A. A. Andreasen, A. J. Hellman, M. M. Jellison, S. S. Hughes, C. G. Pandharipande, P. P. Howard Iii, M. A. Kawasaki, H. Iwata, M. Hefti, M. M. Shinozaki, G. | Transl Psychiatry | 2021 |
Epigenetics and behaviour, Molecular neuroscience |
| Intraoperative hypotension and delirium among older adults undergoing transcatheter aortic valve replacement | Wesselink, E. M. Abawi, M. Kooistra, N. H. M. Kappen, T. H. Agostoni, P. Emmelot-Vonk, M. Pasma, W. van Klei, W. A. van Jaarsveld, R. C. van Dongen, C. S. Doevendans, Pafm Slooter, A. J. C. Stella, P. R. | J Am Geriatr Soc | 2021 |
Aged, 80 and over |
| Patterns of Delirium in a Pediatric Intensive Care Unit and Associations With Noise Pollution | Weatherhead, J. R. Niedner, M. Dahmer, M. K. Malas, N. Owens, T. Kawai, Y. | J Intensive Care Med | 2021 |
delirium |
| Gender Differences and Postoperative Delirium in Adult Patients Undergoing Cardiac Valve Surgery | Wang, H. Guo, X. Zhu, X. Li, Y. Jia, Y. Zhang, Z. Yuan, S. Yan, F. | Front Cardiovasc Med | 2021 |
adult |
| Comparison of restrictive fluid therapy with goal-directed fluid therapy for postoperative delirium in patients undergoing spine surgery: a randomized controlled trial | Wang, D. D. Li, Y. Hu, X. W. Zhang, M. C. Xu, X. M. Tang, J. | Perioper Med (Lond) | 2021 |
Goal-directed fluid therapy |
| Effect of dexmedetomidine on postoperative delirium in patients undergoing brain tumour resections: study protocol of a randomised controlled trial | Wang, D. Li, R. Li, S. Wang, J. Zeng, M. Dong, J. Liu, X. Lin, N. Peng, Y. | BMJ Open | 2021 |
*Brain Neoplasms |
| Association of preoperative frailty with postoperative delirium after elective brain tumor resection: Retrospective analysis of a prospective cohort | Wang, C. M. Ma, Y. L. Yang, X. Y. Ji, R. Q. Gu, W. J. Zhou, J. X. | Surgery | 2021 |
Adult |
| Delirium and other neuropsychiatric manifestations of COVID-19 infection in people with preexisting psychiatric disorders: a systematic review | van Reekum, E. A. Rosic, T. Sergeant, A. Sanger, N. Rodrigues, M. Rebinsky, R. Panesar, B. Deck, E. Kim, N. Woo, J. D'Elia, A. Hillmer, A. Dufort, A. Sanger, S. Thabane, L. Mbuagbaw, L. Samaan, Z. | J Med Case Rep | 2021 |
Bias |
| Suvorexant with or without ramelteon to prevent delirium: a systematic review and meta-analysis | Tian, Y. Qin, Z. Han, Y. | Psychogeriatrics | 2021 |
delirium |
| Nurses' Experience of Caring for Patients with Delirium: Systematic Review and Qualitative Evidence Synthesis | Thomas, N. Coleman, M. Terry, D. | Nurs Rep | 2021 |
anxiety |
| Understanding the decision-making of critical care nurses when restraining a patient with psychomotor agitation secondary to hyperactive delirium: A 'Think Aloud' study | Teece, A. Baker, J. Smith, H | J Clin Nurs | 2022 |
Critical Care |
| Reduced Electroencephalogram Complexity in Postoperative Delirium | Tanabe, S. Parker, M. Lennertz, R. Pearce, R. A. Banks, M. I. Sanders, R. D. | J Gerontol A Biol Sci Med Sci | 2021 |
*Age-related pathology |
| Using Telehealth to Improve the Accuracy of Delirium Screening by Bedside Critical Care Nurses | Sinvani, L. Hertz, C. Chandra, S. Ilyas, A. Ardito, S. Hajizadeh, N. | Am J Crit Care | 2022 | |
| Melatonin for prevention of postoperative delirium after lower limb fracture surgery in elderly patients (DELIRLESS): study protocol for a multicentre randomised controlled trial | Sigaut, S. Couffignal, C. Esposito-Farèse, M. Degos, V. Molliex, S. Boddaert, J. Raynaud-Simon, A. Durand-Zaleski, I. Marcault, E. Jacota, M. Dahmani, S. Paugam-Burtz, C. Weiss, E. | BMJ Open | 2021 |
anaesthesia in orthopaedics |
| Management of delirium in a medical and surgical intensive care unit | Shivji, S. Stabler, S. N. Boyce, K. Haljan, G. J. McGloin, R. | J Clin Pharm Ther | 2021 |
Aged |
| 5-HT(3) receptor antagonists decrease the prevalence of postoperative delirium in older patients undergoing orthopedic lower limb surgery | Shin, H. J. Yoon, J. Na, H. S. | Perioper Med (Lond) | 2021 |
5-HT3 receptor antagonist |
| Neutrophil-Lymphocyte Ratio as a Potential Biomarker for Delirium in the Intensive Care Unit | Seo, C. L. Park, J. Y. Park, J. Kim, H. E. Cho, J. Seok, J. H. Kim, J. J. Shin, C. S. Oh, J. | Front Psychiatry | 2021 |
C-reactive protein |
| Diagnosis and management of delirium in hospital oncology service | Ramírez Zuluaga, L. P. Ruano Restrepo, M. I. Osorio Bermúdez, J. D. Díaz Vallejo, J. A. | J Geriatr Oncol | 2021 |
Cancer |
| Preschool Confusion Assessment Method for the Intensive Care Unit-Spanish (psCAM-ICU-S): Cross-Cultural Adaptation and Validation in Colombia | Pinzón-Casas, E. Soto-Trujillo, M. Camargo-Agón, L. Henao-Castaño, Á Gualdrón, N. Bonilla-González, C. | Front Pediatr | 2021 |
delirium |
| Baseline Vulnerabilities May Play a Larger Role than Depth of Anesthesia or Sedation in Postoperative Delirium | Pandharipande, P. P. Whitlock, E. L. Hughes, C. G. | Anesthesiology | 2021 |
*Anesthesia |
| Prediction of Postoperative Delirium in Geriatric Hip Fracture Patients: A Clinical Prediction Model Using Machine Learning Algorithms | Oosterhoff, J. H. F. Karhade, A. V. Oberai, T. Franco-Garcia, E. Doornberg, J. N. Schwab, J. H. | Geriatr Orthop Surg Rehabil | 2021 |
clinical prediction model |
| REcognizing DElirium in geriatric Emergency Medicine: The REDEEM risk stratification score | Oliveira, J. E. Silva L. Stanich, J. A. Jeffery, M. M. Mullan, A. F. Bower, S. M. Campbell, R. L. Rabinstein, A. A. Pignolo, R. J. Bellolio, F. | Acad Emerg Med | 2021 |
Geriatrics, Emergency department, delirium screening, REDEEM |
| Evaluation of the 3-Minute Diagnostic Confusion Assessment Method for Identification of Postoperative Delirium in Older Patients | Oberhaus, J. Wang, W. Mickle, A. M. Becker, J. Tedeschi, C. Maybrier, H. R. Upadhyayula, R. T. Muench, M. R. Lin, N. Schmitt, E. M. Inouye, S. K. Avidan, M. S. | JAMA Netw Open | 2021 |
3D-CAM, Postoperative Delirium, Major Elective Surgery, Geriatrics, long-form CAM |
| Is delirium associated with negative outcomes in older patients with hip fracture: analysis of the 4904 patients 2017-2018 from the Australian and New Zealand hip fracture registry | Oberai, T. Woodman, R. Laver, K. Crotty, M. Kerkhoffs, G. Jaarsma, R | ANZ J Surg | 2021 |
delirium |
| Postoperative delirium in older patients with cancer: the role of psychological distress and social support | O'Hanlon, S. Baxter, M. Hosie, A. | Curr Opin Support Palliat Care | 2021 | |
| Postoperative delirium and neurocognitive disorders | Migirov, A. Chahar, P. Maheshwari, K. | Curr Opin Crit Care | 2021 |
Aging |
| Development of a delirium predictive model for adult trauma patients in an emergency and critical care center: a retrospective study | Matsuoka, A. Miike, T. Miyazaki, M. Goto, T. Sasaki, A. Yamazaki, H. Komaki, M. Higuchi, M. Mori, K. Shinada, K. Nakayama, K. Sakurai, R. Asahi, M. Futami, A. Yoshitake, K. Narumi, S. Koba, M. Koami, H. Kawaguchi, A. Murakawa, T. H. Monji, A. Sakamoto, Y. | Trauma Surg Acute Care Open | 2021 |
adult |
| Early-onset delirium after spontaneous intracerebral hemorrhage | Marrama, F. Kyheng, M. Pasi, M. Pierre Rutgers, M. Moulin, S. Diomedi, M. Leys, D. Cordonnier, C. Hénon, H. Casolla, B. | Int J Stroke | 2021 |
Intracerebral hemorrhage |
| An Emergency Department Delirium Screening and Management Initiative: The Development and Refinement of the SCREENED-ED Intervention | Mailhot, T. Saczynski, J. S. Malyuta, Y. Inouye, S. K. Darling, C. | J Gerontol Nurs | 2021 |
*Delirium/diagnosis/therapy |
| Impact of a multifaceted and multidisciplinary intervention on pain, agitation and delirium management in an intensive care unit: an experience of a Canadian community hospital in conducting a quality improvement project | Ma, Z. Camargo Penuela, M. Law, M. Joshi, D. Chung, H. O. Lam, J. N. H. Tsang, J. L. | BMJ Open Qual | 2021 |
Canada |
| Prevalence, classification, risk factors and outcome impact of delirium in patients with COVID-19: a meta-analysis protocol for systematic review | Lou, B. Guo, J. Liu, Y. Xiong, C. Shi, J. Zhou, C. | BMJ Open | 2021 |
*COVID-19/complications |
| Effect of Regional vs General Anesthesia on Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery: The RAGA Randomized Trial | Li, T. Li, J. Yuan, L. Wu, J. Jiang, C. Daniels, J. Mehta, R. L. Wang, M. Yeung, J. Jackson, T. Melody, T. Jin, S. Yao, Y. Wu, J. Chen, J. Smith, F. G. Lian, Q. | Jama | 2021 | |
| Opioid and benzodiazepine use in the emergency department and the recognition of delirium within the first 24 hours of hospitalization | Lee, S. Okoro, U. E. Swanson, M. B. Mohr, N. Faine, B. Carnahan, R. | J Psychosom Res | 2021 |
Delirium |
| Awareness and Perspectives among Asian Anesthesiologists on Postoperative Delirium: A Multinational Survey | Lee, H. Kim, J. Lee, K. Y. Gan, T. J. Lekprasert, V. Laosuwan, P. Chew, S. T. H. Seet, E. Lim, V. Ti, L. K. | J Clin Med | 2021 |
NIR spectroscopy |
| Utilization of Kotter's Stages and Statistical Process Control to Implement and Sustain Delirium Screening in PICU | Kupferschmid, M. Tripathi, S. | Pediatr Qual Saf | 2021 |
Delirium, ICU Delirium, ICU morbidity and mortality, Screening compliance, Kotter’s stages |
| Impact of postoperative delirium on days alive and at home after surgery: a prospective cohort study | Kunkel, D. Parker, M. Casey, C. Krause, B. Pearce, R. A. Lennertz, R. Sanders, R. D. | Br J Anaesth | 2021 |
Cohort Studies |
| Delirium in a Tertiary Pediatric Cardiac Intensive Care Unit: Risk Factors and Outcomes | Koth, A. M. Chan, T. Tjoeng, Y. L. Watson, R. S. Dervan, L. A. | J Intensive Care Med | 2021 |
analgesics |
| Postoperative delirium screening tools for post-anaesthetic adult patients in non-intensive care units: A systematic review and meta-analysis | Kim, S. Choi, E. Jung, Y. Jang, I. | J Clin Nurs | 2021 |
adult nursing |
| Factors Related to Delirium of Intensive Care Unit Patients in Korea: A Systematic Review | Kim, N. Y. Ryu, S. A. Kim, Y. H. | Iran J Public Health | 2021 |
Delirium |
| Risk factors for postoperative delirium in patients with colorectal cancer | Kim, H. Park, H. Kim, E. K. | J Clin Nurs | 2022 |
*Colorectal Neoplasms/complications/surgery |
| Influences of remote ischemic preconditioning on postoperative delirium and cognitive dysfunction in adults after cardiac surgery: a meta-analysis of randomized controlled trials | Jing, Y. Gao, B. Li, X. | Perioper Med (Lond) | 2021 |
Cardiac surgery |
| Delirium Reduction by Analgesia Management in Hip Fracture surgery (DRAM-HF): Exploration of perceived facilitators and barriers | Hunter, C. L. Ni Chroinin, D. McEvoy, L. Chuan, A. | Australas J Ageing | 2021 |
*Analgesia |
| Management of Delirium in the Intensive Care Unit | Huang, D. D. Fischer, P. E. | Surg Clin North Am | 2022 |
Age Factors |
| Postoperative delirium and quality of life after transcatheter and surgical aortic valve replacement: A prospective observational study | Hoogma, D. F. Venmans, E. Al Tmimi, L. Tournoy, J. Verbrugghe, P. Jacobs, S. Fieuws, S. Milisen, K. Adriaenssens, T. Dubois, C. Rex, S. | J Thorac Cardiovasc Surg | 2021 |
Savr |
| Construction and Application of a Model for Predicting the Risk of Delirium in Postoperative Patients With Type a Aortic Dissection | He, J. Ling, Q. Chen, Y. | Front Surg | 2021 |
factor |
| The Locus Coeruleus Noradrenaline System in Delirium | Hansen, N. Rediske, A. I. | Front Aging Neurosci | 2021 |
attention |
| Single bolus dexmedetomidine versus propofol for treatment of pediatric emergence delirium following general anesthesia | Han, X. Sun, X. Liu, X. Wang, Q | Paediatr Anaesth | 2021 |
dexmedetomidine |
| Prospective Analysis Between Neutrophil-to-Lymphocyte Ratio on Admission and Development of Delirium Among Older Hospitalized Patients With COVID-19 | Fernández-Jiménez, E. Muñoz-Sanjose, A. Mediavilla, R. Martínez-Alés, G. Louzao,, II Andreo, J. Cebolla, S. Bravo-Ortiz, M. F. Bayón, C. | Front Aging Neurosci | 2021 |
Covid-19 |
| Relationship Between Cerebral Hemodynamics, Tissue Oxygen Saturation, and Delirium in Patients With Septic Shock: A Pilot Observational Cohort Study | Feng, Q. Ai, M. Huang, L. Peng, Q. Ai, Y. Zhang, L. | Front Med (Lausanne) | 2021 |
cerebral oxygen saturation |
| Risk factors for delirium in adult patients receiving specialist palliative care: A systematic review and meta-analysis | Featherstone, I. Sheldon, T. Johnson, M. Woodhouse, R. Boland, J. W. Hosie, A. Lawlor, P. Russell, G. Bush, S. Siddiqi, N. | Palliat Med | 2021 |
Risk factors |
| Feasibility trial of weighted blankets as an intervention for emergence delirium in postoperative pediatric patients | Eull, D. Zachrison, B. Nickel, A. | J Pediatr Nurs | 2021 |
Emergence delirium |
| The LiberAction Project: Implementation of a Pediatric Liberation Bundle to Screen Delirium, Reduce Benzodiazepine Sedation, and Provide Early Mobilization in a Human Resource-Limited Pediatric Intensive Care Unit | Di Nardo, M. Boldrini, F. Broccati, F. Cancani, F. Satta, T. Stoppa, F. Genuini, L. Zampini, G. Perdichizzi, S. Bottari, G. Fischer, M. Gawronski, O. Bonetti, A. Piermarini, I. Recchiuti, V. Leone, P. Rossi, A. Tabarini, P. Biasucci, D. Villani, A. Raponi | Front Pediatr | 2021 |
benzodiazepine (BDZ) |
| Outcomes of a Delirium Prevention Program in Older Persons After Elective Surgery: A Stepped-Wedge Cluster Randomized Clinical Trial | Deeken, F. Sánchez, A. Rapp, M. A. Denkinger, M. Brefka, S. Spank, J. Bruns, C. von Arnim, C. A. F. Küster, O. C. Conzelmann, L. O. Metz, B. R. Maurer, C. Skrobik, Y. Forkavets, O. Eschweiler, G. W. Thomas, C. | JAMA Surg | 2021 |
Delirium, Elective surgery outcomes, Elderly patients, Nonpharmacologic delirium prevention, Delirium Education |
| Advanced Age Is Associated With Catatonia in Critical Illness: Results From the Delirium and Catatonia Prospective Cohort Investigation | Connell, J. Kim, A. Brummel, N. E. Patel, M. B. Vandekar, S. N. Pandharipande, P. Dittus, R. S. Heckers, S. Ely, E. W. Wilson, J. E. | Front Psychiatry | 2021 |
age |
| Identifying frequent drug combinations associated with delirium in older adults: Application of association rules method to a case-time-control design | Chyou, T. Y. Nishtala, P. S. | Pharmacoepidemiol Drug Saf | 2021 |
Aged |
| Risk Factors and a Nomogram Model Establishment for Postoperative Delirium in Elderly Patients Undergoing Arthroplasty Surgery: A Single-Center Retrospective Study | Chen, D. Li, Y. Li, Q. Gao, W. Li, J. Wang, S. Cao, J. | Biomed Res Int | 2021 |
Postoperative Delirium, Geriatrics, Knee and Hip Arthroplasty |
| Detecting Incident Delirium within Routinely Collected Inpatient Rehabilitation Data: Validation of a Chart-Based Method | Ceppi, M. G. Rauch, M. S. Sándor, P. S. Gantenbein, A. R. Krishnakumar, S. Albert, M. Meier, C. R. | Neurol Int | 2021 |
delirium |
| Spinal Anesthesia with Targeted Sedation based on Bispectral Index Values Compared with General Anesthesia with Masked Bispectral Index Values to Reduce Delirium: The SHARP Randomized Controlled Trial | Brown, C. H. Edwards, C. Lin, C. Jones, E. L. Yanek, L. R. Esmaili, M. Gorashi, Y. Skelton, R. Kaganov, D. Curto, R. Lessing, N. L. Cha, S. Colantuoni, E. Neufeld, K. Sieber, F. Dean, C. L. Hogue, C. W. | Anesthesiology | 2021 |
Aged |
| Delirium in Cardiac and Cardiovascular Surgical Intensive Care Units | Breit, H. Bleck, T. P. Koffman, L. | Semin Neurol | 2021 |
Critical Care |
| Are treatment effects consistent with hypothesized mechanisms of action proposed for postoperative delirium interventions? Reanalysis of systematic reviews | Boxell, E. G. Malik, Y. Wong, J. Lee, M. H. Berntsson, H. M. Lee, M. J. Bourne, R. S. McCullagh, I. J. Hind, D. Wilson, M. J. | J Comp Eff Res | 2021 |
*Delirium/prevention & control |
| DelIrium VULnerability in GEriatrics (DIVULGE) study: a protocol for a prospective observational study of electroencephalogram associations with incident postoperative delirium | Boord, M. S. Davis, D. H. J. Psaltis, P. J. Coussens, S. W. Feuerriegel, D. Garrido, M. I. Bourke, A. Keage, H. A. D | BMJ Neurol Open | 2021 |
Eeg |
| Patient Factors That Influence Reliable Delirium Assessments in a Medical Intensive Care Unit During the Routine Clinical Practice | Back, J. S. Jin, T. Jin, H. Lee, S. M. | Clin Nurs Res | 2021 |
Cam-icu |
| Monitoring Delirium in the Intensive Care Unit Practices, perceptions and attitudes of critical care nurses and physicians. A French National Survey | Alaterre, C. Fazilleau, C. Constantin, J. M. James, A. | Intensive Crit Care Nurs | 2021 |
Critical Care |
| Predictors of postoperative delirium in elderly patients following total hip and knee arthroplasty: a systematic review and meta-analysis | Zhou, Q. Zhou, X. Zhang, Y. Hou, M. Tian, X. Yang, H. He, F. Chen, X. Liu, T. | BMC Musculoskelet Disord | 2021 |
Aged |
| Incidence, characteristics, and outcomes of delirium in patients with noninvasive ventilation: a prospective observational study | Zhang, R. Bai, L. Han, X. Huang, S. Zhou, L. Duan, J. | BMC Pulm Med | 2021 |
Aged |
| A systematic review and meta-analysis of the correlation between operation time and postoperative delirium in total hip arthroplasty | Zhang, G. Wang, Z. Wang, D. Jia, Q. Zeng, Y. | Ann Palliat Med | 2021 |
*Arthroplasty, Replacement, Hip/adverse effects |
| The PREvention Program for Alzheimer's RElated Delirium (PREPARED) cluster randomized trial: a study protocol | Wilchesky, M. Ballard, S. A. Voyer, P. McCusker, J. Lungu, O. Champoux, N. Vu, T. T. M. Cole, M. G. Monette, J. Ciampi, A. Belzile, E. Carmichael, P. H. McConnell, T. | BMC Geriatr | 2021 |
Aged |
| Anaesthetic depth and delirium: a challenging balancing act | Whitlock, E. L. Gross, E. R. King, C. R. Avidan, M. S. | Br J Anaesth | 2021 |
Anesthesia, General |
| Identification of risk factors for postoperative delirium in elderly patients with hip fractures by a risk stratification index model: A retrospective study | Wang, Y. Zhao, L. Zhang, C. An, Q. Guo, Q. Geng, J. Guo, Z. Guan, Z. | Brain Behav | 2021 |
health services for the elderly |
| Association between perioperative hypotension and postoperative delirium and atrial fibrillation after cardiac surgery: A post-hoc analysis of the DECADE trial | Wang, J. Mao, G. Malackany, N. Marciniak, D. Donaldson, C. Wakefield, B. Hassan, M. Ruetzler, K. Sessler, D. I. Turan, A. | J Clin Anesth | 2021 |
Anesthesia |
| The effect of the anticholinergic burden on duration and severity of delirium in older hip-surgery patients with and without haloperidol prophylaxis: A post hoc analysis | Tillemans, M. P. H. Butterhoff-Terlingen, M. H. Stuffken, R. Vreeswijk, R. Egberts, T. C. G. Kalisvaart, K. J. | Brain Behav | 2021 |
anticholinergic burden |
| Refractory hyperactive delirium in the dying: pharmacological management | Tham, K. Shiu, A. William, L. Walpole, G. Rashed, S. | BMJ Support Palliat Care | 2021 |
delirium |
| Time to Post-Anesthesia Neurological Evaluation and Hemodynamic Stability in Carotid Endarterectomy Comparing Three General Anesthetic Techniques Targeted to a Preset Bispectral Index Value: A Pilot Study | Temmermand, R. Mitrev, L. van Helmond, N. Roberts, D. Lombardi, J. Vuckovic, D. | Aana j | 2021 |
Anesthesia, General |
| Delirium During Acute Events in Nursing Home Patients | Skretteberg, W. H. Holmefoss, I. Krogseth, M. | J Am Med Dir Assoc | 2021 |
Delirium |
| The impact of emergence delirium on hospital length of stay for children who underwent tonsillectomy/adenotonsillectomy: an observational retrospective study | Simonini, A. Vittori, A. Cascella, M. Calevo, M. G. Marinangeli, F. | Braz J Anesthesiol | 2021 |
Anesthesia |
| Effects of Melatonin on Postoperative Delirium After PCI in Elderly Patients: A Randomized, Single-Center, Double-Blind, Placebo-Controlled Trial | Shi, Y. | Heart Surg Forum | 2021 |
Effects of Melatonin Postoperative Delirium PCI Elderly Patients Randomized Single-Center Double-Blind Placebo-Controlled Trial |
| A Quality Improvement Initiative to Reduce Postoperative Delirium among Cardiac Surgery Patients | Sanjanwala, R. M. Hiebert, B. Kent, D. Warren, S. Grocott, H. Arora, R. C. | Geriatrics (Basel) | 2021 |
cardiac surgery |
| The prevalence of delirium in belgian nursing homes: a cross-sectional evaluation | Sabbe, K. van der Mast, R. Dilles, T. Van Rompaey, B. | BMC Geriatr | 2021 |
Aged |
| Family intervention for delirium for patients in the intensive care unit: A systematic meta-analysis | Qin, M. Gao, Y. Guo, S. Lu, X. Zhu, H. Li, Y. | J Clin Neurosci | 2021 |
Delirium |
| Orthogeriatric co-management reduces incidence of delirium in hip fracture patients | Pollmann, C. T. Mellingsæter, M. R. Neerland, B. E. Straume-Næsheim, T. Årøen, A. Watne, L. O. | Osteoporos Int | 2021 |
*Delirium/epidemiology/etiology/prevention & control |
| Accuracy of delirium assessments in critically ill children: A prospective, observational study during routine care | Paterson, R. S. Kenardy, J. A. Dow, B. L. De Young, A. C. Pearson, K. Aitken, L. M. Long, D. A. | Aust Crit Care | 2021 |
Australia |
| Comparative effectiveness of pharmacological interventions to prevent postoperative delirium: a network meta-analysis | Park, S. K. Lim, T. Cho, H. Yoon, H. K. Lee, H. J. Lee, J. H. Yoo, S. Kim, J. T. Kim, W. H. | Sci Rep | 2021 |
Adult |
| Dexmedetomidine, Delirium, and Adverse Outcomes: Analysis of the Society of Thoracic Surgeons Adult Cardiac Surgery Database | Pal, N. Abernathy, J. H., 3rd Taylor, M. A. Bollen, B. A. Shah, A. S. Feng, X. Shotwell, M. S. Kertai, M. D. | Ann Thorac Surg | 2021 |
Analgesics, Non-Narcotic/adverse effects |
| ICU delirium burden predicts functional neurologic outcomes | Paixao, L. Sun, H. Hogan, J. Hartnack, K. Westmeijer, M. Neelagiri, A. Zhou, D. W. McClain, L. M. Kimchi, E. Y. Purdon, P. L. Akeju, O. Westover, M. B. | PLoS One | 2021 |
ICU delirium functional neurologic outcomes |
| Delirium occurrence and association with outcomes in hospitalized COVID-19 patients | Pagali, S. Fu, S. Lindroth, H. Sohn, S. Burton, M. C. Lapid, M. | Int Psychogeriatr | 2021 |
Adolescent |
| Risk Factors for Delirium in Older Adults in the Emergency Department: A Systematic Review and Meta-Analysis | Oliveira, J. E. Silva L. Berning, M. J. Stanich, J. A. Gerberi, D. J. Murad, M. H. Han, J. H. Bellolio, F. | Ann Emerg Med | 2021 |
Aged |
| Factors associated with delirium among survivors of acute respiratory distress syndrome: a nationwide cohort study | Oh, T. K. Park, H. Y. Song, I. A. | BMC Pulm Med | 2021 |
Critical Care |
| Rapid Handheld Continuous Electroencephalogram (EEG) Has the Potential to Detect Delirium in Older Adults | Mulkey, M. A. Gantt, L. T. Hardin, S. R. Munro, C. L. Everhart, D. E. Kim, S. Schoeman, A. M. Roberson, D. W. McAuliffe, M. Olson, D. M. | Dimens Crit Care Nurs | 2021 |
Aged |
| Delirium and Clusters of Older Patients Affected by Multimorbidity in Acute Hospitals | Monacelli, F. Signori, A. Marengoni, A. Di Santo, S. Rossi, E. Valsecchi, M. G. Morandi, A. Bellelli, G. | J Am Med Dir Assoc | 2021 |
Delirium |
| Major Surgery and Long Term Cognitive Outcomes: The Effect of Postoperative Delirium on Dementia in the Year Following Discharge | Mohanty, S. Gillio, A. Lindroth, H. Ortiz, D. Holler, E. Azar, J. Boustani, M. Zarzaur, B. | J Surg Res | 2021 |
Dementia |
| Elevated neuron-specific enolase level is associated with postoperative delirium and detection of phosphorylated neurofilament heavy subunit: A prospective observational study | Mietani, K. Hasegawa-Moriyama, M. Inoue, R. Ogata, T. Shimojo, N. Kurano, M. Sumitani, M. Uchida, K. | PLoS One | 2021 |
Elevated neuron-specific enolase level postoperative delirium phosphorylated neurofilament heavy subunit prospective observational study |
| Variations in analgesic, sedation, and delirium management between trauma and non-trauma critically ill children | Mehl, S. C. Cunningham, M. E. Chance, M. D. Zhu, H. Fallon, S. C. Naik-Mathuria, B. Ettinger, N. A. Vogel, A. M. | Pediatr Surg Int | 2021 |
Analgesia |
| Simulation Training Exercise to Improve Outcomes of Emergence Delirium in Patients With Posttraumatic Stress Disorder | Lovestrand, D. Beaumont, C. D. Calder, M. S. Schmidt, M. Calaro, R. | Aana j | 2021 |
Anesthesia |
| Effects of Glucocorticoids on Postoperative Delirium in Adult Patients Undergoing Cardiac Surgery: A Systematic Review and Meta-analysis | Liu, W. Wang, Y. Wang, J. Shi, J. Pan, J. Wang, D. | Clin Ther | 2021 |
Glucocorticoids Postoperative Delirium Adult Cardiac Surgery A Systematic Review Meta-analysis |
| The Association Between Preoperative Frailty and Postoperative Delirium: A Systematic Review and Meta-analysis | Liu, C. Y. Gong, N. Liu, W. | J Perianesth Nurs | 2021 |
delirium |
| A complex intervention to promote prevention of delirium in older adults by targeting caregiver's participation during and after hospital discharge - study protocol of the TRAnsport and DElirium in older people (TRADE) project | Leinert, C. Brefka, S. Braisch, U. Denninger, N. Mueller, M. Benzinger, P. Bauer, J. Bahrmann, A. Frey, N. Katus, H. A. Geisler, T. Eschweiler, G. Klaus, J. Seufferlein, T. Schuetze, K. Gebhard, F. Dreyhaupt, J. Muche, R. Pahmeier, K. Biermann-Stallwitz, | BMC Geriatr | 2021 |
Aged |
| Evaluation of Bedside Tests of Attention and Arousal Assessing Delirium in Parkinson's Disease, Dementia, and Older Adults | Lawson, R. A. Richardson, S. J. Kershaw, D. Davis, D. Stephan, B. C. M. Robinson, L. Brayne, C. Barnes, L. Burn, D. J. Yarnall, A. J. Taylor, J. P. Parker, S. Allan, L. M. | J Parkinsons Dis | 2021 |
Delirium |
| Dexmedetomidine and paralytic exposure after damage control laparotomy: risk factors for delirium? Results from the EAST SLEEP-TIME multicenter trial | Krause, C. Kwon, E. Luo-Owen, X. McArthur, K. Cochran-Yu, M. Swentek, L. Burruss, S. Turay, D. Grigorian, A. Nahmias, J. Butt, A. Gutierrez, A. LaRiccia, A. Kincaid, M. Fiorentino, M. N. Glass, N. Toscano, S. Ley, E. Lombardo, S. R. Guillamondegui, O. D. | Eur J Trauma Emerg Surg | 2021 |
Damage control laparotomy |
| The effects of intraoperative magnesium sulfate administration on emergence agitation and delirium in pediatric patients: a systematic review and meta-analysis of randomized controlled trials | Koo, C. H. Koo, B. W. Han, J. Lee, H. T. Lim, D. Shin, H. J. | Paediatr Anaesth | 2021 |
complications |
| The Modified Hospital Elder Life Program (HELP) in geriatric hospitalized patients in internal wards: A double-blind randomized control trial | Kojaie-Bidgoli, A. Sharifi, F. Maghsoud, F. Alizadeh-Khoei, M. Jafari, F. Sadeghi, F. | BMC Geriatr | 2021 |
Aged |