What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia.
- Authors
- Van Leeuwen, E. Petrovic, M. van Driel, M. L. De Sutter, A. I. M. Vander Stichele, R. Declercq, T. Christiaens, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Antipsychotic agents are often used to treat neuropsychiatric symptoms (NPS) in people with dementia although there is uncertainty about the effectiveness of their long-term use for this indication and concern that they may cause harm, including higher mortality. When behavioural strategies have failed and treatment with antipsychotic drugs is instituted, regular attempts to withdraw them have been recommended in guidelines. Physicians, nurses and families of older people with dementia may be reluctant to stop antipsychotics, fearing deterioration of NPS. This is an update of a Cochrane Review published in 2013. Objectives: To evaluate whether withdrawal of antipsychotic agents is successful in older people with dementia and NPS in primary care or nursing home settings, to list the different strategies for withdrawal of antipsychotic agents in older participants with dementia and NPS, and to measure the effects of withdrawal of antipsychotic agents on participants’ behaviour and assess safety. Search methods: We searched the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (ALOIS), theCochrane Library, MEDLINE, Embase, PsycINFO, CINAHL, LILACS, clinical trials registries and grey literature sources up to 11 January 2018. Selection criteria: We included all randomised, controlled trials comparing an antipsychotic withdrawal strategy to continuation of antipsychotics in people with dementia who had been treated with an antipsychotic drug for at least three months. Data collection and analysis: We used standard methodological procedures according to the Cochrane Handbook for Systematic Reviews of Interventions. We rated the quality of evidence for each outcome using the GRADE approach. Main results: We included 10 studies involving 632 participants. One new trial (19 participants) was added for this update. One trial was conducted in a community setting, eight in nursing homes and one in both settings. Different types of antipsychotics at varying doses were discontinued in the studies. Both abrupt and gradual withdrawal schedules were used. Reported data were predominantly from studies at low or unclear risk of bias. We included nine trials with 575 randomised participants that used a proxy outcome for overall success of antipsychotic withdrawal. Pooling data was not possible due to heterogeneity of outcome measures used. Based on assessment of seven studies, discontinuation may make little or no difference to whether or not participants complete the study (low-quality evidence). Two trials included only participants with psychosis, agitation or aggression who had responded to antipsychotic treatment. In these two trials, stopping antipsychotics was associated with a higher risk of leaving the study early due to symptomatic relapse or a shorter time to symptomatic relapse. We found low-quality evidence that discontinuation may make little or no difference to overall NPS, measured using various scales (7 trials, 519 participants). There was some evidence from subgroup analyses in two trials that discontinuation may reduce agitation for participants with less severe NPS at baseline, but may be associated with a worsening of NPS in participants with more severe NPS at baseline. None of the studies assessed withdrawal symptoms. Adverse effects of antipsychotics (such as falls) were not systematically assessed. Low-quality evidence showed that discontinuation may have little or no effect on adverse events (5 trials, 381 participants), quality of life (2 trials, 119 participants), or cognitive function (5 trials, 365 participants). There were insufficient data to determine whether discontinuation of antipsychotics has any effect on mortality (very low-quality evidence). Authors’ conclusions: There is low-quality evidence that antipsychotics may be successfully discontinued in older people with dementia and NPS who have been taking antipsychotics for at least three months, and that discontinuation may have little or no important effect on behavioural and psychological symptoms. This i consistent with the observation that most behavioural complications of dementia are intermittent and often do not persist for longer than three months. Discontinuation may have little or no effect on overall cognitive function. Discontinuation may make no difference to adverse events and quality of life. Based on the trials in this review, we are uncertain whether discontinuation of antipsychotics leads to a decrease in mortality. People with psychosis, aggression or agitation who responded well to long-term antipsychotic drug use, or those with more severe NPS at baseline, may benefit behaviourally from continuation of antipsychotics. Discontinuation may reduce agitation for people with mild NPS at baseline. However, these conclusions are based on few studies or small subgroups and further evidence of benefits and harms associated with withdrawal of antipsychotic is required in people with dementia and mild and severe NPS. The overall conclusions of the review have not changed since 2013 and the number of available trials remains low.
- PMID
- Keywords
chlorpromazine
haloperidol
levomepromazine
lorazepam
loxapine
mesoridazine
neuroleptic agent
olanzapine
perphenazine
placebo
risperidone
thioridazine
tiotixene
trifluoperazine
aggression
agitation
akathisia
behavior disorder
blood pressure
body equilibrium
cardiovascular disease
cognition
confusion
dementia
drug fatality
drug megadose
drug response
drug safety
drug withdrawal
extrapyramidal symptom
falling
fracture
heart rate
human
insomnia
long term care
low drug dose
lung disease
mental disease
motor dysfunction
nausea
neurologic disease
nursing home
parkinsonism
physical mobility
primary medical care
priority journal
psychosis
quality of life
relapse
restlessness
review
sedation
side effect
systematic review
tardive dyskinesia
treatment outcome
vomiting
- Page(s)
- Volume
- Issue
- 3
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Incidence of Postoperative Delirium Is Similar with Regional and General Anesthesia | Rosenberg, K. | Am J Nurs | 2022 |
Aged |
| Delirium and Delirium Severity Predict the Trajectory of the Hierarchical Assessment of Balance and Mobility in Hospitalized Older People: Findings From the DECIDE Study | Richardson, S. Murray, J. Davis, D. Stephan, B. C. M. Robinson, L. Brayne, C. Barnes, L. Parker, S. Sayer, A. A. Dodds, R. M. Allan, L. | J Gerontol A Biol Sci Med Sci | 2022 |
Aged |
| Anesthetic Practice Trends and Perceptions Toward Postoperative Delirium: A Mixed-Methods Analysis | Ragheb, J. Norcott, A. E. Iskander, M. Brooks, J. McKinney, A. Mentz, G. Vlisides, P. E | Anesth Analg | 2022 | |
| Preoperative Vitamin D Deficiency Is Associated With Postoperative Delirium in Critically Ill Patients | Qiu, Y. Sessler, D. I. Chen, L. Halvorson, S. Cohen, B. Bravo, M. Ince, I. Maheshwari, K. Kurz, A. | J Intensive Care Med | 2022 |
Adult |
| Physicians' beliefs and attitudes toward hypoactive delirium in the last days of life | Oya, K. Morita, T. Tagami, K. Matsuda, Y. Naito, A. S. Kashiwagi, H. Otani, H. | J Pain Symptom Manage | 2022 |
antipsychotic |
| Evidence-Based Guideline on Management of Postoperative Delirium in Older People for Low Resource Setting: Systematic Review Article | Mossie, A. Regasa, T. Neme, D. Awoke, Z. Zemedkun, A. Hailu, S. | Int J Gen Med | 2022 |
delirium prevention |
| Delirium diagnosis without a gold standard: Evaluating diagnostic accuracy of combined delirium assessment tools | Moss, S. J. Hee Lee, C. Doig, C. J. Whalen-Browne, L. Stelfox, H. T. Fiest, K. M. | PLoS One | 2022 |
Adult |
| Steroid dosing and delirium after lung transplant surgery | Mody, G. N. Choi, B. Townsend, K. Kerwin, C. Larios, D. Boukedes, S. Coppolino, A. Singh, S. Jin, G. Wolfe, D. Mallidi, H. Goldberg, H. | Gen Hosp Psychiatry | 2022 |
*Delirium/etiology |
| A systematic review of strategies for preventing delirium in patients undergoing vascular surgery | Meulenbroek, A. L. van Mil, S. R. Faes, M. C. Mattace-Raso, F. U. S. Fourneau, I. van der Laan, L. | Ann Vasc Surg | 2022 |
Aneurysm of the abdominal aorta |
| The impact of perioperative stroke and delirium on outcomes after surgical aortic valve replacement | Messé, S. R. Overbey, J. R. Thourani, V. H. Moskowitz, A. J. Gelijns, A. C. Groh, M. A. Mack, M. J. Ailawadi, G. Furie, K. L. Southerland, A. M. James, M. L. Moy, C. S. Gupta, L. Voisine, P. Perrault, L. P. Bowdish, M. E. Gillinov, A. M. O'Gara, P. T. Ou | J Thorac Cardiovasc Surg | 2022 |
aortic valve |
| Tau as a serum biomarker of delirium after major cardiac surgery: a single centre case-control study | McKay, T. B. Qu, J. Liang, F. Mueller, A. Wiener-Kronish, J. Xie, Z. Akeju, O. | Br J Anaesth | 2022 |
Alzheimer’s disease |
| Insulinoma: an uncommon cause of delirium | McComb, K. Roulston, G. Armstrong, L. | Age Ageing | 2022 |
Aged |
| The Twilight Zone: Oxybutynin Overuse Exacerbating Delirium | Marthi, S. Pomerantz, M. A. Mernan, A. J. Berlow, Y. A. | J Geriatr Psychiatry Neurol | 2022 |
anticholinergic medications |
| Corrigendum: Risk Factors for Delirium Are Different in the Very Old: A Comparative One-Year Prospective Cohort Study of 5,831 Patients | Marquetand, J. Bode, L. Fuchs, S. Hildenbrand, F. Ernst, J. von Känel, R. Boettger, S. | Front Psychiatry | 2022 |
comparison |
| The development of the MENTOR_D nursing intervention: Supporting family involvement in delirium management | Mailhot, T. Cossette, S. Lavoie, P. Maheu-Cadotte, M. A. Fontaine, G. Bourbonnais, A. Côté, J. | Int J Older People Nurs | 2022 |
delirium |
| Factors Associated With Severity of Delirium Complicating COVID-19 in Intensive Care Units | Madonna, D. Enrico, P. Ciappolino, V. Boscutti, A. Colombo, E. Turtulici, N. Cantù, F. Cereda, G. Delvecchio, G. De Falco, S. Chierichetti, M. Savioli, M. Grasselli, G. Brambilla, P. | Front Neurol | 2022 |
Ards |
| An open-label clinical trial of oral transmucosal haloperidol and oral transmucosal olanzapine in the treatment of terminal delirium at home | Lyu, X. J. Kan, A. D. Chong, P. H. Lin, K. Koh, Y. H. Yeo, Z. Z. | Trials | 2022 |
*Antipsychotic Agents/adverse effects |
| Family-centred care interventions to reduce the delirium prevalence in critically ill patients: A systematic review and meta-analysis | Lin, L. Peng, Y. Zhang, H. Huang, X. Chen, L. Lin, Y. | Nurs Open | 2022 |
delirium |
| White-Cell Derived Inflammatory Biomarkers in Prediction of Postoperative Delirium in Elderly Patients Undergoing Surgery for Lower Limb Fracture Under Non-General Anaesthesia | Li, X. Wang, G. He, Y. Wang, Z. Zhang, M. | Clin Interv Aging | 2022 |
Aged |
| Comparative salary-related costs of a brief app-directed delirium identification protocol by hospitalists, nurses, and nursing assistants | Leslie, D. L. Fick, D. M. Moore, A. Inouye, S. K. Jung, Y. Ngo, L. H. Boltz, M. Husser, E. Shrestha, P. Boustani, M. Marcantonio, E. R. | J Am Geriatr Soc | 2022 |
cost-analysis |
| Investigation and treatment of asymptomatic bacteriuria in older patients with delirium: a cross-sectional survey of Canadian physicians | Laguë, A. Boucher, V. Joo, P. Yadav, K. Morasse, C. Émond, M. | Cjem | 2022 |
Aged |
| APOE e4 Genotypes Increase Risk of Delirium During COVID-19-Related Hospitalizations: Evidence From a Large UK Cohort | Kuo, C. L. Pilling, L. C. Atkins, J. L. Fortinsky, R. H. Kuchel, G. A. Melzer, D. | J Gerontol A Biol Sci Med Sci | 2022 |
Alleles |
| Nurses' Knowledge about Delirium in the Group of Intensive Care Units Patients | Krupa, S. Friganović, A. Oomen, B. Benko, S. Mędrzycka-Dąbrowska, W. | Int J Environ Res Public Health | 2022 |
Clinical Competence |
| Early Ambulation to Prevent Delirium After Long-Time Head and Neck Cancer Surgery | Kim, J. H. Lee, Y. S. Kim, Y. H. Cho, K. J. Jung, Y. H. Choi, S. H. Nam, S. Y. Kim, S. Y. | Front Surg | 2022 |
ambulation |
| The effect of regional nerve block on perioperative delirium in hip fracture surgery for the elderly: A systematic review and meta-analysis of randomized controlled trials | Kim, C. H. Yang, J. Y. Min, C. H. Shon, H. C. Kim, J. W. Lim, E. J. | Orthop Traumatol Surg Res | 2022 |
Aged |
| Role of multicomponent non-pharmacological nursing interventions on delirium prevention: A randomized controlled study | Kasapoğlu, E. S. Enç, N. | Geriatr Nurs | 2022 |
Critical Illness |
| Early Intervention of Perioperative Delirium in Older Patients (>60 years) with Hip Fracture: A Randomized Controlled Study | Jing, G. W. Xie, Q. Tong, J. Liu, L. Z. Jiang, X. Si, L. | Orthop Surg | 2022 |
Delirium |
| Functional Outcome in Patients with Chronic Subdural Hematoma: Postoperative Delirium and Operative Procedure | Ishida, T. Inoue, T. Inoue, T. Saito, A. Suzuki, S. Uenohara, H. Tominaga, T. | Neurol Med Chir (Tokyo) | 2022 |
*Delirium/etiology |
| Delirium in geriatric patients | Iglseder, B. Frühwald, T. Jagsch, C. | Wien Med Wochenschr | 2022 |
Aged |
| Recognizing Intensive Care Unit Delirium: Are Critical Care Nurses Ready? | Ho, M. H. Chang, H. R. Liu, M. F. Chen, K. H. Shen Hsiao, S. T. Traynor, V. | J Nurs Res | 2022 | |
| Effect of an evidence-based poster on the knowledge of delirium and its prevention in student nurses: A quasi-experimental study | Glass, G. F. Tan, H. Chan, E. Y. | Contemp Nurse | 2022 |
Aged |
| Lack of Association Between Perioperative Medication and Postoperative Delirium in Hip Fracture Patients in an Orthogeriatric Care Pathway | Genet, B. Lamy, T. Cohen-Bittan, J. Glasman, P. Verny, M. Riou, B. Boddaert, J. Zerah, L. | J Am Med Dir Assoc | 2022 |
Aged |
| Dexmedetomidine after Cardiac Surgery for Prevention of Delirium (EXACTUM) trial protocol: a multicentre randomised, double-blind, placebo-controlled trial | Gargadennec, T. Oilleau, J. F. Rozec, B. Nesseler, N. Lasocki, S. Futier, E. Amour, J. Durand, M. Bougle, A. Kerforne, T. Consigny, M. Eddi, D. Huet, O. | BMJ Open | 2022 |
Aged |
| Validation of E-PRE-DELIRIC in cardiac surgical ICU delirium: A retrospective cohort study | Gao, W. Zhang, Y. Jin, J. | Nurs Crit Care | 2022 |
Adult |
| Association Between Sedative Medication Administration and Delirium Development in a Medical Intensive Care Unit | Franz, N. D. Alaniz, C. Miller, J. T. Farina, N. | J Pharm Pract | 2022 |
benzodiazepine |
| Nurse-Driven Assessment, Prevention, and Management of Delirium on an Acute Inpatient Neurology Unit | Francisco, M. A. Gesell, T. Meletis, S. Bohr, N. L. Gleason, L. J. | J Nurs Care Qual | 2022 | |
| Delirium the next frontier | Fong, T. G. Inouye, S. K. | J Gerontol A Biol Sci Med Sci | 2022 |
*Delirium/diagnosis/etiology |
| Presurgical Thalamus Volume in Postoperative Delirium: A Longitudinal Observational Cohort Study in Older Patients | Fislage, M. Feinkohl, I. Pischon, T. Spies, C. D. Borchers, F. Winterer, G. Zacharias, N. | Anesth Analg | 2022 | |
| The association between preoperative Mini-Cog© score and postoperative delirium (POD): a retrospective cohort study | Fiamanya, S. Ma, S. Yates, D. R. A. | Perioper Med (Lond) | 2022 |
Cognitive impairment |
| Delirium severity in critical patients with COVID-19 from an Infectious Disease Intensive Care Unit | Dias, R. Caldas, J. P. Silva-Pinto, A. Costa, A. Sarmento, A. Santos, L. | Int J Infect Dis | 2022 |
*COVID-19/complications |
| Health-Related Quality of Life Following Delirium in the PICU | Dervan, L. A. Killien, E. Y. Smith, M. B. Watson, R. S. | Pediatr Crit Care Med | 2022 |
Aftercare |
| Cuartas, C. F. Davis, M. | Valproic Acid in the Management of Delirium | Am J Hosp Palliat Care | 2022 |
Adult |
| Assessing the Accuracy of International Classification of Diseases (ICD) Coding for Delirium | Chuen, V. L. Chan, A. C. H. Ma, J. Alibhai, S. M. H. Chau, V. | J Appl Gerontol | 2022 |
*Delirium/diagnosis |
| Evaluation of the Impact of Prior-to-Admission Sleep Aid Prescribing Practices on Sleep and Delirium in the Intensive Care Unit | Chudow, M. Paradiso, V. Silva, N. Collette, J. | Ann Pharmacother | 2022 |
Adult |
| Chou, S. T. Pogach, M. Rock, L. K. | Less pharmacotherapy is more in delirium | Intensive Care Med | 2022 | |
| A randomized trial: bispectral-guided anesthesia decreases incidence of delayed neurocognitive recovery and postoperative neurocognitive disorder but not postoperative delirium | Chen, X. Li, L. Yang, L. Li, A. Wu, M. Yu, D. | Am J Transl Res | 2022 |
BIS monitoring |
| Comparative effectiveness of non-pharmacological interventions for preventing delirium in critically ill adults: A systematic review and network meta-analysis | Chen, T. J. Traynor, V. Wang, A. Y. Shih, C. Y. Tu, M. C. Chuang, C. H. Chiu, H. Y. Chang, H. R. | Int J Nurs Stud | 2022 |
Delirium |
| Influence of Renin-Angiotensin System Inhibitors on Postoperative Delirium in Patients With Pulmonary Arterial Hypertension: A Secondary Analysis of a Retrospective Cohort Study | Chen, G. Zhou, S. Deng, F. | Front Psychiatry | 2022 |
ACEIs |
| Delirium in COVID‑19 pneumonia: looking inside the geriatric unit-reply | Callea, A. Conti, G. Caporotundo, S. Della Marca, G. Rollo, E. | Intern Emerg Med | 2022 | |
| Postoperative delirium in the elderly: time to focus on pre- and postoperative management | Bruder, N. | Minerva Anestesiol | 2022 |
Aged |
| Improving ABCDEF Bundle Compliance and Clinical Outcomes in the ICU: Randomized Control Trial to Assess the Impact of Performance Measurement, Feedback, and Data Literacy Training | Brown, J. C. Querubin, J. A. Ding, L. Mack, W. J. Chen-Chan, K. Perez, F. Barr, J. Peden, C. J. Cobb, J. P. | Crit Care Explor | 2022 |
ABCDEF bundle compliance |
| Impact of Cerebral Embolic Protection Devices on the Incidence and Outcomes of Delirium After Transcatheter Aortic Valve Implantation | Bansal, A. Kumar, A. Reed, G. W. Puri, R. Krishnaswamy, A. Linke, A. Yun, J. Kapadia, S. R. | Am J Cardiol | 2022 | |
| Postoperative delirium in older patients after undergoing pelvic organ prolapse surgery | Ackenbom, M. F. Zyczynski, H. M. Butters, M. A. Lopa, S. Orris, S. R. Davis, E. M. | nt Urogynecol J | 2022 |
Cognitive impairment |
| Use of naldemedine is associated with reduced incidence of hyperactive delirium in cancer patients with opioid-induced constipation: a nationwide retrospective cohort study in Japan | Abe, H. Sumitani, M. Matsui, H. Inoue, R. Fushimi, K. Uchida, K. Yasunaga, H. | Pharmacotherapy | 2022 |
delirium |
| Effect of light therapy on delirium in older patients with Alzheimer's disease-related dementia | Zou, C. Mei, X. Li, X. Hu, J. Xu, T. Zheng, C. | J Psychiatr Res | 2022 |
Alzheimer’s disease |
| Association of antipsychotic dose with survival of advanced cancer patients with delirium | Yokomichi, N. Maeda, I. Morita, T. Yoshiuchi, K. Ogawa, A. Hisanaga, T. Sakashita, A. Nakahara, R. Kaneishi, K. Iwase, S. | Ann Palliat Med | 2022 |
Advanced cancer |
| Systematic review and meta-analysis on the incidence of delirium in intensive care unit inpatients after cognitive exercise intervention | Xu, C. Chen, Z. Zhang, L. Guo, H. | Ann Palliat Med | 2022 |
Cognition |
| Electroencephalography in delirium assessment: a scoping review | Wiegand, T. L. T. Rémi, J. Dimitriadis, K. | BMC Neurol | 2022 |
*Delirium/diagnosis/etiology |
| Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial | Wibrow, B. Martinez, F. E. Myers, E. Chapman, A. Litton, E. Ho, K. M. Regli, A. Hawkins, D. Ford, A. van Haren, F. M. P. Wyer, S. McCaffrey, J. Rashid, A. Kelty, E. Murray, K. Anstey, M. | Intensive Care Med | 2022 |
Australia |
| Effect of Electroencephalography Spectral Edge Frequency (SEF) and Patient State Index (PSI)-Guided Propofol-Remifentanil Anesthesia on Delirium After Laparoscopic Surgery: The eMODIPOD Randomized Controlled Trial | Wang, E. Wang, L. Ye, C. Luo, N. Zhang, Y. Zhong, Y. Zhu, M. Zou, Y. Li, Q. Li, L. Song, Z. Luo, H. Dai, F. Liu, H. Gelb, A. W. Guo, Q. Meng, L. | J Neurosurg Anesthesiol | 2022 |
*Anesthesia/adverse effects |
| Hospitalisation costs and Health Related Quality of Life in delirious patients; a scoping review | van Lieshout, C. Schuit, E. Hermes, C. Kerrigan, M. Frederix, G. W. J. | Z Evid Fortbild Qual Gesundhwes | 2022 |
Cost Analysis |
| Rapid cognitive assessment tools for screening of mild cognitive impairment in the preoperative setting: A systematic review and meta-analysis | Tran, J. Nimojan, T. Saripella, A. Tang-Wai, D. F. Butris, N. Kapoor, P. Berezin, L. Englesakis, M. Chung, F. | J Clin Anesth | 2022 |
Cognition |
| Physostigmine for Facilitation of Care in Clozapine-Associated Anticholinergic Delirium | Spring, J. D. Goldstein, B. N. Buster, M. Mahmoud, A. A. Hamm, B. | J Clin Psychopharmacol | 2022 | |
| Relationship between no-visitation policy and the development of delirium in patients admitted to the intensive care unit | Shinohara, F. Unoki, T. Horikawa, M. | PLoS One | 2022 |
Apache |
| USING A REAL-TIME ABCDEF COMPLIANCE TOOL TO UNDERSTAND THE ROLE OF BUNDLE ELEMENTS IN MORTALITY AND DELIRIUM | Shampo, J. C. Wenszell, K. Luo-Owen, X. Mukherjee, N. Cochran-Yu, M. Swentek, L. Burruss, S. K. Markovich, S. Turay, D. Dorotta, I. R. Mukherjee, K. | J Trauma Acute Care Surg | 2022 | |
| Post-discharge Mortality in Patients With Delirium and Dementia: A 3-Year Follow Up Study | Schnorr, T. Fleiner, T. Schroeder, H. Reupke, I. Woringen, F. Trumpf, R. Schroeder, S. Zijlstra, W. Haussermann, P. | Front Psychiatry | 2022 |
aftercare |
| Effects of Physical Exercise on the Incidence of Delirium and Cognitive Function in Acutely Hospitalized Older Adults: A Systematic Review with Meta-Analysis | Sáez de Asteasu, M. L. Cuevas-Lara, C. García-Hermoso, A. Ramírez-Vélez, R. Martínez-Velilla, N. Zambom-Ferraresi, F. Cadore, E. L. Izquierdo, M. | J Alzheimers Dis | 2022 |
Physical exercise |
| Associations Between Stroke Localization and Delirium: A Systematic Review and Meta-Analysis | Rhee, J. Y. Colman, M. A. Mendu, M. Shah, S. J. Fox, M. D. Rost, N. S. Kimchi, E. Y. | J Stroke Cerebrovasc Dis | 2022 |
*Delirium/epidemiology |
| The family in preventing delirium in the intensive care unit: Scoping review | Pabón-Martínez, B. A. Rodríguez-Pulido, L. I. Henao-Castaño, A. M. | Enferm Intensiva (Engl Ed) | 2022 |
Adult |
| The effect of delirium preventive measures on the occurrence of postoperative cognitive dysfunction in older adults undergoing cardiovascular surgery. The DelPOCD randomised controlled trial | Olotu, C. Ascone, L. Wiede, J. Manthey, J. Kuehn, S. Scherwath, A. Kiefmann, R. | J Clin Anesth | 2022 |
Aged |
| Pharmacotherapy for elderly patients with delirium in a general ward setting: A retrospective study | Ohsako, N. Hashimoto, T. Shiko, Y. Kawasaki, Y. Nakagawa, M. Okuma, T. Kurata, T. Suzuki, H. Ishige, M. Kikuchi, S. | Asian J Psychiatr | 2022 |
Aged |
| Regional cerebral hypometabolism on 18F-FDG PET/CT scan in delirium is independent of acute illness and dementia | Nitchingham, A. Pereira, J. V. Wegner, E. A. Oxenham, V. Close, J. Caplan, G. A. | Alzheimers Dement | 2022 |
18F-fluorodeoxyglucose positron emission tomography |
| Delirium screening with 4AT in patients aged 65 years and older admitted to the Emergency Department with suspected sepsis: a prospective cohort study | Myrstad, M. Kuwelker, K. Haakonsen, S. Valebjørg, T. Langeland, N. Kittang, B. R. Hagberg, G. Neerland, B. E. Bakken, M. S. | Eur Geriatr Med | 2022 |
Aged |
| The DEMS-DOSS study: validating a delirium monitoring tool in hospitalised older adults | Montgomery, A. Todd, J. A. Jones, C. Koroitamana, J. Grealish, L. Wand, A. Billett, S. Teodorczuk, A. | Age Ageing | 2022 |
Aged |
| Effectiveness of Interprofessional Consultation-Based Interventions for Delirium: A Scoping Review | Monaghan, C. Martin, G. Kerr, J. Peters, M. L. Versloot, J. | J Appl Gerontol | 2022 |
Accidental Falls/prevention & control |
| PRe-Operative Prediction of postoperative DElirium by appropriate SCreening (PROPDESC) development and validation of a pragmatic POD risk screening score based on routine preoperative data | Menzenbach, J. Kirfel, A. Guttenthaler, V. Feggeler, J. Hilbert, T. Ricchiuto, A. Staerk, C. Mayr, A. Coburn, M. Wittmann, M. | J Clin Anesth | 2022 |
*Delirium/diagnosis/epidemiology/etiology |
| Behavioral Variant Frontotemporal Dementia and Social and Criminal Transgressions | Mendez, M. F. | J Neuropsychiatry Clin Neurosci | 2022 |
Cognition |
| Effects of Abdominal Wall Blocks on Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Surgery: A Randomized Controlled Study | Liu, T. Tuo, J. Wei, Q. Sun, X. Zhao, H. Zhao, X. Qu, M. | Med Sci Monit | 2022 |
Aged |
| Preoperative Status of Gut Microbiota Predicts Postoperative Delirium in Patients With Gastric Cancer | Liu, H. Cheng, G. Xu, Y. L. Fang, Q. Ye, L. Wang, C. H. Liu, X. S. | Front Psychiatry | 2022 |
Shigella |
| Nurses' experiences in the management of delirium among older persons in acute care ward settings: A qualitative systematic review and meta-aggregation | Lim, X. M. Lim, Z. H. T. Ignacio, J. | Int J Nurs Stud | 2022 |
Aged |
| Predicting hospital mortality and length of stay: A prospective cohort study comparing the Intensive Care Delirium Screening Checklist versus Confusion Assessment Method for the Intensive Care Unit | Li, H. C. Chen, C. C. Yeh, T. Y. Liao, S. C. Hsu, A. S. Wei, Y. C. Shun, S. C. Ku, S. C. Inouye, S. K. | Aust Crit Care | 2022 |
CAM-ICU (Confusion Assessment Method for Intensive Care Unit) |
| Can we improve delirium prevention and treatment in the emergency department? A systematic review | Lee, S. Chen, H. Hibino, S. Miller, D. Healy, H. Lee, J. S. Arendts, G. Han, J. H. Kennedy, M. Carpenter, C. R. | J Am Geriatr Soc | 2022 |
delirium |
| Prevalence, management and outcomes of unrecognized delirium in a National Sample of 1,493 older emergency department patients: how many were sent home and what happened to them? | Lee, J. S. Tong, T. Chignell, M. Tierney, M. C. Goldstein, J. Eagles, D. Perry, J. J. McRae, A. Lang, E. Hefferon, D. Rose, L. Kiss, A. Borgundvaag, B. McLeod, S. Melady, D. Boucher, V. Sirois, M. J. Émond, M. | Age Aging | 2022 |
*Aftercare |
| COVID-19 severity and age increase the odds of delirium in hospitalized adults with confirmed SARS-CoV-2 infection: a cohort study | LaHue, S. C. Escueta, D. P. Guterman, E. L. Patel, K. Harrison, K. L. Boscardin, W. J. Douglas, V. C. Newman, J. C. | BMC Psychiatry | 2022 |
Adult |
| Outcomes in heart failure patients discharged to skilled nursing facilities with delirium | Lafo, J. Singh, M. Jiang, L. Correia, S. Madrigal, C. Clements, R. Wu, W. C. Erqou, S. Rudolph, J. L. | ESC Heart Fail | 2022 |
Delirium |
| Distribution of delirium motor subtypes in the intensive care unit: a systematic scoping review | la Cour, K. N. Andersen-Ranberg, N. C. Weihe, S. Poulsen, L. M. Mortensen, C. B. Kjer, C. K. W. Collet, M. O. Estrup, S. Mathiesen, O. | Crit Care | 2022 |
Aged |
| Factors associated with post-operative delirium in hip fracture patients: what should we care | Kong, D. Luo, W. Zhu, Z. Sun, S. Zhu, J. | Eur J Med Res | 2022 |
Aged |
| Factors Associated With Postoperative Delirium in Patients Undergoing Complex Head and Neck Flap Surgery | Kolk, A. Schwarzer, C. Wolff, K. D. Grill, F. Weingart, J. | J Oral Maxillofac Surg | 2022 |
Adolescent |
| Increased postoperative myeloperoxidase concentration associated with low baseline antioxidant capacity as the risk factor of delirium after cardiac surgery | Kaźmierski, J. Miler, P. Pawlak, A. Jerczyńska, H. Nowakowska, K. Walkiewicz, G. Woźniak, K. Krejca, M. Wilczyński, M. | Ann Med | 2022 |
Antioxidants |
| Could neutrophil-to-lymphocyte ratio predict mortality in community-dwelling older people with delirium superimposed on dementia? | Katipoglu, B. Naharci, M. I. | Aging Clin Exp Res | 2022 |
Delirium |
| The efficacy and safety of nurse-initiated sedation management in an intensive care unit: A two-phase prospective study in Japan | Kanda, N. Nakano, H. Naraba, H. Kawasaki, A. Ohno, N. Yoshikawa, Y. Sakuramoto, H. Takahashi, Y. Sonoo, T. Hashimoto, H. Nakamura, K. | Jpn J Nurs Sci | 2022 |
Richmond Agitation-Sedation Scale |
| Albumin/fibrinogen ratio, an independent risk factor for postoperative delirium after total joint arthroplasty | Jiang, L. Lei, G. | Geriatr Gerontol Int | 2022 |
albumin/fibrinogen ratio |
| Association of preoperative vitamin D deficiency with the risk of postoperative delirium and cognitive dysfunction: A meta-analysis | Hung, K. C. Wang, L. K. Lin, Y. T. Yu, C. H. Chang, C. Y. Sun, C. K. Chen, J. Y. | J Clin Anesth | 2022 |
Postoperative cognitive dysfunction |
| Sailing in a sea of perplexity: Family caregivers' experience of patients with delirium | Huang, L. J. Tsai, H. H. Wang, Y. W. Chou, C. L. | Nurs Crit Care | 2022 |
*Caregivers |
| Association Between Hypernatremia and Delirium After Cardiac Surgery: A Nested Case-Control Study | Hong, L. Shen, X. Shi, Q. Song, X. Chen, L. Chen, W. Chen, S. Xue, Y. Zhang, C. Zhou, J. | Front Cardiovasc Med | 2022 |
cardiac surgery |
| Harmonization of Four Delirium Instruments: Creating Crosswalks and the Delirium Item-Bank (DEL-IB) | Helfand, B. K. I. Detroyer, E. Milisen, K. Adamis, D. Metzger, E. D. Boudreaux, E. D. Inouye, S. K. Jones, R. N. | Am J Geriatr Psychiatry | 2022 |
Aged |
| Does delirium prevention reduce risk of in-patient falls among older adults? A systematic review and trial sequential meta-analysis | He, S. Rolls, K. Stott, K. Shekhar, R. Vueti, V. Flowers, K. Moseley, M. Shepherd, B. Mayahi-Neysi, M. Chasle, B. Warner, B. Ni Chroinin, D. Frost, S. A. | Australas J Ageing | 2022 |
accidental falls |
| Detection of delirium by family members in the intensive care unit: Translation, Cross-Cultural adaptation and validation of the Family Confusion Assessment Method for the German-Speaking area | Greindl, S. Weiss, B. Magnolini, R. Lingg, C. Mayer, H. Schaller, S. J. | J Adv Nurs | 2022 |
Family Confusion Assessment Method |
| Patient-related risk factors for in-hospital functional decline in older adults: A systematic review and meta-analysis | Geyskens, L. Jeuris, A. Deschodt, M. Van Grootven, B. Gielen, E. Flamaing, J. | Age Ageing | 2022 |
*Activities of Daily Living |
| Screening for delirium and dementia in older hospitalised adults in Zambia | George, G. Fricker, M. Todd, O. Makowa, D. Tembo, C. Dotchin, C. Gray, W. K. Walker, R. W. Mbwele, B. Paddick, S. M. | J Neurol Sci | 2022 |
Delirium |