What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) for the diagnosis of delirium in adults in critical care settings
- Authors
- Miranda, F. Gonzalez, F. Plana, M. N. Zamora, J. Quinn, T. J. Seron, P.
- Year
- 2023
- Journal
- Cochrane Database Syst Rev
- Abstract
BACKGROUND: Delirium is an underdiagnosed clinical syndrome typified by an acute alteration of mental state. It is an important problem in critical care and intensive care units (ICU) due to its high prevalence and its association with adverse outcomes. Delirium is a very distressing condition for patients, with a huge impact on their well-being. Diagnosis of delirium in the critical care setting is challenging. This is especially true for patients who are mechanically ventilated and are therefore unable to engage in a verbal interview. The Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) is a tool specifically designed to assess for delirium in the context of ICU patients, including those on mechanical ventilation. CAM-ICU can be administered by non-specialists to give a dichotomous delirium present/absent result. OBJECTIVES: To determine the diagnostic accuracy of the CAM-ICU for the diagnosis of delirium in adult patients in critical care units. SEARCH METHODS: We searched MEDLINE (Ovid SP, 1946 to 8 July 2022), Embase (Ovid SP, 1982 to 8 July 2022), Web of Science Core Collection (ISI Web of Knowledge, 1945 to 8 July 2022), PsycINFO (Ovid SP, 1806 to 8 July 2022), and LILACS (BIREME, 1982 to 8 July 2022). We checked the reference lists of included studies and other resources for additional potentially relevant studies. We also searched the Health Technology Assessment database, the Cochrane Library, Aggressive Research Intelligence Facility database, WHO ICTRP, ClinicalTrials.gov, and websites of scientific associations to access any annual meetings and abstracts of conference proceedings in the field. SELECTION CRITERIA: We included diagnostic studies enrolling adult ICU patients assessed using the CAM-ICU tool, regardless of language or publication status and reporting sufficient data on delirium diagnosis for the construction of 2 x 2 tables. Eligible studies evaluated the diagnostic performance of the CAM-ICU versus a clinical reference standard based on any iteration of the Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria applied by a clinical expert. DATA COLLECTION AND ANALYSIS: Two review authors independently selected and collated study data. We assessed the methodological quality of studies using the QUADAS-2 tool. We used two univariate fixed-effect or random-effects models to determine summary estimates of sensitivity and specificity. We performed sensitivity analyses that excluded studies considered to be at high risk of bias and high concerns in applicability, due mainly to the target population included (e.g. patients with traumatic brain injury). We also investigated potential sources of heterogeneity, assessing the effect of reference standard diagnosis and proportion of patients ventilated. MAIN RESULTS: We included 25 studies (2817 participants). The mean age of participants ranged from 48 to 69 years; 15 of the studies included critical care units admitting mixed populations (e.g. medical, trauma, surgery patients). The percentage of patients receiving mechanical ventilation ranged from 11.8% to 100%. The prevalence of delirium in the studies included ranged from 12.5% to 83.9%. Presence of delirium was determined by the application of DSM-IV criteria in 13 out of 25 included studies. We assessed 13 studies as at low risk of bias and low applicability concerns for all QUADAS-2 domains. The most common issue of concern was flow and timing of the tests, followed by patient selection. Overall, we estimated a pooled sensitivity of 0.78 (95% confidence interval (CI) 0.72 to 0.83) and a pooled specificity of 0.95 (95% CI 0.92 to 0.97). Sensitivity analysis restricted to studies at low risk of bias and without any applicability concerns (n = 13 studies) gave similar summary accuracy indices (sensitivity 0.80 (95% CI 0.72 to 0.86), specificity 0.95 (95% CI 0.93 to 0.97)). Subgroup analyses based on diagnostic assessment found summary estimates of sensitivity and specificity for studies using DSM-IV of 0.79 (95% CI 0.72 to 0.85) and 0.94 (95% CI 0.90 to 0.96). For studies that used DSM-5 criteria, summary estimates of sensitivity and specificity were 0.75 (95% CI 0.67 to 0.82) and 0.98 (95% CI 0.95 to 0.99). DSM criteria had no significant effect on sensitivity (P = 0.421), but the specificity for detection of delirium was higher when DSM-5 criteria were used (P = 0.024). The relative specificity comparing DSM-5 versus DSM-IV criteria was 1.05 (95% CI 1.02 to 1.08). Summary estimates of sensitivity and specificity for studies recruiting < 100% of patients with mechanical ventilation were 0.81 (95% CI 0.75 to 0.85) and 0.95 (95% CI 0.91 to 0.98). For studies that exclusively recruited patients with mechanical ventilation, summary estimates of sensitivity and specificity were 0.91 (95% CI 0.76 to 0.97) and 0.98 (95% CI 0.92 to 0.99). Although there was a suggestion of differential performance of CAM-ICU in ventilated patients, the differences were not significant in sensitivity (P = 0.316) or in specificity (P = 0.493). AUTHORS’ CONCLUSIONS: The CAM-ICU tool may have a role in the early identification of delirium, in adult patients hospitalized in intensive care units, including those on mechanical ventilation, when non-specialized, properly trained clinical personnel apply the CAM-ICU. The test is most useful for exclusion of delirium. The test may miss a proportion of patients with incident delirium, therefore in situations where detection of all delirium cases is desirable, it may be best to repeat the test or combine CAM-ICU with another assessment. Future studies should compare different screening tests proposed for bedside assessment of delirium, as this approach will reveal which tool yields superior accuracy. In addition, future studies should consider and report the flow and timing of the tests and clearly report key characteristics related to patient selection. Finally, future research should focus on the impact of CAM-ICU screening on patient outcomes.
- PMID
PMID: 37987526
- Keywords
Adult
Humans
Middle Aged
Aged
*Intensive Care Units
Sensitivity and Specificity
*Delirium/diagnosis
Critical Care
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Delirium prediction in the ICU: designing a screening tool for preventive interventions | Bhattacharyya, A. Sheikhalishahi, S. Torbic, H. Yeung, W. Wang, T. Birst, J. Duggal, A. Celi, L. A. Osmani, V. | JAMIA Open | 2022 |
artificial intelligence |
| Regional vs General Anesthesia and Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery | Zhu, Z. Cao, P. Lin, L. | Jama | 2022 |
Aged |
| Melatonin intervention to prevent delirium in hospitalized patients: A meta-analysis | You, W. Fan, X. Y. Lei, C. Nie, C. C. Chen, Y. Wang, X. L. | World J Clin Cases | 2022 |
Delirium |
| Preoperative Low Physical Activity is a Predictor of Postoperative Delirium in Patients with Gastrointestinal Cancer: A Retrospective Study | Yanagisawa, T. Tatematsu, N. Horiuchi, M. Migitaka, S. Yasuda, S. Itatsu, K. Kubota, T. Sugiura, H. | Asian Pac J Cancer Prev | 2022 |
Activities of Daily Living |
| What is It Like to be Delirious? | Wijdicks, E. F. M. Rabinstein, A. A. | Neurocrit Care | 2022 |
Definitions |
| Impact of Pain, Agitation, and Delirium Bundle on Delirium and Cognitive Function | Wang, X. P. Lv, D. Chen, Y. F. Chen, N. Li, X. D. Xu, C. F. Li, Y. Tian, L. | J Nurs Res | 2022 | |
| Regional vs General Anesthesia and Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery | Uzoigwe, C. E. Campbell-Jones, F. | Jama | 2022 |
Aged |
| Improving delirium screening in older adults at the Royal United Hospital, Bath | Trew, C. A. Cross, R. Howell, K. Dyer, C. | Br J Hosp Med (Lond) | 2022 |
Aged |
| Assessing prevalence and independent predictors of postoperative delirium in patients with head and neck cancer | Tian, T. Xue, F. S. Shao, L. J. Z. Hu, B. | Br J Oral Maxillofac Surg | 2022 |
*Delirium/epidemiology/etiology |
| Delirium due to hip fracture is associated with activated immune-inflammatory pathways and a reduction in negative immunoregulatory mechanisms | Thisayakorn, P. Thipakorn, Y. Tantavisut, S. Sirivichayakul, S. Maes, M. | BMC Psychiatry | 2022 |
Aged |
| Retrospective evaluation of a delirium order set utilizing nonpharmacologic and pharmacologic interventions for the treatment of delirium in medical intensive care unit patients | Taylor, A. D. Chen, A. Reddy, A. J. Lewandowski, A. Torbic, H. | Am J Health Syst Pharm | 2022 |
Adolescent |
| Prevention of dexmedetomidine on postoperative delirium and early postoperative cognitive dysfunction in elderly patients undergoing hepatic lobectomy | Tang, Y. Wang, Y. Kong, G. Zhao, Y. Wei, L. Liu, J. | Zhong Nan Da Xue Xue Bao Yi Xue Ban | 2022 |
Aged |
| Prevalence, clinical features, and risk factors of delusions in patients with delirium | Tachibana, M. Inada, T. Ichida, M. Ozaki, N. | Int J Geriatr Psychiatry | 2022 | |
| Effect of sedative premedication with oral midazolam on postanesthesia care unit delirium in older adults: a secondary analysis following an uncontrolled before-after design | Stuff, K. Kainz, E. Kahl, U. Pinnschmidt, H. Beck, S. von Breunig, F. Nitzschke, R. Funcke, S. Zöllner, C. Fischer, M. | Perioper Med (Lond) | 2022 |
Anesthesia |
| Associations of Smoking With Delirium and Opioid Use in Older Adults With Traumatic Hip Fracture | Salottolo, K. Meinig, R. Fine, L. Kelly, M. Madayag, R. Ekengren, F. Tanner, A., 2nd Bar-Or, D. | J Am Acad Orthop Surg Glob Res Rev | 2022 |
Aged |
| Impact of delirium on mortality in patients hospitalized for heart failure | Ritchie, C. Walters, R. W. Ramaswamy, S. Alla, V. M. | Int J Psychiatry Med | 2022 |
Aged |
| Risk for post-operative delirium related to comorbidities in older adult cardiac patients: An integrative review | Ramos, M. D. Vergara, F. H. Shackleford, J. Briggs, C. Gomez, C. Mofazali, M. Preston, J. | J Clin Nurs | 2022 |
cardiac surgery |
| Diagnosis and management of delirium in hospital oncology services | Ramírez Zuluaga, L. P. Ruano Restrepo, M. I. Osorio Bermúdez, J. D. Díaz Vallejo, J. A. | J Geriatr Oncol | 2022 |
*Delirium/diagnosis/etiology/therapy |
| Cognitive Predictors of Delirium on Long-Term Follow-Up after TIA and Stroke: Population-Based Cohort Study | Pendlebury, S. T. Thomson, R. J. Welch, S. J. V. Rothwell, P. M. | Cerebrovasc Dis | 2022 |
Aged |
| Plasma neurofilament light chain protein as a predictor of days in delirium and deep sedation, mortality and length of stay in critically ill patients | Page, V. J. Watne, L. O. Heslegrave, A. Clark, A. McAuley, D. F. Sanders, R. D. Zetterberg, H. | EBioMedicine | 2022 |
Biomarker |
| Feasibility of Machine Learning and Logistic Regression Algorithms to Predict Outcome in Orthopaedic Trauma Surgery | Oosterhoff, J. H. F. Gravesteijn, B. Y. Karhade, A. V. Jaarsma, R. L. Kerkhoffs, Gmmj Ring, D. Schwab, J. H. Steyerberg, E. W. Doornberg, J. N. | J Bone Joint Surg Am | 2022 |
Algorithms |
| Delirium detection methodologies: Implications for outcome measurement in clinical trials in postoperative delirium | Oh, E. S. Rosenberg, P. B. Wang, N. Y. Sieber, F. E. Neufeld, K. J. | Int J Geriatr Psychiatry | 2022 |
Aged |
| Nurse staffing levels are not associated with appearance, duration or solution of delirium in stroke patients | Nydahl, P. Meyne, J. Osterbrink, J. Margraf, N. G. | Intensive Crit Care Nurs | 2022 |
*Delirium/complications |
| Regional vs General Anesthesia and Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery | Nobuhara, C. Devinney, M., Jr. Berger, M. | Jama | 2022 |
Aged |
| Linking Perioperative Medications and Delirium | Nathan, N. | Anesth Analg | 2022 |
*Delirium/chemically induced/diagnosis |
| Prolonged and severe post-electroconvulsive therapy delirium with concurrent clozapine therapy | Melnikoff, E. Thomas Johnson, E. Walker, F. Itrat, Q. Jagadheesan, K. | Aust N Z J Psychiatry | 2022 |
*Antipsychotic Agents/adverse effects |
| 'Excited Delirium', acute behavioural disturbance, death and diagnosis | McGuinness, T. Lipsedge, M. | Psychol Med | 2022 |
Acute behavioural disturbance |
| Effects of non-pharmacologic prevention on delirium in critically ill patients: A network meta-analysis | Matsuura, Y. Ohno, Y. Toyoshima, M. Ueno, T. | Nurs Crit Care | 2022 |
acute encephalopathy |
| Melatonin Receptor Agonists for the Prevention of Delirium: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials | Maneeton, B. Kongsaengdao, S. Maneeton, N. Likhitsathian, S. Woottiluk, P. Kawilapat, S. Srisurapanont, M. | Curr Neuropharmacol | 2022 |
Delirium |
| Potential Value of Serum Lipid in the Identication of Postoperative Delirium Undergoing Knee/Hip Arthroplasty: The Perioperative Neurocognitive Disorder and Biomarker Lifestyle Study | Lin, Y. Peng, X. Lin, X. Deng, X. Liu, F. Tao, H. Dong, R. Wang, B. Bi, Y. | Front Psychiatry | 2022 |
cholesterol |
| Habitual tea consumption and postoperative delirium after total hip/knee arthroplasty in elderly patients: The PNDABLE study | Lin, X. Li, X. X. Dong, R. Wang, B. Bi, Y. L. | Brain Behav | 2022 |
cholinergic nerve system |
| Delirium and the risk of developing dementia: a cohort study of 12 949 patients | Leighton, S. P. Herron, J. W. Jackson, E. Sheridan, M. Deligianni, F. Cavanagh, J. | J Neurol Neurosurg Psychiatry | 2022 |
Dementia |
| Delirium risk factors analysis post proximal femur fracture surgery in elderly | Leigheb, M. De Sire, A. Zeppegno, P. Forni, F. Sgreccia, M. Gagliardi, V. P. Pogliacomi, F. Sabbatini, M. | Acta Biomed | 2022 |
Aged |
| A Scoping Review of the Incidence, Predictors, and Outcomes of Delirium Among Critically Ill Stroke Patients | Lawson, T. N. Balas, M. C. McNett, M. | J Neurosci Nurs | 2022 |
Adult |
| Non-Pharmacological Nursing Interventions to Prevent Delirium in ICU Patients-An Umbrella Review with Implications for Evidence-Based Practice | Lange, S. Mędrzycka-Dąbrowska, W. Friganovic, A. Oomen, B. Krupa, S. | J Pers Med | 2022 |
Icu |
| A decision tree prediction model for a short-term outcome of delirium in patients with advanced cancer receiving pharmacological interventions: A secondary analysis of a multicenter and prospective observational study (Phase-R) | Kurisu, K. Inada, S. Maeda, I. Ogawa, A. Iwase, S. Akechi, T. Morita, T. Oyamada, S. Yamaguchi, T. Imai, K. Nakahara, R. Kaneishi, K. Nakajima, N. Sumitani, M. Yoshiuchi, K. | Palliat Support Care | 2022 |
Decision Trees |
| Postoperative delirium is an independent factor influencing the length of stay of elderly patients in the intensive care unit and in hospital | Kirfel, A. Guttenthaler, V. Mayr, A. Coburn, M. Menzenbach, J. Wittmann, M. | J Anesth | 2022 |
Aged |
| Cost-effectiveness of clinical interventions for delirium: A systematic literature review of economic evaluations | Kinchin, I. Edwards, L. Hosie, A. Agar, M. Mitchell, E. Trepel, D. | Acta Psychiatr Scand | 2022 |
cost-effectiveness |
| Effects of non-pharmacological interventions for preventing delirium in general ward inpatients: A systematic review & meta-analysis of randomized controlled trials | Kim, Y. H. Kim, N. Y. Ryu, S. | PLoS One | 2022 |
Adult |
| Analysis of the Incidence and Risk Factors of Postoperative Delirium in Patients With Degenerative Cervical Myelopathy | Kim, N. Kim, T. H. Oh, J. K. Lim, J. Lee, K. U. Kim, S. W. | Neurospine | 2022 |
Cervical myelopathy |
| Intraoperative low tidal volume ventilation and the risk of ICD-10 coded delirium and the use for antipsychotic medications | Karalapillai, D. Weinberg, L. Neto, A. S. Peyton, P. J. Ellard, L. Hu, R. Pearce, B. Tan, C. Story, D. O'Donnell, M. Hamilton, P. Oughton, C. Galtieri, J. Appu, S. Wilson, A. Eastwood, G. Bellomo, R. Jones, D. A. | BMC Anesthesiol | 2022 |
Adult |
| Falling for It: Of Falls, Families, and Delirium | Jiménez, J. V. Hyzy, R. C. | Crit Care Med | 2022 |
*Accidental Falls |
| Safety and Effectiveness of Perospirone in Comparison to Risperidone for Treatment of Delirium in Patients with Advanced Cancer: A Multicenter Prospective Observational Study in Real-World Psycho-Oncology Settings | Inoue, S. Maeda, I. Ogawa, A. Yoshiuchi, K. Terada, S. Yamada, N. | Acta Med Okayama | 2022 |
Aged |
| Higher Grade Glioma Increases the Risk of Postoperative Delirium: Deficient Brain Compensation Might Be a Potential Mechanism of Postoperative Delirium | Huang, H. W. Zhang, X. K. Li, H. Y. Wang, Y. G. Jing, B. Chen, Y. Patel, M. B. Ely, E. W. Liu, Y. O. Zhou, J. X. Lin, S. Zhang, G. B. | Front Aging Neurosci | 2022 |
brain cognitive compensation |
| Fluconazole-induced delirium in an older patient with schizophrenia | Hu, T. M. Wu, C. L. | Psychogeriatrics | 2022 | |
| Knowledge assessment is key to identifying the training needs of delirium care | Ho, M. H. | Intensive Crit Care Nurs | 2022 |
*Delirium/nursing/therapy |
| Anticholinergic Drug Exposure Increases the Risk of Delirium in Older Patients Undergoing Elective Surgery | Herrmann, M. L. Boden, C. Maurer, C. Kentischer, F. Mennig, E. Wagner, S. Conzelmann, L. O. Förstner, B. R. Rapp, M. A. von Arnim, C. A. F. Denkinger, M. Eschweiler, G. W. Thomas, C. | Front Med (Lausanne) | 2022 |
acute encephalopathy |
| A prediction model for delirium after cardiac surgery: Another step towards prevention? | Herman, J. A. Urman, R. D. Urits, I. Kaye, A. D. Viswanath, O. | J Clin Anesth | 2022 |
*Cardiac Surgical Procedures/adverse effects |
| The effect of a dexmedetomidine infusion on delirium in the ICU | Herman, J. A. Urman, R. D. Urits, I. Kaye, A. D. Viswanath, O. | J Clin Anesth | 2022 |
*Delirium/chemically induced/drug therapy |
| Which interventions can reduce post-operative delirium in the elderly? Synthesis of multidisciplinary and pharmacological intervention data | Herman, J. Urman, R. D. Urits, I. Kaye, A. D. Viswanath, O. | J Clin Anesth | 2022 |
Aged |
| What is the impact of perioperative cerebral oxygen desaturation on postoperative delirium in old population: a systemic review and meta-analysis | He, K. Q. Wang, S. Zhang, W. Liu, Q. Chai, X. Q. | Aging Clin Exp Res | 2022 |
Cerebral oxygen saturation |
| Midazolam and delirium: can you have it both ways? | Greengrass, R. A. | Reg Anesth Pain Med | 2022 |
*Delirium/chemically induced/diagnosis |
| Music Interventions and Delirium in Adults: A Systematic Literature Review and Meta-Analysis | Golubovic, J. Neerland, B. E. Aune, D. Baker, F. A. | Brain Sci | 2022 |
acute confusion |
| In older adults having hip fracture surgery, regional vs. general anesthesia did not reduce postoperative delirium | Gill, S. S. | Ann Intern Med | 2022 |
Aged |
| Relationship between preoperative anxiety and onset of delirium after cardiovascular surgery in elderly patients: focus on personality and coping process | Fukunaga, H. Sugawara, H. Koyama, A. Okamoto, K. Fukui, T. Ishikawa, T. Takebayashi, M. Sekiyama, K. Hashimoto, M. | Psychogeriatrics | 2022 |
agreeableness |
| Identifying Delirium in Persons With Moderate or Severe Dementia: Review of Challenges and an Illustrative Approach | Fong, T. G. Hshieh, T. T. Tabloski, P. A. Metzger, E. D. Arias, F. Heintz, H. L. Patrick, R. E. Lapid, M. I. Schmitt, E. M. Harper, D. G. Forester, B. P. Inouye, S. K. | Am J Geriatr Psychiatry | 2022 |
Advanced dementia |
| Depression is associated with delirium after cardiac surgery - A population-based cohort study | Falk, A. Kåhlin, J. Nymark, C. Hultgren, R. Stenman, M. | Interact Cardiovasc Thorac Surg | 2022 |
Cardiac surgery |
| Incidence, characteristics and risk factors of delirium in the intensive care unit: An observational study | Erbay Dalli, Ö Kelebek Girgin, N. Kahveci, F. | J Clin Nurs | 2022 |
critically ill |
| Incidence, characteristics and risk factors of delirium in the intensive care unit: An observational study | Erbay Dalli, Ö Kelebek Girgin, N. Kahveci, F. | J Clin Nurs | 2022 |
critically ill |
| Association Between Perioperative Medication Use and Postoperative Delirium and Cognition in Older Adults Undergoing Elective Noncardiac Surgery | Duprey, M. S. Devlin, J. W. Griffith, J. L. Travison, T. G. Briesacher, B. A. Jones, R. Saczynski, J. S. Schmitt, E. M. Gou, Y. Marcantonio, E. R. Inouye, S. K. | Anesth Analg | 2022 |
Aged |
| Comparison of incidence of emergence delirium in pediatric patients with three different techniques of general anesthesia using sevoflurane and propofol: a randomized controlled trial | Deepak, M. Shilpa, G. Nikhil, K. Ankur, S. Rakesh, K. Swati, C. Akhil, G. Pradeep, B. | Braz J Anesthesiol | 2022 | |
| Delirium and long-term psychopathology following surgery in older adults | de Mul, N. van den Bos, Lmec Kant, I. M. J. van Montfort, S. J. T. Schellekens, W. M. Cremer, O. L. Slooter, A. J. C. | J Psychosom Res | 2022 |
Aged |
| Study protocol to test the efficacy of self-administration of dexmedetomidine sedative therapy on anxiety, delirium, and ventilator days in critically ill mechanically ventilated patients: an open-label randomized clinical trial | Chlan, L. L. Weinert, C. R. Tracy, M. F. Skaar, D. J. Gajic, O. Ask, J. Mandrekar, J. | Trials | 2022 |
Aftercare |
| Corticosteroids in patients undergoing cardiac surgery: A meta-analysis of 12,559 patients | Chen, L. Xiang, F. Hu, Y. | Perfusion | 2022 |
cardiac surgery |
| Postoperative outcomes in older surgical patients with preoperative cognitive impairment: A systematic review and meta-analysis | Chen, L. Au, E. Saripella, A. Kapoor, P. Yan, E. Wong, J. Tang-Wai, D. F. Gold, D. Riazi, S. Suen, C. He, D. Englesakis, M. Nagappa, M. Chung, F. | J Clin Anesth | 2022 |
Cognitive impairment |
| Benzodiazepine-Based Sedation Did Not Add an Independent Risk of Delirium? | Cai, X. Gao, R. Zhang, S. Chen, C. | Crit Care Med | 2022 |
*Benzodiazepines/adverse effects |
| Natural language processing and detecting delirium | Burki, T. | Lancet Respir Med | 2022 | |
| Delirium risk factors in hospitalized patient: a comprehensive evaluation of underlying diseases and medications in different wards of a large Urban Hospital Center in Iran | Arbabi, M. Ziaei, E. Amini, B. Ghadimi, H. Rashidi, F. Shohanizad, N. Moradi, S. Beikmarzehei, A. Hasanzadeh, A. Parsaei, A. | BMC Anesthesiol | 2022 |
*Delirium/epidemiology |
| Depression and anxiety increase the odds of developing delirium in ICU patients; a prospective observational study | Arbabi, M. Dezhdar, Z. Amini, B. Dehnavi, A. Z. Ghasemi, M. | Cogn Neuropsychiatry | 2022 |
Anxiety |
| Andersen-Ranberg, N. Poulsen, L. M. Perner, A. Hästbacka, J. Morgan, M. P. G. Citerio, G. Oxenbøll-Collet, M. Weber, S. O. Andreasen, A. S. Bestle, M. H. Uslu, B. Pedersen, H. B. S. Nielsen, L. G. Damgaard, K. Jensen, T. B. Sommer, T. Dey, N. Mathiesen, | Agents intervening against delirium in the intensive care unit trial-Protocol for a secondary Bayesian analysis | Acta Anaesthesiol Scand | 2022 |
Bayesian statistics |
| Sleep monitoring challenges in patients with neurocognitive disorders: A cross-sectional analysis of missing data from activity trackers | Ahuja, M. Siddhpuria, S. Reppas-Rindlisbacher, C. Wong, E. Gormley, J. Lee, J. Patterson, C. | Health Sci Rep | 2022 |
activity monitor |
| The Dilemma of Treating Delirium: the Conundrum of Drug Management | Agar, M. R. Amgarth-Duff, I. | Curr Treat Options Oncol | 2022 |
Antipsychotics |
| Gabapentinoid Use Is Associated With Reduced Occurrence of Hyperactive Delirium in Older Cancer Patients Undergoing Chemotherapy: A Nationwide Retrospective Cohort Study in Japan | Abe, H. Sumitani, M. Matsui, H. Inoue, R. Konishi, M. Fushimi, K. Uchida, K. Yasunaga, H. | Anesth Analg | 2022 |
Gabapentinoid Use Is Associated With Reduced Occurrence of Hyperactive Delirium in Older Cancer Patients Undergoing Chemotherapy: A Nationwide Retrospective Cohort Study in Japan |
| Incidence, predictors and health outcomes of delirium in very old hospitalized patients: a prospective cohort study | Zhang, M. Zhang, X. Gao, L. Yue, J. Jiang, X. | BMC Geriatr | 2022 |
Aged |
| The effect of delirium information training given to intensive care nurses on patient care: quasi-experimental study | Yıldırım, F. Türkleş, S. Altundal Duru, H. | PeerJ | 2022 |
Checklist |
| Mechanical Bowel Preparation Is a Risk Factor for Postoperative Delirium as It Alters the Gut Microbiota Composition: A Prospective Randomized Single-Center Study | Yang, Z. Tong, C. Qian, X. Wang, H. Wang, Y. | Front Aging Neurosci | 2022 |
gastrectomy |
| The Mini-Cog: A simple screening tool for cognitive impairment useful in predicting the risk of delirium after major urological cancer surgery | Yajima, S. Nakanishi, Y. Matsumoto, S. Ookubo, N. Tanabe, K. Kataoka, M. Masuda, H. | Geriatr Gerontol Int | 2022 |
Activities of Daily Living |
| A Novel Radiomics-Based Machine Learning Framework for Prediction of Acute Kidney Injury-Related Delirium in Patients Who Underwent Cardiovascular Surgery | Xue, X. Chen, W. Chen, X. | Comput Math Methods Med | 2022 |
*Acute Kidney Injury/diagnostic imaging/etiology |
| The Effect of Preoperative Methylprednisolone on Postoperative Delirium in Older Patients Undergoing Gastrointestinal Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial | Xiang, X. B. Chen, H. Wu, Y. L. Wang, K. Yue, X. Cheng, X. Q. | J Gerontol A Biol Sci Med Sci | 2022 |
Aged |
| Head-to-head comparison of 14 prediction models for postoperative delirium in elderly non-ICU patients: an external validation study | Wong, C. K. van Munster, B. C. Hatseras, A. Huis In 't Veld, E. van Leeuwen, B. L. de Rooij, S. E. Pleijhuis, R. G. | BMJ Open | 2022 |
Aged |
| Impact of a dementia-friendly program on detection and management of patients with cognitive impairment and delirium in acute-care hospital units: a controlled clinical trial design | Weldingh, N. M. Mellingsæter, M. R. Hegna, B. W. Benth, J. S. Einvik, G. Juliebø, V. Thommessen, B. Kirkevold, M. | BMC Geriatr | 2022 |
Aged |
| Influence of Patient-Specific Covariates on Test Validity of Two Delirium Screening Instruments in Neurocritical Care Patients (DEMON-ICU) | Weiss, B. Paul, N. Spies, C. D. Ullrich, D. Ansorge, I. Salih, F. Wolf, S. Luetz, A. | Neurocrit Care | 2022 |
Critical Care/methods |
| Development and Validation of a Postoperative Delirium Prediction Model for Elderly Orthopedic Patients in the Intensive Care Unit | Wang, G. Zhang, L. Qi, Y. Chen, G. Zhou, J. Zhu, H. Hao, Y. | J Healthc Eng | 2022 |
Aged |
| Effects of Atorvastatin Therapy on Postoperative Delirium After Malignant Tumor Surgeries in Older Adults | Wan, R. Cai, S. Pan, D. Yang, W. Zhou, R. | Neuropsychiatr Dis Treat | 2022 |
30-day all-cause mortality |
| Psychometric Properties of a Delirium Severity Score for Older Adults and Association With Hospital and Posthospital Outcomes | Vasunilashorn, S. M. Fong, T. G. Helfand, B. K. I. Hshieh, T. T. Marcantonio, E. R. Metzger, E. D. Schmitt, E. M. Tabloski, P. A. Travison, T. G. Gou, Y. Jones, R. N. Inouye, S. K. | JAMA Netw Open | 2022 |
Aged |
| Delirium can be safely managed in the community through implementation of a community toolkit: a proof-of-concept pilot study | Vardy, E. Roberts, S. Pratt, H. | Future Healthc J | 2022 |
assessment |
| Delirium as a Presenting Symptom of COVID-19 | Tyson, B. Shahein, A. Erdodi, L. Tyson, L. Tyson, R. Ghomi, R. Agarwal, P. | Cogn Behav Neurol | 2022 | |
| The effect of baseline cognition and delirium on long-term cognitive impairment and mortality: a prospective population-based study | Tsui, A. Searle, S. D. Bowden, H. Hoffmann, K. Hornby, J. Goslett, A. Weston-Clarke, M. Howes, L. H. Street, R. Perera, R. Taee, K. Kustermann, C. Chitalu, P. Razavi, B. Magni, F. Das, D. Kim, S. Chaturvedi, N. Sampson, E. L. Rockwood, K. Cunningham, C. E | Lancet Healthy Longev | 2022 | |
| Delirium with visual hallucinations induced by low-dose olanzapine | Takeuchi, N. Makino, T. Nishihara, M. | Psychogeriatrics | 2022 |
*Antipsychotic Agents/adverse effects |
| Catatonia and Delirium: Similarity and Overlap of Acute Brain Dysfunction | Tachibana, M. Ishizuka, K. Inada, T. | Front Psychiatry | 2022 |
acute brain dysfunction |
| Association between stress hyperglycemia ratio and delirium in older hospitalized patients: a cohort study | Song, Q. Dai, M. Zhao, Y. Lin, T. Huang, L. Yue, J. | BMC Geriatr | 2022 |
Aged |
| Machine Learning to Identify Psychomotor Behaviors of Delirium for Patients in Long-Term Care Facility | Son, C. S. Kang, W. S. Lee, J. H. Moon, K. J. | IEEE J Biomed Health Inform | 2022 |
Adult |
| Parents' Time Perspective as a Predictor of Child's Postsurgical Pain, Emergence Delirium, and Parents' Posttraumatic Stress Disorder Symptoms after Child's Surgery | Sobol, M. Sobol, M. K. | Children (Basel) | 2022 |
Ptsd |
| Applicability of the interventions recommended for patients at risk or with delirium in medical and post-acute settings: a systematic review and a Nominal Group Technique study | Sist, L. Ugenti, N. V. Donati, G. Cedioli, S. Mansutti, I. Zanetti, E. Macchiarulo, M. Messina, R. Rucci, P. Palese, A. | Aging Clin Exp Res | 2022 |
Applicability |
| Prevalence and features of delirium in older patients admitted to rehabilitation facilities: a multicenter study | Sidoli, C. Zambon, A. Tassistro, E. Rossi, E. Mossello, E. Inzitari, M. Cherubini, A. Marengoni, A. Morandi, A. Bellelli, G. | Aging Clin Exp Res | 2022 |
Delirium |
| Nomogram Models for Predicting Delirium of Patients in Emergency Intensive Care Unit: A Retrospective Cohort Study | Shi, Y. Wang, H. Zhang, L. Zhang, M. Shi, X. Pei, H. Bai, Z. | Int J Gen Med | 2022 |
area under curve |
| Effect of midazolam on delirium in critically ill patients: a propensity score analysis | Shi, H. J. Yuan, R. X. Zhang, J. Z. Chen, J. H. Hu, A. M. | J Int Med Res | 2022 |
Midazolam delirium critical care propensity score analysis cohort study risk factor |
| Prediction of Postoperative Delirium After Cardiac Surgery with A Quick Test of Cognitive Speed, Mini-Mental State Examination and Hospital Anxiety and Depression Scale | Segernäs, A. Skoog, J. Ahlgren Andersson, E. Almerud Österberg, S. Thulesius, H. Zachrisson, H. | Clin Interv Aging | 2022 |
Aged |
| A retrospective comparison of haloperidol and hydroxyzine combination therapy with haloperidol alone in the treatment of overactive delirium | Sato, J. Tanaka, R. | Support Care Cancer | 2022 |
*Antipsychotic Agents/therapeutic use |
| Serum folate deficiency and the risks of dementia and all-cause mortality: a national study of old age | Rotstein, A. Kodesh, A. Goldberg, Y. Reichenberg, A. Levine, S. Z. | Evid Based Ment Health | 2022 |
Aged |