What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia.
- Authors
- Van Leeuwen, E. Petrovic, M. van Driel, M. L. De Sutter, A. I. M. Vander Stichele, R. Declercq, T. Christiaens, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Antipsychotic agents are often used to treat neuropsychiatric symptoms (NPS) in people with dementia although there is uncertainty about the effectiveness of their long-term use for this indication and concern that they may cause harm, including higher mortality. When behavioural strategies have failed and treatment with antipsychotic drugs is instituted, regular attempts to withdraw them have been recommended in guidelines. Physicians, nurses and families of older people with dementia may be reluctant to stop antipsychotics, fearing deterioration of NPS. This is an update of a Cochrane Review published in 2013. Objectives: To evaluate whether withdrawal of antipsychotic agents is successful in older people with dementia and NPS in primary care or nursing home settings, to list the different strategies for withdrawal of antipsychotic agents in older participants with dementia and NPS, and to measure the effects of withdrawal of antipsychotic agents on participants’ behaviour and assess safety. Search methods: We searched the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (ALOIS), theCochrane Library, MEDLINE, Embase, PsycINFO, CINAHL, LILACS, clinical trials registries and grey literature sources up to 11 January 2018. Selection criteria: We included all randomised, controlled trials comparing an antipsychotic withdrawal strategy to continuation of antipsychotics in people with dementia who had been treated with an antipsychotic drug for at least three months. Data collection and analysis: We used standard methodological procedures according to the Cochrane Handbook for Systematic Reviews of Interventions. We rated the quality of evidence for each outcome using the GRADE approach. Main results: We included 10 studies involving 632 participants. One new trial (19 participants) was added for this update. One trial was conducted in a community setting, eight in nursing homes and one in both settings. Different types of antipsychotics at varying doses were discontinued in the studies. Both abrupt and gradual withdrawal schedules were used. Reported data were predominantly from studies at low or unclear risk of bias. We included nine trials with 575 randomised participants that used a proxy outcome for overall success of antipsychotic withdrawal. Pooling data was not possible due to heterogeneity of outcome measures used. Based on assessment of seven studies, discontinuation may make little or no difference to whether or not participants complete the study (low-quality evidence). Two trials included only participants with psychosis, agitation or aggression who had responded to antipsychotic treatment. In these two trials, stopping antipsychotics was associated with a higher risk of leaving the study early due to symptomatic relapse or a shorter time to symptomatic relapse. We found low-quality evidence that discontinuation may make little or no difference to overall NPS, measured using various scales (7 trials, 519 participants). There was some evidence from subgroup analyses in two trials that discontinuation may reduce agitation for participants with less severe NPS at baseline, but may be associated with a worsening of NPS in participants with more severe NPS at baseline. None of the studies assessed withdrawal symptoms. Adverse effects of antipsychotics (such as falls) were not systematically assessed. Low-quality evidence showed that discontinuation may have little or no effect on adverse events (5 trials, 381 participants), quality of life (2 trials, 119 participants), or cognitive function (5 trials, 365 participants). There were insufficient data to determine whether discontinuation of antipsychotics has any effect on mortality (very low-quality evidence). Authors’ conclusions: There is low-quality evidence that antipsychotics may be successfully discontinued in older people with dementia and NPS who have been taking antipsychotics for at least three months, and that discontinuation may have little or no important effect on behavioural and psychological symptoms. This i consistent with the observation that most behavioural complications of dementia are intermittent and often do not persist for longer than three months. Discontinuation may have little or no effect on overall cognitive function. Discontinuation may make no difference to adverse events and quality of life. Based on the trials in this review, we are uncertain whether discontinuation of antipsychotics leads to a decrease in mortality. People with psychosis, aggression or agitation who responded well to long-term antipsychotic drug use, or those with more severe NPS at baseline, may benefit behaviourally from continuation of antipsychotics. Discontinuation may reduce agitation for people with mild NPS at baseline. However, these conclusions are based on few studies or small subgroups and further evidence of benefits and harms associated with withdrawal of antipsychotic is required in people with dementia and mild and severe NPS. The overall conclusions of the review have not changed since 2013 and the number of available trials remains low.
- PMID
- Keywords
chlorpromazine
haloperidol
levomepromazine
lorazepam
loxapine
mesoridazine
neuroleptic agent
olanzapine
perphenazine
placebo
risperidone
thioridazine
tiotixene
trifluoperazine
aggression
agitation
akathisia
behavior disorder
blood pressure
body equilibrium
cardiovascular disease
cognition
confusion
dementia
drug fatality
drug megadose
drug response
drug safety
drug withdrawal
extrapyramidal symptom
falling
fracture
heart rate
human
insomnia
long term care
low drug dose
lung disease
mental disease
motor dysfunction
nausea
neurologic disease
nursing home
parkinsonism
physical mobility
primary medical care
priority journal
psychosis
quality of life
relapse
restlessness
review
sedation
side effect
systematic review
tardive dyskinesia
treatment outcome
vomiting
- Page(s)
- Volume
- Issue
- 3
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Delirium prediction in the ICU: designing a screening tool for preventive interventions | Bhattacharyya, A. Sheikhalishahi, S. Torbic, H. Yeung, W. Wang, T. Birst, J. Duggal, A. Celi, L. A. Osmani, V. | JAMIA Open | 2022 |
artificial intelligence |
| Regional vs General Anesthesia and Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery | Zhu, Z. Cao, P. Lin, L. | Jama | 2022 |
Aged |
| Melatonin intervention to prevent delirium in hospitalized patients: A meta-analysis | You, W. Fan, X. Y. Lei, C. Nie, C. C. Chen, Y. Wang, X. L. | World J Clin Cases | 2022 |
Delirium |
| Preoperative Low Physical Activity is a Predictor of Postoperative Delirium in Patients with Gastrointestinal Cancer: A Retrospective Study | Yanagisawa, T. Tatematsu, N. Horiuchi, M. Migitaka, S. Yasuda, S. Itatsu, K. Kubota, T. Sugiura, H. | Asian Pac J Cancer Prev | 2022 |
Activities of Daily Living |
| What is It Like to be Delirious? | Wijdicks, E. F. M. Rabinstein, A. A. | Neurocrit Care | 2022 |
Definitions |
| Impact of Pain, Agitation, and Delirium Bundle on Delirium and Cognitive Function | Wang, X. P. Lv, D. Chen, Y. F. Chen, N. Li, X. D. Xu, C. F. Li, Y. Tian, L. | J Nurs Res | 2022 | |
| Regional vs General Anesthesia and Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery | Uzoigwe, C. E. Campbell-Jones, F. | Jama | 2022 |
Aged |
| Improving delirium screening in older adults at the Royal United Hospital, Bath | Trew, C. A. Cross, R. Howell, K. Dyer, C. | Br J Hosp Med (Lond) | 2022 |
Aged |
| Assessing prevalence and independent predictors of postoperative delirium in patients with head and neck cancer | Tian, T. Xue, F. S. Shao, L. J. Z. Hu, B. | Br J Oral Maxillofac Surg | 2022 |
*Delirium/epidemiology/etiology |
| Delirium due to hip fracture is associated with activated immune-inflammatory pathways and a reduction in negative immunoregulatory mechanisms | Thisayakorn, P. Thipakorn, Y. Tantavisut, S. Sirivichayakul, S. Maes, M. | BMC Psychiatry | 2022 |
Aged |
| Retrospective evaluation of a delirium order set utilizing nonpharmacologic and pharmacologic interventions for the treatment of delirium in medical intensive care unit patients | Taylor, A. D. Chen, A. Reddy, A. J. Lewandowski, A. Torbic, H. | Am J Health Syst Pharm | 2022 |
Adolescent |
| Prevention of dexmedetomidine on postoperative delirium and early postoperative cognitive dysfunction in elderly patients undergoing hepatic lobectomy | Tang, Y. Wang, Y. Kong, G. Zhao, Y. Wei, L. Liu, J. | Zhong Nan Da Xue Xue Bao Yi Xue Ban | 2022 |
Aged |
| Prevalence, clinical features, and risk factors of delusions in patients with delirium | Tachibana, M. Inada, T. Ichida, M. Ozaki, N. | Int J Geriatr Psychiatry | 2022 | |
| Effect of sedative premedication with oral midazolam on postanesthesia care unit delirium in older adults: a secondary analysis following an uncontrolled before-after design | Stuff, K. Kainz, E. Kahl, U. Pinnschmidt, H. Beck, S. von Breunig, F. Nitzschke, R. Funcke, S. Zöllner, C. Fischer, M. | Perioper Med (Lond) | 2022 |
Anesthesia |
| Associations of Smoking With Delirium and Opioid Use in Older Adults With Traumatic Hip Fracture | Salottolo, K. Meinig, R. Fine, L. Kelly, M. Madayag, R. Ekengren, F. Tanner, A., 2nd Bar-Or, D. | J Am Acad Orthop Surg Glob Res Rev | 2022 |
Aged |
| Impact of delirium on mortality in patients hospitalized for heart failure | Ritchie, C. Walters, R. W. Ramaswamy, S. Alla, V. M. | Int J Psychiatry Med | 2022 |
Aged |
| Risk for post-operative delirium related to comorbidities in older adult cardiac patients: An integrative review | Ramos, M. D. Vergara, F. H. Shackleford, J. Briggs, C. Gomez, C. Mofazali, M. Preston, J. | J Clin Nurs | 2022 |
cardiac surgery |
| Diagnosis and management of delirium in hospital oncology services | Ramírez Zuluaga, L. P. Ruano Restrepo, M. I. Osorio Bermúdez, J. D. Díaz Vallejo, J. A. | J Geriatr Oncol | 2022 |
*Delirium/diagnosis/etiology/therapy |
| Cognitive Predictors of Delirium on Long-Term Follow-Up after TIA and Stroke: Population-Based Cohort Study | Pendlebury, S. T. Thomson, R. J. Welch, S. J. V. Rothwell, P. M. | Cerebrovasc Dis | 2022 |
Aged |
| Plasma neurofilament light chain protein as a predictor of days in delirium and deep sedation, mortality and length of stay in critically ill patients | Page, V. J. Watne, L. O. Heslegrave, A. Clark, A. McAuley, D. F. Sanders, R. D. Zetterberg, H. | EBioMedicine | 2022 |
Biomarker |
| Feasibility of Machine Learning and Logistic Regression Algorithms to Predict Outcome in Orthopaedic Trauma Surgery | Oosterhoff, J. H. F. Gravesteijn, B. Y. Karhade, A. V. Jaarsma, R. L. Kerkhoffs, Gmmj Ring, D. Schwab, J. H. Steyerberg, E. W. Doornberg, J. N. | J Bone Joint Surg Am | 2022 |
Algorithms |
| Delirium detection methodologies: Implications for outcome measurement in clinical trials in postoperative delirium | Oh, E. S. Rosenberg, P. B. Wang, N. Y. Sieber, F. E. Neufeld, K. J. | Int J Geriatr Psychiatry | 2022 |
Aged |
| Nurse staffing levels are not associated with appearance, duration or solution of delirium in stroke patients | Nydahl, P. Meyne, J. Osterbrink, J. Margraf, N. G. | Intensive Crit Care Nurs | 2022 |
*Delirium/complications |
| Regional vs General Anesthesia and Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery | Nobuhara, C. Devinney, M., Jr. Berger, M. | Jama | 2022 |
Aged |
| Linking Perioperative Medications and Delirium | Nathan, N. | Anesth Analg | 2022 |
*Delirium/chemically induced/diagnosis |
| Prolonged and severe post-electroconvulsive therapy delirium with concurrent clozapine therapy | Melnikoff, E. Thomas Johnson, E. Walker, F. Itrat, Q. Jagadheesan, K. | Aust N Z J Psychiatry | 2022 |
*Antipsychotic Agents/adverse effects |
| 'Excited Delirium', acute behavioural disturbance, death and diagnosis | McGuinness, T. Lipsedge, M. | Psychol Med | 2022 |
Acute behavioural disturbance |
| Effects of non-pharmacologic prevention on delirium in critically ill patients: A network meta-analysis | Matsuura, Y. Ohno, Y. Toyoshima, M. Ueno, T. | Nurs Crit Care | 2022 |
acute encephalopathy |
| Melatonin Receptor Agonists for the Prevention of Delirium: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials | Maneeton, B. Kongsaengdao, S. Maneeton, N. Likhitsathian, S. Woottiluk, P. Kawilapat, S. Srisurapanont, M. | Curr Neuropharmacol | 2022 |
Delirium |
| Potential Value of Serum Lipid in the Identication of Postoperative Delirium Undergoing Knee/Hip Arthroplasty: The Perioperative Neurocognitive Disorder and Biomarker Lifestyle Study | Lin, Y. Peng, X. Lin, X. Deng, X. Liu, F. Tao, H. Dong, R. Wang, B. Bi, Y. | Front Psychiatry | 2022 |
cholesterol |
| Habitual tea consumption and postoperative delirium after total hip/knee arthroplasty in elderly patients: The PNDABLE study | Lin, X. Li, X. X. Dong, R. Wang, B. Bi, Y. L. | Brain Behav | 2022 |
cholinergic nerve system |
| Delirium and the risk of developing dementia: a cohort study of 12 949 patients | Leighton, S. P. Herron, J. W. Jackson, E. Sheridan, M. Deligianni, F. Cavanagh, J. | J Neurol Neurosurg Psychiatry | 2022 |
Dementia |
| Delirium risk factors analysis post proximal femur fracture surgery in elderly | Leigheb, M. De Sire, A. Zeppegno, P. Forni, F. Sgreccia, M. Gagliardi, V. P. Pogliacomi, F. Sabbatini, M. | Acta Biomed | 2022 |
Aged |
| A Scoping Review of the Incidence, Predictors, and Outcomes of Delirium Among Critically Ill Stroke Patients | Lawson, T. N. Balas, M. C. McNett, M. | J Neurosci Nurs | 2022 |
Adult |
| Non-Pharmacological Nursing Interventions to Prevent Delirium in ICU Patients-An Umbrella Review with Implications for Evidence-Based Practice | Lange, S. Mędrzycka-Dąbrowska, W. Friganovic, A. Oomen, B. Krupa, S. | J Pers Med | 2022 |
Icu |
| A decision tree prediction model for a short-term outcome of delirium in patients with advanced cancer receiving pharmacological interventions: A secondary analysis of a multicenter and prospective observational study (Phase-R) | Kurisu, K. Inada, S. Maeda, I. Ogawa, A. Iwase, S. Akechi, T. Morita, T. Oyamada, S. Yamaguchi, T. Imai, K. Nakahara, R. Kaneishi, K. Nakajima, N. Sumitani, M. Yoshiuchi, K. | Palliat Support Care | 2022 |
Decision Trees |
| Postoperative delirium is an independent factor influencing the length of stay of elderly patients in the intensive care unit and in hospital | Kirfel, A. Guttenthaler, V. Mayr, A. Coburn, M. Menzenbach, J. Wittmann, M. | J Anesth | 2022 |
Aged |
| Cost-effectiveness of clinical interventions for delirium: A systematic literature review of economic evaluations | Kinchin, I. Edwards, L. Hosie, A. Agar, M. Mitchell, E. Trepel, D. | Acta Psychiatr Scand | 2022 |
cost-effectiveness |
| Effects of non-pharmacological interventions for preventing delirium in general ward inpatients: A systematic review & meta-analysis of randomized controlled trials | Kim, Y. H. Kim, N. Y. Ryu, S. | PLoS One | 2022 |
Adult |
| Analysis of the Incidence and Risk Factors of Postoperative Delirium in Patients With Degenerative Cervical Myelopathy | Kim, N. Kim, T. H. Oh, J. K. Lim, J. Lee, K. U. Kim, S. W. | Neurospine | 2022 |
Cervical myelopathy |
| Intraoperative low tidal volume ventilation and the risk of ICD-10 coded delirium and the use for antipsychotic medications | Karalapillai, D. Weinberg, L. Neto, A. S. Peyton, P. J. Ellard, L. Hu, R. Pearce, B. Tan, C. Story, D. O'Donnell, M. Hamilton, P. Oughton, C. Galtieri, J. Appu, S. Wilson, A. Eastwood, G. Bellomo, R. Jones, D. A. | BMC Anesthesiol | 2022 |
Adult |
| Falling for It: Of Falls, Families, and Delirium | Jiménez, J. V. Hyzy, R. C. | Crit Care Med | 2022 |
*Accidental Falls |
| Safety and Effectiveness of Perospirone in Comparison to Risperidone for Treatment of Delirium in Patients with Advanced Cancer: A Multicenter Prospective Observational Study in Real-World Psycho-Oncology Settings | Inoue, S. Maeda, I. Ogawa, A. Yoshiuchi, K. Terada, S. Yamada, N. | Acta Med Okayama | 2022 |
Aged |
| Higher Grade Glioma Increases the Risk of Postoperative Delirium: Deficient Brain Compensation Might Be a Potential Mechanism of Postoperative Delirium | Huang, H. W. Zhang, X. K. Li, H. Y. Wang, Y. G. Jing, B. Chen, Y. Patel, M. B. Ely, E. W. Liu, Y. O. Zhou, J. X. Lin, S. Zhang, G. B. | Front Aging Neurosci | 2022 |
brain cognitive compensation |
| Fluconazole-induced delirium in an older patient with schizophrenia | Hu, T. M. Wu, C. L. | Psychogeriatrics | 2022 | |
| Knowledge assessment is key to identifying the training needs of delirium care | Ho, M. H. | Intensive Crit Care Nurs | 2022 |
*Delirium/nursing/therapy |
| Anticholinergic Drug Exposure Increases the Risk of Delirium in Older Patients Undergoing Elective Surgery | Herrmann, M. L. Boden, C. Maurer, C. Kentischer, F. Mennig, E. Wagner, S. Conzelmann, L. O. Förstner, B. R. Rapp, M. A. von Arnim, C. A. F. Denkinger, M. Eschweiler, G. W. Thomas, C. | Front Med (Lausanne) | 2022 |
acute encephalopathy |
| A prediction model for delirium after cardiac surgery: Another step towards prevention? | Herman, J. A. Urman, R. D. Urits, I. Kaye, A. D. Viswanath, O. | J Clin Anesth | 2022 |
*Cardiac Surgical Procedures/adverse effects |
| The effect of a dexmedetomidine infusion on delirium in the ICU | Herman, J. A. Urman, R. D. Urits, I. Kaye, A. D. Viswanath, O. | J Clin Anesth | 2022 |
*Delirium/chemically induced/drug therapy |
| Which interventions can reduce post-operative delirium in the elderly? Synthesis of multidisciplinary and pharmacological intervention data | Herman, J. Urman, R. D. Urits, I. Kaye, A. D. Viswanath, O. | J Clin Anesth | 2022 |
Aged |
| What is the impact of perioperative cerebral oxygen desaturation on postoperative delirium in old population: a systemic review and meta-analysis | He, K. Q. Wang, S. Zhang, W. Liu, Q. Chai, X. Q. | Aging Clin Exp Res | 2022 |
Cerebral oxygen saturation |
| Midazolam and delirium: can you have it both ways? | Greengrass, R. A. | Reg Anesth Pain Med | 2022 |
*Delirium/chemically induced/diagnosis |
| Music Interventions and Delirium in Adults: A Systematic Literature Review and Meta-Analysis | Golubovic, J. Neerland, B. E. Aune, D. Baker, F. A. | Brain Sci | 2022 |
acute confusion |
| In older adults having hip fracture surgery, regional vs. general anesthesia did not reduce postoperative delirium | Gill, S. S. | Ann Intern Med | 2022 |
Aged |
| Relationship between preoperative anxiety and onset of delirium after cardiovascular surgery in elderly patients: focus on personality and coping process | Fukunaga, H. Sugawara, H. Koyama, A. Okamoto, K. Fukui, T. Ishikawa, T. Takebayashi, M. Sekiyama, K. Hashimoto, M. | Psychogeriatrics | 2022 |
agreeableness |
| Identifying Delirium in Persons With Moderate or Severe Dementia: Review of Challenges and an Illustrative Approach | Fong, T. G. Hshieh, T. T. Tabloski, P. A. Metzger, E. D. Arias, F. Heintz, H. L. Patrick, R. E. Lapid, M. I. Schmitt, E. M. Harper, D. G. Forester, B. P. Inouye, S. K. | Am J Geriatr Psychiatry | 2022 |
Advanced dementia |
| Depression is associated with delirium after cardiac surgery - A population-based cohort study | Falk, A. Kåhlin, J. Nymark, C. Hultgren, R. Stenman, M. | Interact Cardiovasc Thorac Surg | 2022 |
Cardiac surgery |
| Incidence, characteristics and risk factors of delirium in the intensive care unit: An observational study | Erbay Dalli, Ö Kelebek Girgin, N. Kahveci, F. | J Clin Nurs | 2022 |
critically ill |
| Incidence, characteristics and risk factors of delirium in the intensive care unit: An observational study | Erbay Dalli, Ö Kelebek Girgin, N. Kahveci, F. | J Clin Nurs | 2022 |
critically ill |
| Association Between Perioperative Medication Use and Postoperative Delirium and Cognition in Older Adults Undergoing Elective Noncardiac Surgery | Duprey, M. S. Devlin, J. W. Griffith, J. L. Travison, T. G. Briesacher, B. A. Jones, R. Saczynski, J. S. Schmitt, E. M. Gou, Y. Marcantonio, E. R. Inouye, S. K. | Anesth Analg | 2022 |
Aged |
| Comparison of incidence of emergence delirium in pediatric patients with three different techniques of general anesthesia using sevoflurane and propofol: a randomized controlled trial | Deepak, M. Shilpa, G. Nikhil, K. Ankur, S. Rakesh, K. Swati, C. Akhil, G. Pradeep, B. | Braz J Anesthesiol | 2022 | |
| Delirium and long-term psychopathology following surgery in older adults | de Mul, N. van den Bos, Lmec Kant, I. M. J. van Montfort, S. J. T. Schellekens, W. M. Cremer, O. L. Slooter, A. J. C. | J Psychosom Res | 2022 |
Aged |
| Study protocol to test the efficacy of self-administration of dexmedetomidine sedative therapy on anxiety, delirium, and ventilator days in critically ill mechanically ventilated patients: an open-label randomized clinical trial | Chlan, L. L. Weinert, C. R. Tracy, M. F. Skaar, D. J. Gajic, O. Ask, J. Mandrekar, J. | Trials | 2022 |
Aftercare |
| Corticosteroids in patients undergoing cardiac surgery: A meta-analysis of 12,559 patients | Chen, L. Xiang, F. Hu, Y. | Perfusion | 2022 |
cardiac surgery |
| Postoperative outcomes in older surgical patients with preoperative cognitive impairment: A systematic review and meta-analysis | Chen, L. Au, E. Saripella, A. Kapoor, P. Yan, E. Wong, J. Tang-Wai, D. F. Gold, D. Riazi, S. Suen, C. He, D. Englesakis, M. Nagappa, M. Chung, F. | J Clin Anesth | 2022 |
Cognitive impairment |
| Benzodiazepine-Based Sedation Did Not Add an Independent Risk of Delirium? | Cai, X. Gao, R. Zhang, S. Chen, C. | Crit Care Med | 2022 |
*Benzodiazepines/adverse effects |
| Natural language processing and detecting delirium | Burki, T. | Lancet Respir Med | 2022 | |
| Delirium risk factors in hospitalized patient: a comprehensive evaluation of underlying diseases and medications in different wards of a large Urban Hospital Center in Iran | Arbabi, M. Ziaei, E. Amini, B. Ghadimi, H. Rashidi, F. Shohanizad, N. Moradi, S. Beikmarzehei, A. Hasanzadeh, A. Parsaei, A. | BMC Anesthesiol | 2022 |
*Delirium/epidemiology |
| Depression and anxiety increase the odds of developing delirium in ICU patients; a prospective observational study | Arbabi, M. Dezhdar, Z. Amini, B. Dehnavi, A. Z. Ghasemi, M. | Cogn Neuropsychiatry | 2022 |
Anxiety |
| Andersen-Ranberg, N. Poulsen, L. M. Perner, A. Hästbacka, J. Morgan, M. P. G. Citerio, G. Oxenbøll-Collet, M. Weber, S. O. Andreasen, A. S. Bestle, M. H. Uslu, B. Pedersen, H. B. S. Nielsen, L. G. Damgaard, K. Jensen, T. B. Sommer, T. Dey, N. Mathiesen, | Agents intervening against delirium in the intensive care unit trial-Protocol for a secondary Bayesian analysis | Acta Anaesthesiol Scand | 2022 |
Bayesian statistics |
| Sleep monitoring challenges in patients with neurocognitive disorders: A cross-sectional analysis of missing data from activity trackers | Ahuja, M. Siddhpuria, S. Reppas-Rindlisbacher, C. Wong, E. Gormley, J. Lee, J. Patterson, C. | Health Sci Rep | 2022 |
activity monitor |
| The Dilemma of Treating Delirium: the Conundrum of Drug Management | Agar, M. R. Amgarth-Duff, I. | Curr Treat Options Oncol | 2022 |
Antipsychotics |
| Gabapentinoid Use Is Associated With Reduced Occurrence of Hyperactive Delirium in Older Cancer Patients Undergoing Chemotherapy: A Nationwide Retrospective Cohort Study in Japan | Abe, H. Sumitani, M. Matsui, H. Inoue, R. Konishi, M. Fushimi, K. Uchida, K. Yasunaga, H. | Anesth Analg | 2022 |
Gabapentinoid Use Is Associated With Reduced Occurrence of Hyperactive Delirium in Older Cancer Patients Undergoing Chemotherapy: A Nationwide Retrospective Cohort Study in Japan |
| Incidence, predictors and health outcomes of delirium in very old hospitalized patients: a prospective cohort study | Zhang, M. Zhang, X. Gao, L. Yue, J. Jiang, X. | BMC Geriatr | 2022 |
Aged |
| The effect of delirium information training given to intensive care nurses on patient care: quasi-experimental study | Yıldırım, F. Türkleş, S. Altundal Duru, H. | PeerJ | 2022 |
Checklist |
| Mechanical Bowel Preparation Is a Risk Factor for Postoperative Delirium as It Alters the Gut Microbiota Composition: A Prospective Randomized Single-Center Study | Yang, Z. Tong, C. Qian, X. Wang, H. Wang, Y. | Front Aging Neurosci | 2022 |
gastrectomy |
| The Mini-Cog: A simple screening tool for cognitive impairment useful in predicting the risk of delirium after major urological cancer surgery | Yajima, S. Nakanishi, Y. Matsumoto, S. Ookubo, N. Tanabe, K. Kataoka, M. Masuda, H. | Geriatr Gerontol Int | 2022 |
Activities of Daily Living |
| A Novel Radiomics-Based Machine Learning Framework for Prediction of Acute Kidney Injury-Related Delirium in Patients Who Underwent Cardiovascular Surgery | Xue, X. Chen, W. Chen, X. | Comput Math Methods Med | 2022 |
*Acute Kidney Injury/diagnostic imaging/etiology |
| The Effect of Preoperative Methylprednisolone on Postoperative Delirium in Older Patients Undergoing Gastrointestinal Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial | Xiang, X. B. Chen, H. Wu, Y. L. Wang, K. Yue, X. Cheng, X. Q. | J Gerontol A Biol Sci Med Sci | 2022 |
Aged |
| Head-to-head comparison of 14 prediction models for postoperative delirium in elderly non-ICU patients: an external validation study | Wong, C. K. van Munster, B. C. Hatseras, A. Huis In 't Veld, E. van Leeuwen, B. L. de Rooij, S. E. Pleijhuis, R. G. | BMJ Open | 2022 |
Aged |
| Impact of a dementia-friendly program on detection and management of patients with cognitive impairment and delirium in acute-care hospital units: a controlled clinical trial design | Weldingh, N. M. Mellingsæter, M. R. Hegna, B. W. Benth, J. S. Einvik, G. Juliebø, V. Thommessen, B. Kirkevold, M. | BMC Geriatr | 2022 |
Aged |
| Influence of Patient-Specific Covariates on Test Validity of Two Delirium Screening Instruments in Neurocritical Care Patients (DEMON-ICU) | Weiss, B. Paul, N. Spies, C. D. Ullrich, D. Ansorge, I. Salih, F. Wolf, S. Luetz, A. | Neurocrit Care | 2022 |
Critical Care/methods |
| Development and Validation of a Postoperative Delirium Prediction Model for Elderly Orthopedic Patients in the Intensive Care Unit | Wang, G. Zhang, L. Qi, Y. Chen, G. Zhou, J. Zhu, H. Hao, Y. | J Healthc Eng | 2022 |
Aged |
| Effects of Atorvastatin Therapy on Postoperative Delirium After Malignant Tumor Surgeries in Older Adults | Wan, R. Cai, S. Pan, D. Yang, W. Zhou, R. | Neuropsychiatr Dis Treat | 2022 |
30-day all-cause mortality |
| Psychometric Properties of a Delirium Severity Score for Older Adults and Association With Hospital and Posthospital Outcomes | Vasunilashorn, S. M. Fong, T. G. Helfand, B. K. I. Hshieh, T. T. Marcantonio, E. R. Metzger, E. D. Schmitt, E. M. Tabloski, P. A. Travison, T. G. Gou, Y. Jones, R. N. Inouye, S. K. | JAMA Netw Open | 2022 |
Aged |
| Delirium can be safely managed in the community through implementation of a community toolkit: a proof-of-concept pilot study | Vardy, E. Roberts, S. Pratt, H. | Future Healthc J | 2022 |
assessment |
| Delirium as a Presenting Symptom of COVID-19 | Tyson, B. Shahein, A. Erdodi, L. Tyson, L. Tyson, R. Ghomi, R. Agarwal, P. | Cogn Behav Neurol | 2022 | |
| The effect of baseline cognition and delirium on long-term cognitive impairment and mortality: a prospective population-based study | Tsui, A. Searle, S. D. Bowden, H. Hoffmann, K. Hornby, J. Goslett, A. Weston-Clarke, M. Howes, L. H. Street, R. Perera, R. Taee, K. Kustermann, C. Chitalu, P. Razavi, B. Magni, F. Das, D. Kim, S. Chaturvedi, N. Sampson, E. L. Rockwood, K. Cunningham, C. E | Lancet Healthy Longev | 2022 | |
| Delirium with visual hallucinations induced by low-dose olanzapine | Takeuchi, N. Makino, T. Nishihara, M. | Psychogeriatrics | 2022 |
*Antipsychotic Agents/adverse effects |
| Catatonia and Delirium: Similarity and Overlap of Acute Brain Dysfunction | Tachibana, M. Ishizuka, K. Inada, T. | Front Psychiatry | 2022 |
acute brain dysfunction |
| Association between stress hyperglycemia ratio and delirium in older hospitalized patients: a cohort study | Song, Q. Dai, M. Zhao, Y. Lin, T. Huang, L. Yue, J. | BMC Geriatr | 2022 |
Aged |
| Machine Learning to Identify Psychomotor Behaviors of Delirium for Patients in Long-Term Care Facility | Son, C. S. Kang, W. S. Lee, J. H. Moon, K. J. | IEEE J Biomed Health Inform | 2022 |
Adult |
| Parents' Time Perspective as a Predictor of Child's Postsurgical Pain, Emergence Delirium, and Parents' Posttraumatic Stress Disorder Symptoms after Child's Surgery | Sobol, M. Sobol, M. K. | Children (Basel) | 2022 |
Ptsd |
| Applicability of the interventions recommended for patients at risk or with delirium in medical and post-acute settings: a systematic review and a Nominal Group Technique study | Sist, L. Ugenti, N. V. Donati, G. Cedioli, S. Mansutti, I. Zanetti, E. Macchiarulo, M. Messina, R. Rucci, P. Palese, A. | Aging Clin Exp Res | 2022 |
Applicability |
| Prevalence and features of delirium in older patients admitted to rehabilitation facilities: a multicenter study | Sidoli, C. Zambon, A. Tassistro, E. Rossi, E. Mossello, E. Inzitari, M. Cherubini, A. Marengoni, A. Morandi, A. Bellelli, G. | Aging Clin Exp Res | 2022 |
Delirium |
| Nomogram Models for Predicting Delirium of Patients in Emergency Intensive Care Unit: A Retrospective Cohort Study | Shi, Y. Wang, H. Zhang, L. Zhang, M. Shi, X. Pei, H. Bai, Z. | Int J Gen Med | 2022 |
area under curve |
| Effect of midazolam on delirium in critically ill patients: a propensity score analysis | Shi, H. J. Yuan, R. X. Zhang, J. Z. Chen, J. H. Hu, A. M. | J Int Med Res | 2022 |
Midazolam delirium critical care propensity score analysis cohort study risk factor |
| Prediction of Postoperative Delirium After Cardiac Surgery with A Quick Test of Cognitive Speed, Mini-Mental State Examination and Hospital Anxiety and Depression Scale | Segernäs, A. Skoog, J. Ahlgren Andersson, E. Almerud Österberg, S. Thulesius, H. Zachrisson, H. | Clin Interv Aging | 2022 |
Aged |
| A retrospective comparison of haloperidol and hydroxyzine combination therapy with haloperidol alone in the treatment of overactive delirium | Sato, J. Tanaka, R. | Support Care Cancer | 2022 |
*Antipsychotic Agents/therapeutic use |
| Serum folate deficiency and the risks of dementia and all-cause mortality: a national study of old age | Rotstein, A. Kodesh, A. Goldberg, Y. Reichenberg, A. Levine, S. Z. | Evid Based Ment Health | 2022 |
Aged |