What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia.
- Authors
- Van Leeuwen, E. Petrovic, M. van Driel, M. L. De Sutter, A. I. M. Vander Stichele, R. Declercq, T. Christiaens, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Antipsychotic agents are often used to treat neuropsychiatric symptoms (NPS) in people with dementia although there is uncertainty about the effectiveness of their long-term use for this indication and concern that they may cause harm, including higher mortality. When behavioural strategies have failed and treatment with antipsychotic drugs is instituted, regular attempts to withdraw them have been recommended in guidelines. Physicians, nurses and families of older people with dementia may be reluctant to stop antipsychotics, fearing deterioration of NPS. This is an update of a Cochrane Review published in 2013. Objectives: To evaluate whether withdrawal of antipsychotic agents is successful in older people with dementia and NPS in primary care or nursing home settings, to list the different strategies for withdrawal of antipsychotic agents in older participants with dementia and NPS, and to measure the effects of withdrawal of antipsychotic agents on participants’ behaviour and assess safety. Search methods: We searched the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (ALOIS), theCochrane Library, MEDLINE, Embase, PsycINFO, CINAHL, LILACS, clinical trials registries and grey literature sources up to 11 January 2018. Selection criteria: We included all randomised, controlled trials comparing an antipsychotic withdrawal strategy to continuation of antipsychotics in people with dementia who had been treated with an antipsychotic drug for at least three months. Data collection and analysis: We used standard methodological procedures according to the Cochrane Handbook for Systematic Reviews of Interventions. We rated the quality of evidence for each outcome using the GRADE approach. Main results: We included 10 studies involving 632 participants. One new trial (19 participants) was added for this update. One trial was conducted in a community setting, eight in nursing homes and one in both settings. Different types of antipsychotics at varying doses were discontinued in the studies. Both abrupt and gradual withdrawal schedules were used. Reported data were predominantly from studies at low or unclear risk of bias. We included nine trials with 575 randomised participants that used a proxy outcome for overall success of antipsychotic withdrawal. Pooling data was not possible due to heterogeneity of outcome measures used. Based on assessment of seven studies, discontinuation may make little or no difference to whether or not participants complete the study (low-quality evidence). Two trials included only participants with psychosis, agitation or aggression who had responded to antipsychotic treatment. In these two trials, stopping antipsychotics was associated with a higher risk of leaving the study early due to symptomatic relapse or a shorter time to symptomatic relapse. We found low-quality evidence that discontinuation may make little or no difference to overall NPS, measured using various scales (7 trials, 519 participants). There was some evidence from subgroup analyses in two trials that discontinuation may reduce agitation for participants with less severe NPS at baseline, but may be associated with a worsening of NPS in participants with more severe NPS at baseline. None of the studies assessed withdrawal symptoms. Adverse effects of antipsychotics (such as falls) were not systematically assessed. Low-quality evidence showed that discontinuation may have little or no effect on adverse events (5 trials, 381 participants), quality of life (2 trials, 119 participants), or cognitive function (5 trials, 365 participants). There were insufficient data to determine whether discontinuation of antipsychotics has any effect on mortality (very low-quality evidence). Authors’ conclusions: There is low-quality evidence that antipsychotics may be successfully discontinued in older people with dementia and NPS who have been taking antipsychotics for at least three months, and that discontinuation may have little or no important effect on behavioural and psychological symptoms. This i consistent with the observation that most behavioural complications of dementia are intermittent and often do not persist for longer than three months. Discontinuation may have little or no effect on overall cognitive function. Discontinuation may make no difference to adverse events and quality of life. Based on the trials in this review, we are uncertain whether discontinuation of antipsychotics leads to a decrease in mortality. People with psychosis, aggression or agitation who responded well to long-term antipsychotic drug use, or those with more severe NPS at baseline, may benefit behaviourally from continuation of antipsychotics. Discontinuation may reduce agitation for people with mild NPS at baseline. However, these conclusions are based on few studies or small subgroups and further evidence of benefits and harms associated with withdrawal of antipsychotic is required in people with dementia and mild and severe NPS. The overall conclusions of the review have not changed since 2013 and the number of available trials remains low.
- PMID
- Keywords
chlorpromazine
haloperidol
levomepromazine
lorazepam
loxapine
mesoridazine
neuroleptic agent
olanzapine
perphenazine
placebo
risperidone
thioridazine
tiotixene
trifluoperazine
aggression
agitation
akathisia
behavior disorder
blood pressure
body equilibrium
cardiovascular disease
cognition
confusion
dementia
drug fatality
drug megadose
drug response
drug safety
drug withdrawal
extrapyramidal symptom
falling
fracture
heart rate
human
insomnia
long term care
low drug dose
lung disease
mental disease
motor dysfunction
nausea
neurologic disease
nursing home
parkinsonism
physical mobility
primary medical care
priority journal
psychosis
quality of life
relapse
restlessness
review
sedation
side effect
systematic review
tardive dyskinesia
treatment outcome
vomiting
- Page(s)
- Volume
- Issue
- 3
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Prospective clinical intervention study of aripiprazole and risperidone in the management of postoperative delirium in elderly patients after cardiovascular surgery | Sugawara, H. Koyama, A. Maruyama, T. Koda, Y. Fukunaga, H. Ishikawa, T. Takebayashi, M. Okamoto, K. Fukui, T. Hashimoto, M. | Psychiatry Clin Neurosci | 2022 | |
| A simple risk score list can be used to predict the occurrence of delirium in patients admitted to inpatient hospice care: A medical record study | Stoevelaar, R. Juffermans, C. C. M. Roorda, I. M. M. de Nijs, E. J. M. Hoornweg, J. Cannegieter, S. C. van der Linden, Y. M. | Eur J Cancer Care (Engl) | 2022 |
delirium |
| Chemokines in ICU Delirium: An Exploratory Study | Smith, R. J. Rabinstein, A. A. Cartin-Ceba, R. Singh, V. P. Lachner, C. Khatua, B. Trivedi, S. Gajic, O. | Crit Care Explor | 2022 |
chemokine |
| Cytokine profiles in intensive care unit delirium | Smith, R. J. Lachner, C. Singh, V. P. Trivedi, S. Khatua, B. Cartin-Ceba, R. | Acute Crit Care | 2022 |
cytokine |
| Edmonton frailty scale score predicts postoperative delirium: a retrospective cohort analysis | Sieber, F. Gearhart, S. Bettick, D. Wang, N. Y | BMC Geriatr | 2022 |
Cohort Studies |
| Observation of Anesthetic Effect of Dexmedetomidine Combined With Intraspinal Anesthesia in Hip Arthroplasty and its Effect on Postoperative Delirium and Stress Response | Shen, Y. Wang, C. Zhong, X. Wu, Y. He, X. | Front Surg | 2022 |
anesthetic effects |
| Postoperative Application of Dexmedetomidine is the Optimal Strategy to Reduce the Incidence of Postoperative Delirium After Cardiac Surgery: A Network Meta-Analysis of Randomized Controlled Trials | Shang, L. Hou, M. Guo, F. | Ann Pharmacother | 2022 |
cardiac surgery |
| Decreasing delirium through music listening (DDM) in critically ill, mechanically ventilated older adults in the intensive care unit: a two-arm, parallel-group, randomized clinical trial | Seyffert, S. Moiz, S. Coghlan, M. Balozian, P. Nasser, J. Rached, E. A. Jamil, Y. Naqvi, K. Rawlings, L. Perkins, A. J. Gao, S. Hunter, J. D., 3rd Khan, S. Heiderscheit, A. Chlan, L. L. Khan, B. | Trials | 2022 |
Aged |
| Prevention of delirium with agitation by yokukansan in older adults after cancer surgery | Sadahiro, R. Wada, S. Matsuoka, Y. J. Uchitomi, Y. Yamaguchi, T. Sato, T. Esaki, M. Yoshimoto, S. Daiko, H. Kanemitsu, Y. Kawai, A. Kato, T. Fujimoto, H. Uezono, Y. Shimizu, K. Matsuoka, H. | Jpn J Clin Oncol | 2022 |
clinical trial |
| Midazolam impacts acetyl-And butyrylcholinesterase genes: An epigenetic explanation for postoperative delirium? | Rump, K. Holtkamp, C. Bergmann, L. Nowak, H. Unterberg, M. Orlowski, J. Thon, P. Bazzi, Z. Bazzi, M. Adamzik, M. Koos, B. Rahmel, T. | PLoS One | 2022 |
Acetylcholinesterase/metabolism |
| Ren, X. Zhang, S. Yang, Y. Song, A. Liang, F. Zhang, Y. Dong, Y. Wu, X. Xie, Z. | Ketamine Induces Delirium-Like Behavior and Interferes With Endosomal Tau Trafficking | Anesth Analg | 2022 | |
| The crucial factors influencing the development and outcomes of postoperative delirium in proximal femur fractures | Rajeev, A. Railton, C. Devalia, K. | Aging Med (Milton) | 2022 |
delirium |
| Neuromonitoring depth of anesthesia and its association with postoperative delirium | Pérez-Otal, B. Aragón-Benedí, C. Pascual-Bellosta, A. Ortega-Lucea, S. Martínez-Ubieto, J. Ramírez-Rodríguez, J. M. | Sci Rep | 2022 |
Anesthesia, General/adverse effects |
| Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): protocol for a co-design and feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care | Pearson, M. Jackson, G. Jackson, C. Boland, J. Featherstone, I. Huang, C. Ogden, M. Sartain, K. Siddiqi, N. Twiddy, M. Johnson, M. | BMJ Open | 2022 |
*Delirium/diagnosis/prevention & control |
| An Interdisciplinary Reappraisal of Delirium and Proposed Subtypes | Oldham, M. A. Slooter, A. J. C. Ely, E. W. Crone, C. Maldonado, J. R. Rosenthal, L. J. | J Acad Consult Liaison Psychiatry | 2022 |
acute encephalopathy |
| Postoperative Delirium in Patients with Oral Cancer: Is Intraoperative Fluid Administration a Neglected Risk Factor? | Obermeier, K. T. Kraus, M. Smolka, W. Henkel, J. Saller, T. Otto, S. Liokatis, P. | Cancers (Basel) | 2022 |
fluid balance |
| Risk of delirium associated with antimuscarinics in older adults: A case-time-control study | Nishtala, P. S. Chyou, T. Y. | Pharmacoepidemiol Drug Saf | 2022 |
Aged |
| Potential effects of regular use of antihypertensive drugs for in-hospital delirium in geriatric patients with trauma | Nagasawa, H. Omori, K. Ota, S. Muramatsu, K. I. Ishikawa, K. Yanagawa, Y. | Sci Rep | 2022 |
Aged |
| Performance of Melatonin as Prophylaxis in Geriatric Patients with Multifactorial Risk for Postoperative Delirium Development: A Randomized Comparative Study | Mohamed, S. A. Rady, A. Youssry, M. Abdelaziz Mohamed, M. R. Gamal, M. | Turk J Anaesthesiol Reanim | 2022 | |
| Perioperative risk factors associated with increased incidence of postoperative delirium: systematic review, meta-analysis, and Grading of Recommendations Assessment, Development, and Evaluation system report of clinical literature | Mevorach, L. Forookhi, A. Farcomeni, A. Romagnoli, S. Bilotta, F. | Br J Anaesth | 2022 |
Grade |
| Delirium in ICU Patients after Cardiac Arrest: A Scoping Review | Mędrzycka-Dąbrowska, W. Lange, S. Religa, D. Dąbrowski, S. Friganović, A. Oomen, B. Krupa, S. | J Pers Med | 2022 |
Icu |
| Epidemiology of delirium in hospitalized patients in Latin America: A systematic review | Maximiliano, B. Sebastian, B. Estefania, A. Irma, C. Gutierrez, P. Daniela, P. Pv Roberta, C. Eduardo, T. Jose, M. Felipe, S. | Acta Psychiatr Scand | 2022 |
Latin America |
| Effect of Perioperative Dexmedetomidine Infusion on Postoperative Delirium in Elderly Patients Undergoing Oral and Maxillofacial Surgery: A Randomized Controlled Clinical Trial | Liu, T. Tuo, J. Wei, Q. Sun, X. Zhao, H. Zhao, X. Qu, M. | Int J Gen Med | 2022 |
dexmedetomidine |
| Type 2 Diabetes Mellitus with Tight Glucose Control and Poor Pre-Injury Stair Climbing Capacity May Predict Postoperative Delirium: A Secondary Analysis | Liu, K. Song, Y. Yuan, Y. Li, Z. Wang, X. Zhang, W. Li, Y. Mi, X. Han, D. Rong, Y. Guo, X. Wang, G. | Brain Sci | 2022 |
glycemic control |
| Preoperative Plasma Tau-PT217 and Tau-PT181 Are Associated With Postoperative Delirium | Liang, F. Baldyga, K. Quan, Q. Khatri, A. Choi, S. Wiener-Kronish, J. Akeju, O. Westover, B. M. Cody, K. Shen, Y. Marcantonio, E. R. Xie, Z. | Ann Surg | 2022 | |
| Development and Validation of Simplified Delirium Prediction Model in Intensive Care Unit | Kim, M. K. Oh, J. Kim, J. J. Park, J. Y. | Front Psychiatry | 2022 |
critical care |
| The effects of hypomagnesemia on delirium in middle-aged and older adult patients admitted to medical intensive care units | Kim, J. Y. Lee, H. J. Lee, H. Y. Lee, S. M. Lee, J. Park, T. Y. | Acute Crit Care | 2022 |
delirium |
| Structural integrity of the anterior mid-cingulate cortex contributes to resilience to delirium in SuperAging | Katsumi, Y. Wong, B. Cavallari, M. Fong, T. G. Alsop, D. C. Andreano, J. M. Carvalho, N. Brickhouse, M. Jones, R. Libermann, T. A. Marcantonio, E. R. Schmitt, E. Shafi, M. M. Pascual-Leone, A. Travison, T. Barrett, L. F. Inouye, S. K. Dickerson, B. C. Tou | Brain Commun | 2022 |
Mri |
| "Excited delirium," erroneous concepts, dehumanizing language, false narratives, and threat to Black lives | Fiscella, K. Pinals, D. A. Shields, C. G. | Acad Emerg Med | 2022 |
*Delirium/diagnosis |
| Knowing the Older Adult With Delirium Superimposed on Dementia | Fick, D. M. | Am J Geriatr Psychiatry | 2022 |
Delirium |
| Bibliometric Analysis of 100 Most-Cited Articles in Delirium | Fei, X. Zeng, Q. Wang, J. Gao, Y. Xu, F. | Front Psychiatry | 2022 |
bibliometric analysis |
| Transcutaneous Electrical Acupoint Stimulation Combined With Auricular Acupressure Reduces Postoperative Delirium Among Elderly Patients Following Major Abdominal Surgery: A Randomized Clinical Trial | Fan, Q. Lei, C. Wang, Y. Yu, N. Wang, L. Fu, J. Dong, H. Lu, Z. Xiong, L. | Front Med (Lausanne) | 2022 |
abdominal surgery |
| Depression is associated with delirium after cardiac surgery-a population-based cohort study | Falk, A. Kåhlin, J. Nymark, C. Hultgren, R. Stenman, M. | Interact Cardiovasc Thorac Surg | 2022 |
Aged |
| Association of delirium screening on hospitalized adults and postacute care utilization: A retrospective cohort study | Dulin, J. D. Zhang, J. Marsden, J. Mauldin, P. D. Moran, W. P. Kalivas, B. C. | Am J Med Sci | 2022 | |
| Adaptation, implementation, and mixed methods evaluation of an interprofessional modular clinical practice guideline for delirium management on an inpatient palliative care unit | Bush, S. H. Skinner, E. Lawlor, P. G. Dhuper, M. Grassau, P. A. Pereira, J. L. MacDonald, A. R. Parsons, H. A. Kabir, M. | BMC Palliat Care | 2022 |
Adult |
| Older age, delirium, dementia, frailty, and critical care: Care priorities | Bloomer, M. J. Woszczeiko, C. Hutchinson, A. M. | Intensive Crit Care Nurs | 2002 |
Critical care |
| Early Diagnosis of Delirium in Palliative Care Patients Decreases Mortality and Necessity of Palliative Sedation: Results of a Prospective Observational Study | Beretta, M. Uggeri, S. Santucci, C. Cattaneo, M. Ermolli, D. Gerosa, C. Ornaghi, M. Roccasalva, A. Santambrogio, P. Varrassi, G. Corli, O. | Cureus | 2022 |
clinical outcome |
| Incidence and associations of hospital delirium diagnoses in 85,979 people with severe mental illness: A data linkage study | Bauernfreund, Y. Launders, N. Favarato, G. Hayes, J. F. Osborn, D. Sampson, E. L. | Acta Psychiatr Scand | 2022 |
bipolar disorder |
| The Pharmacogenetics of Opiates and Its Impact on Delirium in Mechanically Ventilated Adults: A Pilot Study | Austin, C. A. Szeto, A. Gupta, A. Wiltshire, T. Crona, D. J. Kistler, C. | J Pharm Technol | 2022 |
analgesics |
| Agents intervening against delirium in the intensive care unit trial-Protocol for a secondary Bayesian analysis | Andersen-Ranberg, N. Poulsen, L. M. Perner, A. Hästbacka, J. Morgan, M. P. G. Citerio, G. Oxenbøll-Collet, M. Weber, S. O. Andreasen, A. S. Bestle, M. H. Uslu, B. Pedersen, H. B. S. Nielsen, L. G. Damgaard, K. Jensen, T. B. Sommer, T. Dey, N. Mathiesen, | Acta Anaesthesiol Scand | 2022 |
Adult |
| Increased Direct Current-Electroencephalography Shifts During Induction of Anesthesia in Elderly Patients Developing Postoperative Delirium | Windmann, V. Dreier, J. P. Major, S. Spies, C. Lachmann, G. Koch, S. | Front Aging Neurosci | 2022 |
*dc-eeg |
| The Effect of Propofol versus Sevoflurane on Postoperative Delirium in Parkinson's Disease Patients Undergoing Deep Brain Stimulation Surgery: An Observational Study | Zhou, Y. Li, Z. Ma, Y. Yu, C. Chen, Y. Ding, J. Yu, J. Zhou, R. Wang, X. Liu, T. Guo, X. Fan, T. Shi, C. | Brain Sci | 2022 |
Parkinson’s disease |
| Association between smoking and postoperative delirium in surgical patients with pulmonary hypertension: a secondary analysis of a cohort study | Zhou, S. Shi, S. Xie, C. Chen, G. | BMC Psychiatry | 2022 |
Cohort Studies |
| Comorbidity patterns in institutionalized older adults affected by dementia | Zazzara, M. B. Vetrano, D. L. Carfì, A. Liperoti, R. Damiano, C. Onder, G. | Alzheimers Dement (Amst) | 2022 |
care pathways |
| The Impact of Perioperative and Predisposing Risk Factors on the Development of Postoperative Delirium and a Possible Gender Difference | Wittmann, M. Kirfel, A. Jossen, D. Mayr, A. Menzenbach, J. | Geriatrics (Basel) | 2022 |
gender difference |
| Four-in-One: A Comprehensive Checklist for the Assessment of Pain, Undersedation, Iatrogenic Withdrawal and Delirium in the PICU: A Delphi Study | van Dijk, M. Ista, E. | Front Pediatr | 2022 |
Iws |
| Analgesia, Sedation, Paralytics, Delirium, and Iatrogenic Withdrawal | Valentine, K. Kummick, J. | Pediatr Clin North Am | 2022 |
*Analgesia |
| Antipsychotic prescribing in people admitted to hospital with dementia or delirium | Tumusiime, W. A. Hardman, C. J. Breen, J. L. | Australas J Ageing | 2022 |
*Antipsychotic Agents/therapeutic use |
| Breaking barriers in postoperative delirium | Terrando, N. Akassoglou, K. | Br J Anaesth | 2022 |
biomarker |
| The Relationship Between Suboptimal Social Networks and Postoperative Delirium: The PNDABLE Study | Tang, X. Yv, H. Wang, F. Wang, J. Liu, S. Wu, X. Dong, R. Lin, X. Wang, B. Bi, Y. | Front Aging Neurosci | 2022 |
cerebrospinal fluid |
| Delirium incidence and risk factors in patients undergoing non-invasive ventilation for acute respiratory failure: a multicenter observational trial | Tabbì, L. Tonelli, R. Comellini, V. Dongilli, R. Sorgentone, S. Spacone, A. Paonessa, M. C. Sacchi, M. Falsini, L. Boni, E. Ribuffo, V. Bruzzi, G. Castaniere, I. Fantini, R. Marchioni, A. Pisani, L. Nava, S. Clini, E. | Minerva Anestesiol | 2022 | |
| The association between Monocyte-to-Lymphocyte ratio and postoperative delirium in ICU patients in cardiac surgery | Su, X. Wang, J. Lu, X. | J Clin Lab Anal | 2022 |
inflammatory markers |
| Development of a non-pharmacologic delirium management bundle in paediatric intensive care units | Stenkjaer, R. L. Herling, S. F. Egerod, I. Weis, J. van Dijk, M. Kudchadkar, S. R. Ramelet, A. S. Ista, E. | Nurs Crit Care | 2022 |
delirium |
| Delirium in hospitalised adults with acute burns - A systematic review | Stanley, G. H. M. Barber, A. R. J. O'Brien, A. M. Hamill, C. Boardman, G. Frear, C. C. Edgar, D. W. Seymour, H. Wood, F. M. | Burns | 2022 |
Burns |
| Delirium associated with buprenorphine use in cardiac surgery: A retrospective cohort study | Selvaraj, T. Thangavel, P. Siddhaarth, K. | Indian J Anaesth | 2022 |
Aged |
| Influence of perioperative dexmedetomidine on the incidence of postoperative delirium in adult patients undergoing cardiac surgery | Patel, M. Onwochei, D. N. Desai, N. | Br J Anaesth | 2022 |
Adult |
| Association Between Implementation of a Geriatric Trauma Clinical Pathway and Changes in Rates of Delirium in Older Adults With Traumatic Injury | Park, C. Bharija, A. Mesias, M. Mitchell, A. Krishna, P. Storr-Street, N. Brown, A. Martin, M. Lu, A. C. Staudenmayer, K. L. | JAMA Surg | 2022 | |
| Intraoperative hyperoxygenation may negatively affect postoperative cognitive functions in coronary artery bypass graft operations: A randomized controlled study | Onur, T. Karaca, Ü Ata, F. Sayan, H. E. Onur, A. Yilmaz, C. Balkaya, A. N. Eriş, C. | J Card Surg | 2022 |
cardiopulmonary bypass |
| Investigation of Risk Factors for Postoperative Delirium after Transcatheter Aortic Valve Implantation: A Retrospective Study | Ogata, Y. Kobayashi, N. Yamauchi, M. | J Clin Med | 2022 |
aortic stenosis |
| Mobilization in the evening to prevent delirium: A pilot randomized trial | Nydahl, P. McWilliams, D. Weiler, N. Borzikowsky, C. Howroyd, F. Brobeil, A. Lindner, M. von Haken, R. | Nurs Crit Care | 2022 |
Critical Care |
| Delirium on stroke units: a prospective, multicentric quality-improvement project | Nydahl, P. Baumgarte, F. Berg, D. Bergjan, M. Borzikowsky, C. Franke, C. Green, D. Hannig, A. Hansen, H. C. Hauss, A. Hansen, U. Istel, R. Krämer, N. Krause, K. Lohrmann, R. Mohammadzadeh-Vazifeh, M. Osterbrink, J. Palm, F. Petersen, T. Schöller, B. Sto | J Neurol | 2022 |
*Delirium/diagnosis/epidemiology/etiology |
| The relationship of acute delirium with cognitive and psychiatric symptoms after stroke: a longitudinal study | Nerdal, V. Gjestad, E. Saltvedt, I. Munthe-Kaas, R. Ihle-Hansen, H. Ryum, T. Lydersen, S. Grambaite, R. | BMC Neurol | 2022 |
Aged |
| Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial | Neerland, B. E. Busund, R. Haaverstad, R. Helbostad, J. L. Landsverk, S. A. Martinaityte, I. Norum, H. M. Ræder, J. Selbaek, G. Simpson, M. R. Skaar, E. Skjærvold, N. K. Skovlund, E. Slooter, A. J. Svendsen Ø, S. Tønnessen, T. Wahba, A. Zetterberg, H. | BMJ Open | 2022 |
Adrenergic alpha-2 Receptor Agonists/therapeutic use |
| Does modulation of glymphatic system reduce delirium via waste clearance? | Naaz, S. Asghar, A. | J Anaesthesiol Clin Pharmacol | 2022 | |
| Delirium in elderly postoperative patients: A prospective cohort study | Muzzana, C. Mantovan, F. Huber, M. K. Trevisani, K. Niederbacher, S. Kugler, A. Ausserhofer, D. | Nurs Open | 2022 |
delirium |
| Antimicrobial neurotoxicity: an under-recognised cause of delirium | Moynan, D. Maqbool, E. de Barra, E. | Acute Med | 2022 |
Aged |
| CORR Insights®: Does the SORG Orthopaedic Research Group Hip Fracture Delirium Algorithm Perform Well on an Independent Intercontinental Cohort of Patients With Hip Fractures Who Are 60 Years or Older? | Michelson, J. D. | Clin Orthop Relat Res | 2022 | |
| Drug Choice for Hyperactive Delirium in Terminally-Ill Cancer Patients: A Nationwide Survey | Matsuda, Y. Morita, T. Oya, K. Tagami, K. Naito, A. S. Kashiwagi, H. Otani, H. | J Pain Symptom Manage | 2022 |
cancer |
| Implementing delirium screening in the emergency department: a quality improvement project | Martin, L. Lyons, M. Patton, A. O. Driscoll M McLoughlin, K. Hannon, E. Deasy, C. | BMJ Open Qual | 2022 |
Aged |
| Evaluation of the association of anticholinergic burden and delirium in older hospitalised patients - A cohort study comparing 19 anticholinergic burden scales | Lisibach, A. Gallucci, G. Benelli, V. Kälin, R. Schulthess, S. Beeler, P. E. Csajka, C. Lutters, M. | Br J Clin Pharmacol | 2022 |
Doss |
| Demand Ischemia as a Predictor of Mortality in Older Patients With Delirium | Kumar, M. Patil, S. Godoy, L. D. C. Kuo, C. L. Swede, H. Kuchel, G. A. Chen, K. | Front Cardiovasc Med | 2022 |
clinical outcomes |
| Structured Delirium Management in the Hospital | Krämer, J. Nolte, K. Zupanc, L. Schnitker, S. Roos, A. Göpel, C. Cid, J. S. Eichler, K. Hooven, T. V. D. Hempel, G. Pavenstädt, H. J. Klaas, C. Gosheger, G. Raschke, M. J. Wiendl, H. Duning, T. | Dtsch Arztebl Int | 2022 |
Activities of Daily Living |
| A machine learning approach to identifying delirium from electronic health records | Kim, J. H. Hua, M. Whittington, R. A. Lee, J. Liu, C. Ta, C. N. Marcantonio, E. R. Goldberg, T. E. Weng, C. | JAMIA Open | 2022 |
Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) |
| Effects of nonpharmacological interventions on sleep improvement and delirium prevention in critically ill patients: A systematic review and meta-analysis | Kang, J. Cho, Y. S. Lee, M. Yun, S. Jeong, Y. J. Won, Y. H. Hong, J. Kim, S. | Aust Crit Care | 2022 |
Critical care |
| A machine-learning model to predict postoperative delirium following knee arthroplasty using electronic health records | Jung, J. W. Hwang, S. Ko, S. Jo, C. Park, H. Y. Han, H. S. Lee, M. C. Park, J. E. Ro, D. H. | BMC Psychiatry | 2022 |
*Arthroplasty, Replacement, Knee/adverse effects |
| Tranexamic Acid and the Risk of Delirium after Off-Pump Surgery | Hulde, N. Zittermann, A. Deutsch, M. A. Gummert, J. F. von Dossow, V. Koster, A. | Thorac Cardiovasc Surg | 2022 | |
| Early Serum Metabolism Profile of Post-operative Delirium in Elderly Patients Following Cardiac Surgery With Cardiopulmonary Bypass | Huang, H. Han, J. Li, Y. Yang, Y. Shen, J. Fu, Q. Chen, Y. | Front Aging Neurosci | 2022 |
cardiopulmonary bypass |
| Delirium Item Bank: Utilization to Evaluate and Create Delirium Instruments | Helfand, B. K. I. Tommet, D. Detroyer, E. Milisen, K. Adamis, D. Metzger, E. D. Marcantonio, E. R. Boudreaux, E. D. Inouye, S. K. Jones, R. N. | Dement Geriatr Cogn Disord | 2022 |
Aged |
| Low Dose Antipsychotics for the Treatment of Delirium in Hospitalized Elderly Patients and Their Effects on QTc Interval | Heidari, S. Kargar, M. | J Pharm Pract | 2022 |
adverse drug events |
| Melatonin and Its Analogs for Prevention of Post-cardiac Surgery Delirium: A Systematic Review and Meta-Analysis | Han, Y. Tian, Y. Wu, J. Zhu, X. Wang, W. Zeng, Z. Qin, Z. | Front Cardiovasc Med | 2022 |
cardiac |
| The Role of Acetylcholinesterase Inhibitors in the Treatment of Prolonged Postelectroconvulsive Therapy Delirium | Gutowski, B. Bomasang-Layno, E. | Case Rep Psychiatry | 2022 | |
| Risk factors for delirium in elderly patients after lumbar spinal fusion | Gold, C. Ray, E. Christianson, D. Park, B. Kournoutas, I. A. Kahn, T. A. Perez, E. A. Berger, J. I. Sander, K. Igram, C. A. Pugely, A. Olinger, C. R. Carnahan, R. Chen, P. F. Mueller, R. Hitchon, P. Howard, M. A. Banks, M. Sanders, R. D. Woodroffe, R. W. | Clin Neurol Neurosurg | 2022 |
Geriatric spine surgery |
| Instruments to Identify Delirium in Patients Recovering From Anesthesia: A Scoping Review | Gnatta, J. R. Cavassana, T. M. Nascimento, A. S. D. Poveda, V. B. | J Perianesth Nurs | 2022 |
delirium |
| Identifying Patients With Delirium Based on Unstructured Clinical Notes: Observational Study | Ge, W. Alabsi, H. Jain, A. Ye, E. Sun, H. Fernandes, M. Magdamo, C. Tesh, R. A. Collens, S. I. Newhouse, A. Mvr Moura, L. Zafar, S. Hsu, J. Akeju, O. Robbins, G. K. Mukerji, S. S. Das, S. Westover, M. B. | JMIR Form Res | 2022 |
clinical notes |
| Predictors of post-stroke delirium incidence and duration: results of a prospective observational study using high frequency delirium screening | Fleischmann, R. Andrasch, T. Warwas, S. Kunz, R. Gross, S. Witt, C. Ruhnau, J. Vogelgesang, A. Ulm, L. Mengel, A. von Sarnowski, B. | Int J Stroke | 2022 |
Acute stroke therapy |
| Italian Version of the Cornell Assessment of Pediatric Delirium: Evaluation of the Scale Reliability and Ability to Detect Delirium Compared to Pediatric Intensive Care Unit Physicians Clinical Evaluation | Fazio, P. C. Daverio, M. Masola, M. D'Angelo, I. Frison, S. Zaggia, C. Simeone, S. Pucciarelli, G. Gregori, D. Comoretto, R. Amigoni, A. | Front Pediatr | 2022 |
Capd |
| Regional anesthesia techniques and postoperative delirium: systematic review and meta-analysis | Fanelli, A. Balzani, E. Memtsoudis, S. Abdallah, F. W. Mariano, E. R. | Minerva Anestesiol | 2023 |
Aged |
| Delirium with delayed diagnosis of hereditary coproporphyria | Eroglu, S. Birsenogul, I. | Clin Case Rep | 2022 |
atrial fibrillation |
| The Preventive Effect of Transcutaneous Electrical Acupoint Stimulation on Postoperative Delirium in Elderly Patients with Time Factors: A Randomized Trial | Ding, L. Ning, J. Guo, Y. Wang, Q. Kou, S. Ke, H. Zhou, R. Yu, B. | J Integr Complement Med | 2022 |
inflammation response |
| Prophylactic use of ramelteon for delirium in hospitalized patients: A systematic review and meta-analyses | Dang, V. Mansukhani, M. P. Wang, Z. Vesely, E. K. Kolla, B. P. | J Acad Consult Liaison Psychiatry | 2022 |
Delirium |
| Longest and largest cohort study of delirium to date reinforces association while causation remains elusive | Cunningham, E. | J Neurol Neurosurg Psychiatry | 2022 |
Cognition |
| Documentation and Diagnosis of Delirium in Parkinson's Disease | Cullinan, R. J. Richardson, S. J. Yarnall, A. J. Burn, D. J. Allan, L. M. Lawson, R. A. | Acta Psychiatr Scand | 2022 |
Confusion |
| Avoiding pitfalls in the treatment of delirium | Chuang, Y. C. Lin, C. Y. Wang, J. K. | Aust N Z J Psychiatry | 2022 |
*Delirium/drug therapy |
| Less pharmacotherapy is more in delirium | Chou, S. T. Pogach, M. Rock, L. K. | Intensive Care Med | 2022 |
*Antipsychotic Agents/therapeutic use |
| Accuracies of Training Labels and Machine Learning Models: Experiments on Delirium and Simulated Data | Cheng, Y. Shao, Y. Rudolph, J. Weir, C. R. Sahlmann, B. Zeng-Treitler, Q. | Stud Health Technol Inform | 2022 |
*Delirium |
| E4BP4 Coordinates Circadian Control of Cognition in Delirium | Chen, M. Zhang, L. Shao, M. Du, J. Xiao, Y. Zhang, F. Zhang, T. Li, Y. Zhou, Q. Liu, K. Wang, Z. Wu, B. | Adv Sci (Weinh) | 2022 |
E4bp4 |
| Association Between Anesthetics and Postoperative Delirium in Elderly Patients Undergoing Spine Surgery: Propofol Versus Sevoflurane | Chang, J. E. Min, S. W. Kim, H. Won, D. Lee, J. M. Kim, T. K. Kim, C. Hwang, J. Y. | Global Spine J | 2022 |
anesthesia |
| Validation of a delirium predictive model in patients admitted to surgical intensive care units: a multicentre prospective observational cohort study | Chaiwat, O. Chittawatanarat, K. Mueankwan, S. Morakul, S. Dilokpattanamongkol, P. Thanakiattiwibun, C. Siriussawakul, A. | BMJ Open | 2022 |
Adult |
| Lidocaine Infusion for the Management of Postoperative Pain and Delirium (LIMPP): protocol for a randomised control trial | Buren, M. A. Theologis, A. Zuraek, A. Behrends, M. Clark, A. J. Leung, J. M. | BMJ Open | 2022 |
Aged |
| Factors influencing resilience to postoperative delirium in adults undergoing elective orthopaedic surgery | Bowman, E. M. L. Cardwell, C. McAuley, D. F. McGuinness, B. Passmore, A. P. Beverland, D. Zetterberg, H. Schott, J. M. Cunningham, E. L. | Br J Surg | 2022 |