What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Effectiveness of nursing intervention to reduce delirium in adult critically ill - A protocol for a randomized trial | Gómez Tovar, L. O. Henao-Castaño Á, M. | Contemp Clin Trials Commun | 2023 |
Delirium |
| Variations in Clinical Practice: Assessing Clinical Care Processes According to Clinical Guidelines in a National Cohort of Hospice Patients | de Graaf, E. Grant, M. van de Baan, F. Ausems, M. Verboeket-Crul, C. Leget, C. Teunissen, S. | Am J Hosp Palliat Care | 2023 |
Humans |
| Altered EEG, disrupted hippocampal long-term potentiation and neurobehavioral deficits implicate a delirium-like state in a mouse model of sepsis | Consoli, D. C. Spitznagel, B. D. Owen, B. M. Kang, H. Williams Roberson, S. Pandharipande, P. Wesley Ely, E. Nobis, W. P. Bastarache, J. A. Harrison, F. E. | Brain Behav Immun | 2023 |
Humans |
| Malignant Catatonia: A Review for the Intensivist | Connell, J. Oldham, M. Pandharipande, P. Dittus, R. S. Wilson, A. Mart, M. Heckers, S. Ely, E. W. Wilson, J. E. | J Intensive Care Med | 2023 |
Humans |
| Diagnostic yield of CT head in delirium and altered mental status-A systematic review and meta-analysis | Akhtar, H. Chaudhry, S. H. Bortolussi-Courval, É Hanula, R. Akhtar, A. Nauche, B. McDonald, E. G. | J Am Geriatr Soc | 2022 |
CT head |
| Elevation of serum plasminogen activator inhibitor-1 predicts postoperative delirium independent of neural damage: a sequential analysis | Mietani, K. Hasegawa-Moriyama, M. Yagi, K. Inoue, R. Ogata, T. Shimojo, N. Seto, Y. Uchida, K. Sumitani, M. | Sci Rep | 2022 |
Aged |
| Assessing prevalence and independent predictors of postoperative delirium in patients with head and neck cancer. Re: Crawford J E et al Postoperative delirium in patients with head and neck oral cancer in the West of Scotland. Br J Oral Maxillofac Surg 20 | McCaul, J. A. Young, D. McMahon, J. | Br J Oral Maxillofac Surg | 2022 |
*Delirium |
| Preoperative homocysteine modifies the association between postoperative C-reactive protein and postoperative delirium | Ma, X. Mei, X. Tang, T. Wang, M. Wei, X. Zheng, H. Cao, J. Zheng, H. Cody, K. Xiong, L. Marcantonio, E. R. Xie, Z. Shen, Y. | Front Aging Neurosci | 2022 |
C-reactive protein |
| Head Computed Tomography Findings in Geriatric Emergency Department Patients with Delirium, Altered Mental Status, and Confusion: A Systematic Review | Liu, S. W. Lee, S. Hayes, J. M. Khoujah, D. Lo, A. X. Doering, M. de Wit, K. Nickels, C. H. Kennedy, M. Eagles, D. Carpenter, C. Arendts, G. Ragsdale, L. | Acad Emerg Med | 2022 | |
| Potential value of preoperative fasting blood glucose levels in the identification of postoperative delirium in non-diabetic older patients undergoing total hip replacement: The perioperative neurocognitive disorder and biomarker lifestyle study | Liu, S. Xv, L. Wu, X. Wang, F. Wang, J. Tang, X. Dong, R. Wang, B. Lin, X. Bi, Y. | Front Psychiatry | 2022 |
biomarkers |
| New onset delirium prediction using machine learning and long short-term memory (LSTM) in electronic health record | Liu, S. Schlesinger, J. J. McCoy, A. B. Reese, T. J. Steitz, B. Russo, E. Koh, B. Wright, A. | J Am Med Inform Assoc | 2022 |
deep learning |
| The hotspots and publication trends in postoperative delirium: A bibliometric analysis from 2000 to 2020 | Lin, X. Cao, Y. Liu, X. Yu, K. Miao, H. Li, T. | Front Aging Neurosci | 2022 |
Pod |
| Donepezil treatment is associated with improved outcomes in critically ill dementia patients via a reduction in delirium | Lieberman, O. J. Lee, S. Zabinski, J. | Alzheimers Dement | 2022 |
acetylcholine |
| Association of Incident Delirium With Short-term Mortality in Adults With Critical Illness Receiving Mechanical Ventilation | Li, H. C. Yeh, T. Y. Wei, Y. C. Ku, S. C. Xu, Y. J. Chen, C. C. Inouye, S. Boehm, L. M. | JAMA Netw Open | 2022 |
Adult |
| A Nomogram to Predict Delirium after Hip Replacement in Elderly Patients with Femoral Neck Fractures | Li, B. Ju, J. Zhao, J. Qin, Y. Zhang, Y. | Orthop Surg | 2022 |
Femoral neck fracture |
| Immunological risk factors for sepsis-associated delirium and mortality in ICU patients | Lei, W. Ren, Z. Su, J. Zheng, X. Gao, L. Xu, Y. Deng, J. Xiao, C. Sheng, S. Cheng, Y. Ma, T. Liu, Y. Wang, P. Luo, O. J. Chen, G. Wang, Z. | Front Immunol | 2022 |
Complement C3 |
| Postoperative Delirium in Patients Receiving Hip Bipolar Hemiarthroplasty for Displaced Femoral Neck Fractures: The Risk Factors and Further Clinical Outcomes | Lee, D. H. Chang, C. H. Chang, C. W. Chen, Y. C. Tai, T. W. | J Arthroplasty | 2022 |
bipolar hemiarthroplasty |
| Appraisal of Clinical Practice Guideline: Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU | Lang, J. | J Physiother | 2022 |
Adult |
| Validation of the Korean Version of the Delirium Diagnostic Tool-Provisional (K-DDT-Pro) | Kim, K. M. Shim, M. S. Yi, D. Jeon, S. Y. Kim, J. L. | Psychiatry Investig | 2022 |
Delirium |
| Trazodone and Mianserin for Delirium: A Retrospective Chart Review | Kawano, S. Ide, K. Kodama, K. Kikuchi, Y. Sugihara, H. Fujisawa, D. Uchida, H. Mimura, M. Takeuchi, H. | J Clin Psychopharmacol | 2022 | |
| PAINT I: the effect of art therapy in preventing and managing delirium among hospitalized older adults in the PAINT I study-a proof-of-concept trial | Katrin, S. Masuch, J. Lim, S. Habboub, B. Gosch, M. | Eur Geriatr Med | 2022 |
Art therapy |
| Building collaborative relationships with family caregivers of hospitalized older persons with delirium superimposed on dementia: A qualitative study | Julian, P. Ploeg, J. Kaasalainen, S. Markle-Reid, M. | J Adv Nurs | 2022 |
acute care |
| Volatile Versus Total Intravenous Anesthesia on Postoperative Delirium in Adult Patients Undergoing Cardiac Valve Surgery: A Randomized Clinical Trial | Jiang, J. L. Zhang, L. He, L. L. Yu, H. Li, X. F. Dai, S. H. Yu, H. | Anesth Analg | 2022 | |
| The Effect of Scenario-Based Learning on the Performance of Nurses Regarding Delirium in Cardiac Surgery Intensive Care Units: A Quasi-Experimental Study | Jahanbazi, A. Jokar, F. Kheirollahi, N. | Iran J Nurs Midwifery Res | 2022 |
Delirium |
| Influence of cardioplegic solution on incidence of delirium after CABG surgery: Use of Calafiore blood cardioplegia versus HTK - Bretschneider - solution in a single-center retrospective analysis from 2017 to 2021 | Irqsusi, M. Loos, D. Dielmann, K. Ramzan, R. Wulf, H. Ghazy, T. Vogt, S. Rastan, A. J. | J Card Surg | 2022 |
CABG procedure |
| Should neuroleptics be used in patients with delirium seen by palliative care? | Hui, D. Agar, M. Maeda, I. | J Pain Symptom Manage | 2022 |
antipsychotic agents |
| Risk factors for postoperative delirium in elderly urological patients: A meta-analysis | Hua, Y. Chen, S. Xiong, X. Lin, C. Li, D. Tu, P. | Medicine (Baltimore) | 2022 |
Aged |
| Successful aging after elective surgery II: Study design and methods | Hshieh, T. T. Schmitt, E. M. Fong, T. G. Arnold, S. Cavallari, M. Dickerson, B. C. Dillon, S. T. Jones, R. N. Libermann, T. A. Marcantonio, E. R. Pascual-Leone, A. Shafi, M. M. Touroutoglou, A. Travison, T. G. Gou, R. Y. Tommet, D. Abdeen, A. Earp, B. Kun | J Am Geriatr Soc | 2022 |
biomarkers |
| Overestimation of the Causal Effects of Medications on Delirium During Postoperative Hospital Days | Hindman, B. J. Dexter, F. | Anesth Analg | 2022 |
Humans |
| A new medication-based prediction score for postoperative delirium in surgical patients: Development and proof of feasibility in a retrospective patient cohort | Hindelang, V. Dimitriadis, K. Saller, T. Golla, K. Mannell, H. Hug, M. J. Strobach, D. | Pharmazie | 2022 |
Humans |
| Forecasting Postoperative Delirium in Older Adult Patients with Fast-and-Frugal Decision Trees | Heinrich, M. Woike, J. K. Spies, C. D. Wegwarth, O. | J Clin Med | 2022 |
clinical data prediction |
| Association of Delirium Incidence with Visitation Restrictions due to COVID-19 Pandemic in Patients with Acute Cerebrovascular Disease in a Stroke-Unit Setting: A Retrospective Cohort Study | Hahn, M. Gröschel, S. Gröschel, K. Uphaus, T. | Gerontology | 2022 |
COVID-19 pandemic |
| Nurses' assessment of subsyndromal delirium and barriers to assessment: A cross-sectional survey in the intensive care unit | Gao, Y. Zhang, C. Liao, C. Gan, X. | J Nurs Manag | 2022 |
barriers |
| Anxiety as a Risk Factor for Postoperative Delirium in Elective Spine Deformity Surgeries: A National Database Study | Freedman, Z. Hudock, N. Hallan, D. R. Kelleher, J. | Cureus | 2022 |
anxiety |
| Presurgical diffusion metrics of the thalamus and thalamic nuclei in postoperative delirium: A prospective two-centre cohort study in older patients | Fislage, M. Winzeck, S. Stamatakis, E. Correia, M. M. Preller, J. Feinkohl, I. Spies, C. D. Hendrikse, J. J. C. Slooter A Winterer, G. Pischon, T. Menon, D. K. Zacharias, N. | Neuroimage Clin | 2022 |
Diffusion kurtosis imaging |
| Long-Term Intensive Care Unit (ICU) Stays Can Lead to Long-Term Cognitive Impairment (LTCI): Neurosurgery Nursing Strategies to Minimize Risk | Fiani, B. Figueras, R. A. Samones, P. Lee, C. Castillo, A. Sangalang, B. Garcia Perez, F. | Cureus | 2022 |
cognitive impairment |
| Future without delirium: not quite there yet but we can start by prescribing touch | Fernandes, S. M. Adão-Serrano, M. Rodrigues, A. R. Belo, P. | Crit Care | 2022 |
Humans |
| Using Music for the Prevention of Delirium in Patients After Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial | Esfahanian, F. Mirmohammadsadeghi, A. Gholami, H. Neshat, S. Mansouri, M. Sadeghi, M. Bathaie, S. R. Heidari, Z. Mirmohammadsadeghi, M. | J Cardiothorac Vasc Anesth | 2022 |
clinical trial |
| The association of chronic pain and postoperative delirium: a prospective observational cohort study | Eckert, S. C. Spies, C. D. Mörgeli, R. Kruppa, J. Heinrich, M. | Minerva Anestesiol | 2022 | |
| Functional brain network and trail making test changes following major surgery and postoperative delirium: a prospective, multicentre, observational cohort study | Ditzel, F. L. van Montfort, S. J. T. Vernooij, L. M. Kant, I. M. J. Aarts, E. Spies, C. D. Hendrikse, J. Slooter, A. J. C. van Dellen, E. | Br J Anaesth | 2022 |
brain network |
| Comparison of Intravenous and Inhalational Anesthetic on Postoperative Cognitive Outcomes in Elderly Patients Undergoing Cancer Surgery: Systematic Review and Meta-analysis | Ding, Y. Yu, J. Cui, F. Li, J. | J Perianesth Nurs | 2022 |
Aged |
| Examining Subjective Psychological Experiences of Postoperative Delirium in Older Cardiac Surgery Patients | Cohen, C. L. Atkins, K. J. Evered, L. A. Silbert, B. S. Scott, D. A. | Anesth Analg | 2022 | |
| Instruments to measure postintensive care syndrome: a scoping review protocol | Chu, Y. Timmins, F. Thompson, D. Eustace-Cook, J. | BMJ Open | 2022 |
Adult |
| Leucine-rich glioma-inactivated 1 antibody encephalitis as a rare cause of delirium | Ching, E. Murdoch, H. Mohammed, H. | Geriatr Gerontol Int | 2022 | |
| A novel semiautomatic Chinese keywords instrument screening delirium based on electronic medical records | Chen, L. Li, N. Zheng, Y. Gao, L. Ge, N. Xie, D. Yue, J. | BMC Geriatr | 2022 |
Aged |
| Effect of Preoperative Oral Saline Administration on Postoperative Delirium in Older Persons: A Randomized Controlled Trial | Chen, J. Xie, S. Chen, Y. Qiu, T. Lin, J. | Clin Interv Aging | 2022 |
Humans |
| Frailty and delirium in hospitalized older adults: A systematic review with meta-analysis | Cechinel, C. Lenardt, M. H. Rodrigues, J. A. M. Binotto, M. A. Aristides, M. M. Kraus, R. | Rev Lat Am Enfermagem | 2022 |
Humans |
| QEEG abnormalities in cognitively unimpaired patients with delirium | Carrarini, C. Calisi, D. De Rosa, M. A. Di Iorio, A. D'Ardes, D. Pellegrino, R. Gazzina, S. Pilotto, A. Arighi, A. Carandini, T. Cagnin, A. Mozzetta, S. Gallucci, M. Bonifati, D. M. Costa, C. D'Antonio, F. Bruno, G. Cipollone, F. Babiloni, C. Padovani, A. | J Neurol Neurosurg Psychiatry | 2022 |
Cognition |
| Prediction models for postoperative delirium after cardiac surgery: Systematic review and critical appraisal | Cai, S. Li, J. Gao, J. Pan, W. Zhang, Y. | Int J Nurs Stud | 2022 |
Cardiac surgery |
| Implementing a Delirium Risk Stratification Tool and Rounds to Identify and Prevent Delirium in Hospitalized Older Adults | Byrnes, T. Woodward, J. | J Nurs Care Qual | 2022 | |
| The Assessment of Immediate Postoperative Delirium in Neurologically Intact Adult Patients Admitted to the Post-anesthesia Care Unit: A Cross-Sectional Study | Burad, J. Date, R. Al Ismaili, M. Sharma, P. Kuriakose, N. Kodange, S. Birur, S. K. Al Yaqoubi, K. Al Mawali, A. Padmalayan, A. El Mady, H. Elawdy, M. Jaju, S. Al Abady, A. | Cureus | 2022 |
anesthesia recovery period |
| Deconstructing delirium in the post anaesthesia care unit | Banerji, A. Sleigh, J. W. Voss, L. J. Garcia, P. S. Gaskell, A. L. | Front Aging Neurosci | 2022 |
3d-cam |
| Association between remimazolam and postoperative delirium in older adults undergoing elective cardiovascular surgery: a prospective cohort study | Aoki, Y. Kurita, T. Nakajima, M. Imai, R. Suzuki, Y. Makino, H. Kinoshita, H. Doi, M. Nakajima, Y. | J Anesth | 2022 |
Cardiovascular surgical procedures |
| Haloperidol for the Treatment of Delirium in ICU Patients | Andersen-Ranberg, N. C. Poulsen, L. M. Perner, A. Wetterslev, J. Estrup, S. Hästbacka, J. Morgan, M. Citerio, G. Caballero, J. Lange, T. Kjær, M. N. Ebdrup, B. H. Engstrøm, J. Olsen, M. H. Oxenbøll Collet, M. Mortensen, C. B. Weber, S. O. Andreasen, A | N Engl J Med | 2022 | |
| Needs assessment survey of healthcare providers' perceptions and practices regarding delirium prevention at a university medical center | Alghamdi, B. Koroukian, S. M. Kresevic, D. Drummond, C. K. | Front Aging | 2022 |
assessment |
| Incidence, Associated Factors, and Outcome of Delirium among Patients Admitted to ICUs in Oman | Al-Hoodar, R. K. Lazarus, E. R. Al Omari, O. Al Zaabi, O. | Crit Care Res Pract | 2022 | |
| Dose-dependent relationship between intra-procedural hypoxaemia or hypocapnia and postoperative delirium in older patients | Ahrens, E. Tartler, T. M. Suleiman, A. Wachtendorf, L. J. Ma, H. Chen, G. Kendale, S. M. Kienbaum, P. Subramaniam, B. Wagner, S. Schaefer, M. S. | Br J Anaesth | 2022 |
haemodynamics |
| The Preventive Effect of Dexmedetomidine Against Delirium in Patients with Aortic Dissection: A Retrospective Cohort Study | Zhang, S. Yin, Q. Wang, Y. Yu, K. Shen, P. | Heart Surg Forum | 2022 |
*Aneurysm, Dissecting/complications/surgery |
| Prediction model for delirium in patients with cardiovascular surgery: development and validation | Xu, Y. Meng, Y. Qian, X. Wu, H. Liu, Y. Ji, P. Chen, H. | J Cardiothorac Surg | 2022 |
Calibration |
| Knowledge, attitudes and practices of ICU nurses regarding subsyndromal delirium among 20 hospitals in China: a descriptive cross-sectional survey | Xing, H. Zhu, S. Liu, S. Xia, M. Jing, M. Dong, G. Ni, W. Li, L. | BMJ Open | 2022 |
Attitude of Health Personnel |
| The prevention of delirium in elderly surgical patients with obstructive sleep apnea (PODESA): a randomized controlled trial | Wong, J. Doherty, H. R. Singh, M. Choi, S. Siddiqui, N. Lam, D. Liyanage, N. Tomlinson, G. Chung, F. | BMC Anesthesiol | 2022 |
Acetaminophen |
| Feasibility and potential of a bedside mini-EEG for diagnosing delirium superimposed on dementia | Wijnen, V. J. M. Oudewortel, L. van Luijtelaar, G. Witlox, J. Slooter, A. J. C. van Gool, W. A. | Clin Neurophysiol | 2022 |
Benzodiazepines |
| Recipe for primary prevention of delirium in hospitalized older patients | Vreeswijk, R. Maier, A. B. Kalisvaart, K. J. | Aging Clin Exp Res | 2022 |
Delirium |
| Demographic and clinical characteristics of patients with delirium: analysis of a nationwide Japanese medical database | Ueda, N. Igarashi, M. Okuyama, K. Sano, H. Takahashi, K. P. Qureshi Z Tokita, S. Ogawa, A. Okumura, Y. Okuda, S. | BMJ Open | 2022 |
Aged |
| Pharmacologic Management of Delirium in the Intensive Care Unit | Tiberio, P. J. Prendergast, N. T. Girard, T. D. | Clin Chest Med | 2022 |
*Delirium/drug therapy/etiology |
| Prevalence of Emergence Delirium and Associated Factors among Older Patients Who Underwent Elective Surgery: A Multicenter Observational Study | Tesfaye Mekonin, G. Kelbesa Olika, M. Birhanu Wedajo, M. Tolasa Badada, A. Dukessa Dubiwak, A. Tageza Ilala, T. Gebre, M. N. | Anesthesiol Res Pract | 2022 | |
| Impact of combined epidural anaesthesia/analgesia on postoperative cognitive impairment in patients receiving general anaesthesia: a meta-analysis of randomised controlled studies | Teng, I. C. Sun, C. K. Ho, C. N. Wang, L. K. Lin, Y. T. Chang, Y. J. Chen, J. Y. Chu, C. C. Hsing, C. H. Hung, K. C. | Anaesth Crit Care Pain Med | 2022 |
Adult |
| Computerized tool and interdisciplinary care for older patients with delirium in the emergency department: a novel model in Taiwan | Tan, T. H. Yang, T. Y. Chen, Y. M. Chung, S. Y. Liu, H. H. Yang, P. C. Kao, P. H. Peng, A. C. Shu, Y. M. Chu, Y. S. Tsai, K. T. Hsu, C. C. Ho, C. H. Lin, H. J. Huang, C. C. | Aging Clin Exp Res | 2022 |
Computerized |
| Use of Valproic Acid for the Management of Delirium and Agitation in the Intensive Care Unit | Swayngim, R. Preslaski, C. Dawson, J. | J Pharm Pract | 2022 |
agitation |
| Risk Factors for Acute Postoperative Delirium in Cardiac Surgery Patients >65 Years Old | Spiropoulou, E. Samanidis, G. Kanakis, M. Nenekidis, I. | J Pers Med | 2022 |
acute delirium |
| Systemic immune-inflammation index predicts postoperative delirium in elderly patients after surgery: a retrospective cohort study | Song, Y. Luo, Y. Zhang, F. Ma, Y. Lou, J. Li, H. Liu, Y. Mi, W. Cao, J. | BMC Geriatr | 2022 |
Aged |
| The influence of orthopedic surgery on the incidence of post-operative delirium in geriatric patients: results of a prospective observational study | Sircar, K. Yagdiran, A. Bredow, J. Annecke, T. Eysel, P. Scheyerer, M. J. | J Clin Orthop Trauma | 2022 |
Arthroplasty |
| Paternal Occupation and Delirium Risk in Older Adults: A Potential Marker of Early-Life Exposures | Shiff, H. M. Arias, F. Dufour, A. B. Carr, D. Chen, F. Gou, Y. Jones, R. Schmitt, E. Travison, T. G. Kunicki, Z. J. Okereke, O. I. Inouye, S. K. | Innov Aging | 2022 |
Cognitive reserve |
| Flurbiprofen used in one-lung ventilation improves intraoperative regional cerebral oxygen saturation and reduces the incidence of postoperative delirium | Shen, L. Chen, J. Q. Yang, X. L. Hu, J. C. Gao, W. Chai, X. Q. Wang, D. | Front Psychiatry | 2022 |
flurbiprofen |
| Derivation and validation of a prediction score for postoperative delirium in geriatric patients undergoing hip fracture surgery or hip arthroplasty | Shen, J. An, Y. Jiang, B. Zhang, P. | Front Surg | 2022 |
arthroplasty |
| Cognitive decline and dementia: does delirium matter? | Selbæk, G. Neerland, B. E. | Lancet Healthy Longev | 2022 |
*Cognitive Dysfunction |
| Understanding why delirium is often missed in older emergency department patients: a qualitative descriptive study | Schonnop, R. Dainty, K. N. McLeod, S. L. Melady, D. Lee, J. S. | Cjem | 2022 |
Acute care |
| Association between post-operative delirium and use of volatile anesthetics in the elderly: A real-world big data approach | Saller, T. Hubig, L. Seibold, H. Schroeder, Z. Wang, B. Groene, P. Perneczky, R. von Dossow, V. Hinske, L. C. | J Clin Anesth | 2022 |
Aged [D000368] |
| Risk Factors for Postoperative Delirium Identified | Rosenberg, K. | Am J Nurs | 2022 |
*Delirium/etiology |
| Delirium-associated medication in people at risk. A systematic update review, meta-analyses and GRADE-profiles | Reisinger, M. Reininghaus, E. Z. De Biasi, J. Fellendorf, F. T. Schoberer, D. | Acta Psychiatr Scand | 2022 |
Statements |
| The Predictive Role of Inflammatory Biochemical Markers in Post-Operative Delirium After Vascular Surgery Procedures | Pasqui, E. de Donato, G. Brancaccio, B. Casilli, G. Ferrante, G. Cappelli, A. Palasciano, G. | Vasc Health Risk Manag | 2022 |
Aged |
| Potential Usefulness of Blood Urea Nitrogen to Creatinine Ratio in the Prediction and Early Detection of Delirium Motor Subtype in the Intensive Care Unit | Park, W. R. Kim, H. R. Park, J. Y. Kim, H. E. Cho, J. Oh, J. | J Clin Med | 2022 |
biomarker |
| Perioperative Gabapentin Use and In-Hospital Adverse Clinical Events Among Older Adults After Major Surgery | Park, C. M. Inouye, S. K. Marcantonio, E. R. Metzger, E. Bateman, B. T. Lie, J. J. Lee, S. B. Levin, R. Kim, D. H. | JAMA Intern Med | 2022 | |
| Follow the Money: The Widening Coding Disparity Between Acute Encephalopathy and Delirium | Oldham, M. A. | J Acad Consult Liaison Psychiatry | 2022 |
*Brain Diseases |
| Use of Automated Infrared Pupillometry to Predict Delirium in the Intensive Care Unit: A Prospective Observational Study | Okamoto, S. Ishizawa, M. Inoue, S. Sakuramoto, H. | SAGE Open Nurs | 2022 |
automated infrared pupillometry |
| The Role of High Sensitivity C-reactive Protein to Predict Delirium Persistence in Elderly Patients with Pneumonia: A Prospective Cohort Study | Mulyana, R. Syafrita, Y. Ali, H. Murni, A. W. | Acta Med Indones | 2022 |
Aged |
| Peripheral interleukin-6-associated microglial QUIN elevation in basolateral amygdala contributed to cognitive dysfunction in a mouse model of postoperative delirium | Mu, J. L. Liu, X. D. Dong, Y. H. Fang, Y. Y. Qiu, S. D. Zhang, F. Liu, K. X. | Front Med (Lausanne) | 2022 |
Bla |
| The effect of taurine supplementation on delirium post liver transplantation: A randomized controlled trial | Mottaghi, S. Nikoupour, H. Firoozifar, M. Jalali, S. S. Jamshidzadeh, A. Vazin, A. Shafiekhani, M. | Clin Nutr | 2022 |
Delirium |
| The association of depression and postoperative delirium: we may need more information | Mestres, C. A. Quintana, E. | Interact Cardiovasc Thorac Surg | 2022 |
*Cardiac Surgical Procedures |
| Is mood associated with perception of recovery? Preoperative depression versus postoperative delirium after cardiac surgery | Mennander, A. A. | Interact Cardiovasc Thorac Surg | 2022 |
*Cardiac Surgical Procedures/adverse effects |
| An Automated Algorithm for Determining Sleep Using Single-Channel Electroencephalography to Detect Delirium: A Prospective Observational Study in Intensive Care Units | Matsui, K. Sato, N. Idei, M. Arakida, M. Seino, Y. Ishikawa, J. Y. Nakagawa, M. Akaho, R. Nishimura, K. Nomura, T. | Healthcare (Basel) | 2022 |
critically ill patients |
| Drug Choice for Hyperactive Delirium in Terminally-Ill Cancer Patients: A Nationwide Survey | Matsuda, Y. Morita, T. Oya, K. Tagami, K. Naito, A. S. Kashiwagi, H. Otani, H. | J Pain Symptom Manage | 2022 |
*Delirium/drug therapy |
| Dexmedetomidine potential in attenuating postoperative delirium in elderly patients after total hip joint replacement | Lv, Y. Gu, L. | Rev Assoc Med Bras (1992) | 2022 | |
| Challenges in detecting and managing mild cognitive impairment in primary care: a focus group study in Shanghai, China | Lu, Y. Liu, C. Wells, Y. Yu, D. | BMJ Open | 2022 |
Caregivers/psychology |
| The Age-adjusted Charlson Comorbidity Index predicts post-operative delirium in the elderly following thoracic and abdominal surgery: A prospective observational cohort study | Liu, J. Li, J. He, J. Zhang, H. Liu, M. Rong, J. | Front Aging Neurosci | 2022 |
Age-adjusted Charlson Comorbidity Index |
| Early alteration of peripheral blood lymphocyte subsets as a risk factor for delirium in critically ill patients after cardiac surgery: A prospective observational study | Li, X. Cheng, W. Zhang, J. Li, D. Wang, F. Cui, N. | Front Aging Neurosci | 2022 |
CD4+ T cells |
| Association of electroencephalogram epileptiform discharges during cardiac surgery with postoperative delirium: An observational study | Li, N. Liu, X. Gao, Y. Yin, L. Zhao, W. Ma, R. Ni, X. | Front Surg | 2022 |
cardiac surgery |
| Patients' and Relatives' Experiences of Delirium in the Intensive Care Unit-A Qualitative Study | Lange, S. Mędrzycka-Dąbrowska, W. Friganović, A. Religa, D. Krupa, S. | Int J Environ Res Public Health | 2022 |
Aged |
| Survey on Current Practice of Canadian Physicians Regarding the Investigation in Older Patients with Delirium | Laguë, A. Boucher, V. Joo, P. Yadav, K. Morasse, C. Émond, M. | Can Geriatr J | 2022 |
delirium |
| Clinical phenotypes of delirium in patients admitted to the cardiac intensive care unit | Ko, R. E. Kim, S. Lee, J. Park, S. Bae, D. Choi, K. H. Park, T. K. Chung, C. R. Yang, J. H. | PLoS One | 2022 |
*Delirium/epidemiology/etiology |