What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Extracellular Vesicle MicroRNAs as Predictive Biomarkers in Postoperative Delirium After Spine Surgery: Preliminary Study
- Authors
- Cho, Y. E. Kim, J. Vorn, R. Cho, H. Baek, W. Park, H. Yun, S. Kim, H. S. Cashion, A. K. Gill, J. Koo, B. N. Lee, H.
- Year
- 2024
- Journal
- J Gerontol A Biol Sci Med Sci
- Abstract
Postoperative delirium (POD) can cause poor patient outcomes in older adults who undergo surgery. In this study, we tested plasma extracellular vesicle (EV) miRNAs obtained before the delirium event to find predictive POD biomarkers after spine surgery. We recruited patients who are more than 70 years old and have undergone spine surgery. Finally, POD patients (n = 31) were included, with no-POD patients matched in age, sex, medical history, and type of surgery (n = 31). Peripheral blood was collected from patients in the operating room after the operation was completed. EVs were isolated from plasma, and the 798 miRNA expression level from EVs was measured using a NanoString platform. Sixty-two patients were included in the study; all were Korean, 67.7% were females, and the median age was 75 years. Preoperative medical history was not statistically different between no-POD and POD patients except for hypertension and the American Society of Anesthesiologists physical status. From the miRNA profiling, we identified 142 significantly differentially expressed miRNAs in POD patients compared with no-POD patients, which are associated with psychological/neurological disorders. The top 10 differentially expressed miRNAs including miR-548ar-5p and miR-627-5p were all upregulated in POD patients and the results were validated using qRT-PCR from the independent sets of samples (n = 96). We demonstrated the potential of plasma EV-miRNAs as predictive biomarkers to identify the risk group of POD after spine surgery. It also provides opportunities for future studies investigating the role of EV-miRNAs in delirium pathology.
- PMID
PMID: 38970345
PMCID: PMC11398910
- Keywords
Humans
Female
Male
Aged
*Extracellular Vesicles/metabolism
*MicroRNAs/blood
*Biomarkers/blood
*Delirium/blood/etiology
*Postoperative Complications/blood
Spine/surgery
Aged, 80 and over
Exosome
Genomics
Prediction
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Risk factors and outcomes of delirium in hospitalized older Ghanaians | Omuojine, J. P. Bello, T. Wemakor, S. Mante, P. K. Amponsah, G. S. Kusi-Mensah, K. Owusu-Antwi, R. Sarfo, F. S. Ohene, S. Ojagbemi, A. | Int J Geriatr Psychiatry | 2023 |
Humans, Aged, *Delirium/epidemiology, Ghana, Hospitalization, Prospective Studies, Risk Factors, Africa, delirium, incident, length of stay, mortality, older adult, outcome |
| Prospective analysis of plasma amyloid beta and postoperative delirium in the Interventions for Postoperative Delirium: Biomarker-3 study | Payne, T. Taylor, J. Casey, C. Kunkel, D. Parker, M. Blennow, K. Zetterberg, H. Pearce, R. A. Lennertz, R. C. Sanders, R. D. | Br J Anaesth | 2023 |
Humans, Amyloid beta-Peptides, *Emergence Delirium/diagnosis, Cohort Studies, *Alzheimer Disease, Biomarkers, Alzheimer’s disease, amyloid beta, anaesthesia, delirium, dementia, neurocognitive disorders, surgery |
| Machine learning for prediction of delirium in patients with extensive burns after surgery | Ren, Y. Zhang, Y. Zhan, J. Sun, J. Luo, J. Liao, W. Cheng, X. | CNS Neurosci Ther | 2023 |
delirium, extensive burns, external validation, machine learning, prediction model |
| A Pilot Study of the Fluctuating Mental Status Evaluation: A Novel Delirium Screening Tool for Neurocritical Care Patients | Reznik, M. E. Margolis, S. A. Moody, S. Drake, J. Tremont, G. Furie, K. L. Mayer, S. A. Ely, E. W. Jones, R. N. | Neurocrit Care | 2023 |
Humans, Male, Middle Aged, Aged, 80 and over, Female, Prospective Studies, *Delirium/diagnosis, Pilot Projects, *Stroke, Cerebral Hemorrhage, Coma, Delirium, Intracerebral hemorrhage, Neurocritical care, Stroke |
| Measures for the Core Outcome Set for Research Evaluating Interventions to Prevent and/or Treat Delirium in Critically Ill Adults: An International Consensus Study | Rose, L. Blackwood, B. Needham, D. M. Devlin, J. W. Clarke, M. Burry, L. D. | Crit Care Explor | 2023 |
clinical trials, core outcome set, critical care, delirium, intensive care, outcome, measure instruments, interest |
| Predicting delirium in older non-intensive care unit inpatients: development and validation of the DELIrium risK Tool (DELIKT) | Schulthess-Lisibach, A. E. Gallucci, G. Benelli, V. Kälin, R. Schulthess, S. Cattaneo, M. Beeler, P. E. Csajka, C. Lutters, M. | Int J Clin Pharm | 2023 |
Adverse effects, Aged, Cholinergic antagonists, Clinical decision rules, Delirium |
| Postoperative C-Reactive Protein Predicts Postoperative Delirium in Colorectal Cancer Following Surgery | Sun, Y. Peng, H. P. Wu, T. T. | Clin Interv Aging | 2023 |
Aged, Humans, C-Reactive Protein/analysis, Colorectal, Neoplasms/surgery/diagnosis, Emergence Delirium, Postoperative, Complications/etiology, Pulmonary Disease, Chronic Obstructive/complications, Risk Factors, C-reactive protein, colorectal cancer, postoperative delirium |
| A randomised controlled trial of dexmedetomidine for delirium in adults undergoing heart valve surgery | Wang, H. B. Jia, Y. Zhang, C. B. Zhang, L. Li, Y. N. Ding, J. Wu, X. Zhang, Z. Wang, J. H. Wang, Y. Yan, F. X. Yuan, S. Sessler, D. I. | Anaesthesia | 2023 |
Humans, Adult, *Dexmedetomidine/therapeutic use, *Delirium/prevention & control/epidemiology, *Cardiac Surgical Procedures/adverse effects, Incidence, Heart Valves/surgery, Double-Blind Method, acute kidney injury, anaesthesia, cardiac surgery, cardiopulmonary bypass, dexmedetomidine, postoperative delirium |
| The effect of parecoxib sodium on postoperative delirium in elderly patients with hip arthroplasty | Wang, J. H. Liu, T. Bai, Y. Chen, Y. Q. Cui, Y. H. Gao, X. Y. Guo, J. R. | Front Pharmacol | 2023 |
Ho-1, anesthesiology, inflammation, parecoxib sodium, postoperative delirium |
| Optimal strategy for delirium detection in older patients admitted to intensive care unit after non-cardiac surgery | Wang, K. Su, X. Ma, J. H. Wang, D. X. | Front Surg | 2023 |
CAM-ICU (confusion assessment method for the intensive care unit), cognitive function, delirium, elderly, noncardiac surgery |
| Prolonged Double-Low Time and the Incidence of Postoperative Delirium in Surgical ICU Patients | Yamanoi, T. Suzuki, S. Kaku, R. Morimatsu, H. | Acta Med Okayama | 2023 |
Humans, *Emergence Delirium/complications, *Delirium/epidemiology/etiology, Postoperative Complications/epidemiology, Incidence, Intensive Care Units, bispectral index, double-low condition, general anesthesia, hypotension, postoperative delirium |
| Predicting Postoperative Emergence Delirium From the Heart Rate Variability of Patients Undergoing Elective Cardiac Surgery | Satomoto, M. | Cureus | 2023 |
anesthesia, heart rate variability, mmse, postoperative delirium, surgery |
| Revisiting "Excited Delirium": Does the Diagnosis Reflect and Promote Racial Bias? | Walsh, B. M. Agboola, I. K. Coupet, E., Jr. Rozel, J. S. Wong, A. H. | West J Emerg Med | 2023 |
Humans, *Racism, *Delirium/diagnosis, agitation, emergency medicine |
| Haloperidol vs. placebo for the treatment of delirium in ICU patients: a pre-planned, secondary Bayesian analysis of the AID-ICU trial | Andersen-Ranberg, N. C. Poulsen, L. M. Perner, A. Hästbacka, J. Morgan, M. Citerio, G. Collet, M. O. Weber, S. O. Andreasen, A. S. Bestle, M. Uslu, B. Pedersen, H. S. Nielsen, L. G. Damgaard, K. Jensen, T. B. Sommer, T. Dey, N. Mathiesen, O. Granholm, A. | Intensive Care Med | 2023 |
Bayesian analysis, Delirium, Haloperidol, ICU, acute |
| Factors associated with intensive care unit delirium in patients with acute myocardial infarction | Aono-Setoguchi, H. Sakakura, K. Jinnouchi, H. Taniguchi, Y. Tsukui, T. Watanabe, Y. Yamamoto, K. Seguchi, M. Wada, H. Fujita, H. | Heart Vessels | 2023 |
Humans, Female, Child, Male, *Delirium, Retrospective Studies, Hospital Mortality, Intensive Care Units, *Myocardial Infarction, *Coronary Artery Disease, Acute myocardial infarction, Cam-icu, Delirium, Intensive care unit |
| Cortical reactivity to transcranial magnetic stimulation predicts risk of post-stroke delirium | Bai, Y. Belardinelli, P. Thoennes, C. Blum, C. Baur, D. Laichinger, K. Lindig, T. Ziemann, U. Mengel, A. | Cortical reactivity to transcranial magnetic stimulation predicts risk of post-stroke delirium | 2023 |
Humans, Cross-Sectional Studies, *Delirium/etiology, *Electroencephalography, *Stroke/complications/physiopathology, *Transcranial Magnetic Stimulation, *Cerebral Cortex/physiopathology, Risk, Delirium prediction, Natural frequency, Perturbational complexity index, Stroke, Tms-eeg |
| Does melatonin administration reduce the incidence of postoperative delirium in adults? Systematic review and meta-analysis | Barnes, J. Sewart, E. Armstrong, R. A. Pufulete, M. Hinchliffe, R. Gibbison, B. Mouton, R. | BMJ Open | 2023 |
Humans, Adult, *Melatonin/therapeutic use, *Emergence Delirium, Incidence, Length of Stay, adult anaesthesia, clinical pharmacology, neurology, psychiatry, surgery, therapeutics |
| Delirium and Behavioral Symptoms in Persons With Dementia at Hospital Admission: Mediating Factors | Boltz, M. Kuzmik, A. Resnick, B. BeLue, R. Jao, Y. L. Paudel, A. Behrens, L. Leslie, D. Sinvani, L. Galvin, J. E. | Alzheimer Dis Assoc Disord | 2023 |
dementia, delirium, behavioral symptoms, delirium severity, hospital admission |
| The impact of rounds with a psychiatry team in the intensive care unit: A prospective observational pilot study evaluating the effects on delirium incidence and outcomes | Choi, K. J. Tan, M. Jones, K. Sheski, D. Cho, S. Garrick, T. Yau, A. Solio, D. Sinclair, K. Cervantes, E. Castillo, R. A. Clark, D. Biswas, S. Alvarez, C. Grunstein, I. Cobb, J. P. Kuza, C. M. | J Psychiatr Res | 2023 |
Adult, Humans, *Delirium/epidemiology/prevention & control, Prospective Studies, Pilot Projects, Incidence, Aftercare, Patient Discharge, Intensive Care Units, Length of Stay, Critical care, Delirium prevention, Multidisciplinary care, Postoperative delirium |
| Brain injury biomarkers do not predict delirium in acutely ill older patients: a prospective cohort study | de Alencar, J. C. G. Garcez, F. B. Pinto, A. A. S. Silva, Loje Soler, L. M. Fernandez, S. S. M. Van Vaisberg, V. Gomez Gomez, L. M. Ribeiro, S. M. L. Avelino-Silva, T. J. Souza, H. P. | Sci Rep | 2023 |
Humans, Aged, Prospective Studies, Biomarkers, Inflammation/complications, *Brain Injuries/complications, *Delirium/etiology |
| Standardized pharmacological management of delirium after on-pump cardiac surgery reduces ICU stay and ventilation in a retrospective pre-post study | Deininger, M. M. Schnitzler, S. Benstoem, C. Simon, T. P. Marx, G. Panagiotidis, D. Ziles, D. Schnoering, H. Karasimos, E. Breuer, T. | Sci Rep | 2023 |
Humans, Retrospective Studies, *Emergence Delirium, Respiration, *Cardiac Surgical Procedures/adverse effects, Postoperative Complications/drug therapy/etiology, Intensive Care Units |
| Thiamine Administration and the Prevalence of Delirium in the Intensive Care Unit: A Retrospective Before and After Interventional Study | Dichtwald, S. Varbarbut, N. Dana, E. Zohar, E. Ifrach, N. Fredman, B. | Isr Med Assoc J | 2023 |
Humans, Retrospective Studies, Prospective Studies, Prevalence, Thiamine |
| The effects of computerised cognitive training on post-CABG delirium and cognitive change: A prospective randomised controlled trial | Greaves, D. Astley, J. Psaltis, P. J. Lampit, A. Davis, D. H. Ghezzi, E. S. Smith, A. E. Bourke, A. Worthington, M. G. Valenzuela, M. J. Keage, H. A. | Delirium (Bielef) | 2023 |
Coronary artery bypass grafting, cognition, cognitive training, delirium, post-operative |
| Risk Factors and 120-Day Functional Outcomes of Delirium After Hip Fracture Surgery: A Prospective Cohort Study Using the UK National Hip Fracture Database (NHFD) | Hawley, S. Inman, D. Gregson, C. L. Whitehouse, M. Johansen, A. Judge, A. | J Am Med Dir Assoc | 2023 |
4at, Hip fracture, cognitive decline, delirium, epidemiology, recovery |
| In a secondary analysis from a randomised, double-blind placebo-controlled trial Dexmedetomidine blocks cholinergic dysregulation in delirium pathogenesis in patients with major surgery | Jacob, Y. Schneider, B. Spies, C. Heinrich, M. von Haefen, C. Kho, W. Pohrt, A. Müller, A. | Sci Rep | 2023 |
Humans, *Dexmedetomidine/pharmacology/therapeutic use, Acetylcholinesterase, Butyrylcholinesterase, *Delirium/drug therapy/etiology, *Emergence Delirium/drug therapy, Double-Blind Method |
| Relationship between neutrophil/lymphocyte ratio and postoperative delirium in elderly patients with proximal femoral nail anti-rotation for intertrochanteric fractures | Ji, S. Li, Z. Li, M. Lu, Y. Ma, T. Qi, H. Cui, Y. Du, B. Huang, Q. Zhang, K. Lin, H. Yang, Y. | Am J Transl Res | 2023 |
Pfna, Postoperative delirium, intertrochanteric fracture, neutrophil/lymphocyte ratio, risk factor |
| Association of drug burden index with delirium in community-dwelling older adults with dementia: a longitudinal observational study | Katipoglu, B. Demircan, S. K. Naharci, M. I. | Int J Clin Pharm | 2023 |
Adverse effect, Anticholinergic, Delirium, Dementia, Drug burden index, Older adults, Risk factors, Sedatives |
| The Usefulness of Quantitative Electroencephalography in Diagnosis and Severity Evaluation of Delirium: A Retrospective Study | Kim, S. B. Bong, S. H. Lee, J. H. Choi, T. Y. Yoon, S. Y. Kim, J. W. | Psychiatry Investig | 2023 |
Biomarker, Delirium, Disease severity, Electroencephalography, Retrospective study |
| Associations of albumin and nutritional index factors with delirium in patients admitted to the cardiac intensive care unit | Kim, T. W. Ko, R. E. Na, S. J. Chung, C. R. Choi, K. H. Park, C. M. Yang, J. H. | Front Cardiovasc Med | 2023 |
albumin, cardiac intensive care unit, delirium, malnutrition, nutrition indexes |
| The Perioperative Frontal Relative Ratio of the Alpha Power of Electroencephalography for Predicting Postoperative Delirium After Highly Invasive Surgery: A Prospective Observational Study | Kinoshita, H. Saito, J. Kushikata, T. Oyama, T. Takekawa, D. Hashiba, E. Sawa, T. Hirota, K. | Anesth Analg | 2023 |
postoperative delirium, electroencephalography, cancer, inflammatory markers, predictive model |
| Six-Year Cognitive Trajectory in Older Adults Following Major Surgery and Delirium | Kunicki, Z. J. Ngo, L. H. Marcantonio, E. R. Tommet, D. Feng, Y. Fong, T. G. Schmitt, E. M. Travison, T. G. Jones, R. N. Inouye, S. K. | JAMA Intern Med | 2023 |
dementia, delirium, older adults, prospective study, Cognitive Trajectory, follow-up, surgical |
| Risk factors and effect of postoperative delirium on adverse surgical outcomes in older adults after elective abdominal cancer surgery in Taiwan | Lai, C. C. Liu, K. H. Tsai, C. Y. Hsu, J. T. Hsueh, S. W. Hung, C. Y. Chou, W. C. | Asian J Surg | 2023 |
Humans, Aged, *Emergence Delirium/complications, *Delirium/etiology/complications, Taiwan/epidemiology, Postoperative, Complications/epidemiology/etiology, *Abdominal Neoplasms/surgery, Risk Factors, Treatment Outcome, Cancer surgery, Delirium, Elderly, Oncogeriatric patient, Taiwan |
| Nurses' knowledge, barriers and practice in the care of patients with delirium in the intensive care unit in Poland-A cross-sectional study | Lange, S. Mȩdrzycka-Da Browska, W. Tomaszek, L. Wujtewicz, M. Krupa, S. | Front Public Health | 2023 |
Humans, Female, Cross-Sectional Studies, Clinical Competence, Poland, *Delirium/diagnosis, Health Knowledge, Attitudes, Practice, *Nursing Staff,, Hospital/psychology, Intensive Care Units, Icu, barriers, delirium, delirium assessment, evidence-based nursing practice, knowledge, nursing practice |
| Risk factors for delirium among patients with advanced cancer in palliative care: a multicenter, patient-based registry cohort in South Korea | Lee, S. W. Jung, E. H. Kim, H. J. Min, C. Yoo, S. H. Kim, Y. J. Rha, S. Y. Yon, D. K. Kang, B. | Eur Rev Med Pharmacol Sci | 2023 |
Humans, Male, Aged, Palliative Care, Analgesics, Opioid, Cohort Studies, Thinness/complications, *Delirium/epidemiology, *Neoplasms/complications/epidemiology, Risk Factors, Republic of Korea/epidemiology, Registries |
| Prophylactic dexmedetomidine use did not decrease the incidence of delirium in patients undergoing cardiac surgery: A meta-analysis | Li, W. Liu, H. Yang, C. | Perfusion | 2022 |
Humans, Incidence, Bradycardia/epidemiology/etiology, *Cardiac Surgical, Procedures/adverse effects, Intensive Care Units, *Hypotension/etiology, *Delirium/epidemiology/etiology/prevention & control, Randomized Controlled, Trials as Topic, cardiac surgery, delirium, dexmedetomidine, meta-analysis, randomized controlled trials |
| Preoperative serum ribose concentrations may be associated with postoperative delirium in older patients with a hip fracture | Liu, K. Chen, L. Zou, B. Liu, T. Han, D. Wang, Q. Mi, X. Kang, N. Hong, J. Li, Y. Li, Y. Guo, X. Li, Z. Yang, N. | Clin Neurol Neurosurg | 2023 |
Humans, Aged, *Emergence Delirium/complications, Ribose, *Delirium/diagnosis/etiology, *Hip Fractures/complications/surgery, Postoperative Complications, Biomarkers, Hip fracture, Molecular biomarker, Older patient, Postoperative delirium |
| Correlation and influencing factors of preoperative anxiety, postoperative pain, and delirium in elderly patients undergoing gastrointestinal cancer surgery | Liu, Q. Li, L. Wei, J. Xie, Y. | BMC Anesthesiol | 2023 |
Aged, Humans, *Emergence Delirium/epidemiology, Postoperative, Complications/epidemiology/etiology, *Delirium/etiology/complications, Pain,, Postoperative/epidemiology/complications, Anxiety/epidemiology, Risk Factors, *Gastrointestinal Neoplasms/complications/surgery, Anxiety, Delirium, Elderly, Gastrointestinal cancer, Pain |
| Postoperative delirium and its influencing factors in elderly patients with lung cancer in the intensive care unit | Lu, Y. Liu, X. | J Thorac Dis | 2023 |
Lung cancer, elderly patients, factors, intensive care unit (ICU), postoperative delirium (POD) |
| Dexmedetomidine for the prevention of delirium in adults admitted to the intensive care unit or post-operative care unit: A systematic review of randomised clinical trials with meta-analysis and Trial Sequential Analysis | Maagaard, M. Barbateskovic, M. Andersen-Ranberg, N. C. Kronborg, J. R. Chen, Y. X. Xi, H. H. Perner, A. Wetterslev, J. | Acta Anaesthesiol Scand | 2023 |
Adult, Humans, Critical Care, *Delirium/prevention & control, *Dexmedetomidine/therapeutic use, Hospitalization, Intensive Care Units, delirium, dexmedetomidine, intensive care unit, meta-analysis, post-operative, systematic review |
| Delirium: Prevalence and outcome in the very old in 27 medical departments during a one-year prospective study | Marquetand, J. Bode, L. Fuchs, S. Ernst, J. von Känel, R. Boettger, S. | Palliat Support Care | 2022 |
Humans, Prospective Studies, Prevalence, *Delirium/diagnosis, Critical Care, Nursing Homes, Intensive Care Units, Risk Factors, Consultation, Death, Loss of independence, Psychiatric, Risk, Services |
| Pharmacological prevention of postoperative delirium in patients undergoing cardiac surgery: a bayesian network meta-analysis | Meco, M. Giustiniano, E. Cecconi, M. Albano, G. | J Anesth | 2023 |
Humans, *Emergence Delirium/prevention & control/complications, Network, Meta-Analysis, Bayes Theorem, *Delirium/etiology/prevention & control/epidemiology, *Cardiac Surgical Procedures/adverse effects, Postoperative Complications/epidemiology, Cardiac surgery, Pharmacological prevention, Postoperative delirium, Randomized controlled trials meta-analysis |
| Development and validation of a delirium risk prediction model using a modified version of the Delirium Elderly at Risk (mDEAR) screen in hospitalized patients aged 65 and older: A medical record review | Meehan, A. J. Gabra, J. N. Distelhorst, K. S. Whyde, C. Mangira, C. | Acta Psychiatr Scand | 2023 |
Delirium, Delirium risk prediction older adults, Nursing delirium admission screen, aged, screening |
| Evaluating the performance of machine learning methods for risk estimation of delirium in patients hospitalized from the emergency department | Mueller, B. Street, W. N. Carnahan, R. M. Lee, S. | Acta Psychiatr Scand | 2023 |
delirium, emergency department, risk estimation, health record review, machine learning |
| Relationship between angiotensin-converting enzyme inhibitors and angiotensin receptor blockers prescribing and delirium in the ICU-A secondary analysis | Mulkey, M. A. Khan, S. Perkins, A. Gao, S. Wang, S. Campbell, N. Khan, B. | J Am Geriatr Soc | 2023 |
ACE inhibitor, angiotensin receptor blocker, critical care, delirium, intensive care |
| Bispectral EEG (BSEEG) Algorithm Captures High Mortality Risk Among 1,077 Patients: Its Relationship to Delirium Motor Subtype | Nishizawa, Y. Yamanashi, T. Saito, T. Marra, P. Crutchley, K. J. Wahba, N. E. Malicoat, J. Shibata, K. Nishiguchi, T. Lee, S. Cho, H. R. Kanazawa, T. Shinozaki, G. | Am J Geriatra Psychiatry | 2023 |
Bseeg, Bispectral electroencephalogram, delirium, mortality, motor subtype |
| Computable Phenotypes to Characterize Changing Patient Brain Dysfunction in the Intensive Care Unit | Ren, Y. Loftus, T. J. Guan, Z. Uddin, R. Shickel, B. Maciel, C. B. Busl, K. Rashidi, P. Bihorac, A. Ozrazgat-Baslanti, T. | ArXiv | 2023 |
Acute brain dysfunction, delirium, Intensive Care Unit, automated computable phenotypes, algorithm |
| Association between obstructive sleep apnea and atrial fibrillation and delirium after cardiac surgery. Sub-analysis of DECADE trial | Rivas, E. Shehata, P. Bravo, M. Almonacid-Cardenas, F. Shah, K. Kopac, O. Ruetzler, K. Troianos, C. A. Turan, A. | J Clin Anesth | 2023 |
Atrial fibrillation, Cardiac surgery, Delirium, Obstructive sleep apnea, Intensive Care Unit |
| Spinal Dexamethasone Effect on Cognitive Disorders After Hip Surgery | Sakic, L. Tonkovicc, D. Hrgovic, Z. Klasan, A. | Med Arch | 2023 |
Humans, Aged, Levobupivacaine, Hydrocortisone, *Cognition Disorders, *Cognitive Dysfunction, Dexamethasone/therapeutic use, delirium, dexamethasone, proximal femoral fracture, spinal anesthesia |
| Effects of Melatonin Administration on Post-Stroke Delirium in Patients with Intracerebral Hemorrhage | Siokas, V. Roesch, S. Stefanou, M. I. Buesink, R. Wilke, V. Sartor-Pfeiffer, J. Adeyemi, K. Poli, S. Dardiotis, E. Ziemann, U. Feil, K. Mengel, A. | J Clin Med | 2023 |
intracerebral hemorrhage, melatonin, post-stroke delirium, prospective study, stroke unit |
| Clinical Risk Group as a predictor of mortality in delirious older adults in the emergency department | Soler-Sanchis, A. Martínez-Arnau, F. M. Sánchez-Frutos, J. Pérez-Ros, P. | Exp Gerontol | 2023 |
Male, Humans, Aged, Aged, 80 and over, Female, Prospective Studies, *Delirium/diagnosis/complications, Hospitalization, Risk Factors, Emergency Service, Hospital, Chronicity, Delirium, Emergency department, Survival |
| Plasma biomarkers and delirium in critically ill patients after cardiac surgery: A prospective observational cohort study | Su, L. J. Chen, M. J. Yang, R. Zou, H. Chen, T. T. Li, S. L. Guo, Y. Hu, R. F. | Heart Lung | 2023 |
Humans, Middle Aged, Prospective Studies, Tumor Necrosis Factor-alpha, Interleukin-6, *Delirium/diagnosis/etiology, Critical Illness, Biomarkers, Intensive Care Units, *Cardiac Surgical Procedures/adverse effects, Cardiac surgery, Delirium, Intensive care unit |
| Safety of baclofen versus tizanidine for older adults with musculoskeletal pain | Su Zhang, V. R. Niu, F. Lee, E. A. DiStasio, C. Broder, B. I. Steinberg, S. G. Hui, R. L. | J Am Geriatr Soc | 2023 |
baclofen, delirium, injury, safety, tizanidine |
| Delirium Risk Score in Elderly Patients with Cervical Spinal Cord Injury and/or Cervical Fracture | Tanner, M.Tamai, K. Terai, H. Nakamura, H. Yokogawa, N. Sasagawa, T. Nakashima, H. Segi, N. Ito, S. Funayama, T. Eto, F. Yamaji, A. Watanabe, K. Yamane, J. Takeda, K. Furuya, T. Yunde, A. Nakajima, H. Yamada, T. Hasegawa, T. Terashima, Y. Hirota, R. Suzuk | J Clin Med | 2023 |
cervical fracture, cervical spinal cord injury, delirium, elderly, prediction |
| Persistent delirium in older hospital patients: an updated systematic review and meta-analysis | Whitby, J. Nitchingham, A. Caplan, G. Davis, D. Tsui, A. | PLoS One | 2022 |
Humans, Aged, *Delirium/etiology, Inpatients, *Cognition Disorders/complications, *Cognitive Dysfunction/complications, Risk Factors, Geriatric Assessment |
| Delirium in older hospitalized patients-A prospective analysis of the detailed course of delirium in geriatric inpatients | Wilke, S. Steiger, E. Bärwolff, T. L. Kleine, J. F. Müller-Werdan, U. Rosada, A. | PLoS One | 2023 |
Humans, Aged, *Delirium/etiology, Inpatients, *Cognition Disorders/complications, *Cognitive Dysfunction/complications, Risk Factors, Geriatric Assessment |
| Anti-inflammatory medication use associated with reduced delirium risk and all-cause mortality: A retrospective cohort study | Yamanashi, T. Sullivan, E. J. Comp, K. R. Nishizawa, Y. Akers, C. C. Chang, G. Modukuri, M. Tran, T. Anderson, Z. E. M. Marra, P. S. Crutchley, K. J. Wahba, N. E. Iwata, M. Karam, M. D. Noiseux, N. O. Cho, H. R. Shinozaki, G. | J Psychosom Res | 2023 |
Anti-inflammatory medication, Delirium, Glucosamine, Mortality, NSAIDs |
| Application of a flexible visitation system in critically ill patients: A randomized clinical trial | Yang, H. Y. Feng, F. Yang, W. W. Chen, Y. | Sci Prog | 2023 |
Humans, Critical Illness/therapy, *Delirium, Intensive Care Units, Length of Stay, *Cross Infection, ChiCTR2200059093, Flexible visitation system, Trial registration: ChiCTR, delirium, high-quality care |
| Association between preoperative anxiety and postoperative delirium in older patients: a systematic review and meta-analysis | Yang, K. L. Detroyer, E. Van Grootven, B. Tuand, K. Zhao, D. N. Rex, S. Milisen, K. | BMC Geriatr | 2023 |
Humans, Aged, 80 and over, *Emergence Delirium, *Delirium/diagnosis/epidemiology/etiology, Prospective Studies, Anxiety/diagnosis, Postoperative, Complications/diagnosis/epidemiology/etiology, Risk Factors |
| Ramelteon for delirium prevention in hospitalized patients: An updated meta-analysis and trial sequential analysis of randomized controlled trials | Yu, C. L. Carvalho, A. F. Thompson, T. Tsai, T. C. Tseng, P. T. Tu, Y. K. Yang, S. N. Yang, F. C. Chang, C. H. Hsu, C. W. Hsu, T. W. Liang, C. S. | J Pineal Res | 2023 |
Humans, Middle Aged, *Delirium/prevention & control/drug therapy/epidemiology, *Melatonin/therapeutic use, Randomized Controlled Trials as Topic, Reproducibility of Results, delirium prevention, hospitalized patients, meta-analysis, ramelteon, trial sequential analysis |
| A large-scale causal analysis of gut microbiota and delirium: A Mendelian randomization study | Yu, H. Wan, X. Yang, M. Xie, J. Xu, K. Wang, J. Wang, G. Xu, P. | J Affect Disord | 2023 |
Humans, *Gastrointestinal Microbiome/genetics, Mendelian Randomization, Analysis, Causality, *Delirium/epidemiology/genetics, Genome-Wide Association Study, Causal correlation, Delirium, Gut microbiota, Large scale analysis, Mendelian randomization |
| Effectiveness of dexmedetomidine on postoperative cognitive dysfunction in elderly patients with fracture: A systematic review | Zeng, T., Lv, J., Cui, Y., Li, X., F. Zhang, Q. | Medicine (Baltimore) | 2023 |
Aged, Humans, Cognition, *Cognitive Dysfunction/etiology,, *Delirium/epidemiology/etiology, *Dexmedetomidine/adverse effects, *Postoperative Cognitive Complications, Postoperative, Complications/epidemiology, Randomized Controlled Trials as Topic |
| Pharmacologic Interventions to Prevent Delirium in Trauma Patients: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials | Zitikyte, G. Roy, D. C. Tran, A. Fernando, S. M. Rosenberg, E. Kanji, S. Engels, P. T. Wells, G. A. & Vaillancourt, C. | Crit Care Explor | 2023 |
critical care, delirium, dexmedetomidine, propofol, systematic review, trauma, interest |
| A novel predictive model for postoperative delirium using multiple geriatric screening factors | Yajima, S. Nakanishi, Y. Sugimoto, M. Kobayashi, S. Kudo, M. Yasujima, R. Hirose, K. Sekiya, K. Umino, Y. Okubo, N. Kataoka, M. Gotohda, N. Masuda, H. | J Surg Oncol | 2023 |
Mini-Cog |
| The Effect of Consultation-Liaison Psychiatry on Postoperative Delirium in Elderly Hip Fracture Patients in the General Hospital | Xie, Q. Liu, X. B. Jing, G. W. Jiang, X. Liu, H. Zhong, B. L. Li, Y. | Orthop Surg | 2023 |
Humans |
| Quantitative EEG signatures of delirium and coma in mechanically ventilated ICU patients | Williams Roberson, S. Azeez, N. A. Fulton, J. N. Zhang, K. C. Lee, A. X. T. Ye, F. Pandharipande, P. Brummel, N. E. Patel, M. B. Ely, E. W. | Clin Neurophysiol | 2023 |
Humans |
| Delirium in trauma ICUs: a review of incidence, risk factors, outcomes, and management | Williams, E. C. Estime, S. Kuza, C. M. | Curr Opin Anaesthesiol | 2023 | |
| Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients | Watne, L. O. Pollmann, C. T. Neerland, B. E. Quist-Paulsen, E. Halaas, N. B. Idland, A. V. Hassel, B. Henjum, K. Knapskog, A. B. Frihagen, F. Raeder, J. Godø, A. Ueland, P. M. McCann, A. Figved, W. Selbæk, G. Zetterberg, H. Fang, E. F. Myrstad, M. Giil, | J Clin Invest | 2023 |
Humans |
| Effect of perioperative benzodiazepine use on intraoperative awareness and postoperative delirium: a systematic review and meta-analysis of randomised controlled trials and observational studies | Wang, E. Belley-Côté, E. P. Young, J. He, H. Saud, H. D'Aragon, F. Um, K. Alhazzani, W. Piticaru, J. Hedden, M. Whitlock, R. Mazer, C. D. Kashani, H. H. Zhang, S. Y. Lucas, A. Timmerman, N. Nishi, C. Jain, D. Kugler, A. Beaver, C. Kloppenburg, S. Schulm | Br J Anaesth | 2023 |
benzodiazepines |
| Sustained adherence to a delirium guideline five years after implementation in an intensive care setting: A retrospective cohort study | van Bochove-Waardenburg, M. van der Jagt, M. de Man-van Ginkel, J. Ista, E. | Intensive Crit Care Nurs | 2023 |
Adherence |
| A survey of current practices in sedation, analgesia, withdrawal, and delirium management in paediatric cardiac ICUs | Valentine, K. Cisco, M. J. Lasa, J. J. Achuff, B. J. Kudchadkar, S. R. Staveski, S. L. | Cardiol Young | 2023 |
Delirium |
| Understanding the association between admission source and in-hospital delirium: A cross-sectional study | Thomas, M. K. Heincelman, M. E. Zhang, J. Marsden, J. Dulin, J. Robbins, P. Hunt, K. Mauldin, P. Moran, W. P. Kalivas, B. | J Investig Med | 2023 |
Adult |
| Sevoflurane dose and postoperative delirium: a prospective cohort analysis | Taylor, J. Payne, T. Casey, C. Kunkel, D. Parker, M. Rivera, C. Zetterberg, H. Blennow, K. Pearce, R. A. Lennertz, R. C. McCulloch, T. Gaskell, A. Sanders, R. D. | Br J Anaesth | 2023 |
Humans |
| Efficacy of transcranial direct current stimulation on postoperative delirium in elderly patients undergoing lower limb major arthroplasty: A randomized controlled trial | Tao, M. Zhang, S. Han, Y. Li, C. Wei, Q. Chen, D. Zhao, Q. Yang, J. Liu, R. Fang, J. Li, X. Zhang, H. Liu, H. Cao, J. L. | Brain Stimul | 2023 |
Lower limb major arthroplasty |
| Medical and economic burden of delirium on hospitalization outcomes of acute respiratory failure: A retrospective national cohort | Taha, A. Xu, H. Ahmed, R. Karim, A. Meunier, J. Paul, A. Jawad, A. Patel, M. L. | Medicine (Baltimore) | 2023 |
Humans |
| Poor prognostic impact of delirium: especially on mortality and institutionalisation | Tachibana, M. Inada, T. | Psychogeriatrics | 2023 |
Humans |
| Processed electroencephalography-guided general anaesthesia to reduce postoperative delirium: a systematic review and meta-analysis | Sumner, M. Deng, C. Evered, L. Frampton, C. Leslie, K. Short, T. Campbell, D. | Br J Anaesth | 2023 |
Humans |
| Expanding options to include language barriers for predicting postoperative delirium in geriatric patients | Streetman, D. Hagley, A. Shalom, M. Gendreau, J. L. | J Am Geriatr Soc | 2023 |
Humans |
| Comparison of logistic regression and machine learning methods for predicting postoperative delirium in elderly patients: A retrospective study | Song, Y. X. Yang, X. D. Luo, Y. G. Ouyang, C. L. Yu, Y. Ma, Y. L. Li, H. Lou, J. S. Liu, Y. H. Chen, Y. Q. Cao, J. B. Mi, W. D. | CNS Neurosci Ther | 2023 |
Humans |
| Effects of anti-ulcer drugs on delirium in trauma patients | Sogawa, R. Matsuoka, A. Murakawa-Hirachi, T. Kikkawa, N. Kamo, M. Tobita, S. Shinada, K. Mizoguchi, Y. Monji, A. Sakamoto, Y. Shimanoe, C. | Gen Hosp Psychiatry | 2023 |
Humans |
| Delirium superimposed on dementia in post-acute care: Nurse documentation of symptoms and interventions | Sillner, A. Y. Berish, D. Mailhot, T. Sweeder, L. Fick, D. M. Kolanowski, A. M. | Geriatr Nurs | 2023 |
Humans |
| Postoperative Delirium after Dexmedetomidine versus Propofol Sedation in Healthy Older Adults Undergoing Orthopedic Lower Limb Surgery with Spinal Anesthesia: A Randomized Controlled Trial | Shin, H. J. Woo Nam, S. Kim, H. Yim, S. Han, S. H. Hwang, J. W. Do, S. H. Na, H. S. | Anesthesiology | 2023 |
Humans |
| Preoperative characterization of baseline EEG recordings for risk stratification of post-anesthesia care unit delirium | Schüßler, J. Ostertag, J. Georgii, M. T. Fleischmann, A. Schneider, G. Pilge, S. Kreuzer, M. | J Clin Anesth | 2023 |
Anesthesia |
| Certified Nursing Assistants' Perspectives on Delirium Care | Sabbe, K. Aerts, N. van der Mast, R. Van Rompaey, B. | J Gerontol Nurs | 2023 |
Humans |
| Neurophysiologic predictors of individual risk for post-operative delirium after elective surgery | Ross, J. M. Santarnecchi, E. Lian, S. J. Fong, T. G. Touroutoglou, A. Cavallari, M. Travison, T. G. Marcantonio, E. R. Libermann, T. A. Schmitt, E. M. Inouye, S. K. Shafi, M. M. Pascual-Leone, A. | J Am Geriatr Soc | 2023 |
Humans |
| Nighttime dexmedetomidine for delirium prevention in non-mechanically ventilated patients after cardiac surgery (MINDDS): A single-centre, parallel-arm, randomised, placebo-controlled superiority trial | Qu, J. Z. Mueller, A. McKay, T. B. Westover, M. B. Shelton, K. T. Shaefi, S. D'Alessandro, D. A. Berra, L. Brown, E. N. Houle, T. T. Akeju, O. | EClinicalMedicine | 2023 |
Cardiac surgery |
| Effect of seasons on delirium in postoperative critically ill patients: a retrospective analysis | Qiu, Y. Rivas, E. Tanios, M. Sreedharan, R. Mao, G. Ince, I. Salih, A. Saab, R. Devarajan, J. Ruetzler, K. Turan, A. | Braz J Anesthesiol | 2023 |
Adult |
| Transcutaneous electrical acupoint stimulation combined with an integrated perioperative nursing program prevents subsyndromal delirium in older patients after joint replacement | Qian, J. He, M. Zhan, X. Ren, L. Sun, Q. | Geriatr Nurs | 2023 |
Humans |
| Web-Based Delirium Prevention Application for Long-Term Care Facilities | Park, M. Moon, K. J. | J Am Med Dir Assoc | 2023 |
Delirium |
| The effect of all-cause hospitalization on cognitive decline in older adults: a longitudinal study using databases of the National Health Insurance Service and the memory clinics of a self-run hospital | Park, D. Kim, H. S. Kim, J. H. | BMC Geriatr | 2023 |
Humans |
| Investigating nurses' knowledge and attitudes about delirium in older persons: a cross-sectional study | Papaioannou, M. Papastavrou, E. Kouta, C. Tsangari, H. Merkouris, A. | BMC Nurs | 2023 |
Acute confusion |
| Risk factors and consequences of post-esophagectomy delirium: a systematic review and meta-analysis | Papaconstantinou, D. Frountzas, M. Ruurda, J. P. Mantziari, S. Tsilimigras, D. I. Koliakos, N. Tsivgoulis, G. Schizas, D. | Dis Esophagus | 2023 |
anastomotic leakage |
| Natural Language Processing CAM Algorithm Improves Delirium Detection Compared With Conventional Methods | Pagali, S. R. Kumar, R. Fu, S. Sohn, S. Yousufuddin, M. | Am J Med Qual | 2023 |
Humans |
| Predisposing and Precipitating Factors Associated With Delirium: A Systematic Review | Ormseth, C. H. LaHue, S. C. Oldham, M. A. Josephson, S. A. Whitaker, E. Douglas, V. C. | JAMA Netw Open | 2023 |
Adult |
| Prevalence of pre-operative undiagnosed cognitive impairment and its association with handgrip strength, oral hygiene, and nutritional status in older elective surgical patients in Japan | Nakatani, S. Ida, M. Uyama, K. Kinugasa, Y. Kawaguchi, M. | J Anesth | 2023 |
Humans |
| Preoperative anxiety as an independent predictor of postoperative delirium in older patients undergoing elective surgery for lumbar disc herniation | Mou, Q. Gao, M. Liu, X. Wei, C. Lan, G. Zhao, X. Shan, Y. Wu, C. | Aging Clin Exp Res | 2023 |
Humans |
| Tracheostomy Is Associated With a Decrease in Delirium and Sedation for Intubated COVID-19 Patients | Morton, C. Pisani, M. Doyle, M. Puchalski, J | J Bronchology Interv Pulmonol | 2023 |
Humans |
| Characterising the prodromal phase in dementia with Lewy bodies | Mellergaard, C. Waldemar, G. Vogel, A. Frederiksen, K. S. | Parkinsonism Relat Disord | 2023 |
Humans |
| Mobilisation in the EveNing to TreAt deLirium (MENTAL): protocol for a mixed-methods feasibility randomised controlled trial | McWilliams, D. King, E. Nydahl, P. Darbyshire, J. L. Gallie, L. Barghouthy, D. Bassford, C. Gustafson, O. | BMJ Open | 2023 |
Humans |
| Could a Tailored Exercise Intervention for Hospitalised Older Adults Have a Role in the Resolution of Delirium? Secondary Analysis of a Randomised Clinical Trial | Martinez Velilla, N. Lozano-Vicario, L. Sáez de Asteasu, M. L. Zambom-Ferraresi, F. Galbete, A. Sanchez-Latorre, M. Izquierdo, M. | J Frailty Aging | 2023 |
Humans |
| Dexmedetomidine for the prevention of delirium in adults admitted to the intensive care unit or postoperative care unit: a systematic review of randomised clinical trials with meta-analysis and Trial Sequential Analysis | Maagaard, M. Barbateskovic, M. Andersen-Ranberg, N. C. Kronborg, J. R. Chen, Y. X. Xi, H. H. Perner, A. Wetterslev, J. | Acta Anaesthesiol Scand | 2023 |
Dexmedetomidine |